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Organized flaking techniques to obtain predetermined stone tools have been traced back to the early Acheulean (also known as mode 2) in Africa and are seen as indicative of the emergence of advanced technical abilities and in-depth planning skills among early humans. Here, we report one of the earliest known examples of prepared core technology in the archaeological record, at the Cenjiawan (CJW) site in the Nihewan basin of China, dated 1.1 Mya. The operational schemes reconstructed from the CJW refit sets, together with shaping patterns observed in the retouched tools, suggest that Nihewan basin toolmakers had the technical abilities of mode 2 hominins, and developed different survival strategies to adapt to local raw materials and environments. This finding predates the previously earliest known prepared core technology from Eurasia by 0.3 My, and the earliest known mode 2 sites in East Asia by a similar amount of time, thus suggesting that hominins with advanced technologies may have migrated into high latitude East Asia as early as 1.1 million years ago.

Organized flaking techniques to obtain predetermined stone tools have been traced back to the early Acheulean (also known as Mode 2) in Africa, and are seen as indicative of the emergence of advanced technical abilities and in-depth planning skills among early humans. Here we report one of the earliest known examples of prepared core technology in the archaeological record, at the Cenjiawan site in the Nihewan basin of China, dated 1.1 million years ago. The operational schemes reconstructed from the Cenjiawan refit sets, together with shaping patterns observed in the retouched tools, suggest that Nihewan basin toolmakers had the technical abilities of Mode 2 hominins, and developed new survival strategies to adapt to local raw materials and environments. This discovery predates the previously earliest known prepared core technology from Eurasia by 0.3 million years, and the earliest known Mode 2 sites in East Asia by a similar amount of time, thus suggesting that hominins with advanced technologies may have migrated into high latitude East Asia as early as 1.1 million years ago.

Tian QX, Zhang ZH, Ye QL, et al. J Inflamm Res. 2021;14:2253–2265. We, the Editors and Publisher of Journal of Inflammation Research, have retracted the following article. Following publication of the article, the authors raised concerns regarding the duplication of images from Figure 1. Specifically, The images for Figure 1A, PC-3, MT, 12h and 24h have been duplicated. The images for Figure 1B, DU145, MT and Figure 1C, PC-3, Control and MT+LPS have been duplicated. The images for Figure 1C, DU145, MT+LPS and PC-3, MT have been duplicated. The authors explained the incorrect use of images occurred during figure preparation and did provide some of the original data for the study. However, the provided data and the authors explanation regarding the duplicated images did not sufficiently alleviate the journal’s concerns regarding the validity of the findings. As verifying the validity of published work is core to the integrity of the scholarly record, we are therefore retracting the article and the authors do not agree with this decision. We have been informed in our decision-making by our editorial policies and COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.

With ever-increasing power-density requirements, technologies such as energy storage systems and electric-vehicles can benefit greatly from interfacing medium-voltage (MV)-AC grid like 13.8kV or 30kV using high-AC/low-DC voltage converter. Using modular high-AC/low-DC voltage converter can help increase power-density and efficiency, while reducing total conversion steps and providing flexibility. Full-bridge modular multilevel converters (FB-MMC) and solid-state transformers are existing solutions for such operations, but suffer from limitations of high semiconductor requirements, large submodule capacitors and/or many high-frequency transformers. Three new hybrid-MMC (HMMC) topologies are proposed in this paper as alternative solutions for such high-AC/low-DC voltage operations. Each of the three developed HMMCs utilizes a unique combination of low-frequency high-voltage switches and fast-switching lowvoltage switch based submodules to generate multilevel-AC voltage. HMMCs are compared extensively to state-of-the-art FB-MMC and are shown to have semiconductor savings of over 27%, 38% lower submodule capacitor size, and 53% lower losses for 13.8-kV-AC/6-kV-DC operation. Due to these benefits like higher efficiency, significantly smaller submodule capacitance requirements, and fewer semiconductors, HMMCs can be an excellent option for high-AC/low-DC applications. Practical considerations like snubber and DC split-capacitor requirement are also elaborated for developing and commercializing HMMCs. Comparison results are verified using a 17.5 kW three-phase MV laboratory prototype.

The Chinese Space Station Telescope (CSST) slitless spectroscopic survey will observe objects to a limiting magnitude of ~ 23 mag (5$\sigma$, point sources) in U, V, and I over 17500 deg$^2$. The spectroscopic observations are expected to be highly efficient and complete for mapping galaxies over 0 < z < 1 with secure redshift measurements at spectral resolutions of R ~ 200, providing unprecedented data sets for cosmological studies. To quantitatively examine the survey potential, we develop a software tool, namely the CSST Emulator for Slitless Spectroscopy (CESS), to quickly generate simulated 1D slitless spectra with limited computing resources. We introduce the architecture of CESS and the detailed process of creating simulated CSST slitless spectra. The extended light distribution of a galaxy induces the self-broadening effect on the 1D slitless spectrum. We quantify the effect using morphological parameters: S\'ersic index, effective radius, position angle, and axis ratio. Moreover, we also develop a module for CESS to estimate the overlap contamination rate for CSST grating observations of galaxies in galaxy clusters. Applying CESS to the high-resolution model spectra of a sample of ~ 140 million galaxies with m_z < 21 mag selected from the Dark Energy Spectroscopic Instrument LS DR9 catalogue, we obtain the simulated CSST slitless spectra. We examine the dependence of measurement errors on different types of galaxies due to instrumental and observational effects and quantitatively investigate the redshift completeness for different environments out to z ~ 1. Our results show that the CSST spectroscopy is able to provide secure redshifts for about one-quarter of the sample galaxies., Comment: 14 pages, 15 figures, 2 tables, accepted for publication in MNRAS

