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The James Webb Space Telescope (JWST) has now started its exploration of exoplanetary worlds. In particular, the Mid-InfraRed Instrument (MIRI) with its Low-Resolution Spectrometer (LRS) carries out transit, eclipse, and phase-curve spectroscopy of exoplanetary atmospheres with unprecedented precision in a so far almost uncharted wavelength range. The precision and significance in the detection of molecules in exoplanetary atmospheres rely on a thorough understanding of the instrument itself and accurate data reduction methods. This paper aims to provide a clear description of the instrumental systematics that affect observations of transiting exoplanets through the use of simulations. We carried out realistic simulations of transiting-exoplanet observations with the MIRI LRS instrument that included the model of the exoplanet system, the optical path of the telescope, the MIRI detector performances, and instrumental systematics and drifts that could alter the atmospheric features we are meant to detect in the data. After introducing our pipeline, we show its performance on the transit of L168-9b, a super-Earth-sized exoplanet observed during the commissioning of the MIRI instrument. This paper provides a better understanding of the data themselves and of the best practices in terms of reduction and analysis through comparisons between simulations and real data. We show that simulations validate the current data-analysis methods. Simulations also highlight instrumental effects that impact the accuracy of our current spectral extraction techniques. These simulations are proven to be essential in the preparation of JWST observation programs and help us assess the detectability of various atmospheric and surface scenarios.

Hot Jupiters are among the best-studied exoplanets, but it is still poorly understood how their chemical composition and cloud properties vary with longitude. Theoretical models predict that clouds may condense on the nightside and that molecular abundances can be driven out of equilibrium by zonal winds. Here we report a phase-resolved emission spectrum of the hot Jupiter WASP-43b measured from 5-12 $\mu$m with JWST's Mid-Infrared Instrument (MIRI). The spectra reveal a large day-night temperature contrast (with average brightness temperatures of 1524$\pm$35 and 863$\pm$23 Kelvin, respectively) and evidence for water absorption at all orbital phases. Comparisons with three-dimensional atmospheric models show that both the phase curve shape and emission spectra strongly suggest the presence of nightside clouds which become optically thick to thermal emission at pressures greater than ~100 mbar. The dayside is consistent with a cloudless atmosphere above the mid-infrared photosphere. Contrary to expectations from equilibrium chemistry but consistent with disequilibrium kinetics models, methane is not detected on the nightside (2$\sigma$ upper limit of 1-6 parts per million, depending on model assumptions)., Comment: 61 pages, 13 figures, 4 tables. This preprint has been submitted to and accepted in principle for publication in Nature Astronomy without significant changes

We present a comprehensive analysis of the Hubble Space Telescope observations of the atmosphere of WASP-121 b, a ultra-hot Jupiter. After reducing the transit, eclipse, and phase-curve observations with a uniform methodology and addressing the biases from instrument systematics, sophisticated atmospheric retrievals are used to extract robust constraints on the thermal structure, chemistry, and cloud properties of the atmosphere. Our analysis shows that the observations are consistent with a strong thermal inversion beginning at ~0.1 bar on the dayside, solar to subsolar metallicity Z (i.e., -0.77 < log(Z) < 0.05), and super-solar C/O ratio (i.e., 0.59 < C/O < 0.87). More importantly, utilizing the high signal-to-noise ratio and repeated observations of the planet, we identify the following unambiguous time-varying signals in the data: i) a shift of the putative hotspot offset between the two phase-curves and ii) varying spectral signatures in the transits and eclipses. By simulating the global dynamics of WASP-121 b atmosphere at high-resolution, we show that the identified signals are consistent with quasi-periodic weather patterns, hence atmospheric variability, with signatures at the level probed by the observations (~5% to ~10%) that change on a timescale of ~5 planet days; in the simulations, the weather patterns arise from the formation and movement of storms and fronts, causing hot (as well as cold) patches of atmosphere to deform, separate, and mix in time., Comment: Accepted for publication in ApJS. 43 pages, 31 figures, 2 animations (available online at the journal)

