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MCJ is a mitochondrial Tim23-related co-chaperonin known for its role in regulating oxidative phosphorylation efficiency, oxidative stress response and lipid metabolism. Recently, it has been proposed that the loss of MCJ correlates with cisplatin (CDDP)-resistance onset in ovarian cancer (OC), suggesting this protein as a potential prognostic factor during OC progression. However, the molecular mechanisms through which MCJ contributes to CDDP response remains poorly investigated. The present dataset collect data regarding the association between MCJ levels and accumulation of lipid droplets, tumorigenic features and sensitivity to CDDP in OC cells. Moreover, this dataset provides information on lipid peroxidation and ferroptosis induction in cells overexpressing MCJ, in presence or absence of Ferrostatin 1.