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20 results on '"Eshed I"'

1. Monitoring total-body inflammation and damage in joints and entheses:the first follow-up study of whole-body magnetic resonance imaging in rheumatoid arthritis

Author

Axelsen, M. B., Eshed, I., Østergaard, M., Hetland, M. L., Møller, J. M., Jensen, D. V., Krintel, S. B., Hansen, M. S., Terslev, L., Klarlund, M., Poggenborg, R. P., Balding, L., Pedersen, S. J., Axelsen, M. B., Eshed, I., Østergaard, M., Hetland, M. L., Møller, J. M., Jensen, D. V., Krintel, S. B., Hansen, M. S., Terslev, L., Klarlund, M., Poggenborg, R. P., Balding, L., and Pedersen, S. J.

Abstract

Objective: To investigate changes in whole-body magnetic resonance imaging (WBMRI) inflammatory and structural lesions in most joints and entheses in patients with rheumatoid arthritis (RA) treated with adalimumab. Methods: WBMRI was obtained at weeks 0, 6, 16, and 52 in a 52 week follow-up study of 37 RA patients starting treatment with adalimumab. Readability and reliability of WBMRI were investigated for 76 peripheral joints, 23 discovertebral units, the sacroiliac joints, and 33 entheses. Changes in WBMRI joint and entheses counts were investigated. Results: The readability of peripheral and axial joints was 82–100%, being less for elbows and small joints of the feet. For entheses, 72–100% were readable, except for entheses at the anterior chest wall, elbow, knee, and plantar fascia. The intrareader agreement was high for bone marrow oedema (BMO), bone erosion (80–100%), and enthesitis (77–100%), and slightly lower for synovitis and soft tissue inflammation (50–100%). All synovitis, BMO, and soft tissue inflammation counts decreased numerically during treatment. The 26-joint synovitis WBMRI count decreased significantly during the first 16 weeks for patients with a good European League Against Rheumatism (EULAR) response (from median 6 to 4, p < 0.05), but not for patients with a moderate or no EULAR response. There were no overall changes in structural lesions. Conclusions: WBMRI allows simultaneous monitoring of most axial and peripheral joints and entheses in RA patients and can visualize a decrease in inflammatory counts during treatment. This first WBMRI follow-up study of patients with RA encourages further investigation of the usefulness of WBMRI in RA.

Published
2017

2. Effect of a treat-to-target strategy based on methotrexate and intra-articular betamethasone with or without additional cyclosporin on MRI-assessed synovitis, osteitis, tenosynovitis, bone erosion, and joint space narrowing in early rheumatoid arthritis:results from a 2-year randomized double-blind placebo-controlled trial (CIMESTRA)

Author

Møller-Bisgaard, S, Ejbjerg, B J, Eshed, I, Hørslev-Petersen, K, Hetland, M L, Jurik, A G, Thomsen, H, Torfing, T, Stengaard-Pedersen, K, Junker, P, Krogh, N S, Lottenburger, T, Ellingsen, T, Andersen, L S, Skjødt, H, Svendsen, A J, Tarp, U, Hansen, I T, Pødenphant, J, Pedersen, J K, Lindegaard, H, Hanson, L G, Vestergaard, A, Glinatsi, D, Østergaard, M, Møller-Bisgaard, S, Ejbjerg, B J, Eshed, I, Hørslev-Petersen, K, Hetland, M L, Jurik, A G, Thomsen, H, Torfing, T, Stengaard-Pedersen, K, Junker, P, Krogh, N S, Lottenburger, T, Ellingsen, T, Andersen, L S, Skjødt, H, Svendsen, A J, Tarp, U, Hansen, I T, Pødenphant, J, Pedersen, J K, Lindegaard, H, Hanson, L G, Vestergaard, A, Glinatsi, D, and Østergaard, M

