11 results on '"De Lorenzis, E"'
Number of results to display per page
Search Results
2. Real-life efficacy and safety of nintedanib in systemic sclerosis-interstitial lung disease: data from an Italian multicentre study
- Author
-
Campochiaro, C., De Luca, G., Lazzaroni, M. -G., Armentaro, G., Spinella, A., Vigone, B., Ruaro, B., Stanziola, A., Benfaremo, D., De Lorenzis, E., Moccaldi, B., Bosello, Silvia Laura, Cuomo, G., Beretta, Carlo Luigi, Zanatta, E., Giuggioli, D., Del Papa, N., Airo, P., Confalonieri, Marco, Moroncini, G., Dagna, L., Matucci-Cerinic, M., Bosello S. L. (ORCID:0000-0002-4837-447X), Beretta L. (ORCID:0000-0001-9924-2066), Confalonieri M. (ORCID:0000-0002-3708-379X), Campochiaro, C., De Luca, G., Lazzaroni, M. -G., Armentaro, G., Spinella, A., Vigone, B., Ruaro, B., Stanziola, A., Benfaremo, D., De Lorenzis, E., Moccaldi, B., Bosello, Silvia Laura, Cuomo, G., Beretta, Carlo Luigi, Zanatta, E., Giuggioli, D., Del Papa, N., Airo, P., Confalonieri, Marco, Moroncini, G., Dagna, L., Matucci-Cerinic, M., Bosello S. L. (ORCID:0000-0002-4837-447X), Beretta L. (ORCID:0000-0001-9924-2066), and Confalonieri M. (ORCID:0000-0002-3708-379X)
- Abstract
Introduction Nintedanib (NTD) has been shown to be effective in systemic sclerosis (SSc)-interstitial lung disease (ILD). Here we describe the efficacy and safety of NTD in a real-life setting. Methods Patients with SSc-ILD treated with NTD were retrospectively evaluated at 12 months prior to NTD introduction; at baseline and at 12 months after NTD introduction. The following parameters were recorded: SSc clinical features, NTD tolerability, pulmonary function tests and modified Rodnan skin score (mRSS). Results 90 patients with SSc-ILD (65% female, mean age 57.6±13.4 years, mean disease duration 8.8±7.6 years) were identified. The majority were positive for anti-topoisomerase I (75%) and 77 (85%) patients were on immunosuppressants. A significant decline in %predicted forced vital capacity (%pFVC) in the 12 months prior to NTD introduction was observed in 60%. At 12 months after NTD introduction, follow-up data were available for 40 (44%) patients and they showed a stabilisation in %pFVC (64±14 to 62±19, p=0.416). The percentage of patients with significant lung progression at 12 months was significantly lower compared with the previous 12 months (60% vs 17.5%, p=0.007). No significant mRSS change was observed. Gastrointestinal (GI) side effects were recorded in 35 (39%) patients. After a mean time of 3.6±3.1 months, NTD was maintained after dose adjustment in 23 (25%) patients. In nine (10%) patients, NTD was stopped after a median time of 4.5 (1-6) months. During the follow-up, four patients died. Conclusions In a real-life clinical scenario, NTD, in combination with immunosuppressants, may stabilise lung function. GI side effects are frequent and NTD dose adjustment may be necessary to retain the drug in patients with SSc-ILD.
