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Background: Pediatric investigation plans (PIPs) describe how adult drugs can be studied in children. In 2015, PIPs for Amyotrophic Lateral Sclerosis (ALS) became mandatory for European marketing-authorization of adult treatments, unless a waiver is granted by the European Medicines Agency (EMA). Objective: To assess the feasibility of clinical studies on the effect of therapy in children (<18 years) with ALS in Europe. Methods: The EMA database was searched for submitted PIPs in ALS. A questionnaire was sent to 58 European ALS centers to collect the prevalence of pediatric ALS during the past ten years, the recruitment potential for future pediatric trials, and opinions of ALS experts concerning a waiver for ALS. Results: Four PIPs were identified; two were waived and two are planned for the future. In total, 49 (84.5%) centers responded to the questionnaire. The diagnosis of 44,858 patients with ALS was reported by 46 sites; 39 of the patients had an onset < 18 years (prevalence of 0.008 cases per 100,000 or 0.087% of all diagnosed patients). The estimated recruitment potential (47 sites) was 26 pediatric patients within five years. A majority of ALS experts (75.5%) recommend a waiver should apply for ALS due to the low prevalence of pediatric ALS. Conclusions: ALS with an onset before 18 years is extremely rare and may be a distinct entity from adult ALS. Conducting studies on the effect of disease-modifying therapy in pediatric ALS may involve lengthy recruitment periods, high costs, ethical/legal implications, challenges in trial design and limited information.

Background: Pediatric investigation plans (PIPs) describe how adult drugs can be studied in children. In 2015, PIPs for Amyotrophic Lateral Sclerosis (ALS) became mandatory for European marketing-authorization of adult treatments, unless a waiver is granted by the European Medicines Agency (EMA). Objective: To assess the feasibility of clinical studies on the effect of therapy in children (<18 years) with ALS in Europe. Methods: The EMA database was searched for submitted PIPs in ALS. A questionnaire was sent to 58 European ALS centers to collect the prevalence of pediatric ALS during the past ten years, the recruitment potential for future pediatric trials, and opinions of ALS experts concerning a waiver for ALS. Results: Four PIPs were identified; two were waived and two are planned for the future. In total, 49 (84.5%) centers responded to the questionnaire. The diagnosis of 44,858 patients with ALS was reported by 46 sites; 39 of the patients had an onset < 18 years (prevalence of 0.008 cases per 100,000 or 0.087% of all diagnosed patients). The estimated recruitment potential (47 sites) was 26 pediatric patients within five years. A majority of ALS experts (75.5%) recommend a waiver should apply for ALS due to the low prevalence of pediatric ALS. Conclusions: ALS with an onset before 18 years is extremely rare and may be a distinct entity from adult ALS. Conducting studies on the effect of disease-modifying therapy in pediatric ALS may involve lengthy recruitment periods, high costs, ethical/legal implications, challenges in trial design and limited information.

Background: Pediatric investigation plans (PIPs) describe how adult drugs can be studied in children. In 2015, PIPs for Amyotrophic Lateral Sclerosis (ALS) became mandatory for European marketing-authorization of adult treatments, unless a waiver is granted by the European Medicines Agency (EMA). Objective: To assess the feasibility of clinical studies on the effect of therapy in children (<18 years) with ALS in Europe. Methods: The EMA database was searched for submitted PIPs in ALS. A questionnaire was sent to 58 European ALS centers to collect the prevalence of pediatric ALS during the past ten years, the recruitment potential for future pediatric trials, and opinions of ALS experts concerning a waiver for ALS. Results: Four PIPs were identified; two were waived and two are planned for the future. In total, 49 (84.5%) centers responded to the questionnaire. The diagnosis of 44,858 patients with ALS was reported by 46 sites; 39 of the patients had an onset < 18 years (prevalence of 0.008 cases per 100,000 or 0.087% of all diagnosed patients). The estimated recruitment potential (47 sites) was 26 pediatric patients within five years. A majority of ALS experts (75.5%) recommend a waiver should apply for ALS due to the low prevalence of pediatric ALS. Conclusions: ALS with an onset before 18 years is extremely rare and may be a distinct entity from adult ALS. Conducting studies on the effect of disease-modifying therapy in pediatric ALS may involve lengthy recruitment periods, high costs, ethical/legal implications, challenges in trial design and limited information.

