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Ngozi R Mbanefo,1 Samuel N Uwaezuoke,1 Chizoma I Eneh,2 Chioma L Odimegwu,1 Ugo N Chikani,1 Uzoamaka V Muoneke,1 Charles E Nwolisa,3 Kenneth E Odo,1 Francis N Ogbuka,2 Anthony T Akwue4 1Department of Pediatrics, the University of Nigeria Teaching Hospital Ituku-Ozalla Enugu, Enugu, Nigeria; 2Department of Pediatrics, Enugu State University Teaching Hospital Enugu, Enugu, Nigeria; 3Department of Pediatrics, Federal Medical Centre, Owerri, Imo State, Nigeria; 4Emergency Department, ASEER Field Hospital, Al Rabwah, Kingdom of Saudi ArabiaCorrespondence: Samuel N Uwaezuoke, Tel +2348033248108, Email snuwaezuoke@yahoo.comIntroduction: Frequent relapses and steroid dependence are common treatment challenges of steroid-sensitive nephrotic syndrome (SSNS) in children. Acute respiratory infection (ARI) is the most frequently reported trigger of relapse. Given the role of zinc supplementation in preventing ARI, some studies show that this targeted intervention may reduce relapses in childhood SSNS.Aim: This systematic review aimed to determine if oral zinc supplementation can significantly reduce relapses in this disease.Methods: We searched the PubMed and Google Scholar electronic databases for interventional and observational analytical studies without limiting their year or language of publication. We selected studies with primary data that met our inclusion criteria, screened their titles and abstracts, and removed duplicates. We used a preconceived structured form to extract data items from selected studies and conducted a quality assessment of randomized controlled trials (RCTs) and non-randomized studies with the Cochrane collaboration tool and the Newcastle Ottawa Scale, respectively. We qualitatively synthesized the extracted data to validate the review’s objective.Results: Eight full-text articles were selected, comprising four RCTs and four observational analytical studies. Two of the RCTs had a high risk of bias in three parameters of the Cochrane collaboration

Public health messaging campaigns can be useful tools for addressing vaccine hesitancy. Behavior change theory-driven formative research, which guides campaign planners in message topic selection, is necessary for campaigns’ success. However, such research cannot advise on how to communicate campaign messages. Information processing theories propose avenues through which messages can be made more persuasive. Focusing on Black Americans, this dissertation aims to test an approach to improve future public health messaging campaigns targeting COVID-19 vaccine hesitancy. Specifically, it investigates whether source credibility (an information processing theory variable) can enhance the persuasiveness of differentially promising campaign message topics. These message topics refer to beliefs associated with intention to receive a COVID-19 vaccine. Study 1 was a two-part belief elicitation. In the first part (Study 1A) participants (N=117) reported their most salient beliefs related to the COVD-19 vaccine in an open-ended survey. The second part involved topic modeling on 5945 tweets discussing the vaccine. Beliefs identified from these studies were transformed into cross-sectional survey items for Study 2. Results from this study highlighted the utility in combining traditional survey data with publicly available social media data to learn about the health concerns of a target population. Study 2 (N=500) identified beliefs varying in promise, following the Hornik & Woolf approach, to be transformed into message topics. Study 3 was a message experiment where participants (N=245) were exposed to messages, addressing either a “more” or “less” promising topic, designed to increase vaccination intention. The messages were also either communicated by a health professional, or layperson source. Results of Study 3 indicated no main effects of neither message promise, nor source credibility on vaccination intention. Messages targeting the “less” promising topic shifted the linked