Dust attenuation in star-forming galaxies (SFGs), as parameterized by the infrared excess (IRX $\equiv L_{\rm IR}/L_{\rm UV}$), is found to be tightly correlated with star formation rate (SFR), metallicity and galaxy size, following a universal IRX relation up to $z=3$. This scaling relation can provide a fundamental constraint for theoretical models to reconcile galaxy star formation, chemical enrichment, and structural evolution across cosmic time. We attempt to reproduce the universal IRX relation over $0.1\leq z\leq 2.5$ using the EAGLE hydrodynamical simulations and examine sensitive parameters in determining galaxy dust attenuation. Our findings show that while the predicted universal IRX relation from EAGLE approximately aligns with observations at $z\leq 0.5$, noticeable disparities arise at different stellar masses and higher redshifts. Specifically, we investigate how modifying various galaxy parameters can affect the predicted universal IRX relation in comparison to the observed data. We demonstrate that the simulated gas-phase metallicity is the critical quantity for the shape of the predicted universal IRX relation. We find that the influence of the infrared luminosity and infrared excess is less important while galaxy size has virtually no significant effect. Overall, the EAGLE simulations are not able to replicate some of the observed characteristics between IRX and galaxy parameters of SFGs, emphasizing the need for further investigation and testing for our current state-of-the-art theoretical models., Comment: 19 pages, 15 figures, accepted for publication in MNRAS

Cun Zhang,1,&ast; Lei Jiang,2,3,&ast; Ke Hu,2,&ast; Liang Chen,2 Yi-Jia Zhang,2 Hao-Zhe Shi,2 Su-Mei He,4 Xiao Chen,5 Dong-Dong Wang2 1Department of Pharmacy, Xuzhou Oriental Hospital Affiliated to Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People’s Republic of China; 2Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy & School of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People’s Republic of China; 3Department of Pharmacy, Taixing People’s Hospital, Taixing, Jiangsu, 225400, People’s Republic of China; 4Department of Pharmacy, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, Jiangsu, 215153, People’s Republic of China; 5School of Nursing, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Su-Mei He, Department of Pharmacy, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 1 Lijiang Road, Suzhou, Jiangsu, 215153, People’s Republic of China, Email hehe8204@163.com Dong-Dong Wang, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy & School of Pharmacy, Xuzhou Medical University, No. 209 Tongshan Road, Xuzhou, Jiangsu, 221004, People’s Republic of China, Email 13852029591@163.comObjective: Olanzapine has already been used to treat schizophrenia patients; however, the initial dosage recommendation when multiple drugs are used in combination, remains unclear. The purpose of this study was to explore the drug–drug interaction (DDI) of multiple drugs combined with olanzapine and to recommend the optimal administration of olanzapine in schizophrenia patients.Methods: In this study, we obtained olanzapine concentrations from therapeutic drug monitoring (TDM) database. In addition, related medical information, such as physiological, biochemical indexes, and concomitant drugs was acquired using medical log. Sixty-five sch

Segment Anything Model (SAM) has garnered significant attention in segmentation tasks due to their zero-shot generalization ability. However, a broader application of SAMs to real-world practice has been restricted by their low inference speed and high computational memory demands, which mainly stem from the attention mechanism. Existing work concentrated on optimizing the encoder, yet has not adequately addressed the inefficiency of the attention mechanism itself, even when distilled to a smaller model, which thus leaves space for further improvement. In response, we introduce SAM-Lightening, a variant of SAM, that features a re-engineered attention mechanism, termed Dilated Flash Attention. It not only facilitates higher parallelism, enhancing processing efficiency but also retains compatibility with the existing FlashAttention. Correspondingly, we propose a progressive distillation to enable an efficient knowledge transfer from the vanilla SAM without costly training from scratch. Experiments on COCO and LVIS reveal that SAM-Lightening significantly outperforms the state-of-the-art methods in both run-time efficiency and segmentation accuracy. Specifically, it can achieve an inference speed of 7 milliseconds (ms) per image, for images of size 1024*1024 pixels, which is 30.1 times faster than the vanilla SAM and 2.1 times than the state-of-the-art. Moreover, it takes only 244MB memory, which is 3.5\% of the vanilla SAM. The code and weights are available at https://anonymous.4open.science/r/SAM-LIGHTENING-BC25/.

Organized flaking techniques to obtain predetermined stone tools have been traced back to the early Acheulean (also known as Mode 2) in Africa, and are seen as indicative of the emergence of advanced technical abilities and in-depth planning skills among early humans. Here we report one of the earliest known examples of prepared core technology in the archaeological record, at the Cenjiawan site in the Nihewan basin of China, dated 1.1 million years ago. The operational schemes reconstructed from the Cenjiawan refit sets, together with shaping patterns observed in the retouched tools, suggest that Nihewan basin toolmakers had the technical abilities of Mode 2 hominins, and developed new survival strategies to adapt to local raw materials and environments. This discovery predates the previously earliest known prepared core technology from Eurasia by 0.3 million years, and the earliest known Mode 2 sites in East Asia by a similar amount of time, thus suggesting that hominins with advanced technologies may have migrated into high latitude East Asia as early as 1.1 million years ago.

Understanding the mechanisms underlying phenotypic innovation is a key goal of comparative genomic studies. Here, we investigated the evolutionary landscape of lineage-specific accelerated regions (LinARs) across 49 primate species. Genomic comparison with dense taxa sampling of primate species significantly improved LinAR detection accuracy and revealed many novel human LinARs associated with brain development or disease. Our study also yielded detailed maps of LinARs in other primate lineages that may have influenced lineage-specific phenotypic innovation and adaptation. Functional experimentation identified gibbon LinARs, which could have participated in the developmental regulation of their unique limb structures, whereas some LinARs in the Colobinae were associated with metabolite detoxification which may have been adaptive in relation to their leaf-eating diet. Overall, our study broadens knowledge of the functional roles of LinARs in primate evolution.

The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact of genomic diversity on fundamental biological processes. Analysis of that diversity provides insight into long-standing questions in evolutionary and conservation biology and is urgent given severe threats these species are facing. Here, we present high-coverage wholegenome data from 233 primate species representing 86% of genera and all 16 families. This dataset was used, together with fossil calibration, to create a nuclear DNA phylogeny and to reassess evolutionary divergence times among primate clades. We found within-species genetic diversity across families and geographic regions to be associated with climate and sociality, but not with extinction risk. Furthermore, mutation rates differ across species, potentially influenced by effective population sizes. Lastly, we identified extensive recurrence of missense mutations previously thought to be human specific. This study will open a wide range of research avenues for future primate genomic research.

