1. Clinical potential of SLAMF7 antibodies – focus on elotuzumab in multiple myeloma
- Author
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Friend,Reed, Bhutani,Manisha, Voorhees,Peter, Usmani,Saad, Friend,Reed, Bhutani,Manisha, Voorhees,Peter, and Usmani,Saad
- Abstract
Reed Friend, Manisha Bhutani, Peter M Voorhees, Saad Z Usmani Department of Hematologic Oncology & Blood Disorders, Levine Cancer Institute, Carolinas Healthcare System, UNC School of Medicine, Charlotte, NC, USA Abstract: Elotuzumab is one of the first monoclonal antibodies to be approved for the treatment of multiple myeloma. It is a humanized immunoglobulin G kappa (IgGκ) antibody that targets signaling lymphocytic activation molecule family member 7 (SLAMF7), a surface marker that is highly expressed on normal and malignant plasma cells. This review summarizes the preclinical and clinical data that led to the approval of elotuzumab, along with a discussion on the ongoing and future clinical investigations. Keywords: multiple myeloma, relapsed, refractory, treatment, elotuzumab, SLAMF7, CS1
- Published
- 2017