Gravity modes (g modes), mixed gravito-acoustic modes (mixed modes), and gravito-inertial modes (gi modes) possess unmatched properties as probes for stars with radiative interiors. The structural and dynamical constraints that they are able to provide cannot be accessed by other means. While they provide precious insights into the internal dynamics of evolved stars as well as massive and intermediate-mass stars, their non-detection in main sequence (MS) solar-type stars make them a crucial missing piece in our understanding of angular momentum transport in radiative zones and stellar rotational evolution. In this work, we aim to apply certain analysis tools originally developed for helioseismology in order to look for g-mode signatures in MS solar-type stars. We select a sample of the 34 most promising MS solar-type stars with Kepler four-year long photometric time series. All these stars are well-characterised late F-type stars with thin convective envelopes, fast convective flows, and stochastically excited acoustic modes (p modes). For each star, we compute the background noise level of the Fourier power spectrum to identify significant peaks at low frequency. After successfully detecting individual peaks in 12 targets, we further analyse four of them and observe distinct patterns of surrounding peaks with a low probability of being noise artifacts. Comparisons with the predictions from reference models suggest that these patterns are compatible with the presence of non-asymptotic low-order pure g modes, pure p modes, and mixed modes. Given their sensitivity to both the convective core interface stratification and the coupling between p- and g-mode resonant cavities, such modes are able to provide strong constraints on the structure and evolutionary states of the related targets. [abridged], Comment: 19 pages, 19 figures, accepted for publication in A&A

Aims. We analyse unpublished Spitzer observations of the thermal phase-curve of WASP-121 b, a benchmark ultra-hot Jupiter. Methods. We adopted the wavelet pixel-independent component analysis technique to remove challenging instrumental systematic effects in these datasets and we fit them simultaneously with parametric light-curve models. We also performed phase-curve retrievals to better understand the horizontal and vertical thermal structure of the planetary atmosphere. Results. We measured planetary brightness temperatures of $\sim$2700\,K (dayside) and $\sim$700--1100\,K (nightside), along with modest peak offsets of 5.9$^{\circ} \pm$1.6 (3.6\,$\mu$m) and 5.0$^{\circ}$$_{-3.1}^{+3.4}$ (4.5\,$\mu$m) after mid-eclipse. These results suggest inefficient heat redistribution in the atmosphere of WASP-121 b. The inferred atmospheric Bond albedo and circulation efficiency align well with observed trends for hot giant exoplanets. Interestingly, the measured peak offsets correspond to a westward hot spot, which has rarely been observed. We also report consistent transit depths at 3.6 and 4.5\,$\mu$m, along with updated geometric and orbital parameters. Finally, we compared our Spitzer results with previous measurements, including recent JWST observations. Conclusions. We extracted new information on the thermal properties and dynamics of an exoplanet atmosphere from an especially problematic dataset. This study probes the reliability of exoplanet phase-curve parameters obtained from Spitzer observations when state-of-the-art pipelines are adopted to remove the instrumental systematic effects. It demonstrates that Spitzer phase-curve observations provide a useful baseline for comparison with JWST observations, and shows the increase in parameters precision achieved with the newer telescope., Comment: 14 pages, 10 figures

