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Purpose: There are few data in the literature regarding sepsis or septic shock due to extended-spectrum fi-lactamases (ESBL)-producing Enterobacteriaceae (E). The aim of this study was to assess predictors of outcome in septic patients with bloodstream infection (BSI) caused by ESBL-E. Methods: Patients with severe sepsis or septic shock and BSI due to ESBL-E were selected from the INCREMENT database. The primary endpoint of the study was the evaluation of predictors of outcome after 30 days from development of severe sepsis or septic shock due to ESBL-E infection. Three cohorts were created for analysis: global, empirical-therapy and targeted-therapy cohorts. Results: 367 septic patients were analysed. Overall mortality was 43.9% at 30 days. Escherichia coli (62.4%) and Klebsiella pneumoniae (27.2%) were the most frequent isolates. fi-lactam/fi-lactamase inhibitor (BLBLI) combinations were the most empirically used drug (43.6%), followed by carbapenems (29.4%). Empirical therapy was active in vitro in 249 (67.8%) patients, and escalation of antibiotic therapy was reported in 287 (78.2%) patients. Cox regression analysis showed that age, Charlson Comorbidity Index, McCabe classification, Pitt bacteremia score, abdominal source of infection and escalation of antibiotic therapy were independently associated with 30-day mortality. No differences in survival were reported in patients treated with BLBLI combinations or carbapenems in empirical or definitive therapy. Conclusions: BSI due to ESBL-E in patients who developed severe sepsis or septic shock was associated with high 30-day mortality. Comorbidities, severity scores, source of infection and antibiotic therapy escalation were important determinants of unfavorable outcome. (C) 2018 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Purpose: There are few data in the literature regarding sepsis or septic shock due to extended-spectrum fi-lactamases (ESBL)-producing Enterobacteriaceae (E). The aim of this study was to assess predictors of outcome in septic patients with bloodstream infection (BSI) caused by ESBL-E. Methods: Patients with severe sepsis or septic shock and BSI due to ESBL-E were selected from the INCREMENT database. The primary endpoint of the study was the evaluation of predictors of outcome after 30 days from development of severe sepsis or septic shock due to ESBL-E infection. Three cohorts were created for analysis: global, empirical-therapy and targeted-therapy cohorts. Results: 367 septic patients were analysed. Overall mortality was 43.9% at 30 days. Escherichia coli (62.4%) and Klebsiella pneumoniae (27.2%) were the most frequent isolates. fi-lactam/fi-lactamase inhibitor (BLBLI) combinations were the most empirically used drug (43.6%), followed by carbapenems (29.4%). Empirical therapy was active in vitro in 249 (67.8%) patients, and escalation of antibiotic therapy was reported in 287 (78.2%) patients. Cox regression analysis showed that age, Charlson Comorbidity Index, McCabe classification, Pitt bacteremia score, abdominal source of infection and escalation of antibiotic therapy were independently associated with 30-day mortality. No differences in survival were reported in patients treated with BLBLI combinations or carbapenems in empirical or definitive therapy. Conclusions: BSI due to ESBL-E in patients who developed severe sepsis or septic shock was associated with high 30-day mortality. Comorbidities, severity scores, source of infection and antibiotic therapy escalation were important determinants of unfavorable outcome. (C) 2018 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

The theoretical debate about the scattered city versus the compact city, in the worldwide and particularly in Latin America, this put in evidence the necessary key aspects to propose a new city model, where the quality of life in the present and future generations will be the focus point of reflection. Throughout the study of the state of the art about this topic, it concludes that the returning to a compact city model is the alternative for a possible sustainable development in the intermediate cities of Latin America. In the Cuenca case is concentrated in the study of the densities of the city from the 1950s until today. It is amazing to prove that Cuenca was a compact city with a high quality of life, but gradually it is unnecessarily expanding, with all the problems involved.

