10 results on '"Fotakis, Anna Katerina"'
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2. Pan-genome Analysis of Ancient and Modern Salmonella enterica Demonstrates Genomic Stability of the Invasive Para C Lineage for Millennia
- Author
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Zhou, Zhemin, Lundstrøm, Inge Kristine Conrad, Tran-Dien, Alicia, Duchêne, Sebastián, Alikhan, Nabil-Fareed, Sergeant, Martin J., Langridge, Gemma, Fotakis, Anna Katerina, Nair, Satheesh, Stenøien, Hans K., Hamre, Stian S., Casjens, Sherwood, Christophersen, Axel, Quince, Christopher, Thomson, Nicholas R., Weill, Francois-Xavier, Ho, Simon Y. W., Gilbert, Tom, Achtman, Mark, Zhou, Zhemin, Lundstrøm, Inge Kristine Conrad, Tran-Dien, Alicia, Duchêne, Sebastián, Alikhan, Nabil-Fareed, Sergeant, Martin J., Langridge, Gemma, Fotakis, Anna Katerina, Nair, Satheesh, Stenøien, Hans K., Hamre, Stian S., Casjens, Sherwood, Christophersen, Axel, Quince, Christopher, Thomson, Nicholas R., Weill, Francois-Xavier, Ho, Simon Y. W., Gilbert, Tom, and Achtman, Mark
- Published
- 2018
3. Proteomic profiling of archaeological human bone
- Author
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Sawafuji, Rikai, Cappellini, Enrico, Nagaoka, Tomohito, Fotakis, Anna Katerina, Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper Velgaard, Hirata, Kazuaki, Ueda, Shintaroh, Sawafuji, Rikai, Cappellini, Enrico, Nagaoka, Tomohito, Fotakis, Anna Katerina, Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper Velgaard, Hirata, Kazuaki, and Ueda, Shintaroh
- Published
- 2017
4. Proteomic profiling of archaeological human bone
- Author
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Sawafuji, Rikai, Cappellini, Enrico, Nagaoka, Tomohito, Fotakis, Anna Katerina, Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper Velgaard, Hirata, Kazuaki, Ueda, Shintaroh, Sawafuji, Rikai, Cappellini, Enrico, Nagaoka, Tomohito, Fotakis, Anna Katerina, Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper Velgaard, Hirata, Kazuaki, and Ueda, Shintaroh
- Published
- 2017
5. Protein sequences bound to mineral surfaces persist into deep time
- Author
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Demarchi, Beatrice, Hall, Shaun, Roncal-Herrero, Teresa, Freeman, Colin L., Woolley, Jos, Crisp, Molly K., Wilson, Julie, Fotakis, Anna Katerina, Fischer, Roman, Kessler, Benedikt M., Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper Velgaard, Haile, James, Thomas, Jessica, Marean, Curtis W., Parkington, John, Presslee, Samantha, Lee-Thorp, Julia, Ditchfield, Peter, Hamilton, Jacqueline F., Ward, Martyn W., Wang, Chunting Michelle, Shaw, Marvin D., Harrison, Terry, Domínguez-Rodrigo, Manuel, MacPhee, Ross D. E., Kwekason, Amandus, Ecker, Michaela, Kolska Horwitz, Liora, Chazan, Michael, Kröger, Roland, Thomas-Oates, Jane, Harding, John H., Cappellini, Enrico, Penkman, Kirsty, Collins, Matthew James, Demarchi, Beatrice, Hall, Shaun, Roncal-Herrero, Teresa, Freeman, Colin L., Woolley, Jos, Crisp, Molly K., Wilson, Julie, Fotakis, Anna Katerina, Fischer, Roman, Kessler, Benedikt M., Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper Velgaard, Haile, James, Thomas, Jessica, Marean, Curtis W., Parkington, John, Presslee, Samantha, Lee-Thorp, Julia, Ditchfield, Peter, Hamilton, Jacqueline F., Ward, Martyn W., Wang, Chunting Michelle, Shaw, Marvin D., Harrison, Terry, Domínguez-Rodrigo, Manuel, MacPhee, Ross D. E., Kwekason, Amandus, Ecker, Michaela, Kolska Horwitz, Liora, Chazan, Michael, Kröger, Roland, Thomas-Oates, Jane, Harding, John H., Cappellini, Enrico, Penkman, Kirsty, and Collins, Matthew James