- Published
- 2023
3. Survival and prognostic factors from a multicentre large cohort of unselected Italian systemic sclerosis patients
- Author
-
Cacciapaglia, F., Airo, P., Fornaro, M., Trerotoli, Paolo, De Lorenzis, E., Corrado, A., Lazzaroni, M. G., Natalello, G., Montini, F., Altomare, Annamaria, Urso, L., Verardi, Lucrezia, Bosello, Silvia Laura, Cantatore, F. P., Iannone, F., Trerotoli P., Altomare A., Verardi L., Bosello S. L. (ORCID:0000-0002-4837-447X), Cacciapaglia, F., Airo, P., Fornaro, M., Trerotoli, Paolo, De Lorenzis, E., Corrado, A., Lazzaroni, M. G., Natalello, G., Montini, F., Altomare, Annamaria, Urso, L., Verardi, Lucrezia, Bosello, Silvia Laura, Cantatore, F. P., Iannone, F., Trerotoli P., Altomare A., Verardi L., and Bosello S. L. (ORCID:0000-0002-4837-447X)
- Abstract
Objectives: Survival and death prognostic factors of SSc patients varied during the past decades. We aimed to update the 5- and 10-year survival rates and identify prognostic factors in a multicentre cohort of Italian SSc patients diagnosed after 2009. Material and methods: Patients who received a diagnosis of SSc after 1 January 2009 and were longitudinally followed up in four Italian rheumatologic centres were retrospectively assessed up to 31 December 2020. Overall survival of SSc patients was described using the Kaplan–Meier method. Predictors of mortality at 10-year follow-up were assessed by the Cox regression model. A comparison of our cohort with the Italian general population was performed by determining the standardized mortality ratio (SMR). Results: A total of 912 patients (91.6% females, 20% dcSSc) were included. Overall survival rates at 5 and 10 years were 94.4% and 89.4%, respectively. The SMR was 0.96 (95% CI 0.81, 1.13), like that expected in the Italian general population. Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) associated with pulmonary hypertension (PH) significantly reduced survival (P < 0.0001). Main death predictors were male gender (HR 1⁄4 2.76), diffuse cutaneous involvement (HR 1⁄4 3.14), older age at diagnosis (HR 1⁄4 1.08), PAH (HR 1⁄4 3.21), ILD-associated PH (HR 1⁄4 4.11), comorbidities (HR 1⁄4 3.53) and glucocorticoid treatment (HR1⁄4 2.02). Conclusions: In the past decade, SSc patients have reached similar mortality of that expected in the Italian general population. Male gender, diffuse cutaneous involvement, comorbidities and PAH with or without ILD represent the main poor prognostic factors.
- Published
- 2023
4. Lung vascular changes as biomarkers of severity in systemic sclerosis-associated interstitial lung disease
- Author
-
Bruni, C., Occhipinti, M., Pienn, M., Camiciottoli, G., Bartolucci, M., Bosello, Silvia Laura, Payer, C., Balint, Z., Larici, Anna Rita, Tottoli, A., Tofani, L., De Lorenzis, E., Lepri, G., Bellando-Randone, S., Spinella, A., Giuggioli, D., Masini, F., Cuomo, G., Lavorini, F., Colagrande, S., Olschewski, H., Matucci-Cerinic, M., Bosello S. L. (ORCID:0000-0002-4837-447X), Larici A. R. (ORCID:0000-0002-1882-6244), Bruni, C., Occhipinti, M., Pienn, M., Camiciottoli, G., Bartolucci, M., Bosello, Silvia Laura, Payer, C., Balint, Z., Larici, Anna Rita, Tottoli, A., Tofani, L., De Lorenzis, E., Lepri, G., Bellando-Randone, S., Spinella, A., Giuggioli, D., Masini, F., Cuomo, G., Lavorini, F., Colagrande, S., Olschewski, H., Matucci-Cerinic, M., Bosello S. L. (ORCID:0000-0002-4837-447X), and Larici A. R. (ORCID:0000-0002-1882-6244)
- Abstract
OBJECTIVES: It has recently become possible to assess lung vascular and parenchymal changes quantitatively in thoracic CT images using automated software tools. We investigated the vessel parameters of patients with SSc, quantified by CT imaging, and correlated them with interstitial lung disease (ILD) features. METHODS: SSc patients undergoing standard of care pulmonary function testing and CT evaluation were retrospectively evaluated. CT images were analysed for ILD patterns and total pulmonary vascular volume (PVV) extents with Imbio lung texture analysis. Vascular analysis (volumes, numbers and densities of vessels, separating arteries and veins) was performed with an in-house developed software. A threshold of 5% ILD extent was chosen to define the presence of ILD, and commonly used cut-offs of lung function were adopted. RESULTS: A total of 79 patients [52 women, 40 ILD, mean age 56.2 (s.d. 14.2) years, total ILD extent 9.5 (10.7)%, PVV/lung volume % 2.8%] were enrolled. Vascular parameters for total and separated PVV significantly correlated with functional parameters and ILD pattern extents. SSc-associated ILD (SSc-ILD) patients presented with an increased number and volume of arterial vessels, in particular those between 2 and 4 mm of diameter, and with a higher density of arteries and veins of <6 mm in diameter. Considering radiological and functional criteria concomitantly, as well as the descriptive trends from the longitudinal evaluations, the normalized PVVs, vessel numbers and densities increased progressively with the increase/worsening of ILD extent and functional impairment. CONCLUSION: In SSc patients CT vessel parameters increase in parallel with ILD extent and functional impairment, and may represent a biomarker of SSc-ILD severity.
