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1. The Reactivation of Dimethylcarbamoyl-Acetylcholinesterase

Author

CHEMICAL DEFENCE ESTABLISHMENT PORTON DOWN (UNITED KINGDOM), Barrass, B. C., Cole, B. R., Coult, D. B., CHEMICAL DEFENCE ESTABLISHMENT PORTON DOWN (UNITED KINGDOM), Barrass, B. C., Cole, B. R., and Coult, D. B.

Abstract

Several quaternary ammonium salts have been prepared as possible enzyme reactivators for the treatment of carbamate poisoning. Compounds which possess one or more free hydroxy groups accelerated the rate of spontaneous reactivation, but compounds lacking hydroxy groups either had no effect or actually inhibited the rate of spontaneous reactivation. It is concluded that the acceleration factors observed were sufficiently high to warrant testing of the compounds in vivo.

Published
1971

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