Background: Pediatric investigation plans (PIPs) describe how adult drugs can be studied in children. In 2015, PIPs for Amyotrophic Lateral Sclerosis (ALS) became mandatory for European marketing-authorization of adult treatments, unless a waiver is granted by the European Medicines Agency (EMA). Objective: To assess the feasibility of clinical studies on the effect of therapy in children (<18 years) with ALS in Europe. Methods: The EMA database was searched for submitted PIPs in ALS. A questionnaire was sent to 58 European ALS centers to collect the prevalence of pediatric ALS during the past ten years, the recruitment potential for future pediatric trials, and opinions of ALS experts concerning a waiver for ALS. Results: Four PIPs were identified; two were waived and two are planned for the future. In total, 49 (84.5%) centers responded to the questionnaire. The diagnosis of 44,858 patients with ALS was reported by 46 sites; 39 of the patients had an onset < 18 years (prevalence of 0.008 cases per 100,000 or 0.087% of all diagnosed patients). The estimated recruitment potential (47 sites) was 26 pediatric patients within five years. A majority of ALS experts (75.5%) recommend a waiver should apply for ALS due to the low prevalence of pediatric ALS. Conclusions: ALS with an onset before 18 years is extremely rare and may be a distinct entity from adult ALS. Conducting studies on the effect of disease-modifying therapy in pediatric ALS may involve lengthy recruitment periods, high costs, ethical/legal implications, challenges in trial design and limited information.

Background: Pediatric investigation plans (PIPs) describe how adult drugs can be studied in children. In 2015, PIPs for Amyotrophic Lateral Sclerosis (ALS) became mandatory for European marketing-authorization of adult treatments, unless a waiver is granted by the European Medicines Agency (EMA). Objective: To assess the feasibility of clinical studies on the effect of therapy in children (<18 years) with ALS in Europe. Methods: The EMA database was searched for submitted PIPs in ALS. A questionnaire was sent to 58 European ALS centers to collect the prevalence of pediatric ALS during the past ten years, the recruitment potential for future pediatric trials, and opinions of ALS experts concerning a waiver for ALS. Results: Four PIPs were identified; two were waived and two are planned for the future. In total, 49 (84.5%) centers responded to the questionnaire. The diagnosis of 44,858 patients with ALS was reported by 46 sites; 39 of the patients had an onset < 18 years (prevalence of 0.008 cases per 100,000 or 0.087% of all diagnosed patients). The estimated recruitment potential (47 sites) was 26 pediatric patients within five years. A majority of ALS experts (75.5%) recommend a waiver should apply for ALS due to the low prevalence of pediatric ALS. Conclusions: ALS with an onset before 18 years is extremely rare and may be a distinct entity from adult ALS. Conducting studies on the effect of disease-modifying therapy in pediatric ALS may involve lengthy recruitment periods, high costs, ethical/legal implications, challenges in trial design and limited information.

Fe Mössbauer spectra have been recorded from the hexagonal (6H)- and trigonal (15R)- modifications of BaFeOF and are compared with those previously recorded from the cubic form of BaFeOF. The spectra, recorded over a temperature range from 15 to 650 K show that all of the iron in all the compounds is in the Fe state. Spectra from the 6H- and 15R-modifications were successfully fitted with components that were related to the Fe(1) and Fe(2) structural sites in the 6H variant and to the Fe(1), Fe(2) and Fe(3) structural sites in the 15R form. The magnetic ordering temperatures were determined as 597 ± 3 K for 6H-BaFeOF and 636 ± 3 K for 15R-BaFeOF. These values are surprisingly close to the value of 645 ± 5 K determined for the cubic form. The magnetic interactions in the three forms are compared with a view to explaining this similarity of magnetic ordering temperature.