Background Health-related quality of life (HRQOL) is a critical aspect to consider when making treatment decisions for patients with non-Hodgkin-lymphoma (NHL). This international study by the European Organisation for Research and Treatment of Cancer (EORTC) tested the psychometric properties of two newly developed measures for patients with high-grade (HG)- and low-grade (LG)-NHL: the EORTC QLQ-NHL-HG29 and the EORTC QLQ-NHL-LG20 to supplement the core questionnaire (EORTC QLQ-C30). Methods Overall, 768 patients with HG-NHL (N = 423) and LG-NHL (N = 345) from 12 countries completed the QLQ-C30, QLQ-NHL-HG29/QLQ-NHL-LG20 and a debriefing questionnaire at baseline, and a subset at follow-up for either retest (N = 125/124) or responsiveness to change (RCA; N = 98/49). Results Confirmatory factor analysis showed an acceptable to good fit of the 29 items of the QLQ-NHL-HG29 on its five scales (symptom burden [SB], neuropathy, physical condition/fatigue [PF], emotional impact [EI], and worries about health/functioning [WH]), and of the 20 items of the QLQ-NHL-LG20 on its four scales (SB, PF, EI, and WH). Completion took on average 10 minutes. Test-retest reliability, convergent validity, known-group comparisons, and RCA find satisfactory results of both measures. A total of 31%-78% of patients with HG-NHL and 22%-73% of patients with LG-NHL reported symptoms and/or worries (e.g., tingling in hands/feet, lack of energy, and worries about recurrence). Patients reporting symptoms/worries had substantially lower HRQOL compared to those without. Discussion The use of the EORTC QLQ-NHL-HG29 and QLQ-NHL-LG20 questionnaires in clinical research and practice will provide clinically relevant data to better inform treatment decision-making. Plain language summary The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group developed two questionnaires. These questionnaires measure health-related quality

Hodgkin lymphoma (HL) has become 1 of the most curable cancers. Therefore, rigorous assessment of health-related quality of life (HRQoL) and symptom burden of these patients is essential to support informed clinical decisions. The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group previously developed the EORTC Quality of Life Questionnaire (QLQ) Hodgkin Lymphoma 27. This paper reports the final results of an international study by the EORTC group to develop a HRQoL disease-specific measure for these patients: the EORTC QLQ-HL27. Patients with a confirmed diagnosis of HL (N = 381) were enrolled from 12 countries and completed the EORTC QLQ-C30, QLQ-HL27, and a debriefing questionnaire at baseline (any time after diagnosis). A subset completed a retest (n = 126) or responsiveness-to-change analyses (RCA) second measurement (n = 98). Psychometrics were evaluated. Confirmatory factor analysis showed an acceptable fit of the 27 items of the QLQ-HL27 on its 4 scales (symptom burden, physical condition/fatigue, emotional impact, and worries about health/functioning). Test–retest reliability, convergent validity, known-group comparisons, and RCA find satisfactory results. Symptom burden and fatigue was higher among patients on treatment (with 36%-83% reporting at least a few problems) compared with those who had completed treatment (19%-61% reporting at least a few problems). Prevalence of worries about health and functioning (reporting at least some worry) was similar for patients on treatment (51%-81%) vs those who had completed treatment (52%-78%). Implementation of the EORTC QLQ-HL27 in research and clinical applications will increase sensitivity of HRQoL assessment in patients with HL. High quality data generated through use of this questionnaire are expected to facilitate clinical decision making in the HL setting.

Reaction of sulfonimidoyl fluorides with anilines and Ca(NTf2)2 results in the formation of chiral sulfonimidamides. The reaction proceeds with inversion of the stereocenter at a sulfur atom. Enantiospecificity of the reaction was observed for all studied non-heterocyclic anilines. Combined experimental and computational mechanistic studies highlight chelate-type coordination of the sulfonimidoyl group to Ca(NTf2)2 and the formation of a SN2-like transition state, in which leaving F- coordinates with the Ca2+ ion.

Related Article: Dong-Dong Liang, Natassa Lional, Bas Scheepmaker, Muthusamy Subramaniam, Guanna Li, Fedor M. Miloserdov, Han Zuilhof|2023|Org.Lett.|||doi:10.1021/acs.orglett.3c02132, Related Article: Dong-Dong Liang, Natassa Lional, Bas Scheepmaker, Muthusamy Subramaniam, Guanna Li, Fedor M. Miloserdov, Han Zuilhof|2023|Org.Lett.|||doi:10.1021/acs.orglett.3c02132

Although species can arise through hybridization, compelling evidence for hybrid speciation has been reported only rarely in animals. Here, we present phylogenomic analyses on genomes from 12 macaque species and show that the fascicularis group originated from an ancient hybridization between the sinica and silenus groups ~3.45 to 3.56 million years ago. The X chromosomes and low-recombination regions exhibited equal contributions from each parental lineage, suggesting that they were less affected by subsequent backcrossing and hence could have played an important role in maintaining hybrid integrity. We identified many reproduction-associated genes that could have contributed to the development of the mixed sexual phenotypes characteristic of the fascicularis group. The phylogeny within the silenus group was also resolved, and functional experimentation confirmed that all extant Western silenus species are susceptible to HIV-1 infection. Our study provides novel insights into macaque evolution and reveals a hybrid speciation event that has occurred only very rarely in primates., Although species can arise through hybridization, compelling evidence for hybrid speciation has been reported only rarely in animals. Here, we present phylogenomic analyses on genomes from 12 macaque species and show that the fascicularis group originated from an ancient hybridization between the sinica and silenus groups ~3.45 to 3.56 million years ago. The X chromosomes and low-recombination regions exhibited equal contributions from each parental lineage, suggesting that they were less affected by subsequent backcrossing and hence could have played an important role in maintaining hybrid integrity. We identified many reproduction-associated genes that could have contributed to the development of the mixed sexual phenotypes characteristic of the fascicularis group. The phylogeny within the silenus group was also resolved, and functional experimentation confirmed that all extant Western silenus species are susceptible to HIV-1 infection. Our study provides novel insights into macaque evolution and reveals a hybrid speciation event that has occurred only very rarely in primates.

