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3 results on '"Cangiano B"'

1. Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life

Author

Cangiano, B, Giusti, E, Premoli, C, Soranna, D, Vitale, G, Grottoli, S, Cambria, V, Mantovani, G, Mungari, R, Maffei, P, Dassie, F, Giampietro, A, Chiloiro, S, Tanda, M, Ippolito, S, Cannavo, S, Ragonese, M, Zambon, A, Persani, L, Fatti, L, Scacchi, M, Cavagnini, F, Ferone, D, Corbetta, S, Bartalena, L, Peccoz, P, Arosio, M, Lania, A, Colao, A, Pivonello, R, Uberti, E, Ghigo, E, Giustina, A, Martino, E, Pontecorvi, A, Sicolo, N, Trimarchi, F, Cangiano B., Giusti E., Premoli C., Soranna D., Vitale G., Grottoli S., Cambria V., Mantovani G., Mungari R., Maffei P., Dassie F., Giampietro A., Chiloiro S., Tanda M. L., Ippolito S., Cannavo S., Ragonese M., Zambon A., Persani L., Fatti L. M., Scacchi M., Cavagnini F., Ferone D., Corbetta S., Bartalena L., Peccoz P. B., Arosio M., Lania A., Colao A., Pivonello R., Uberti E. D., Ghigo E., Giustina A., Martino E., Pontecorvi A., Sicolo N., Trimarchi F., Cangiano, B, Giusti, E, Premoli, C, Soranna, D, Vitale, G, Grottoli, S, Cambria, V, Mantovani, G, Mungari, R, Maffei, P, Dassie, F, Giampietro, A, Chiloiro, S, Tanda, M, Ippolito, S, Cannavo, S, Ragonese, M, Zambon, A, Persani, L, Fatti, L, Scacchi, M, Cavagnini, F, Ferone, D, Corbetta, S, Bartalena, L, Peccoz, P, Arosio, M, Lania, A, Colao, A, Pivonello, R, Uberti, E, Ghigo, E, Giustina, A, Martino, E, Pontecorvi, A, Sicolo, N, Trimarchi, F, Cangiano B., Giusti E., Premoli C., Soranna D., Vitale G., Grottoli S., Cambria V., Mantovani G., Mungari R., Maffei P., Dassie F., Giampietro A., Chiloiro S., Tanda M. L., Ippolito S., Cannavo S., Ragonese M., Zambon A., Persani L., Fatti L. M., Scacchi M., Cavagnini F., Ferone D., Corbetta S., Bartalena L., Peccoz P. B., Arosio M., Lania A., Colao A., Pivonello R., Uberti E. D., Ghigo E., Giustina A., Martino E., Pontecorvi A., Sicolo N., and Trimarchi F.

Abstract

Purpose: Current treatment of acromegaly restores a normal life expectancy in most cases. So, the study of persistent complications affecting patients’ quality of life (QoL) is of paramount importance, especially motor disability and depression. In a large cohort of acromegalic patients we aimed at establishing the prevalence of depression, to look for clinical and sociodemographic factors associated with it, and to investigate the respective roles (and interactions) of depression and arthropathy in influencing QoL. Methods: One hundred and seventy-one acromegalic patients (95 women and 76 men, aged 20–85 years) among those recruited in a cross-sectional Italian multicentric study were investigated. Each patient filled in three validated questionnaires: AcroQoL, WOMAC (measuring articular pain, stiffness and functionality), and AIMS (evaluating articular symptoms and depression). Results: A very high (up to 28%) depression rate was detected in acromegalic subjects. Two patients showing pathological AIMS depression scores, committed suicide during the three years observational period. In our population poor psychological status was significantly associated with female sex. Furthermore, a significant strong correlation was found between AIMS depression score and WOMAC score. Both depression and arthropathy-related motor disability turned out to independently contribute with similar strength to the impairment of QoL. Conclusions: We report a high prevalence of depression in acromegaly, which is associated with female sex and arthropathy. Both depression and arthropathy strongly and independently contribute to the impaired QoL of patients. Our study shows that assessment and monitoring of psychological status is mandatory in acromegaly, also suggesting an inexpensive tool for this assessment.

Published
2022

2. Arthropathy in acromegaly: a questionnaire-based estimation of motor disability and its relation with quality of life and work productivity