Members of the Mueller family play shuffleboard near their home at Lake Maxinkuckee., This photograph album, dated 1935–1944, was created by the Clemens O. Mueller family and includes photographs of family members in Indianapolis, at Lake Maxinkuckee in Culver, and at DePauw University in Greencastle. This album features many photos of Clemens' daughter, Marjorie Jean Mueller, from her time at DePauw University and John Herron School of Arts. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926) of Indianapolis. The Mueller family was known for the Mooney-Mueller Drug Company of Indianapolis.

This photograph, captioned "Going to the Lake" shows several friends of Clemens O. Mueller arriving at Culver, Indiana to spend time at the Mueller family's cottage at Lake Maxinkuckee., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage. These three families also owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

The Mooney Mueller Drug Company of Indianapolis was formed by William J. Mooney and J. George Mueller in 1902. This photo shows the company's building at 101 N. Meridian Street in 1910., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage. These three families also owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

Alex Vonnegut, son of noted Indianapolis architect Bernard Vonnegut, was photographed studying in his room. Clemens O. Mueller and Alex Vonnegut were first cousins through their mothers Nannie (Schnull) Vonnegut and Julia (Schnull) Mueller. In addition to spending much time together in Indianapolis and vacationing at Lake Maxinkuckee, cousins Clemens and Alex also attended Harvard University together from around 1906-1911., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage. These three families also owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

Clemens O. Mueller, age 11, wrote this short poem about Lake Maxinkuckee as part his handwritten newspaper. His family owned a cottage along the lake's east shore where they spent summers starting in the 1880s.

Clemens O. Mueller, son of J. George and Julia Schnull Mueller, made this list of guests that he titled "People at Maxinkuckee - Three Cottages (Potts, Mueller-Vonnegut, C. Vonnegut)." The handwritten list of guests includes many notable vacationers from Indianapolis including Mr. and Mrs. Meredith Nicholson, Mr. and Mrs. Alfred F. Potts, and the families of Mr. and Mrs. Clemens Vonnegut, Jr. and Mr. and Mrs. Bernard Vonnegut. The Schnull, Mueller, and Vonnegut families all owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

Clemens O. Mueller kept this score sheet for the tennis matches that he had with his cousins and friends while vacationing at Lake Maxinkuckee in the summer of 1905. Mueller played several matches with his first cousins Alex, Kurt (Sr.), and Irma Vonnegut, the children of noted Indianapolis architect Bernard Vonnegut and his wife Nannie. The Schnull, Mueller, and Vonnegut families all owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

Sisters Nannie Schnull Vonnegut and and Emma Schnull Vonnegut stand on the Vonnegut Pier on the east shore of Lake Maxinkuckee in Culver, Indiana. The Schnull sisters were married to brothers Bernard Vonnegut and Clemens Vonnegut Jr., respectively. The families vacationed in cottages on Lake Maxinkuckee. The sisters were aunts to Clemens Mueller, who labeled this photo, through his mother Julia Schnull Mueller., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage. These three families also owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

Marjorie Mueller (left) stands with her friend Anne Rose on the family pier at Lake Maxinkuckee in Culver, Indiana., This photograph album, dated 1935–1944, was created by the Clemens O. Mueller family and includes photographs of family members in Indianapolis, at Lake Maxinkuckee in Culver, and at DePauw University in Greencastle. This album features many photos of Clemens' daughter, Marjorie Jean Mueller, from her time at DePauw University and John Herron School of Arts. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926) of Indianapolis. The Mueller family was known for the Mooney-Mueller Drug Company of Indianapolis.

Jeannie O., a friend of the Mueller family, poses by a car in front of a cottage at Lake Maxinkuckee., This photograph album, dated 1935–1944, was created by the Clemens O. Mueller family and includes photographs of family members in Indianapolis, at Lake Maxinkuckee in Culver, and at DePauw University in Greencastle. This album features many photos of Clemens' daughter, Marjorie Jean Mueller, from her time at DePauw University and John Herron School of Arts. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926) of Indianapolis. The Mueller family was known for the Mooney-Mueller Drug Company of Indianapolis.