- Abstract
Proteins persist longer in the fossil record than DNA, but the longevity, survival mechanisms and substrates remain contested. Here, we demonstrate the role of mineral binding in preserving the protein sequence in ostrich (Struthionidae) eggshell, including from the palaeontological sites of Laetoli (3.8 Ma) and Olduvai Gorge (1.3 Ma) in Tanzania. By tracking protein diagenesis back in time we find consistent patterns of preservation, demonstrating authenticity of the surviving sequences. Molecular dynamics simulations of struthiocalcin-1 and -2, the dominant proteins within the eggshell, reveal that distinct domains bind to the mineral surface. It is the domain with the strongest calculated binding energy to the calcite surface that is selectively preserved. Thermal age calculations demonstrate that the Laetoli and Olduvai peptides are 50 times older than any previously authenticated sequence (equivalent to ~16 Ma at a constant 10°C).
- Published
- 2016
6. Protein sequences bound to mineral surfaces persist into deep time
- Author
-
Demarchi, Beatrice, Hall, Shaun, Roncal-Herrero, Teresa, Freeman, Colin L., Woolley, Jos, Crisp, Molly K., Wilson, Julie, Fotakis, Anna Katerina, Fischer, Roman, Kessler, Benedikt M., Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper Velgaard, Haile, James, Thomas, Jessica, Marean, Curtis W., Parkington, John, Presslee, Samantha, Lee-Thorp, Julia, Ditchfield, Peter, Hamilton, Jacqueline F., Ward, Martyn W., Wang, Chunting Michelle, Shaw, Marvin D., Harrison, Terry, Domínguez-Rodrigo, Manuel, MacPhee, Ross D. E., Kwekason, Amandus, Ecker, Michaela, Kolska Horwitz, Liora, Chazan, Michael, Kröger, Roland, Thomas-Oates, Jane, Harding, John H., Cappellini, Enrico, Penkman, Kirsty, Collins, Matthew James, Demarchi, Beatrice, Hall, Shaun, Roncal-Herrero, Teresa, Freeman, Colin L., Woolley, Jos, Crisp, Molly K., Wilson, Julie, Fotakis, Anna Katerina, Fischer, Roman, Kessler, Benedikt M., Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper Velgaard, Haile, James, Thomas, Jessica, Marean, Curtis W., Parkington, John, Presslee, Samantha, Lee-Thorp, Julia, Ditchfield, Peter, Hamilton, Jacqueline F., Ward, Martyn W., Wang, Chunting Michelle, Shaw, Marvin D., Harrison, Terry, Domínguez-Rodrigo, Manuel, MacPhee, Ross D. E., Kwekason, Amandus, Ecker, Michaela, Kolska Horwitz, Liora, Chazan, Michael, Kröger, Roland, Thomas-Oates, Jane, Harding, John H., Cappellini, Enrico, Penkman, Kirsty, and Collins, Matthew James
- Abstract
Proteins persist longer in the fossil record than DNA, but the longevity, survival mechanisms and substrates remain contested. Here, we demonstrate the role of mineral binding in preserving the protein sequence in ostrich (Struthionidae) eggshell, including from the palaeontological sites of Laetoli (3.8 Ma) and Olduvai Gorge (1.3 Ma) in Tanzania. By tracking protein diagenesis back in time we find consistent patterns of preservation, demonstrating authenticity of the surviving sequences. Molecular dynamics simulations of struthiocalcin-1 and -2, the dominant proteins within the eggshell, reveal that distinct domains bind to the mineral surface. It is the domain with the strongest calculated binding energy to the calcite surface that is selectively preserved. Thermal age calculations demonstrate that the Laetoli and Olduvai peptides are 50 times older than any previously authenticated sequence (equivalent to ~16 Ma at a constant 10°C).