Edge computing has been emerging as a popular scenario for model inference. However, the inference performance on edge devices (e.g., Multi-Core DSP, FGPA, etc.) suffers from inefficiency due to the lack of highly optimized inference frameworks. Previous model inference frameworks are mainly developed in an operator-centric way, which provides insufficient acceleration to edge-based inference. Besides, the operator-centric framework incurs significant costs for continuous development and maintenance. In this paper, we propose Xenos, which can automatically conduct dataflow-centric optimization of the computation graph and accelerate inference in two dimensions. Vertically, Xenos develops operator linking technique to improve data locality by restructuring the inter-operator dataflow. Horizontally, Xenos develops DSP-aware operator split technique to enable higher parallelism across multiple DSP units. Our evaluation proves the effectiveness of vertical and horizontal dataflow optimization, which reduce the inference time by 21.2\%--84.9\% and 17.9\%--96.2\% , respectively. Besides, Xenos also outperforms the widely-used TVM by 3.22$\times$--17.92$\times$. Moreover, we extend Xenos to a distributed solution, which we call d-Xenos. d-Xenos employs multiple edge devices to jointly conduct the inference task and achieves a speedup of 3.68x--3.78x compared with the single device., Comment: The preliminary version is accepted by the 28th International Conference on Database Systems for Advanced Applications (DASFAA-2023)

Expected to be of the highest survey power telescope in the northern hemisphere, the Wide Field Survey Telescope (WFST) will begin its routine observations of the northern sky since 2023. WFST will produce a lot of scientific data to support the researches of time-domain astronomy, asteroids and the solar system, galaxy formation and cosmology and so on. We estimated that the 5 $\sigma$ limiting magnitudes of WFST with 30 second exposure are $u=22.31$ mag, $g=23.42$ mag, $r=22.95$ mag, $i=22.43$ mag, $z=21.50$ mag, $w=23.61$ mag. The above values are calculated for the conditions of $airmass=1.2$, seeing = 0.75 arcsec, precipitable water vapour (PWV) = 2.5 mm and Moon-object separation = $45^{\circ}$ at the darkest New Moon night of the Lenghu site (V=22.30 mag, Moon phase $\theta=0^{\circ}$). The limiting magnitudes in different Moon phase conditions are also calculated. The calculations are based on the empirical transmittance data of WFST optics, the vendor provided CCD quantum efficiency, the atmospherical model transmittance and spectrum of the site. In the absence of measurement data such as sky transmittance and spectrum, we use model data., Comment: Figure 5 (a,b,c) has been updated in this latest version. 12 pages, 5 figures, published in RAA (Research in Astronomy and Astrophysics)

Comparative analysis of primate genomes within a phylogenetic context is essential for understanding the evolution of human genetic architecture and primate diversity. We present such a study of 50 primate species spanning 38 genera and 14 families, including 27 genomes first reported here, with many from previously less well represented groups, the New World monkeys and the Strepsirrhini. Our analyses reveal heterogeneous rates of genomic rearrangement and gene evolution across primate lineages. Thousands of genes under positive selection in different lineages play roles in the nervous, skeletal, and digestive systems and may have contributed to primate innovations and adaptations. Our study reveals that many key genomic innovations occurred in the Simiiformes ancestral node and may have had an impact on the adaptive radiation of the Simiiformes and human evolution.

Although species can arise through hybridization, compelling evidence for hybrid speciation has been reported only rarely in animals. Here, we present phylogenomic analyses on genomes from 12 macaque species and show that the fascicularis group originated from an ancient hybridization between the sinica and silenus groups ~3.45 to 3.56 million years ago. The X chromosomes and low-recombination regions exhibited equal contributions from each parental lineage, suggesting that they were less affected by subsequent backcrossing and hence could have played an important role in maintaining hybrid integrity. We identified many reproduction-associated genes that could have contributed to the development of the mixed sexual phenotypes characteristic of the fascicularis group. The phylogeny within the silenus group was also resolved, and functional experimentation confirmed that all extant Western silenus species are susceptible to HIV-1 infection. Our study provides novel insights into macaque evolution and reveals a hybrid speciation event that has occurred only very rarely in primates.

The Y chromosome usually plays a critical role in determining male sex and comprises sequence classes that have experienced unique evolutionary trajectories. Here we generated 19 new primate sex chromosome assemblies, analysed them with 10 existing assemblies and report rapid evolution of the Y chromosome across primates. The pseudoautosomal boundary has shifted at least six times during primate evolution, leading to the formation of a Simiiformes-specific evolutionary stratum and to the independent start of young strata in Catarrhini and Platyrrhini. Different primate lineages experienced different rates of gene loss and structural and chromatin change on their Y chromosomes. Selection on several Y-linked genes has contributed to the evolution of male developmental traits across the primates. Additionally, lineage-specific expansions of ampliconic regions have further increased the diversification of the structure and gene composition of the Y chromosome. Overall, our comprehensive analysis has broadened our knowledge of the evolution of the primate Y chromosome.

Black hole (BH) ultracompact X-ray binaries (UCXBs) are potential Galactic low-frequency gravitational wave (GW) sources. As an alternative channel, BH UCXBs can evolve from BH+He star binaries. In this work, we perform a detailed stellar evolution model for the formation and evolution of BH UCXBs evolving from the He star channel to diagnose their detectability as low-frequency GW sources. Our calculations found that some nascent BH+He star binaries after the common-envelope (CE) phase could evolve into UCXB-LISA sources with a maximum GW frequency of $\sim5~\rm mHz$, which can be detected in a distance of 10 kpc (or 100 kpc). Once BH+He star systems become UCXBs through mass transfer, they would emit X-ray luminosities of $\sim10^{38}~\rm erg\, s^{-1}$, making them ideal multimessenger objects. If the initial He-star masses are $\geq 0.7 M_{\odot}$, those systems are likely to experience two Roche lobe overflows, and the X-ray luminosity can reach a maximum of $3.5\times 10^{39}~\rm erg\, s^{-1}$ in the second mass-transfer stage. The initial He-star masses and initial orbital periods of progenitors of Galactic BH UCXB-LISA sources are in the range of 0.32-2.9 $M_{\odot}$ and 0.02-0.19 days, respectively. Nearly all BH+He star binaries in the above parameter space can evolve into GW sources whose chirp masses can be accurately measured. Employing a population synthesis simulation, we predict the birthrate and detection number of Galactic BH UCXB-LISA source evolving from the He star channel are $R=2.2\times10^{-6}~\rm yr^{-1}$ and 33 for an optimistic CE parameter, respectively., Comment: 17 pages, 9 figures, ApJ in press