Author

Fatti, L, Cangiano, B, Vitale, G, Persani, L, Mantovani, G, Sala, E, Arosio, M, Maffei, P, Dassie, F, Mormando, M, Giampietro, A, Tanda, L, Masiello, E, Nazzari, E, Ferone, D, Corbetta, S, Passeri, E, Guaraldi, F, Grottoli, S, Cannavo, S, Torre, M, Soranna, D, Zambon, A, Cavagnini, F, Scacchi, M, Fatti L. M., Cangiano B., Vitale G., Persani L., Mantovani G., Sala E., Arosio M., Maffei P., Dassie F., Mormando M., Giampietro A., Tanda L., Masiello E. R., Nazzari E., Ferone D., Corbetta S., Passeri E., Guaraldi F., Grottoli S., Cannavo S., Torre M. L. T., Soranna D., Zambon A., Cavagnini F., Scacchi M., Fatti, L, Cangiano, B, Vitale, G, Persani, L, Mantovani, G, Sala, E, Arosio, M, Maffei, P, Dassie, F, Mormando, M, Giampietro, A, Tanda, L, Masiello, E, Nazzari, E, Ferone, D, Corbetta, S, Passeri, E, Guaraldi, F, Grottoli, S, Cannavo, S, Torre, M, Soranna, D, Zambon, A, Cavagnini, F, Scacchi, M, Fatti L. M., Cangiano B., Vitale G., Persani L., Mantovani G., Sala E., Arosio M., Maffei P., Dassie F., Mormando M., Giampietro A., Tanda L., Masiello E. R., Nazzari E., Ferone D., Corbetta S., Passeri E., Guaraldi F., Grottoli S., Cannavo S., Torre M. L. T., Soranna D., Zambon A., Cavagnini F., and Scacchi M.

Abstract

Purpose: Arthropathy is a common and disabling complication of acromegaly. Since in this condition radiological findings rarely correspond to functional impairment, we elected to quantify in a large cohort of acromegalic patients: the degree of motor disability compared with data from general population, the impact of joint involvement on quality of life and work productivity, and to look for associated factors. Methods: In 211 acromegalic patients, 131 with controlled disease and 80 with active disease, eight validated scales were used to evaluate the (i) prevalence and distribution of arthropathy, (ii) degree of motor disability and joint symptoms (VAS, AIMS symptoms and WOMAC), (iii) quality of life (AcroQoL and PASQ) and work capability (WPAI:GH) as consequences of joint complications. Results: Using the WOMAC questionnaire, for which population based normative values are available, a significantly higher prevalence and severity of motor disability was detected in acromegalics compared to the general population from literature. The results provided by the different questionnaires turned out to be highly concordant. All measures of motor disability correlated both with impaired quality of life and motor disability and were worse in females and in patients with higher BMI. Conclusions: The questionnaires VAS, AIMS symptoms, and WOMAC (this latter both as a whole and with its functionality subscale), with their scores, proved to be the most adequate tools to evaluate motor disability and its consequences on both quality of life and work productivity in acromegaly. Female gender and higher BMI are associated with worse articular symptoms.