- Published
- 2023
5. Chronic related group classification system as a new public health tool to predict risk and outcome of COVID-19 in patients with systemic rheumatic diseases: A population-based study of more than forty thousand patients
- Author
-
De Lorenzis, E., Parente, Paolo, Natalello, G., Soldati, S., Bosello, Silvia Laura, Barbara, A., Sorge, C., Axelrod, S., Verardi, Lucrezia, Cerasuolo, Pier Giacomo, Peluso, Giusy, Gemma, A., Davoli, Marina, Biliotti, D., Bruzzese, Vincenzo, Goletti, M., Di Martino, M., D'Agostino, M. A., Parente P., Bosello S. L. (ORCID:0000-0002-4837-447X), Verardi L., Cerasuolo P. G., Peluso G., Davoli M., Bruzzese V., De Lorenzis, E., Parente, Paolo, Natalello, G., Soldati, S., Bosello, Silvia Laura, Barbara, A., Sorge, C., Axelrod, S., Verardi, Lucrezia, Cerasuolo, Pier Giacomo, Peluso, Giusy, Gemma, A., Davoli, Marina, Biliotti, D., Bruzzese, Vincenzo, Goletti, M., Di Martino, M., D'Agostino, M. A., Parente P., Bosello S. L. (ORCID:0000-0002-4837-447X), Verardi L., Cerasuolo P. G., Peluso G., Davoli M., and Bruzzese V.
- Published
- 2023
6. Telemedicine will not keep us apart in COVID-19 pandemic
- Author
-
Perniola, S., Alivernini, Stefano, Varriano, V., Paglionico, A., Tanti, G., Rubortone, Pietro, Lanzo, Lucia, Melpignano, Fabrizio, Tur, Carlo, De Lorenzis, E., Peluso, Giusy, Capacci, A., Gremese, Elisa, Alivernini S. (ORCID:0000-0002-7383-4212), Rubortone P., Lanzo L., Melpignano F., Tur C., Peluso G., Gremese E. (ORCID:0000-0002-2248-1058), Perniola, S., Alivernini, Stefano, Varriano, V., Paglionico, A., Tanti, G., Rubortone, Pietro, Lanzo, Lucia, Melpignano, Fabrizio, Tur, Carlo, De Lorenzis, E., Peluso, Giusy, Capacci, A., Gremese, Elisa, Alivernini S. (ORCID:0000-0002-7383-4212), Rubortone P., Lanzo L., Melpignano F., Tur C., Peluso G., and Gremese E. (ORCID:0000-0002-2248-1058)
- Abstract
not applicable
- Published
- 2021
7. Postural control and disability in patients with early rheumatoid arthritis
- Author
-
De Lorenzis, E., Crudo, Fabrizio, Fedele, Anna Laura, Fiorita, Antonella, Bruno, Dario, Paludetti, Gaetano, Alivernini, Stefano, Giraldi, Luca, Picciotti, Pasqualina Maria, Zoli, Angelo, Cadoni, Gabriella, Crudo F., Fedele A. L., Fiorita A., Bruno D., Paludetti G. (ORCID:0000-0003-2480-1243), Alivernini S. (ORCID:0000-0002-7383-4212), Giraldi L., Picciotti P. M. (ORCID:0000-0002-1502-6508), Zoli