Zuleme Mueller (seated left) entertains friends on the lawn at her home on Lake Macinkuckee in Culver, Indiana., This photograph album, dated 1935–1944, was created by the Clemens O. Mueller family and includes photographs of family members in Indianapolis, at Lake Maxinkuckee in Culver, and at DePauw University in Greencastle. This album features many photos of Clemens' daughter, Marjorie Jean Mueller, from her time at DePauw University and John Herron School of Arts. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926) of Indianapolis. The Mueller family was known for the Mooney-Mueller Drug Company of Indianapolis.

Knobby, the Mueller family dog, is pictured in the family's boat at Lake Maxinkuckee., This photograph album, dated 1935–1944, was created by the Clemens O. Mueller family and includes photographs of family members in Indianapolis, at Lake Maxinkuckee in Culver, and at DePauw University in Greencastle. This album features many photos of Clemens' daughter, Marjorie Jean Mueller, from her time at DePauw University and John Herron School of Arts. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926) of Indianapolis. The Mueller family was known for the Mooney-Mueller Drug Company of Indianapolis.

Marjorie Mueller poses for a photo in a boat at Lake Maxinkuckee near her family's cottage., This photograph album, dated 1935–1944, was created by the Clemens O. Mueller family and includes photographs of family members in Indianapolis, at Lake Maxinkuckee in Culver, and at DePauw University in Greencastle. This album features many photos of Clemens' daughter, Marjorie Jean Mueller, from her time at DePauw University and John Herron School of Arts. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926) of Indianapolis. The Mueller family was known for the Mooney-Mueller Drug Company of Indianapolis.

Clemens O. Mueller's July 1907-May 1908 diary chronicles his family's summer trip to Europe, as well as his freshman year at Harvard University. His cousin and close friend Alex Vonnegut also attended Harvard that fall. The diary includes several scrapbook items such as ticket stubs and programs from European travel and Harvard. Mueller was the son of Indianapolis druggist J. George Mueller and Julia Schnull Mueller. His extended family, the Muellers, Schnulls, and Vonneguts, were prominent German Americans who lived in close proximity to each other on what is now Indianapolis's Old North Side., Related Material: Images from the Schnull-Mueller-Vonnegut Collection http://images.indianahistory.org/cdm/search/collection/p16797coll30/searchterm/1908/order/title

Clemens O. Mueller, a student at Shortridge High School, dedicated his 1905 diary to the "memory of my Grandfather Henry Schnull Died November 4, 1905." Mueller's diary chronicles daily life in Indianapolis as part of the extended Mueller, Schnull, and Vonnegut families. These prominent German American families lived in close proximity to each other on what is now Indianapolis's Old North Side. Mueller often writes of outings with his cousins and close companions Kurt and Alex Vonnegut, sons of his Uncle Bernard Vonnegut and Aunt Nannie Schnull Vonnegut. In his diary, Mueller also describes his summer at Lake Maxinkuckee with his extended family who owned cottages along the east shore of the lake, including Uncle Clemens Vonnegut, Sr. and Aunt Emma Schnull Vonnegut and children Ella, Tony, and Walter. In the summer of 1905, Mueller also went on a hiking and camping trip to Brown County, Indiana with cousins Kurt Vonnegut and Jacob Schramm., Related Materials: Images from the Schnull-Mueller-Vonnegut Collection http://images.indianahistory.org/cdm/search/collection/p16797coll30/searchterm/1905/order/title

Clemens O. Mueller's March 1912-January 1913 diary chronicles his daily life as a young professional working at Mooney-Mueller Drug Co. in Indianapolis, following his graduation from Harvard. Mueller, a member of the Männerchor (Men's Chorus), and his close friends and relatives were active in the German American and arts scene in Indianapolis. In 1912 he became engaged to Zuleme Kinney during a trip to his family's cottage on Lake Maxinkuckee. Mueller was the son of Indianapolis druggist J. George Mueller and Julia Schnull Mueller. His extended family, the Muellers, Schnulls, and Vonneguts, were prominent German Americans who lived in close proximity to each other on what is now Indianapolis's Old North Side.