Published
2019

3. Characteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH)

Author

Bonomi, M., Vezzoli, V., Krausz, C., Guizzardi, F., Vezzani, S., Simoni, M., Bassi, I., Duminuco, P., Di Iorgi, N., Giavoli, C., Pizzocaro, A., Russo, G., Moro, M., Fatti, L., Ferlin, A., Mazzanti, L., Zatelli, M. C., Cannavo, S., Isidori, A. M., Pincelli, A. I., Prodam, F., Mancini, A., Limone, P., Tanda, M. L., Gaudino, R., Salerno, M., Francesca, P., Maghnie, M., Maggi, M. C., Persani, L., Aimaretti, G., Altobell, M., Ambrosio, M. R., Andrioli, M., Angelett, G., Arecco, F., Arnald, G., Arosio, M., Balsamo, A., Baldassarr, M., Bartalena, L., Bazzon, N., Beccari, L., Beck-Peccoz, P., Bellastella, G., Bellizz, M., Benedicent, F., Bernasconi, S., Bizzarri, C., Bona, G., Bonadonna, S., Borrett, G., Boschetti, M., Brunani, A., Brunelli, V., Buz, F., Cacciatore, C., Cangiano, B., Cappa, M., Casalone, R., Cassio, A., Cavarzere, P., Cherubini, V., Ciampani, T., Cicognan, D., Cignarell, A., Cisternin, M., Colombo, P., Corbetta, S., Corciul, N., Corona, G., Cozzi, R., Crivellaro, C., Dalle Mule, I., Danesi, L., Eli, A. V. D., Degli Uberti, E., De Leo, S., Della Valle, E., De Marchi, M., Di Mambr, A., Fabbri, A., Foresta, C., Forti, G., Franceschi, A. R., Garolla, A., Ghezzi, M., Giacomozzi, C., Giusti, M., Grosso, E., Guabello, G., Guarneri, M. P., Grugni, G., Lanfranco, F., Lania, A., Lanzi, R., Larizza, L., Lenzi, A., Loche, S., Loli, P., Lombardi, V., Mandrile, G., Manieri, C., Mantovani, G., Marelli, S., Marzullo, M., Mencarelli, M. A., Migone, N., Motta, G., Neri, G., Padov, G., Parenti, G., Pasquino, B., Pia, A., Piantanida, E., Pignatti, E., Pilotta, A., Pivett, B., Pollazzon, M., Pontecorvi, A., Porcelli, P., Pozza, G. B., Pozzobon, G., Radetti, G., Razzore, P., Rocchett, L., Roncoron, R., Rossi, G., Sala, E., Salvatoni, A., Salvini, F., Secc, A., Segni, M., Selice, R., Sgaramella, P., Sileo, F., Sinisi, A. A., Sirchia, F., Spada, A., Tresoldi, A., Vigneri, R., Weber, G., Zucchini, S., Bassi I., Moro M., Pincelli A. I., Mancini A. (ORCID:0000-0002-7707-4564), Cappa M., Corbetta S., Corona G., Danesi L., Ghezzi M., Giusti M. (ORCID:0000-0001-5767-8785), Grugni G., Parenti G., Pontecorvi A. (ORCID:0000-0003-0570-6865), Sala E., Bonomi, M., Vezzoli, V., Krausz, C., Guizzardi, F., Vezzani, S., Simoni, M., Bassi, I., Duminuco, P., Di Iorgi, N., Giavoli, C., Pizzocaro, A., Russo, G., Moro, M., Fatti, L., Ferlin, A., Mazzanti, L., Zatelli, M. C., Cannavo, S., Isidori, A. M., Pincelli, A. I., Prodam, F., Mancini, A., Limone, P., Tanda, M. L., Gaudino, R., Salerno, M., Francesca, P., Maghnie, M., Maggi, M. C., Persani, L., Aimaretti, G., Altobell, M., Ambrosio, M. R., Andrioli, M., Angelett, G., Arecco, F., Arnald, G., Arosio, M., Balsamo, A., Baldassarr, M., Bartalena, L., Bazzon, N., Beccari, L., Beck-Peccoz, P., Bellastella, G., Bellizz, M., Benedicent, F., Bernasconi, S., Bizzarri, C., Bona, G., Bonadonna, S., Borrett, G., Boschetti, M., Brunani, A., Brunelli, V., Buz, F., Cacciatore, C., Cangiano, B., Cappa, M., Casalone, R., Cassio, A., Cavarzere, P., Cherubini, V., Ciampani, T., Cicognan, D., Cignarell, A., Cisternin, M., Colombo, P., Corbetta, S., Corciul, N., Corona, G., Cozzi, R., Crivellaro, C., Dalle Mule, I., Danesi, L., Eli, A. V. D., Degli Uberti, E., De Leo, S., Della Valle, E., De Marchi, M., Di Mambr, A., Fabbri, A., Foresta, C., Forti, G., Franceschi, A. R., Garolla, A., Ghezzi, M., Giacomozzi, C., Giusti, M., Grosso, E., Guabello, G., Guarneri, M. P., Grugni, G., Lanfranco, F., Lania, A., Lanzi, R., Larizza, L., Lenzi, A., Loche, S., Loli, P., Lombardi, V., Mandrile, G., Manieri, C., Mantovani, G., Marelli, S., Marzullo, M., Mencarelli, M. A., Migone, N., Motta, G., Neri, G., Padov, G., Parenti, G., Pasquino, B., Pia, A., Piantanida, E., Pignatti, E., Pilotta, A., Pivett, B., Pollazzon, M., Pontecorvi, A., Porcelli, P., Pozza, G. B., Pozzobon, G., Radetti, G., Razzore, P., Rocchett, L., Roncoron, R., Rossi, G., Sala, E., Salvatoni, A., Salvini, F., Secc, A., Segni, M., Selice, R., Sgaramella, P., Sileo, F., Sinisi, A. A., Sirchia, F., Spada, A., Tresoldi, A., Vigneri, R., Weber, G., Zucchini, S., Bassi I., Moro M., Pincelli A. I., Mancini A. (ORCID:0000-0002-7707-4564), Cappa M., Corbetta S., Corona G., Danesi L., Ghezzi M., Giusti M. (ORCID:0000-0001-5767-8785), Grugni G., Parenti G., Pontecorvi A. (ORCID:0000-0003-0570-6865), and Sala E.

Abstract

Objective: Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and nonreproductive anomalies might be present although information on their frequency are scanty, particularly according to the age of presentation. Design: Observational cohort study carried out between January 2008 and June 2016 within a national network of academic or general hospitals. Methods: We performed a detailed phenotyping of 503 IHH patients with: (1) manifestations of hypogonadism with low sex steroid hormone and low/normal gonadotropins; (2) absence of expansive hypothalamic/pituitary lesions or multiple pituitary hormone defects. Cohort was divided on IHH onset (PPO, pre-pubertal onset or AO, adult onset) and olfactory function: PPO-nIHH (n = 275), KS (n = 184), AO-nIHH (n = 36) and AO-doIHH (AO-IHH with defective olfaction, n = 8). Results: 90% of patients were classifed as PPO and 10% as AO. Typical midline and olfactory defects, bimanual synkinesis and familiarity for pubertal delay were also found among the AO-IHH. Mean age at diagnosis was signifcantly earlier and more frequently associated with congenital hypogonadism stigmata in patients with Kallmann's syndrome (KS). Synkinesis, renal and male genital tract anomalies were enriched in KS. Overweight/obesity are signifcantly associated with AO-IHH rather than PPO-IHH. Conclusions: Patients with KS are more prone to develop a severe and complex phenotype than nIHH. The presence of typical extra-gonadal defects and familiarity for PPO-IHH among the AO-IHH patients indicates a common predisposition with variable clinical expression. Overall, these fndings improve the understanding of IHH and may have a positive impact on the management of patients and their families.

Published
2018

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