There are no planets intermediate in size between Earth and Neptune in our Solar System, yet these objects are found around a substantial fraction of other stars. Population statistics show that close-in planets in this size range bifurcate into two classes based on their radii. It is hypothesized that the group with larger radii (referred to as "sub-Neptunes") is distinguished by having hydrogen-dominated atmospheres that are a few percent of the total mass of the planets. GJ 1214b is an archetype sub-Neptune that has been observed extensively using transmission spectroscopy to test this hypothesis. However, the measured spectra are featureless, and thus inconclusive, due to the presence of high-altitude aerosols in the planet's atmosphere. Here we report a spectroscopic thermal phase curve of GJ 1214b obtained with JWST in the mid-infrared. The dayside and nightside spectra (average brightness temperatures of 553 $\pm$ 9 and 437 $\pm$ 19 K, respectively) each show >3$\sigma$ evidence of absorption features, with H$_2$O as the most likely cause in both. The measured global thermal emission implies that GJ 1214b's Bond albedo is 0.51 $\pm$ 0.06. Comparison between the spectroscopic phase curve data and three-dimensional models of GJ 1214b reveal a planet with a high metallicity atmosphere blanketed by a thick and highly reflective layer of clouds or haze., Comment: Published online in Nature on May 10, 2023

The TRAPPIST-1 system is remarkable for its seven planets that are similar in size, mass, density, and stellar heating to the rocky planets Venus, Earth, and Mars in our own Solar System (Gillon et al. 2017). All TRAPPIST-1 planets have been observed with the transmission spectroscopy technique using the Hubble or Spitzer Space Telescopes, but no atmospheric features have been detected or strongly constrained (Ducrot et al. 2018; de Wit et al. 2018; Zhang et al. 2018; Garcia et al. 2022). TRAPPIST-1 b is the closest planet to the system's M dwarf star, and it receives 4 times as much irradiation as Earth receives from the Sun. This relatively large amount of stellar heating suggests that its thermal emission may be measurable. Here we present photometric secondary eclipse observations of the Earth-sized TRAPPIST-1 b exoplanet using the F1500W filter of the MIRI instrument on JWST. We detect the secondary eclipse in each of five separate observations with 8.7-$\sigma$ confidence when all data are combined. These measurements are most consistent with the re-radiation of the TRAPPIST-1 star's incident flux from only the dayside hemisphere of the planet. The most straightforward interpretation is that there is little or no planetary atmosphere redistributing radiation from the host star and also no detectable atmospheric absorption from carbon dioxide (CO$_2$) or other species., Comment: This preprint has not undergone any substantive post-submission improvements or corrections. The Version of Record of this article is published in Nature here: https://www.nature.com/articles/s41586-023-05951-7

We observed a full-orbit phase curve of the hot Jupiter WASP-43b with MIRI/LRS as part of the Transiting Exoplanet Community Early Release Science Program. Here we report preliminary findings for the instrument performance from the team's MIRI Working Group. Overall we find that MIRI's performance for phase curve observations is excellent, with a few minor caveats. The key takeaways for Cycle 2 planning with MIRI/LRS are: (1) long-duration observations (> 24 hours) have now been successfully executed; (2) for phase curves, we recommend including a one-hour burn-in period prior to taking science data to mitigate the effects of the ramp systematic; and (3) we do not yet recommend partial phase curve observations. In addition, we also find that: the position of the spectrum on the detector is stable to within 0.03 pixels over the full 26.5-hour observation; the light curves typically show a systematic downward ramp that is strongest for the first 30 minutes, but continues to decay for hours; from 10.6-11.8 microns, the ramp effect has remarkably different behavior, possibly due to a different illumination history for the affected region of the detector; after trimming the integrations most affected by the initial ramps and correcting the remaining systematics with analytic models, we obtain residuals to the light-curve fits that are typically within 25% of the photon noise limit for 0.5-micron spectroscopic bins; non-linearity correction is not a significant source of additional noise for WASP-43, though it may be an issue for brighter targets; the gain value of 5.5 electrons/DN currently on CRDS and JDox is known to be incorrect, and the current best estimate for the gain is approximately 3.1 electrons/DN; new reference files for the JWST calibration pipeline reflecting these findings are under development at STScI.