In his 1902 diary, Clemens O. Mueller chronicled daily life in Indianapolis and summers at Lake Maxinkuckee with his extended Mueller, Schnull, and Vonnegut family. In this excerpt, Mueller describes his summers at Lake Maxinkuckee, the family cottages along the east shore of the lake, and also a little bit of history and geographical information about the lake. On the third page of the excerpt is a drawing by Mueller of Lake Maxinkuckee showing many landmarks around the lake including Culver Military Academy, the Henry Culver residence, Mueller-Vonnegut Pier, Palmer House, Lakeview Hotel, and Norris Farm.

Mother and daughter, Zuleme and Marjorie Mueller, pose on the Vonnegut Pier located on the east shore of Lake Maxinkuckee in Culver, Indiana. The Schnull, Vonnegut, and Mueller families of Indianapolis owned cottages along the east shore of the lake and spent summers there starting in the 1880s., This photograph album was created by Clemens O. and Zuleme Kinney Mueller. Photographs from the album are dated from June 1918 through December 1921, and document the first three years of Marjorie Jean Mueller's life in Indianapolis and Culver, Indiana. The Mueller family was known for the Mooney-Mueller Drug Company of Indianapolis.

Clemens O. Mueller's 1906 diary was a Christmas gift from his mother, Julia Schnull Mueller. Mueller's diary chronicles daily life in Indianapolis as a junior at Shortridge High School. His extended family, the Muellers, Schnulls, and Vonneguts, were prominent German Americans who lived in close proximity to each other on what is now Indianapolis's Old North Side. Mueller often writes of outings with his cousins and close companions Kurt, Alex, and Irma Vonnegut, children of his Uncle Bernard Vonnegut and Aunt Nannie Schnull Vonnegut. He also describes his summer at Lake Maxinkuckee with his extended family who owned cottages along the east shore of the lake, including Uncle Clemens Vonnegut, Sr. and Aunt Emma Schnull Vonnegut and children Ella, Tony, and Walter. Notable events in 1906 were a family trip to Cuba and his camping trip along the Ohio River with cousins Kurt Vonnegut and Jacob Schramm., Related Material: Images from the Schnull-Mueller-Vonnegut Collection http://images.indianahistory.org/cdm/search/collection/p16797coll30/searchterm/1906/order/title

Clemens O. Mueller took this photo of Bean Blossom during a camping trip in Brown County in 1905., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage.

The Mueller family poses in front of a body of water with friends on a visit to Massachusetts to see their son Clemens who attended Harvard University. Seated are Mrs. John Rach, Sr. and J. George Mueller. Standing at left is John G. Rauch (a roommate and friend of Clemens), Norma Mueller, and John Rauch, Sr., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage.

Clemens O. Mueller (class of 1911), with robe and pipe, studies in his Harvard University dormitory. He attended Harvard with a group of young men from Indianapolis, including friend John G. Rauch and cousin Alex Vonnegut who were both from prominent families of German heritage., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage.

Teenagers Clemens Mueller, Kurt Vonnegut Sr., and Jacob Schramm documented their 1906 Ohio River camping trip in these photo album pages. Mueller and Vonnegut of Indianapolis were first cousins through their mothers Julia Schnull Mueller and Nannie Schnull Vonnegut. Jacob Schramm, from Hancock County, was their first cousin once removed through the Schramm and Schnull families., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage.

This photograph, labeled "View of sailboat from Vonnegut Platform," shows a pier and sailboat near the east shore of Lake Maxinkuckee, as viewed from the Vonnegut family's deck., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage.

These photo albums pages show Harvard University's campus in 1910. Clemens O. Mueller (class of 1911) attended Harvard along with his cousin Alex Vonnegut and friend John G. Rauch. These young men were all from Indianapolis, from prominent German families., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage.

Zuleme and Marjorie Mueller (age 2) pose on the Vonnegut Pier located on the east shore of Lake Maxinkuckee in Culver, Indiana. The Schnull, Vonnegut, and Mueller families of Indianapolis owned cottages along the east shore of the lake and spent summers there starting in the 1880s., This photograph album was created by Clemens O. and Zuleme Kinney Mueller. Photographs from the album are dated from June 1918 through December 1921, and document the first three years of Marjorie Jean Mueller's life in Indianapolis and Culver, Indiana. The Mueller family was known for the Mooney-Mueller Drug Company of Indianapolis.

