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Agnieszka Batko-Szwaczka,1 Tomasz Francuz,2 Agnieszka Kosowska,2 Anna Cogiel,1 Joanna Dudzińska-Griszek,1 Krzysztof Wilczyński,1 Beata Hornik,3 Magdalena Janusz-Jenczeń,3 Iwona Włodarczyk,3 Bartosz Wnuk,4 Joanna Szołtysek,4 Jacek Durmała,4 Jan Dulawa,5 Jan Szewieczek1 1Department of Geriatrics, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland; 2Department of Biochemistry, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland; 3Department of Internal Nursing, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland; 4Department of Rehabilitation, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland; 5Department of Internal Medicine and Metabolic Diseases, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, PolandCorrespondence: Agnieszka Batko-Szwaczka, Department of Geriatrics, Faculty of Health Sciences in Katowice, Medical University of Silesia, Poniatowskiego 15, Katowice, 40-055, Poland, Tel +48323598239, Fax +48322059483, Email abatko-szwaczka@sum.edu.plBackground: Societal aging – as a global demographic phenomenon – shows no indication of abating. As a result, the problem of age-associated disability and related long-term care is emerging as a major public health challenge. It is important that methods for identifying older adults at risk of adverse outcomes are implemented early.Methods: The study group consisted of 145 individuals, 44.1% women, who were randomized from community-dwelling 60– 74-year-old adults. A comprehensive geriatric assessment was supplemented with Fried frailty phenotype evaluation and blood tests (including adhesion molecules, matrix metalloproteinases and neurotrophic factors). A follow-up by phone call was made for at least 3 years after the initial examination. Composite endpoint (CE) included f