Abstract

OBJECTIVES: To investigate whether a treat-to-target strategy based on methotrexate (MTX) and intra-articular (IA) betamethasone suppresses magnetic resonance imaging (MRI)-determined measures of disease activity and reduces joint destruction in early rheumatoid arthritis (eRA) patients, and to investigate whether concomitant cyclosporin A (CyA) provides an additional effect.METHOD: In the 2-year randomized, double-blind, treat-to-target trial CIMESTRA, 160 patients with eRA (< 6 months) were randomized to MTX, intra-articular betamethasone and CyA, or placebo CyA. A total of 129 patients participated in the MRI substudy, and had contrast-enhanced MR images of the non-dominant hand at months 0, 6, 12, and 24. MR images were evaluated for osteitis, synovitis, tenosynovitis, bone erosion, and joint space narrowing (JSN), using validated scoring methods.RESULTS: Significant reductions were seen at 6 months in all inflammatory parameters [synovitis, mean change -1.6 (p < 0.001, Wilcoxon), tenosynovitis, -3.5 (p < 0.001), and osteitis, -1.3 (p < 0.05)] and at 12/24 months in synovitis and tenosynovitis [-1.6/-2.2 and -3.6/-3.8, respectively; all p < 0.001]. MRI signs of inflammation were not fully eliminated, and increases in erosion and JSN scores were observed at 6 months [0.4 (p < 0.01)/0.1 (p < 0.05)], 12 months [0.8 (p < 0.001)/0.3 (p < 0.01)], and 24 months [1.0 (p < 0.001)/0.4 (p < 0.001)]. Clinical measures decreased significantly (p < 0.001) at all time points. There were no consistent statistically significant differences between treatment groups.CONCLUSIONS: In this eRA treat-to-target trial, MTX and intra-articular glucocorticoids markedly reduced, but did not eliminate, MRI osteitis, synovitis, and tenosynovitis. Accordingly, minimal but statistically significant increases in bone erosion and JSN were observed. No additional effect of CyA was demonstrated.

Published
2017

3. Magnetic Resonance Imaging Joint Space Narrowing Is An Independent Predictor of Radiographic and MRI Damage Progression in Patients with Early Rheumatoid Arthritis

Author

Møller-Bisgaard, S., Ejbjerg, B., Eshed, I., Hørslev-Petersen, K., Hetland, M., Jurik, A. G., Thomsen, H., Torfing, T., Stengaard-Pedersen, K., Junker, P., Krogh, N. S., Lottenburger, T., Ellingsen, T., Andersen, L. S., Skjødt, H., Svendsen, A., Tarp, U., Hansen, I., Pødenphanth, J., Pedersen, J. K., Lindegaard, H., Vestergaard, A., Glinatsi, D., Østergaard, M., Møller-Bisgaard, S., Ejbjerg, B., Eshed, I., Hørslev-Petersen, K., Hetland, M., Jurik, A. G., Thomsen, H., Torfing, T., Stengaard-Pedersen, K., Junker, P., Krogh, N. S., Lottenburger, T., Ellingsen, T., Andersen, L. S., Skjødt, H., Svendsen, A., Tarp, U., Hansen, I., Pødenphanth, J., Pedersen, J. K., Lindegaard, H., Vestergaard, A., Glinatsi, D., and Østergaard, M.

Published
2016

4. Clinical considerations and key issues in the management of patients with Erdheim-Chester Disease: A seven case series

Author

Mazor, RD, Manevich-Mazor, M, Kesler, A, Aizenstein, O, Eshed, I, Jaffe, R, Pessach, Y, Goldberg, I, Sprecher, E, Yaish, I, Gural, A, Ganzel, C, Shoenfeld, Y, Mazor, RD, Manevich-Mazor, M, Kesler, A, Aizenstein, O, Eshed, I, Jaffe, R, Pessach, Y, Goldberg, I, Sprecher, E, Yaish, I, Gural, A, Ganzel, C, and Shoenfeld, Y

Abstract

Background: Erdheim-Chester Disease (ECD), a non Langerhans' cell histiocytosis of orphan nature and propensity for multi-systemic presentations, comprises an intricate medical challenge in terms of diagnosis, treatment and complication management. Objectives: The objectives are to report the clinical, radiological and pathological characteristics, as well as cardinal therapeutic approaches to ECD patients and to provide clinical analyses of the medical chronicles of these complex patients. Methods: Patients with biopsy proven ECD were audited by a multi-disciplinary team of specialists who formed a coherent timeline of all the substantial clinical events in the evolution of their patients' illness. Results: Seven patients (five men, two women) were recruited to the study. The median age at presentation was 53 years (range: 39 to 62 years). The median follow-up time was 36 months (range: 1 to 72 months). Notable ECD involvement sites included the skeleton (seven), pituitary gland (seven), retroperitoneum (five), central nervous system (four), skin (four), lungs and pleura (four), orbits (three), heart and great vessels (three) and retinae (one). Prominent signs and symptoms were fever (seven), polyuria and polydipsia (six), ataxia and dysarthria (four), bone pain (four), exophthalmos (three), renovascular hypertension (one) and dyspnea (one). The V600E BRAF mutation was verified in three of six patients tested. Interferon-α treatment was beneficial in three of six patients treated. Vemurafenib yielded dramatic neurological improvement in a BRAF mutated patient. Infliximab facilitated pericardial effusion volume reduction. Cladribine improved cerebral blood flow originally compromised by perivenous lesions. Conclusions: ECD is a complex, multi-systemic, clonal entity coalescing both neoplastic and inflammatory elements and strongly dependent on impaired RAS/RAF/MEK/ERK signaling.