This diary excerpt, dated July-August 1904, was created by Clemens O. Mueller and includes descriptions of his family's summer vacation at Lake Maxinkuckee. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married the Vonnegut brothers Clemens Jr. and Bernard, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis families of German heritage. These three families owned cottages along the east shore of the lake and spent summers there starting in the 1880s. Highlights of this diary excerpt include descriptions of the weather, conditions of sailing on the lake, family sports and recreation, outings, and parties. Among the noted visitors to the cottages that summer was Meredith Nicholson, who later wrote House of Thousand Candles, which was set in a small town based on the Culver area and Lake Maxinkuckee., Related material: Guest List for Lake Maxinkuckee Cottages, 1904 http://images.indianahistory.org/cdm/singleitem/collection/p16797coll30/id/121/rec/8

The piano in Clemens Mueller's dormitory at Harvard displays several pieces of sheet music. He enjoyed playing the piano and likely entertained his dorm mates and fellow students., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage.

This photograph album page, created by Marjorie Mueller, shows 4th year students at the Herron School of Art in Indianapolis, Indiana. Students named in the photos include Vi Adkins; Verona, Lucy, Jim Darlington, and Marjorie Mueller., This photograph album, dated 1935–1944, was created by the Clemens O. Mueller family and includes photographs of family members in Indianapolis, at Lake Maxinkuckee in Culver, and at DePauw University in Greencastle. This album features many photos of Clemens' daughter, Marjorie Jean Mueller, from her time at DePauw University and John Herron School of Arts. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926) of Indianapolis. The Mueller family was known for the Mooney-Mueller Drug Company of Indianapolis.

This photograph captioned "Gertrude, Norma [Mueller], Edna, and Bertha" shows four young women bathing in Lake Maxinkuckee in Culver, Indiana. Norma Mueller was the daughter of J. George and Julia (Schnull Mueller) who owned a cottage on the east shore of Lake Maxinkuckee. Gertrude, Edna and Bertha Schnull were her first cousins, daughters of Gustav Schnull of Indianapolis. The Schnull, Mueller, and Vonnegut families of Indianapolis spent summers at the lake starting in the 1880s., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage. These three families also owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

The J. G. Mueller family's boat "Hilarity" is shown near the east shore of Lake Maxinkuckee in Culver, Indiana. The Mueller family owned a cottage on the lake named Hilarity Hill., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage. These three families also owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

Members of the Schnull, Mueller and Vonnegut family and their friends gathered for a picture at their tennis court near the family cottages at Lake Maxinkuckee. Members of the group are identified in the photo album by Clemens O. Mueller. First row (left to right): Clemens O. Mueller, Walter [Vonnegut], Will Fleet, Dr. Clark. Second row (left to right): Mrs. [May] Potts, Aunt Nannie [Vonnegut], Edna, Josephine Parrott, Deborah [Potts], Irma [Vonnegut], Aunt Emma [Vonnegut], Ella [Vonnegut], Marjorie [Potts], Mrs. Clark, Norma [Mueller], Mama [Julia Schnull Mueller]., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage. These three families also owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

Julia (Schnull) and J. George Mueller pose under their pergola at their Lake Maxinkuckee cottage which they called Hilarity Hill. Hilarity Hill, built in 1907-1908, was located at 844 East Shore Drive in Culver, Indiana., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage. These three families also owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

A view of a sailboat is shown on Lake Maxinkuckee from Hilarity Hill, the home of J. George Mueller. The cottage, built in 1907-1908, was located at 844 East Shore Drive in Culver, Indiana., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage. These three families also owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

Clemens O. Mueller poses in a track uniform while vacationing at Lake Maxinkuckee. At the time he attended Harvard University and may have been on the track team there, as 1911 was his graduating year., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage. These three families also owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

This view of the Vonnegut family pier on Lake Maxinkuckee was photographed by Clemens Mueller from the bluff above where his Uncles Bernard and Clemens Vonnegut had cottages on the east shore of of the lake., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage. These three families also owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

J. George Mueller poses outside his Lake Maxinkuckee cottage which was called Hilarity Hill. The cottage, built in 1907-1908, was located at 844 East Shore Drive in Culver, Indiana., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage. These three families also owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