WASP-107b is a warm ($\sim$740 K) transiting planet with a Neptune-like mass of $\sim$30.5 $M_{\oplus}$ and Jupiter-like radius of $\sim$0.94 $R_{\rm J}$, whose extended atmosphere is eroding. Previous observations showed evidence for water vapour and a thick high-altitude condensate layer in WASP-107b's atmosphere. Recently, photochemically produced sulphur dioxide (SO$_2$) was detected in the atmosphere of a hot ($\sim$1,200 K) Saturn-mass planet from transmission spectroscopy near 4.05 $\mu$m, but for temperatures below $\sim$1,000 K sulphur is predicted to preferably form sulphur allotropes instead of SO$_2$. Here we report the 9$\sigma$-detection of two fundamental vibration bands of SO$_2$, at 7.35 $\mu$m and 8.69 $\mu$m, in the transmission spectrum of WASP-107b using the Mid-Infrared Instrument (MIRI) of the JWST. This discovery establishes WASP-107b as the second irradiated exoplanet with confirmed photochemistry, extending the temperature range of exoplanets exhibiting detected photochemistry from $\sim$1,200 K down to $\sim$740 K. Additionally, our spectral analysis reveals the presence of silicate clouds, which are strongly favoured ($\sim$7$\sigma$) over simpler cloud setups. Furthermore, water is detected ($\sim$12$\sigma$), but methane is not. These findings provide evidence of disequilibrium chemistry and indicate a dynamically active atmosphere with a super-solar metallicity.

We explore how finite integration time or temporal binning can affect the analysis of exoplanet phase-curves. We provide analytical formulae to account for this effect or, if neglected, to estimate the potential biases in the retrieved parameters. As expected, due to their smoother variations over longer time-scales, phase curves can be binned more heavily than transits without causing severe biases. In the simplest case of a sinusoidal phase curve with period $P$, the integration time $\Delta t$ reduces its amplitude by the scaling factor $\text{sinc}{ \left ( \pi \Delta t / P \right ) }$, without altering its phase or shape. We also provide formulae to predict reasonable parameter error bars from phase-curve observations. Our findings are tested with both synthetic and real datasets, including unmodelled astrophysical signals and/or instrumental systematic effects. Tests with the Spitzer data show that binning can affect the best-fitting parameters beyond predictions, due to the correction of high-frequency correlated noise. Finally, we summarize key guidelines for speeding up the analysis of exoplanet phase curves without introducing significant biases in the retrieved parameters., Comment: Published in MNRAS (here with extended acknowledgments)

Cell transplantation, to replace lost dopamine (DA) neurons in Parkinson’s disease (PD), offers hope for many patients. While proof of principle has been demonstrated in the clinic, a number of limitations have prevented its widespread application. One such limitation has been the lack of sufficient innervation by the grafted tissue, as well as the failure to restore normal brain circuitry. Improving the connectivity of these grafted cells will be dependent on understanding how these neurons are normally wired during development. Several growth and guidance cues have been identified in the maturation of the DA pathways, however, they fail to account for all developmental events. This thesis explores the role of Wnt proteins in this context; focusing on understanding the roles of Wnts in DA axon growth and guidance during development as well as their potential for in vivo application to promote graft integration in PD. Wnts are a family of secreted proteins that have previously been shown to play important roles in the proliferation and differentiation of midbrain DA neurons during development. Elsewhere within the central nervous system, Wnts have been shown to also have roles in axon growth, guidance, and synapse formation. This research examines whether Wnts play a later role in the maturation of the DA pathways, regulating axon morphogenesis and chemotaxis. Our results demonstrate that while several Wnts are expressed within the developing midbrain, Wnt5a and Wnt7a show highly controlled spatial and temporal patterns suggestive of roles in DA axon growth and guidance. We further pursued the role of Wnt5a. We show that early in development Wnt5a, expressed within the ventral midbrain (VM), is capable of repelling DA axons out of the VM and promoting axonal elongation. Later in development of the pathway, Wnt5a expression within the VM ensures DA axons maintain their rostral trajectory, but interestingly, preventing neurite growth. We show that this negative effect