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Endoscopic submucosal dissection (ESD) in colorectal lesions is demanding, and a significant rate of non-curative procedures is expected. We aimed to assess the rate of residual lesion after a piecemeal ESD resection, or after an en bloc resection but with positive horizontal margins (local-risk resection—LocRR), for colorectal benign neoplasia. A retrospective multicenter analysis of consecutive colorectal ESDs was performed. Patients with LocRR ESDs for the treatment of benign colorectal lesions with at least one follow-up endoscopy were included. A cohort of en bloc resected lesions, with negative margins, was used as the control. A total of 2255 colorectal ESDs were reviewed; 352 of the ESDs were “non-curative”. Among them, 209 were LocRR: 133 high-grade dysplasia and 76 low-grade dysplasia. Ten cases were excluded due to missing data. A total of 146 consecutive curative resections were retrieved for comparison. Compared to the “curative group”, LocRRs were observed in lengthier procedures, with larger lesions, and in non-granular LSTs. Recurrence was higher in the LocRR group (16/199, 8% vs. 1/146, 0.7%; p = 0.002). However, statistical significance was lost when considering only en bloc resections with positive horizontal margins (p = 0.068). In conclusion, a higher rate of residual lesion was found after a piecemeal ESD resection, but not after an en bloc resection with positive horizontal margins., SCOPUS: ar.j, info:eu-repo/semantics/published

For efficient operation of heating and cooling grids, underground thermal energy storage (UTES) can be a key element. This is due to its ability to seasonally store heat or cold addressing the large mismatch between supply and demand. This technology is already available and there are many operational examples, both within and outside a district heating network. Given the range of available UTES technologies, they are feasible to install almost everywhere. Compared to other storage systems, UTES have the advantage of being able to manage large quantities and fluxes of heat without occupying much surface area, although the storage characteristics are always site specific and depend on the geological and geothermal characteristics of the subsoil. UTES can manage fluctuating production from renewable energy sources, both in the short and long term, and fluctuating demand. It can be used as an instrument to exploit heat available from various sources, e.g., solar, waste heat from industry, geothermal, within the same district heating system. The optimization of energy production, the reduction in consumption of primary energy and the reduction in emission of greenhouse gases are guaranteed with UTES, especially when coupled with district heating and cooling networks., Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., Water Resources, Geo-engineering

Submarine buried pipelines interact with shallow soil layers that are often loose and prone to fluidization/liquefaction. Such occurrence is a possible consequence of pore pressure build-up induced by hydrodynamic loading, earthquakes, and/or structural vibrations. When liquefaction is triggered in sand, the soil tends to behave as a viscous solid–fluid mixture of negligible shear strength, possibly unable to constrain pipeline movements. Therefore, pipelines may experience excessive displacement, for instance, in the form of vertical flotation or sinking. To date, there are no well-established methods to predict pipe displacement in the event of liquefaction. To fill such a gap, this work proposes a computational fluid dynamics (CFD) framework enriched with soil mechanics principles. It is shown that the interaction between pipe and liquefied sand can be successfully analyzed via one-phase Bingham fluid modeling of the soil. Postliquefaction enhancement of rheological properties, viscosity, and yield stress can also be accounted for by linking soil–pipe CFD simulations to a separate analysis of the pore pressure dissipation. The proposed approach is thoroughly validated against the results of small-scale pipe flotation and pipe dragging tests from the literature., Geo-engineering

This study reports the first investigation of atmospheric illicit drug concentrations in Northern Europe usingmeasurements of cocaine and cannabinoids in Amsterdam, London and Stockholm. Further, these measurements were compared to those made in Rome to explore the geographical and inter-city variability. Co-located measurements of atmospheric particulate mass and PAHs were used to help describe and interpret the illicit drug measurements with respect to atmospheric dispersion. Cocaine concentrations ranged from 0.03 to 0.14 ng/m(3) in Amsterdam, from 0.02 to 0.33 ng/m(3) in London and were below quantification limit (3pg/m(3)) in Stockholm. Cannabinol was the only cannabinoidmolecule detected in the three cities. During this campaign, London reported the highest concentrations of cocaine and meaningful differences were detected between the urban background and city centre London sites. Mean cocaine concentrations measured in Amsterdam during March 2011 were also compared with those measured simultaneously in eight Italian cities. The cocaine concentration inAmsterdamwas comparable to that measured at an urban background inMilan and at a densely populated site in Florence. Although correlating atmospheric concentrations directlywith drug prevalence is not possible using current data, links between concentrations of cocaine and estimates of abuse prevalence assessed by the more routinely usedwastewater analysiswere also examined. A statistically significant correlationwas found between the two sets of data (R-2= 0.66; p= 0.00131). Results confirmed that meteorology, population rate and habits of consumption influence the atmospheric concentrations of drugs. If these confounding factors were better controlled for, the techniques described here could became an easy and cost effective tool to index the impact of cocaine abuse in the area; especially where local hot spots need to be identified.

In this work, a new thermo-mechanical model is developed, applicable to large-scale, deep-seated landslides consisting of a coherent mass sliding on a thin clayey layer. The considered time window is that of catastrophic acceleration, starting at incipient failure and ending when the acquired displacement and velocity are such that the sliding material begins to break up into pieces. The model accounts for temperature rise in the slip zone due to the heat produced by friction, leading to water expansion, thermoplastic collapse of the soil skeleton, and subsequent increase of pore water pressure. The model incorporates the processes of heat production and diffusion, pore pressure generation and diffusion, and an advanced constitutive law for the thermo-mechanical behavior of soil. An analysis of the Vajont landslide is presented as an example. A sensitivity analysis shows that friction softening is the mechanism most affecting the timescale of the final collapse of a slide, but also that the mechanism of thermal pressurization alone can cause a comparably catastrophic dynamic evolution. It is also shown that, all other factors being equal, thermo-mechanical collapse will cause thicker slides to accelerate faster than shallow ones. © 2010 John Wiley & Sons, Ltd.

In this work, a new thermo-mechanical model is developed by improving on an existing one, applicable to large deep seated landslides and rockslides consisting of a coherent mass sliding on a thin clayey layer. The considered time window is that of catastrophic acceleration, starting at incipient failure and ending a few seconds later, when the acquired displacement and velocity are such that the sliding material begins to break up into pieces. The model accounts for temperature rise in the slip zone due to the heat produced by friction, leading to thermoplastic collapse of the soil skeleton and subsequent increase of pore water pressure. This in turn drastically decreases the resistance to motion and allows the overlying mass to move downslope ever more freely. The proposed model is implemented numerically and validated by back-analysing the two well-documented catastrophic landslide case histories of Vajont and Jiufengershan. The model is then employed to carry out a parametric study to systematically investigate the development of catastrophic failure in uniform slopes. It was found that the most influential parameters in promoting catastrophic collapse are (1) the static friction-softening rate a1, (2) the slope inclination ?, (3) the soil permeability kw, (4) the dynamic residual friction angle rd ? and (5) the overburden thickness H. The most dangerous situation is when a1, ? and H are very large and kw and rd ? are very low. Of the above, the ‘thermo-mechanical parameters’ kw and H deserve more attention as they have been introduced by the thermo-mechanical model and are not normally considered in standard stability analyses of uniform slopes. A second parametric study was performed to demonstrate that thermo-mechanical parameters alone can make a difference between a relatively non-catastrophic event and a catastrophic one. Hence, further insight into the design of landslide risk mitigation measures can be gained if, in addition to the standard site