- Published
- 2016
7. Direct evidence of milk consumption from ancient human dental calculus
- Author
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Warinner, Christina, Hendy, Jessica, Speller, Camilla, Cappellini, Enrico, Fischer, Roman, Trachsel, Christian, Arneborg, Jette, Lynnerup, Niels, Craig, Oliver, Swallow, Dallas M., Fotakis, Anna Katerina, Christensen, R. J., Olsen, Jesper Velgaard, Liebert, Anke, Montalva, Nicholas, Fiddyment, Sarah, Mackie, Meaghan, Canci, Alessandro, Bouwman, Abigail, Ruhli, Frank, Gilbert, M Thomas P, Collins, Matthew J., Warinner, Christina, Hendy, Jessica, Speller, Camilla, Cappellini, Enrico, Fischer, Roman, Trachsel, Christian, Arneborg, Jette, Lynnerup, Niels, Craig, Oliver, Swallow, Dallas M., Fotakis, Anna Katerina, Christensen, R. J., Olsen, Jesper Velgaard, Liebert, Anke, Montalva, Nicholas, Fiddyment, Sarah, Mackie, Meaghan, Canci, Alessandro, Bouwman, Abigail, Ruhli, Frank, Gilbert, M Thomas P, and Collins, Matthew J.
- Published
- 2015
8. Direct evidence of milk consumption from ancient human dental calculus
- Author
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Warinner, C., Hendy, J., Speller, C., Cappellini, Enrico, Fischer, R., Trachsel, C., Arneborg, J., Lynnerup, Niels, Craig, O. E., Swallow, D. M., Fotakis, Anna Katerina, Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper Velgaard, Liebert, A., Montalva, N., Fiddyment, S., Charlton, S., Mackie, Meaghan Emma, Canci, A., Bouwman, A., Rühli, F., Gilbert, M Thomas P, Collins, M. J., Warinner, C., Hendy, J., Speller, C., Cappellini, Enrico, Fischer, R., Trachsel, C., Arneborg, J., Lynnerup, Niels, Craig, O. E., Swallow, D. M., Fotakis, Anna Katerina, Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper Velgaard, Liebert, A., Montalva, N., Fiddyment, S., Charlton, S., Mackie, Meaghan Emma, Canci, A., Bouwman, A., Rühli, F., Gilbert, M Thomas P, and Collins, M. J.
- Abstract
Milk is a major food of global economic importance, and its consumption is regarded as a classic example of gene-culture evolution. Humans have exploited animal milk as a food resource for at least 8500 years, but the origins, spread, and scale of dairying remain poorly understood. Indirect lines of evidence, such as lipid isotopic ratios of pottery residues, faunal mortality profiles, and lactase persistence allele frequencies, provide a partial picture of this process; however, in order to understand how, where, and when humans consumed milk products, it is necessary to link evidence of consumption directly to individuals and their dairy livestock. Here we report the first direct evidence of milk consumption, the whey protein β-lactoglobulin (BLG), preserved in human dental calculus from the Bronze Age (ca. 3000 BCE) to the present day. Using protein tandem mass spectrometry, we demonstrate that BLG is a species-specific biomarker of dairy consumption, and we identify individuals consuming cattle, sheep, and goat milk products in the archaeological record. We then apply this method to human dental calculus from Greenland's medieval Norse colonies, and report a decline of this biomarker leading up to the abandonment of the Norse Greenland colonies in the 15(th) century CE.