The Y chromosome usually plays a critical role in determining male sex and comprises sequence classes that have experienced unique evolutionary trajectories. Here we generated 19 new primate sex chromosome assemblies, analysed them with 10 existing assemblies and report rapid evolution of the Y chromosome across primates. The pseudoautosomal boundary has shifted at least six times during primate evolution, leading to the formation of a Simiiformes-specific evolutionary stratum and to the independent start of young strata in Catarrhini and Platyrrhini. Different primate lineages experienced different rates of gene loss and structural and chromatin change on their Y chromosomes. Selection on several Y-linked genes has contributed to the evolution of male developmental traits across the primates. Additionally, lineage-specific expansions of ampliconic regions have further increased the diversification of the structure and gene composition of the Y chromosome. Overall, our comprehensive analysis has broadened our knowledge of the evolution of the primate Y chromosome., The Y chromosome usually plays a critical role in determining male sex and comprises sequence classes that have experienced unique evolutionary trajectories. Here we generated 19 new primate sex chromosome assemblies, analysed them with 10 existing assemblies and report rapid evolution of the Y chromosome across primates. The pseudoautosomal boundary has shifted at least six times during primate evolution, leading to the formation of a Simiiformes-specific evolutionary stratum and to the independent start of young strata in Catarrhini and Platyrrhini. Different primate lineages experienced different rates of gene loss and structural and chromatin change on their Y chromosomes. Selection on several Y-linked genes has contributed to the evolution of male developmental traits across the primates. Additionally, lineage-specific expansions of ampliconic regions have further increased the diversification of the structure and gene composition of the Y chromosome. Overall, our comprehensive analysis has broadened our knowledge of the evolution of the primate Y chromosome.

Comparative analysis of primate genomes within a phylogenetic context is essential for understanding the evolution of human genetic architecture and primate diversity. We present such a study of 50 primate species spanning 38 genera and 14 families, including 27 genomes first reported here, with many from previously less well represented groups, the New World monkeys and the Strepsirrhini. Our analyses reveal heterogeneous rates of genomic rearrangement and gene evolution across primate lineages. Thousands of genes under positive selection in different lineages play roles in the nervous, skeletal, and digestive systems and may have contributed to primate innovations and adaptations. Our study reveals that many key genomic innovations occurred in the Simiiformes ancestral node and may have had an impact on the adaptive radiation of the Simiiformes and human evolution., Comparative analysis of primate genomes within a phylogenetic context is essential for understanding the evolution of human genetic architecture and primate diversity. We present such a study of 50 primate species spanning 38 genera and 14 families, including 27 genomes first reported here, with many from previously less well represented groups, the New World monkeys and the Strepsirrhini. Our analyses reveal heterogeneous rates of genomic rearrangement and gene evolution across primate lineages. Thousands of genes under positive selection in different lineages play roles in the nervous, skeletal, and digestive systems and may have contributed to primate innovations and adaptations. Our study reveals that many key genomic innovations occurred in the Simiiformes ancestral node and may have had an impact on the adaptive radiation of the Simiiformes and human evolution.

Partial Label Learning (PLL) is a type of weakly supervised learning where each training instance is assigned a set of candidate labels, but only one label is the ground-truth. However, this idealistic assumption may not always hold due to potential annotation inaccuracies, meaning the ground-truth may not be present in the candidate label set. This is known as Unreliable Partial Label Learning (UPLL) that introduces an additional complexity due to the inherent unreliability and ambiguity of partial labels, often resulting in a sub-optimal performance with existing methods. To address this challenge, we propose the Unreliability-Robust Representation Learning framework (URRL) that leverages unreliability-robust contrastive learning to help the model fortify against unreliable partial labels effectively. Concurrently, we propose a dual strategy that combines KNN-based candidate label set correction and consistency-regularization-based label disambiguation to refine label quality and enhance the ability of representation learning within the URRL framework. Extensive experiments demonstrate that the proposed method outperforms state-of-the-art PLL methods on various datasets with diverse degrees of unreliability and ambiguity. Furthermore, we provide a theoretical analysis of our approach from the perspective of the expectation maximization (EM) algorithm. Upon acceptance, we pledge to make the code publicly accessible.

We report the first spatially resolved measurements of gas-phase metallicity radial gradients in star-forming galaxies in overdense environments at $z\gtrsim2$. The spectroscopic data are acquired by the \mg\ survey, a Hubble Space Telescope (HST) cycle-28 medium program. This program is obtaining 45 orbits of WFC3/IR grism spectroscopy in the density peak regions of three massive galaxy protoclusters (BOSS 1244, BOSS 1542 and BOSS 1441) at $z=2-3$. Our sample in the BOSS 1244 field consists of 20 galaxies with stellar-mass ranging from $10^{9.0}$ to $10^{10.3}$ \Msun\ , star formation rate (SFR) from 10 to 240 \Msun\,yr$^{-1}$, and global gas-phase metallicity (\oh) from 8.2 to 8.6. At $1\sigma$ confidence level, 2/20 galaxies in our sample show positive (inverted) gradients -- the relative abundance of oxygen increasing with galactocentric radius, opposite the usual trend. Furthermore, 1/20 shows negative gradients and 17/20 are consistent with flat gradients. This high fraction of flat/inverted gradients is uncommon in simulations and previous observations conducted in blank fields at similar redshifts. To understand this, we investigate the correlations among various observed properties of our sample galaxies. We find an anticorrelation between metallicity gradient and global metallicity of our galaxies residing in extreme overdensities, and a marked deficiency of metallicity in our massive galaxies as compared to their coeval field counterparts. We conclude that the cold-mode gas accretion plays an active role in shaping the chemical evolution of galaxies in the protocluster environments, diluting their central chemical abundance, and flattening/inverting their metallicity gradients., Comment: 13 pages, 6 figures, 1 table. Accepted for publication in ApJL