Norma Mueller, the daughter of J. George and Julia (Schnull) Mueller, poses with her tennis racket. The family maintained a tennis court near their Lake Maxinkuckee cottage in Culver, Indiana., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage. These three families also owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

Clemens O. Mueller rows his boat past an ornate boathouse labeled "Indiana" in Lake Maxinkuckee. His family's cottage was located nearby on the east shore of Lake Maxinkuckee., This photograph album, dated April 1907–October 1910, was created by Clemens O. Mueller and includes photographs of his family at Lake Maxinkuckee, Brown County, and Harvard. Clemens Otto Mueller (1889-1963) was the son of John George Mueller (1860–1932) and Julia Wilhemine Schnull (1864–1926). Julia's sisters Emma and Nannie married into the Vonnegut family, linking the Schnull, Mueller, and Vonnegut families who were all prominent Indianapolis famlies of German heritage. These three families also owned cottages along the east shore of the lake and spent summers there starting in the 1880s.

J. George Mueller poses with his grandchildren Marjorie J. Mueller (age 3) and Horace G. Mueller (infant) during a family trip to Lake Maxinkuckee in Culver, Indiana., This photograph album was created by Clemens O. and Zuleme Kinney Mueller. Photographs from the album are dated from June 1918 through December 1921, and document the first three years of Marjorie Jean Mueller's life in Indianapolis and Culver, Indiana. The Mueller family was known for the Mooney-Mueller Drug Company of Indianapolis.

The three generations of the Mueller and Kinney families of Indianapolis pose on the lawn of the Mueller cottage at Lake Maxinkuckee in Culver, Indiana. Seated from left to right are: Horace E. Kinney, Marjorie Jean Mueller, J. George Mueller, and Horace George Mueller (infant). Standing from left to right are: Zuleme (Kinney) Mueller, Laura J. Kinney Julia (Schnull) Mueller, and Clemens O. Mueller. The Schnull, Vonnegut, and Mueller families of Indianapolis owned cottages along the east shore of the lake and spent summers there starting in the 1880s., This photograph album was created by Clemens O. and Zuleme Kinney Mueller. Photographs from the album are dated from June 1918 through December 1921, and document the first three years of Marjorie Jean Mueller's life in Indianapolis and Culver, Indiana. The Mueller family was known for the Mooney-Mueller Drug Company of Indianapolis.

J. George and Julia (Schnull) Mueller posed with their granddaughter Marjorie on the lawn of their cottage at Lake Maxinkuckee on July 4, 1920. The family hung a large American flag by the lake in celebration of Independence Day., This photograph album was created by Clemens O. and Zuleme Kinney Mueller. Photographs from the album are dated from June 1918 through December 1921, and document the first three years of Marjorie Jean Mueller's life in Indianapolis and Culver, Indiana. The Mueller family was known for the Mooney-Mueller Drug Company of Indianapolis.

This photo captioned "Our Ford sedan in its garage at the Lake" shows the Clemens O. Mueller family car parked at their cottage at Lake Maxinkuckee at Culver, Indiana. Prior to the widespread use of automobiles for travel, vacationers took the train to Lake Maxinkuckee., This photograph album was created by Clemens O. and Zuleme Kinney Mueller. Photographs from the album are dated from June 1918 through December 1921, and document the first three years of Marjorie Jean Mueller's life in Indianapolis and Culver, Indiana. The Mueller family was known for the Mooney-Mueller Drug Company of Indianapolis.

Julia and Marjorie Mueller (age 2) pose on the lawn of their cottage on the east shore of Lake Maxinkuckee in Culver, Indiana. The Schnull, Vonnegut, and Mueller families of Indianapolis owned cottages along the east shore of the lake and spent summers there starting in the 1880s., This photograph album was created by Clemens O. and Zuleme Kinney Mueller. Photographs from the album are dated from June 1918 through December 1921, and document the first three years of Marjorie Jean Mueller's life in Indianapolis and Culver, Indiana. The Mueller family was known for the Mooney-Mueller Drug Company of Indianapolis.