A. (ORCID:0000-0003-1597-058X), Cadoni G. (ORCID:0000-0001-8244-784X), De Lorenzis, E., Crudo, Fabrizio, Fedele, Anna Laura, Fiorita, Antonella, Bruno, Dario, Paludetti, Gaetano, Alivernini, Stefano, Giraldi, Luca, Picciotti, Pasqualina Maria, Zoli, Angelo, Cadoni, Gabriella, Crudo F., Fedele A. L., Fiorita A., Bruno D., Paludetti G. (ORCID:0000-0003-2480-1243), Alivernini S. (ORCID:0000-0002-7383-4212), Giraldi L., Picciotti P. M. (ORCID:0000-0002-1502-6508), Zoli A. (ORCID:0000-0003-1597-058X), and Cadoni G. (ORCID:0000-0001-8244-784X)
- Abstract
PMID: 33427617 Abstract Objectives: Rheumatoid arthritis (RA) may affect the postural control through abnormal sensory inputs and impaired motor responses. Sensory Organization Test (SOT) objectively evaluates contribution of different sensorial afferences in postural control. The aim of the study is to assess mechanisms of postural instability and their relations with disability and disease characteristics in an early RA(ERA) cohort. Methods: The equilibrium scores were assessed in 30 ERA patients and 30 age- and sex-matched controls. The somatosensory (SOM), visual (VIS) and vestibular (VEST) ratios were computed to assess the use of different sensory and the composite equilibrium score (CES) as a measure of global balance performance. Results: ERA patients had lower CES (78.4±6.0% vs. 83.4±5.0%, p=0.002), SOM ratio (98.5±1.8% vs. 99.6±2.1%, p=0.035), VIS ratio (85.2±7.6% vs. 91.5±6.0%, p=0.001) and VEST ratio (70.8±10.0% vs. 80.3±7.8%, p<0.001) compared to controls. The presence of ankle arthritis correlated negatively to both SOM (r=-0.369, p=0.045) and VIS ratio (r=0.470, p=0.009), pain severity to CES (r=-0.389, p=0.045) and VIS ratio (r=-0.385, p=0.048) and HAQ-DI to CES (r=-0.591, p=0.001), SOM (r=-0.510, p=0.004) and VIS ratio (r=-0.390, p=0.033.). Patients-reported postural instability was associated with lower CES (75.4±5.4% vs. 80.7±5.5%, p=0.016) and VEST ratios (66.5±10.1% vs. 74.1±8.8%, p=0.036). SOT outcomes did not differ according to acute phase reactants, disease activity or autoantibody positivity. Conclusions: RA patients showed an early impairment of postural control related to the degree of disability and subjective postural instability. Our data suggest that the lack of balance could result from both impaired motor response and abnormal sensory organisation.
