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Iulia Antioch,1 Tsumugu Furuta,2 Ryutaro Uchikawa,3 Masayo Okumura,4 Junichi Otogoto,2 Eiji Kondo,4 Norio Sogawa,5 Alin Ciobica,1 Mihoko Tomida2 1Department of Research, Faculty of Biology, “Alexandru Ioan Cuza” University of Iasi, Iasi, Romania; 2Department of Oral Health Promotion, Graduate School of Oral Medicine, Matsumoto Dental University, Nagano, Japan; 3Department of Dental Conservation, Matsumoto Dental University, Nagano, Japan; 4Department of Oral Anatomy, Matsumoto Dental University, Nagano, Japan; 5Department of Dental Pharmacology, Matsumoto Dental University, Nagano, JapanCorrespondence: Mihoko TomidaDepartment of Oral Health Promotion, Graduate School of Oral Medicine, Matsumoto Dental University, 1780 Gobara Hirooka, Shiojiri-Shi, Nagano 399-0781, JapanTel +81-263-51-2208Email mihoko.tomida@mdu.ac.jpPurpose: Music therapy is widely used to enhance well-being, reduce pain, and distract patients from unpleasant symptoms in the clinical setting. However, the degree to which music modulates pain perception is unknown. The medial pain pathway including the limbic system is associated with emotion, but how music alters pathway activity is unclear. The aim of the study was to investigate pain thresholds and pain-related responses in the anterior cingulate cortex (ACC) and whether they were modulated when subjects listened to their favorite music genre.Subjects and Methods: First, 30 subjects were examined for left forearm pain threshold using electrical stimulation with Pain Vision PS-2011N. The pain thresholds with and without music were compared. Second, when an 80-μA current from Pain Vision was applied to the left ankle of eight women, the pain-related responses of the ACC with and without music were observed with functional magnetic resonance device (fMRI). The changes in the pain-related activity in both parameters were discussed.Results: The median pain threshold with favorite music was 38.9 μA, compared to 29.0 &am

This paper will zoom-in upon one of the greatest modernist writers and influential figures of the twentieth century, James Joyce. In this way, following his life’s developments, from his troubled childhood to his frantic life abroad with Nora Barnacle, his literary work and his inspirational sources, we will try to establish whether alcohol consumption hindered or aided his creative process. In order to do so, this article will present events that might have triggered the drinking, the rituals and ‘customs’ of the process, as they seem to be in some kind of interrelation. These facts will be rendered while using close textual analyses of his literary works in the context of addiction.

In this paper we followed the links that are established between alcohol consumption and writing, and especially on how creativity and alcohol consumption are related. Thus, we will discuss the effects of drinking, as demonstrated until now, on the creative flow, and we will try to provide a substantial number of case examples of brilliant creative minds, that had been either diagnosed as being alcoholics or just known to be heavy drinkers. Our article will also comment on the general and particular theories that refer to this much discussed and somewhat controversial subject.

Schizophrenia is an extremely complex psychiatric disease where perception of pain is altered, varying from abolition to lack of any kind of changes compared to normal controls and even hypersensitivity. In this way, the hypothesis of amending schizophrenia through pain therapy enhanced the importance of pain medication. But managing pain phenomenon in schizophrenia has large and unknown implications. Nevertheless, pharmacological interactions between the medications for these two entities are unknown and most likely would have a lot of side-effects and therefore ethnopharmacological methods became once again an interesting option. Traditional medicine wisdom was followed in the pursuit of finding connections between ancient knowledge and current scientific proven facts.To our best of knowledge, this is the first time when pain, plants and schizophrenia are discussed together. In this way, it seems that by replacing fully synthesized chemical products, the risk of side-effects decreases. Also, it appears that some plants besides treating pain may have curing effects on the psychotic activities in schizophrenia.Therefore, through this mini-review we emphasized on the advantages of the ethonopharmacological approaches in pain conditions in the context of schizophrenia, but also highlighted some cases of inappropriate usage of plants in traditional therapy.

Schizophrenia is an extremely complex psychiatric disease where perception of pain is altered, varying from abolition to lack of any kind of changes compared to normal controls and even hypersensitivity. In this way, the hypothesis of amending schizophrenia through pain therapy enhanced the importance of pain medication. But managing pain phenomenon in schizophrenia has large and unknown implications. Nevertheless, pharmacological interactions between the medications for these two entities are unknown and most likely would have a lot of side-effects and therefore ethnopharmacological methods became once again an interesting option. Traditional medicine wisdom was followed in the pursuit of finding connections between ancient knowledge and current scientific proven facts.To our best of knowledge, this is the first time when pain, plants and schizophrenia are discussed together. In this way, it seems that by replacing fully synthesized chemical products, the risk of side-effects decreases. Also, it appears that some plants besides treating pain may have curing effects on the psychotic activities in schizophrenia.Therefore, through this mini-review we emphasized on the advantages of the ethonopharmacological approaches in pain conditions in the context of schizophrenia, but also highlighted some cases of inappropriate usage of plants in traditional therapy.

Many of the traditional medicinal plants belong to one of the largest plant families: the Asteraceae family. These plants are widely used in alternative medicine due to their effects on the nervous system, being studied both on cellular and animal models. In this way, medicinal plants are preferred in drug therapy research due to the wide population interest. The Asteraceae plants phytochemical composition is mainly consisted in cholinergic, dopaminergic or serotonergic molecules which are involved in the pathophysiology of the neuropsychiatric disorders such as Alzheimer’s disease, Parkinson’s disease, schizophrenia, autism, anxiety or depression. Therefore, this review aims to comprise all the available information regarding the neurological activity of Asteraceae family plants in order to find further correlations between different components in order to explain their neuropsychiatric potential use.

Many of the traditional medicinal plants belong to one of the largest plant families: the Asteraceae family. These plants are widely used in alternative medicine due to their effects on the nervous system, being studied both on cellular and animal models. In this way, medicinal plants are preferred in drug therapy research due to the wide population interest. The Asteraceae plants phytochemical composition is mainly consisted in cholinergic, dopaminergic or serotonergic molecules which are involved in the pathophysiology of the neuropsychiatric disorders such as Alzheimer’s disease, Parkinson’s disease, schizophrenia, autism, anxiety or depression. Therefore, this review aims to comprise all the available information regarding the neurological activity of Asteraceae family plants in order to find further correlations between different components in order to explain their neuropsychiatric potential use.