Submillimetre galaxies represent a rapid growth phase of both star formation and massive galaxies. Mapping SMGs in galaxy protoclusters provides key insights into where and how these extreme starbursts take place in connections with the assembly of the large-scale structure in the early Universe. We search for SMGs at 850$\,\mu m$ using JCMT/SCUBA-2 in two massive protoclusters at $z=2.24$, BOSS1244 and BOSS1542, and detect 43 and 54 sources with $S_{850}>4\,$mJy at the $4\sigma$ level within an effective area of 264$\,$arcmin$^2$, respectively. We construct the intrinsic number counts and find that the abundance of SMGs is $2.0\pm0.3$ and $2.1\pm0.2$ times that of the general fields, confirming that BOSS1244 and BOSS1542 contain a higher fraction of dusty galaxies with strongly enhanced star formation. The volume densities of the SMGs are estimated to be $\sim15-$30 times the average, significantly higher than the overdensity factor ($\sim 6$) traced by H$\alpha$ emission-line galaxies (HAEs). More importantly, we discover a prominent offset between the spatial distributions of the two populations in these two protoclusters -- SMGs are mostly located around the high-density regions of HAEs, and few are seen inside these regions. This finding may have revealed for the first time the occurrence of violent star formation enhancement in the outskirts of the HAE density peaks, likely driven by the boosting of gas supplies and/or starburst triggering events. Meanwhile, the lack of SMGs inside the most overdense regions at $z\sim2$ implies a transition to the environment disfavouring extreme starbursts., Comment: 16pages, 11figures, accepted for publication in MNRAS

While the slope of the dust attenuation curve ($\delta$) is found to correlate with effective dust attenuation ($A_V$) as obtained through spectral energy distribution (SED) fitting, it remains unknown how the fitting degeneracies shape this relation. We examine the degeneracy effects by fitting SEDs of a sample of local star-forming galaxies (SFGs) selected from the Galaxy And Mass Assembly survey, in conjunction with mock galaxy SEDs of known attenuation parameters. A well-designed declining starburst star formation history is adopted to generate model SED templates with intrinsic UV slope ($\beta_0$) spanning over a reasonably wide range. The best-fitting $\beta_0$ for our sample SFGs shows a wide coverage, dramatically differing from the limited range of $\beta_0<-2.2$ for a starburst of constant star formation. Our results show that strong degeneracies between $\beta_0$, $\delta$, and $A_V$ in the SED fitting induce systematic biases leading to a false $A_V$--$\delta$ correlation. Our simulation tests reveal that this relationship can be well reproduced even when a flat $A_V$--$\delta$ relation is taken to build the input model galaxy SEDs. The variations in best-fitting $\delta$ are dominated by the fitting errors. We show that assuming a starburst with constant star formation in SED fitting will result in a steeper attenuation curve, smaller degeneracy errors, and a stronger $A_V$--$\delta$ relation. Our findings confirm that the $A_V$--$\delta$ relation obtained through SED fitting is likely driven by the systematic biases induced by the fitting degeneracies between $\beta_0$, $\delta$, and $A_V$., Comment: 21 pages, 13 figures, accepted for publication in the MNRAS, Comments welcome!

In the process of urbanization, various urban problems have become increasingly prominent, and the heat island effect is one of them. The expansion of urban land, the increase in construction intensity and the increase in population make the urban heat island effect even worse. The construction of park cities improves the ecological environment of the city and is considered to have a positive effect on alleviating the heat island effect, but it is not clear whether it has such an effect or not. This article explores whether the construction of Park City can help to improve the urban thermal environment effectively, and also, seek solutions for how to improve the construction of park cities so that the heat island effect can be better mitigated. Landsat8 remote sensing images in 2014 and 2019 were used to estimate the fractional vegetation cover (FVC) and land surface temperature (LST) in the Third Ring Road of Chengdu. Land use data were also introduced into the study to analyze LST changes in different surfaces and FVC.The results indicate that: (1) the area of the heat island zone in the Third Ring Road of Chengdu decreased by 0.91% from 2014 to 2019, and the area of the cold island zone increased by 17.89% ; (2) the urban blue-green space is conductive to mitigating the urban heat island effect, in which the water provides the best mitigation, while impervious surface and bare land may aggravate the urban heat island effect; (3) the FVC in the area of the Third Ring Road in Chengdu is on the rise as a whole, and there is a significant negative correlation between FVC and LST (p < 0.01). Based on the above results, this paper shows that Park City construction is beneficial to alleviate the urban heat island effect, and more attention should be paid to blue-green space layout and quality, along with urban ventilation and FVC control. Our results provide useful input for green space planning and the construction of Park City in the future.

Invited Poster for Session on Brainstorming for Game-Changing Ideas.

LICSOJ : (R)-4-(trifluoromethoxy)phenyl N-benzoyl-4-methylbenzene-1-sulfonimidate, Related Article: Yang Chao, Akash Krishna, Muthusamy Subramaniam, Dong‐Dong Liang, Sidharam P. Pujari, Andrew C.‐H. Sue, Guanna Li, Fedor M. Miloserdov, Han Zuilhof|2022|Angew.Chem.,Int.Ed.|61|e202207456|doi:10.1002/anie.202207456

Lorises are a group of globally threatened strepsirrhine primates that exhibit many unusual physiological and behavioral features, including a low metabolic rate, slow movement, and hibernation. Here, we assembled a chromosome-level genome sequence of the pygmy loris (Xanthonycticebus pygmaeus) and resequenced whole genomes from 50 pygmy lorises and 6 Bengal slow lorises (Nycticebus bengalensis). We found that many gene families involved in detoxification have been specifically expanded in the pygmy loris, including the GSTA gene family, with many newly derived copies functioning specifically in the liver. We detected many genes displaying evolutionary convergence between pygmy loris and koala, including PITRM1. Significant decreases in PITRM1 enzymatic activity in these two species may have contributed to their characteristic low rate of metabolism. We also detected many evolutionarily convergent genes and positively selected genes in the pygmy loris that are involved in muscle development. Functional assays demonstrated the decreased ability of one positively selected gene, MYOF, to up-regulate the fast-type muscle fiber, consistent with the lower proportion of fast-twitch muscle fibers in the pygmy loris. The protein product of another positively selected gene in the pygmy loris, PER2, exhibited weaker binding to the key circadian core protein CRY, a finding that may be related to this species’ unusual circadian rhythm. Finally, population genomics analysis revealed that these two extant loris species, which coexist in the same habitat, have exhibited an inverse relationship in terms of their demography over the past 1 million years, implying strong interspecies competition after speciation.

Aspects are described for line frequency commutated voltage source converters for multiphase modular multilevel converters. A voltage source converter (VSC) capacitor voltage of a multiphase VSC of a multiphase power converter can be identified. The multiphase VSC can include a half-bridge circuit for each phase of the multiphase power converter. A circuit parameter can be identified and utilized to determine an arm voltage of an arm of a branch of the multiphase converter. Switch control signals can be generated to insert or bypass the VSC capacitor for the arm of the branch of the multiphase converter device, based at least in part on a comparison between the arm voltage and the VSC capacitor voltage.