- Published
- 2014
9. Direct evidence of milk consumption from ancient human dental calculus
- Author
-
Warinner, C., Hendy, J., Speller, C., Cappellini, Enrico, Fischer, R., Trachsel, C., Arneborg, J., Lynnerup, Niels, Craig, O. E., Swallow, D. M., Fotakis, Anna Katerina, Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper Velgaard, Liebert, A., Montalva, N., Fiddyment, S., Charlton, S., Mackie, Meaghan Emma, Canci, A., Bouwman, A., Rühli, F., Gilbert, M Thomas P, Collins, M. J., Warinner, C., Hendy, J., Speller, C., Cappellini, Enrico, Fischer, R., Trachsel, C., Arneborg, J., Lynnerup, Niels, Craig, O. E., Swallow, D. M., Fotakis, Anna Katerina, Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper Velgaard, Liebert, A., Montalva, N., Fiddyment, S., Charlton, S., Mackie, Meaghan Emma, Canci, A., Bouwman, A., Rühli, F., Gilbert, M Thomas P, and Collins, M. J.
- Abstract
Milk is a major food of global economic importance, and its consumption is regarded as a classic example of gene-culture evolution. Humans have exploited animal milk as a food resource for at least 8500 years, but the origins, spread, and scale of dairying remain poorly understood. Indirect lines of evidence, such as lipid isotopic ratios of pottery residues, faunal mortality profiles, and lactase persistence allele frequencies, provide a partial picture of this process; however, in order to understand how, where, and when humans consumed milk products, it is necessary to link evidence of consumption directly to individuals and their dairy livestock. Here we report the first direct evidence of milk consumption, the whey protein β-lactoglobulin (BLG), preserved in human dental calculus from the Bronze Age (ca. 3000 BCE) to the present day. Using protein tandem mass spectrometry, we demonstrate that BLG is a species-specific biomarker of dairy consumption, and we identify individuals consuming cattle, sheep, and goat milk products in the archaeological record. We then apply this method to human dental calculus from Greenland's medieval Norse colonies, and report a decline of this biomarker leading up to the abandonment of the Norse Greenland colonies in the 15(th) century CE.
- Published
- 2014
10. Direct evidence of milk consumption from ancient human dental calculus
- Author
-
Warinner, C., Hendy, J., Speller, C., Cappellini, Enrico, Fischer, R., Trachsel, C., Arneborg, J., Lynnerup, Niels, Craig, O. E., Swallow, D. M., Fotakis, Anna Katerina, Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper Velgaard, Liebert, A., Montalva, N., Fiddyment, S., Charlton, S., Mackie, Meaghan Emma, Canci, A., Bouwman, A., Rühli, F., Gilbert, M Thomas P, Collins, M. J., Warinner, C., Hendy, J., Speller, C., Cappellini, Enrico, Fischer, R., Trachsel, C., Arneborg, J., Lynnerup, Niels, Craig, O. E., Swallow, D. M., Fotakis, Anna Katerina, Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper Velgaard, Liebert, A., Montalva, N., Fiddyment, S., Charlton, S., Mackie, Meaghan Emma, Canci, A., Bouwman, A., Rühli, F., Gilbert, M Thomas P, and Collins, M. J.
- Abstract
Milk is a major food of global economic importance, and its consumption is regarded as a classic example of gene-culture evolution. Humans have exploited animal milk as a food resource for at least 8500 years, but the origins, spread, and scale of dairying remain poorly understood. Indirect lines of evidence, such as lipid isotopic ratios of pottery residues, faunal mortality profiles, and lactase persistence allele frequencies, provide a partial picture of this process; however, in order to understand how, where, and when humans consumed milk products, it is necessary to link evidence of consumption directly to individuals and their dairy livestock. Here we report the first direct evidence of milk consumption, the whey protein β-lactoglobulin (BLG), preserved in human dental calculus from the Bronze Age (ca. 3000 BCE) to the present day. Using protein tandem mass spectrometry, we demonstrate that BLG is a species-specific biomarker of dairy consumption, and we identify individuals consuming cattle, sheep, and goat milk products in the archaeological record. We then apply this method to human dental calculus from Greenland's medieval Norse colonies, and report a decline of this biomarker leading up to the abandonment of the Norse Greenland colonies in the 15(th) century CE.
- Published
- 2014
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