- Published
- 2021
8. No higher risk of respiratory symptoms in Italian rheumatological patients under IL-6R-inhibitor therapy in SARS-CoV-2 pandemic
- Author
-
Alivernini, Stefano, Petricca, L., Perniola, S., Fedele, A. L., Gigante, M. R., Capacci, A., Paglionico, A., Varriano, V., De Lorenzis, E., Lanzo, Lucia, Melpignano, Fabrizio, Rubortone, Pietro, Tanti, Giacomo, Tur, Carlo, Bruno, Dario, Gigante, Laura, Natalello, Gerlando, Verardi, Lucrezia, Di Mario, Clara, Tolusso, Barbara, Mirone, Luisa, Lizzio, Marco Maria, Zoli, Angelo, Peluso, G., Bosello, Silvia Laura, Gremese, Elisa, Alivernini S. (ORCID:0000-0002-7383-4212), Lanzo L., Melpignano F., Rubortone P., Tanti G., Tur C., Bruno D., Gigante L., Natalello G., Verardi L., Di Mario C., Tolusso B. (ORCID:0000-0002-9108-6609), Mirone L. (ORCID:0000-0001-5820-5533), Lizzio M. M., Zoli A. (ORCID:0000-0003-1597-058X), Bosello S. L. (ORCID:0000-0002-4837-447X), Gremese E. (ORCID:0000-0002-2248-1058), Alivernini, Stefano, Petricca, L., Perniola, S., Fedele, A. L., Gigante, M. R., Capacci, A., Paglionico, A., Varriano, V., De Lorenzis, E., Lanzo, Lucia, Melpignano, Fabrizio, Rubortone, Pietro, Tanti, Giacomo, Tur, Carlo, Bruno, Dario, Gigante, Laura, Natalello, Gerlando, Verardi, Lucrezia, Di Mario, Clara, Tolusso, Barbara, Mirone, Luisa, Lizzio, Marco Maria, Zoli, Angelo, Peluso, G., Bosello, Silvia Laura, Gremese, Elisa, Alivernini S. (ORCID:0000-0002-7383-4212), Lanzo L., Melpignano F., Rubortone P., Tanti G., Tur C., Bruno D., Gigante L., Natalello G., Verardi L., Di Mario C., Tolusso B. (ORCID:0000-0002-9108-6609), Mirone L. (ORCID:0000-0001-5820-5533), Lizzio M. M., Zoli A. (ORCID:0000-0003-1597-058X), Bosello S. L. (ORCID:0000-0002-4837-447X), and Gremese E. (ORCID:0000-0002-2248-1058)
- Abstract
NA
- Published
- 2020
9. No higher risk of respiratory symptoms in Italian rheumatological patients under IL-6R-inhibitor therapy in SARS-CoV-2 pandemic
- Author
-
Alivernini, Stefano, Petricca, L., Perniola, S., Fedele, A. L., Gigante, M. R., Capacci, A., Paglionico, A., Varriano, V., De Lorenzis, E., Lanzo, Lucia, Melpignano, Fabrizio, Rubortone, Pietro, Tanti, Giacomo, Tur, Carlo, Bruno, Dario, Gigante, Laura, Natalello, Gerlando, Verardi, Lucrezia, Di Mario, Clara, Tolusso, Barbara, Mirone, Luisa, Lizzio, Marco Maria, Zoli, Angelo, Peluso, G., Bosello, Silvia Laura, Gremese, Elisa, Alivernini S. (ORCID:0000-0002-7383-4212), Lanzo L., Melpignano F., Rubortone P., Tanti G., Tur C., Bruno D., Gigante L., Natalello G., Verardi L., Di Mario C., Tolusso B. (ORCID:0000-0002-9108-6609), Mirone L. (ORCID:0000-0001-5820-5533), Lizzio M. M., Zoli A. (ORCID:0000-0003-1597-058X), Bosello S. L. (ORCID:0000-0002-4837-447X), Gremese E. (ORCID:0000-0002-2248-1058), Alivernini, Stefano, Petricca, L., Perniola, S., Fedele, A. L., Gigante, M. R., Capacci, A., Paglionico, A., Varriano, V., De Lorenzis, E., Lanzo, Lucia, Melpignano, Fabrizio, Rubortone, Pietro, Tanti, Giacomo, Tur, Carlo, Bruno, Dario, Gigante, Laura, Natalello, Gerlando, Verardi, Lucrezia, Di Mario, Clara, Tolusso, Barbara, Mirone, Luisa, Lizzio, Marco Maria, Zoli, Angelo, Peluso, G., Bosello, Silvia Laura, Gremese, Elisa, Alivernini S. (ORCID:0000-0002-7383-4212), Lanzo L., Melpignano F., Rubortone P., Tanti G., Tur C., Bruno D., Gigante L., Natalello G., Verardi L., Di Mario C., Tolusso B. (ORCID:0000-0002-9108-6609), Mirone L. (ORCID:0000-0001-5820-5533), Lizzio M. M., Zoli A. (ORCID:0000-0003-1597-058X), Bosello S. L. (ORCID:0000-0002-4837-447X), and Gremese E. (ORCID:0000-0002-2248-1058)