Simultaneously imposed challenges of high-voltage insulation, high dv/dt, high-switching frequency, fast protection, and thermal management associated with the adoption of 10 kV SiC MOSFET, often pose nearly insurmountable barriers to potential users, undoubtedly hindering their penetration in medium-voltage (MV) power conversion. Key novel technologies such as enhanced gatedriver, auxiliary power supply network, PCB planar dc-bus, and high-density inductor are presented, enabling the SiC-based designs in modular MV converters, overcoming aforementioned challenges. However, purely substituting SiC design instead of Sibased ones in modular MV converters, would expectedly yield only limited gains. Therefore, to further elevate SiC-based designs, novel high-bandwidth control strategies such as switching-cycle control (SCC) and integrated capacitor-blocked transistor (ICBT), as well as high-performance/high-bandwidth communication network are developed. All these technologies combined, overcome barriers posed by state-of-the-art Si designs and unlock system level benefits such as very high power density, high-efficiency, fast dynamic response, unrestricted line frequency operation, and improved power quality, all demonstrated throughout this paper.

The products of the SuFEx reaction between sulfonimidoyl fluorides and phenols, sulfonimidates, are shown to display dynamic covalent chemistry with other phenols. This reaction was shown to be enantiospecific, finished in minutes at room temperature in high yields, and useful for both asymmetric synthesis and sustainable polymer production. Its wide scope further extends the usefulness of SuFEx and related click chemistries.

FATSEC : (R,R)-N,N-((1S,4S)-cyclohexane-1,4-diyldicarbonyl)bis(4-methylbenzene-1-sulfonimidoyl fluoride), Related Article: Dong-Dong Liang, Sidharam P. Pujari, Muthusamy Subramaniam, Maarten Besten, Han Zuilhof|2022|Angew.Chem.,Int.Ed.|61||doi:10.1002/anie.202116158

We present an analysis of physical properties of 34 [O III] emission-line galaxies (ELGs) at z=3.254$\pm$0.029 in the Extended Chandra Deep Field South (ECDFS). These ELGs are selected from deep narrow H2S(1) and broad Ks imaging of 383 arcmin$^{2}$ obtained with CFHT/WIRCam. We construct spectral energy distributions (SEDs) from U to Ks to derive the physical properties of ELGs. These [O III] ELGs are identified as starburst galaxies with strong [O III] lines of L([O III]) ~ 10$^{42.6}$ - 10$^{44.2}$ erg s$^{-1}$, and have stellar masses of M* ~ 10$^{9.0}$-10$^{10.6}$ M$_\odot$ and star formation rates of ~ 10-210 M$_\odot$ yr$^{-1}$. Our results show that 24% of our sample galaxies are dusty with Av > 1 mag and EW(OIII)$_{rest}$ ~ 70-500 $\AA$, which are often missed in optically selected [O III] ELG samples. Their rest-frame UV and optical morphologies from HST/ACS and HST/WFC3 deep imaging reveal that these [O III] ELGs are mostly multiple-component systems (likely mergers) or compact. And 20% of them are nearly invisible in the rest-frame UV owing to heavy dust attenuation. Interestingly, we find that our samples reside in an overdensity consisting of two components: one southeast (SE) with an overdensity factor of $\delta_{gal}$ ~ 41 over a volume of 13$^{3}$ cMpc$^{3}$ and the other northwest (NW) with $\delta_{gal}$ ~ 38 over a volume of 10$^{3}$ cMpc$^{3}$. The two overdense substructures are expected to be virialized at z=0 with a total mass of ~ 1.1 x 10$^{15}$ M$_\odot$ and ~ 4.8 x 10$^{14}$ M$_\odot$, and probably merge into a Coma-like galaxy cluster., Comment: 22 pages, 11 figures, 3 tables. Accepted for publication in ApJ

Lakeshore environments offer an excellent opportunity to explore how early humans adapted to changing landscapes and environments. The Nihewan fluvio-lacustrine sequence in North China contains one of the densest concentrations of Early Pleistocene Palaeolithic sites outside of Africa. Among these, the Cenjiawan site, dated at 1.1 Ma, draws attention due to the large number of stone tool refits. We present here Cenjiawan's sedimentary context, artefact spatial patterns, size distribution and taphonomic features, which are complemented by an experimental programme to better understand archaeological debitage size patterns, thus enabling a detailed analysis of formation processes at the site. The Cenjiawan assemblage is also interpreted in the light of its geographical and geological context, where a synsedimentary fault induced a minor topographic relief across the lacustrine lakeshore. This resulted in a shallow-water setting in the down-thrown hanging wall of the fault compartment, and a fluvial environment in the uplifted footwall. Our results indicate that Cenjiawan, situated in the hanging wall of the fault, underwent minimal disturbance, constituting a remarkable example of optimal preservation of archaeological assemblages in Early Pleistocene lakeshore environments.

Novel methods to make synthetic chiral polymers are highly desirable given their potential in a rapidly increasing number of bio-inspired applications. The enantiospecific sulfur–fluorine exchange (SuFEx) reaction of chiral di-sulfonimidoyl fluorides (di-SFs) with diphenols, was used to produce high-molecular-weight chiral polymers with configurational backbone chirality. The resulting new class of polymers, polysulfonimidates, can be efficiently produced via this step-growth mechanism for a wide range of di-SFs and diphenols, yielding MnPS up to 283 kDa with a typical dispersity Đ around 1.6. The optical activity of the resulting chiral polymers is largely due to the intrinsic asymmetry of the S atoms (configurational chirality). Finally, the enantiospecificity (ee>98 %) of the polymerization reaction was demonstrated by the degradation of a disulfide-containing polysulfonimidate. This novel route towards configurational main-chain chirality opens up new approaches towards tailor-made chiral polymers with precisely defined properties.