Published
2014

6. Validation of the newly proposed OMERACT joint space narrowing scoring system in rheumatoid arthritis wrist and metacarpophalangeal joints.

Author

Møller Døhn, Uffe, Conaghen, P.G., Eshed, I., Boonen, A., Bøyesen, P., Gandjbakhch, F., Lillegraven, S., Bird, P., Foltz, V., Peterfy, C.G., Genant, H.K., Haavardsholm, A., Mcqueen, F.M., Østergaard, Mikkel, Møller Døhn, Uffe, Conaghen, P.G., Eshed, I., Boonen, A., Bøyesen, P., Gandjbakhch, F., Lillegraven, S., Bird, P., Foltz, V., Peterfy, C.G., Genant, H.K., Haavardsholm, A., Mcqueen, F.M., and Østergaard, Mikkel

Published
2012

7. Psoriatic arthritis and spondyloarthritis: inflammation assessed by “head to toe” wholebody magnetic resonance imaging—A comparison with clinical joint examination.

Author

Poggenborg, René Panduro, Pedersen, Susanne Juhl, Eshed, I., Sørensen, Inge Juul, Madsen, Ole Rintek, Møller, Jakob Møllenbach, Østergaard, Mikkel, Poggenborg, René Panduro, Pedersen, Susanne Juhl, Eshed, I., Sørensen, Inge Juul, Madsen, Ole Rintek, Møller, Jakob Møllenbach, and Østergaard, Mikkel

Published
2012

8. Comparison of conventional and wholebody magnetic resonance imaging for assessing inflammation and structural damage in psoriatic arthritis and axial spondyloarthritis.

Author

Poggenborg, René Panduro, Pedersen, Susanne Juhl, Eshed, I., Sørensen, Inge Juul, Madsen, Ole Rintek, Møller, Jakob Møllenbach, Østergaard, Mikkel, Poggenborg, René Panduro, Pedersen, Susanne Juhl, Eshed, I., Sørensen, Inge Juul, Madsen, Ole Rintek, Møller, Jakob Møllenbach, and Østergaard, Mikkel

Published
2012

9. Bone marrow edema assessment by magnetic resonance imaging in rheumatoid arthritis wrist and MCP joints – The importance of field strength, coil type and image resolution.

Author

Krabbe, Simon, Eshed, I., Pedersen, Susanne Juhl, Bøyesen, P., Møller, Jakob Møllenbach, Therkildsen, F.R., Madsen, Ole Rintek, Østergaard, Mikkel, Krabbe, Simon, Eshed, I., Pedersen, Susanne Juhl, Bøyesen, P., Møller, Jakob Møllenbach, Therkildsen, F.R., Madsen, Ole Rintek, and Østergaard, Mikkel

Published
2012

10. Is contrast material needed for the MRI scoring of synovitis of the hand in patients with rheumatoid arthritis: A systematic comparison of 0.23, 0.6, 1.5 and 3.0 tesla MRI.

Author

Eshed, I., Krabbe, Simon, Østergaard, Mikkel, Bøyesen, P., Møller, Jakob Møllenbach, Therkildsen, F., Madsen, Ole Rintek, Pedersen, Susanne Juhl, Eshed, I., Krabbe, Simon, Østergaard, Mikkel, Bøyesen, P., Møller, Jakob Møllenbach, Therkildsen, F., Madsen, Ole Rintek, and Pedersen, Susanne Juhl

Published
2012

11. Enthesitis assessed by whole-body MRI in peripheral psoriatic arthritis, axial spoldyloarthritis and healthy subjects – A comparison with 7 clinical enthesitis indices.