- Abstract
No abstract available
- Published
- 2020
10. Gut microbiota analysis in systemic sclerosis according to disease characteristics and nutritional status
- Author
-
Natalello, Gerlando, Bosello, Silvia Laura, Sterbini, F. P., Posteraro, Brunella, de Lorenzis, E., Canestrari, G. B., Gigante, Laura, Verardi, Lucrezia, Ferraccioli, Gianfranco, Sanguinetti, Maurizio, Gremese, Elisa, Natalello G., Bosello S. L. (ORCID:0000-0002-4837-447X), Posteraro B. (ORCID:0000-0002-1663-7546), Gigante L., Verardi L., Ferraccioli G. (ORCID:0000-0001-6246-2428), Sanguinetti M. (ORCID:0000-0002-9780-7059), Gremese E. (ORCID:0000-0002-2248-1058), Natalello, Gerlando, Bosello, Silvia Laura, Sterbini, F. P., Posteraro, Brunella, de Lorenzis, E., Canestrari, G. B., Gigante, Laura, Verardi, Lucrezia, Ferraccioli, Gianfranco, Sanguinetti, Maurizio, Gremese, Elisa, Natalello G., Bosello S. L. (ORCID:0000-0002-4837-447X), Posteraro B. (ORCID:0000-0002-1663-7546), Gigante L., Verardi L., Ferraccioli G. (ORCID:0000-0001-6246-2428), Sanguinetti M. (ORCID:0000-0002-9780-7059), and Gremese E. (ORCID:0000-0002-2248-1058)
- Abstract
Objective. Systemic sclerosis (SSc) is a rare multi-organ disorder with a prominent gastrointestinal (GI) involvement. Altered gut microbiota is now considered a pivotal factor associated with the development of immune-mediated and inflammatory diseases. We performed a 16S ribosomal RNA (rRNA) gene-sequencing analysis of fecal microbiota in a cohort of SSc patients and matched healthy controls (HCs), with the aim to obtain some hints about a possible role of dysbiosis in the onset, progression, and severity of the disease. Methods. We analysed stool samples from 63 SSc patients with different disease duration, phenotype, and nutritional status and from 17 HCs through 16S ribosomal RNA (rRNA) gene-sequencing. Results. Microbial richness was lower for patients with long-standing disease. A similar observation was made for patients with diffuse cutaneous SSc (dsSSc) compared to those with limited variant (lcSSc) and for patients who reported a recent weight loss. Consistent with previous reports, we noted a deviation of the intestinal microbial composition in patients with SSc compared to HCs, with a greater expression of Lactobacillus and Streptococcus and a depletion of Sutterella. Nutritional status, assessed using BMI as a surrogate, appeared to have a marked impact on the gut microbiota, with overweight patients showing lower richness compared both to underweight and normal-BMI patients. Conclusion. Our findings expand the current knowledge of gut microbiota in SSc and could be useful to identify patients who would most benefit from treatments aimed at restoring the eubiosis.
- Published
- 2020
11. Urolithiasis practice patterns following the COVID-19 pandemic: overview from the EULIS collaborative research working group
- Author
-
Kiremit, Murat Can, Tefik, T.; Güven, S.; Villa, L.; Gökçe, M.I.; Kallidonis, P.; Petkova, K.; Kiremit, M.C.; Sönmez, M.G.; de Lorenzis E.; Eryıldırım, B.; Sarıca, K., School of Medicine, Kiremit, Murat Can, Tefik, T.; Güven, S.; Villa, L.; Gökçe, M.I.; Kallidonis, P.; Petkova, K.; Kiremit, M.C.; Sönmez, M.G.; de Lorenzis E.; Eryıldırım, B.; Sarıca, K., and School of Medicine
- Abstract
NA
- Published
- 2020
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.