In November 2018, a scientific scandal broke when news emerged that the world’s first gene edited babies had been born in China on the eve of the 2nd International Summit on Human Genome Editing in Hong Kong. He Jiankui had recruited a total of seven couples who were in need of fertility treatment to participate in an effort to clinically apply human embryo editing with the promise that, if successful, their future children would be protected from HIV. While He Jiankui has since been jailed for illegal medical practice and much has been written about his unethical and flawed “experiment,” in this article we suggest that the Hong Kong summit nevertheless marked the moment when human embryo editing came to be platformed. Human embryo editing brings together a complete set of new reproductive and genetic technologies into a total bio-reproductive platform shaped by socio-technical “disease free” imaginaries.

Background: Species domestication is generally characterized by the exploitation of high-impact mutations through processes that involve complex shifting demographics of domesticated species. These include not only inbreeding and artificial selection that may lead to the emergence of evolutionary bottlenecks, but also post-divergence gene flow and introgression. Although domestication potentially affects the occurrence of both desired and undesired mutations, the way wild relatives of domesticated species evolve and how expensive the genetic cost underlying domestication is remain poorly understood. Here, we investigated the demographic history and genetic load of chicken domestication. Results: We analyzed a dataset comprising over 800 whole genomes from both indigenous chickens and wild jungle fowls. We show that despite having a higher genetic diversity than their wild counterparts (average π, 0.00326 vs. 0.00316), the red jungle fowls, the present-day domestic chickens experienced a dramatic population size decline during their early domestication. Our analyses suggest that the concomitant bottleneck induced 2.95% more deleterious mutations across chicken genomes compared with red jungle fowls, supporting the “cost of domestication” hypothesis. Particularly, we find that 62.4% of deleterious SNPs in domestic chickens are maintained in heterozygous states and masked as recessive alleles, challenging the power of modern breeding programs to effectively eliminate these genetic loads. Finally, we suggest that positive selection decreases the incidence but increases the frequency of deleterious SNPs in domestic chicken genomes. Conclusion: This study reveals a new landscape of demographic history and genomic changes associated with chicken domestication and provides insight into the evolutionary genomic profiles of domesticated animals managed under modern human selection.

Background: Species domestication is generally characterized by the exploitation of high-impact mutations through processes that involve complex shifting demographics of domesticated species. These include not only inbreeding and artificial selection that may lead to the emergence of evolutionary bottlenecks, but also post-divergence gene flow and introgression. Although domestication potentially affects the occurrence of both desired and undesired mutations, the way wild relatives of domesticated species evolve and how expensive the genetic cost underlying domestication is remain poorly understood. Here, we investigated the demographic history and genetic load of chicken domestication. Results: We analyzed a dataset comprising over 800 whole genomes from both indigenous chickens and wild jungle fowls. We show that despite having a higher genetic diversity than their wild counterparts (average π, 0.00326 vs. 0.00316), the red jungle fowls, the present-day domestic chickens experienced a dramatic population size decline during their early domestication. Our analyses suggest that the concomitant bottleneck induced 2.95% more deleterious mutations across chicken genomes compared with red jungle fowls, supporting the “cost of domestication” hypothesis. Particularly, we find that 62.4% of deleterious SNPs in domestic chickens are maintained in heterozygous states and masked as recessive alleles, challenging the power of modern breeding programs to effectively eliminate these genetic loads. Finally, we suggest that positive selection decreases the incidence but increases the frequency of deleterious SNPs in domestic chicken genomes. Conclusion: This study reveals a new landscape of demographic history and genomic changes associated with chicken domestication and provides insight into the evolutionary genomic profiles of domesticated animals managed under modern human selection.

The MAMMOTH-Grism slitless spectroscopic survey is a Hubble Space Telescope (HST) cycle-28 medium program, which is obtaining 45 orbits of WFC3/IR grism spectroscopy in the density peak regions of three massive galaxy protoclusters at $z=2-3$ discovered using the MAMMOTH technique. We introduce this survey by presenting the first measurement of the mass-metallicity relation (MZR) at high redshift in overdense environments via grism spectroscopy. From the completed MAMMOTH-Grism observations in the field of the BOSS1244 protocluster at $z=2.24\pm0.02$, We secure a sample of 36 protocluster member galaxies at $z\sim2.24$, showing strong nebular emission lines ([O III], H$\beta$ and [O II]) in their G141 spectra. Using the multi-wavelength broad-band deep imaging from HST and ground-based telescopes, we measure their stellar masses in the range of $[10^{9},10^{10.4}]M_\odot$, instantaneous star formation rates (SFR) from 10 to 240$M_\odot yr^{-1}$, and global gas-phase metallicities [$\frac{1}{3}$,1] of solar. Compared with similarly selected field galaxy sample at the same redshift, our galaxies show on average increased SFRs by $\sim$0.06dex and $\sim$0.18dex at $\sim$10$^{10.1}M_\odot$ and $\sim$10$^{9.8}M_\odot$, respectively. Using the stacked spectra of our sample galaxies, we derive the MZR in the BOSS1244 protocluster core as $12+\log({\rm O/H})=(0.136\pm0.018)\times\log(M_\ast/M_\odot)+(7.082\pm0.175)$, showing significantly shallower slope than that in the field. This shallow MZR slope is likely caused by the combined effects of efficient recycling of feedback-driven winds and cold-mode gas accretion in protocluster environments. The former effect helps low-mass galaxies residing in overdensities retain their metal production, whereas the latter effect dilutes the metal content of high-mass galaxies, making them more metal poor than their coeval field counterparts., Comment: 15 pages, 5 figures, and 4 tables, accepted to ApJ

Ferroelectric materials are promising for solar energy conversion due to the unique spontaneous polarization effect, leading to effective control of electron-hole recombination and potentially high power conversion efficiency of perovskite solar cells. Herein, the ultrathin ferroelectric hafnia alumina (HfAlO) films were obtained by atomic layer deposition and applied to modify the electron transport layer of PSCs. The XPS and AFM characterizations indicate that the Hf0.39Al0.10O films feature smooth, dense, and compact surface morphology. For the devices incorporating the ultrathin HfAlO films, the oriented ferroelectric effect-induced spontaneous polarization and internal electric field are crucial factors to enhance the charge separation during charge transfer. Accordingly, the short circuit current, open-circuit voltage, and power conversion efficiency (PCE) are increased by 11.8%, 9.0%, and 29.8%, respectively. Moreover, the HfAlO incorporating devices retained ~ 80% of the original PCE after 500 h ageing, much better than that of the pristine devices showing the retention of only ~ 50% of the original PCE.