Author

Poggenborg, René Panduro, Eshed, I., Pedersen, Susanne Juhl, Sørensen, Inge Juul, Madsen, Ole Rintek, Møller, Jakob Møllenbach, Østergaard, Mikkel, Poggenborg, René Panduro, Eshed, I., Pedersen, Susanne Juhl, Sørensen, Inge Juul, Madsen, Ole Rintek, Møller, Jakob Møllenbach, and Østergaard, Mikkel

Published
2012

12. Enthesitis assessed by whole-body MRI in peripheral psoriatic arthritis, axial spoldyloarthritis and healthy subjects – A comparison with 7 clinical enthesitis indices.

Author

Poggenborg, René Panduro, Eshed, I., Pedersen, Susanne Juhl, Sørensen, Inge Juul, Madsen, Ole Rintek, Møller, Jakob Møllenbach, Østergaard, Mikkel, Poggenborg, René Panduro, Eshed, I., Pedersen, Susanne Juhl, Sørensen, Inge Juul, Madsen, Ole Rintek, Møller, Jakob Møllenbach, and Østergaard, Mikkel

Published
2012

13. Bone marrow edema assessment by magnetic resonance imaging in rheumatoid arthritis wrist and MCP joints – The importance of field strength, coil type and image resolution.

Author

Krabbe, Simon, Eshed, I., Pedersen, Susanne Juhl, Bøyesen, P., Møller, Jakob Møllenbach, Therkildsen, F.R., Madsen, Ole Rintek, Østergaard, Mikkel, Krabbe, Simon, Eshed, I., Pedersen, Susanne Juhl, Bøyesen, P., Møller, Jakob Møllenbach, Therkildsen, F.R., Madsen, Ole Rintek, and Østergaard, Mikkel

Published
2012

14. Validation of the newly proposed OMERACT joint space narrowing scoring system in rheumatoid arthritis wrist and metacarpophalangeal joints.

Author

Møller Døhn, Uffe, Conaghen, P.G., Eshed, I., Boonen, A., Bøyesen, P., Gandjbakhch, F., Lillegraven, S., Bird, P., Foltz, V., Peterfy, C.G., Genant, H.K., Haavardsholm, A., Mcqueen, F.M., Østergaard, Mikkel, Møller Døhn, Uffe, Conaghen, P.G., Eshed, I., Boonen, A., Bøyesen, P., Gandjbakhch, F., Lillegraven, S., Bird, P., Foltz, V., Peterfy, C.G., Genant, H.K., Haavardsholm, A., Mcqueen, F.M., and Østergaard, Mikkel

Published
2012

16. Psoriatic arthritis and spondyloarthritis: inflammation assessed by “head to toe” wholebody magnetic resonance imaging—A comparison with clinical joint examination.

Author

Poggenborg, René Panduro, Pedersen, Susanne Juhl, Eshed, I., Sørensen, Inge Juul, Madsen, Ole Rintek, Møller, Jakob Møllenbach, Østergaard, Mikkel, Poggenborg, René Panduro, Pedersen, Susanne Juhl, Eshed, I., Sørensen, Inge Juul, Madsen, Ole Rintek, Møller, Jakob Møllenbach, and Østergaard, Mikkel

Published
2012

18. Is contrast material needed for the MRI scoring of synovitis of the hand in patients with rheumatoid arthritis: A systematic comparison of 0.23, 0.6, 1.5 and 3.0 tesla MRI.

Author

Eshed, I., Krabbe, Simon, Østergaard, Mikkel, Bøyesen, P., Møller, Jakob Møllenbach, Therkildsen, F., Madsen, Ole Rintek, Pedersen, Susanne Juhl, Eshed, I., Krabbe, Simon, Østergaard, Mikkel, Bøyesen, P., Møller, Jakob Møllenbach, Therkildsen, F., Madsen, Ole Rintek, and Pedersen, Susanne Juhl

Published
2012

19. Comparison of conventional and wholebody magnetic resonance imaging for assessing inflammation and structural damage in psoriatic arthritis and axial spondyloarthritis.

Author

Poggenborg, René Panduro, Pedersen, Susanne Juhl, Eshed, I., Sørensen, Inge Juul, Madsen, Ole Rintek, Møller, Jakob Møllenbach, Østergaard, Mikkel, Poggenborg, René Panduro, Pedersen, Susanne Juhl, Eshed, I., Sørensen, Inge Juul, Madsen, Ole Rintek, Møller, Jakob Møllenbach, and Østergaard, Mikkel

Published
2012

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