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Chiseon Ryu,1 Hwangjae Lee,1 Hohyeon Kim,2 Seong Hwang,1 Yaser Hadadian,2,3 Ayeskanta Mohanty,4 In-Kyu Park,4 Beongki Cho,1 Jungwon Yoon,2,3 Jae Young Lee1 1School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea; 2School of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea; 3Research Center for Nanorobotics in Brain, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea; 4Department of Biomedical Sciences, Chonnam National University Medical School, Hwasun-gun, Jeollanam-do, Republic of KoreaCorrespondence: Jungwon Yoon; Jae Young Lee Tel +82 62 715 5332; +82 62 715 2358Email jyoon@gist.ac.kr; jaeyounglee@gist.ac.krIntroduction: Iron oxide magnetic nanoparticles (IONPs) have attracted considerable attention for various biomedical applications owing to their ease of synthesis, strong magnetic properties, and biocompatibility. In particular, IONPs can generate heat under an alternating magnetic field, the effects of which have been extensively studied for magnetic hyperthermia therapy. However, the development of IONPs with high heating efficiency, biocompatibility, and colloidal stability in physiological environments is still required for their safe and effective application in biomedical fields.Methods: We synthesized magnetic IONP/polymer nanocomposites (MNCs) by embedding IONPs in a poly(L-lactic acid) (PLA) matrix via nanoemulsion. The IONP contents (Fe: 9– 22 [w/w]%) in MNCs were varied to investigate their effects on the magnetic and hyperthermia performances based on their optimal interparticle interactions. Further, we explored the stability, cytocompatibility, biodistribution, and in vivo tissue compatibility of the MNCs.Results: The MNCs showed enhanced heating efficiency with over two-fold increase compared to nonembedded bare IONPs. The relationship between the IONP content and heating performance in MNCs was

Chiseon Ryu,1 Hwangjae Lee,1 Hohyeon Kim,2 Seong Hwang,1 Yaser Hadadian,2,3 Ayeskanta Mohanty,4 In-Kyu Park,4 Beongki Cho,1 Jungwon Yoon,2,3 Jae Young Lee1 1School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea; 2School of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea; 3Research Center for Nanorobotics in Brain, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea; 4Department of Biomedical Sciences, Chonnam National University Medical School, Hwasun-gun, Jeollanam-do, Republic of KoreaCorrespondence: Jungwon Yoon; Jae Young Lee Tel +82 62 715 5332; +82 62 715 2358Email jyoon@gist.ac.kr; jaeyounglee@gist.ac.krIntroduction: Iron oxide magnetic nanoparticles (IONPs) have attracted considerable attention for various biomedical applications owing to their ease of synthesis, strong magnetic properties, and biocompatibility. In particular, IONPs can generate heat under an alternating magnetic field, the effects of which have been extensively studied for magnetic hyperthermia therapy. However, the development of IONPs with high heating efficiency, biocompatibility, and colloidal stability in physiological environments is still required for their safe and effective application in biomedical fields.Methods: We synthesized magnetic IONP/polymer nanocomposites (MNCs) by embedding IONPs in a poly(L-lactic acid) (PLA) matrix via nanoemulsion. The IONP contents (Fe: 9– 22 [w/w]%) in MNCs were varied to investigate their effects on the magnetic and hyperthermia performances based on their optimal interparticle interactions. Further, we explored the stability, cytocompatibility, biodistribution, and in vivo tissue compatibility of the MNCs.Results: The MNCs showed enhanced heating efficiency with over two-fold increase compared to nonembedded bare IONPs. The relationship between the IONP content and heating performance in MNCs was

We performed angle-resolved photoemission (ARPES) experiments on Bi2Te3 with circularly polarized light. ARPES data show very strong circular dichroism, indicating the existence of orbital angular momentum (OAM). Moreover, the alignment of OAM is found to have a strong binding energy dependence. Such energy dependence comes from a relatively strong band warping effect in Bi2Te3 compared to Bi2Se3. OAM close to the Dirac point has an ideal chiral structure (sinθ) without an out-of-plane component. The warping effect comes in as the binding energy decreases, and circular dichroism along a constant energy contour can no longer be explained by a simple sinθ function but requires a sin3θ term. When the warping effect becomes even stronger near the Fermi energy, circular dichroism gains an additional sin6θ term. Such behavior is found to be compatible with the theoretically predicted OAM structure.