The Appellations of Origin “Jerez-Xérès-Sherry” and “Manzanilla-Sanlúcar de Barrameda” occupy one of the oldest and most world renowned viticultural areas in the peninsula, but it is not exempt from the serious problems that are to be found throughout the sector. In order to try to adapt to the present situation, zoning plans are being promoted whereby priority is given to the quality of the product, sustainable development and the economic interests. This work undertakes an approach to the viticultural zoning. The nutritional state of the grapevines is studied by means of foliage analysis at veraison. The quality of production was measured by means of the berry weight and the analysis of the most usual variables of the must at the time of harvest (°Baumé, pH and titratable acidity) over five seasons, in the 21 plots where the soil profiles were opened for analysis. As a result of applying statistical analysis, the plots are grouped into five classes, two of which are subdivided. The most significant differences were established between the plots of class CL1, on Miocene limestone, and those of class CL5, on Pliocene-Quaternary sands and clays. Class CL1 presented the highest content of ash (mean ± sd CL1; CL5) (15.36 ± 1.73; 12.36 ± 1.77) and calcium (3.42 ± 0.90; 2.65 ± 0.72), the lowest berry weight (2.10 ± 0.30; 2.47 ± 0.50) and a greater Baumé degree (10.55 ± 0.86; 9.63 ± 0.98) than the CL5. This new approach takes other essential factors for the quality of the production into account such as the climate and the geomorphology (altitude, slope, and physiography), Las Denominaciones de Origen Jerez-Xérès-Sherry y Manzanilla-Sanlúcar de Barrameda ocupan una de las zonas de producción más antiguas de la península y de mayor reconocimiento a nivel mundial, aunque no están exentas de la grave problemática por la que atraviesa el sector. Para intentar adaptarse a la situación actual se están promoviendo planes de zonificación en donde prima la calidad del producto, el desarrollo sostenible y los intereses económicos. En este trabajo se realiza una aproximación a la zonificación vitícola. Para ello, se estudia el estado nutricional de las vides mediante el análisis foliar en el envero, la calidad de producción mediante el peso de los granos de uva y el análisis de las variables más usuales del mosto en la época de vendimia (°Baumé, pH y acidez total) durante 5 campañas, en 21 parcelas coincidentes con la apertura de los perfiles. Como resultado de aplicar el análisis estadístico, se han agrupado las parcelas en cinco clases, dos de ellas a su vez subdivididas. Las principales diferencias significativas se encontraron en las parcelas de las clases CL1, sobre albarizas del Mioceno, y las de la clase CL5, sobre arenas y arcillas del Plioceno-Cuaternario. La clase CL1 presenta el contenido más elevado de cenizas (mean ± sd CL1; CL5) (15,36 ± 1,73; 12,36 ± 1,77) y calcio (3,42 ± 0,90; 2,65 ± 0,72), el menor peso de grano de uva (2,10 ± 0,30; 2,47 ± 0,50) y un mayor grado Baumé (10,55 ± 0,86; 9,63 ± 0,98) que la CL5. Esta nueva aproximación tiene en cuenta otros factores esenciales para la calidad de la producción como son el clima y la geomorfología (altitud, pendiente, fisiografía)

The Appellations of Origin “Jerez-Xérès-Sherry” and “Manzanilla-Sanlúcar de Barrameda” occupy one of the oldest and most world renowned viticultural areas in the peninsula, but it is not exempt from the serious problems that are to be found throughout the sector. In order to try to adapt to the present situation, zoning plans are being promoted whereby priority is given to the quality of the product, sustainable development and the economic interests. This work undertakes an approach to the viticultural zoning. The nutritional state of the grapevines is studied by means of foliage analysis at veraison. The quality of production was measured by means of the berry weight and the analysis of the most usual variables of the must at the time of harvest (°Baumé, pH and titratable acidity) over five seasons, in the 21 plots where the soil profiles were opened for analysis. As a result of applying statistical analysis, the plots are grouped into five classes, two of which are subdivided. The most significant differences were established between the plots of class CL1, on Miocene limestone, and those of class CL5, on Pliocene-Quaternary sands and clays. Class CL1 presented the highest content of ash (mean ± sd CL1; CL5) (15.36 ± 1.73; 12.36 ± 1.77) and calcium (3.42 ± 0.90; 2.65 ± 0.72), the lowest berry weight (2.10 ± 0.30; 2.47 ± 0.50) and a greater Baumé degree (10.55 ± 0.86; 9.63 ± 0.98) than the CL5. This new approach takes other essential factors for the quality of the production into account such as the climate and the geomorphology (altitude, slope, and physiography), Las Denominaciones de Origen Jerez-Xérès-Sherry y Manzanilla-Sanlúcar de Barrameda ocupan una de las zonas de producción más antiguas de la península y de mayor reconocimiento a nivel mundial, aunque no están exentas de la grave problemática por la que atraviesa el sector. Para intentar adaptarse a la situación actual se están promoviendo planes de zonificación en donde prima la calidad del producto, el desarrollo sostenible y los intereses económicos. En este trabajo se realiza una aproximación a la zonificación vitícola. Para ello, se estudia el estado nutricional de las vides mediante el análisis foliar en el envero, la calidad de producción mediante el peso de los granos de uva y el análisis de las variables más usuales del mosto en la época de vendimia (°Baumé, pH y acidez total) durante 5 campañas, en 21 parcelas coincidentes con la apertura de los perfiles. Como resultado de aplicar el análisis estadístico, se han agrupado las parcelas en cinco clases, dos de ellas a su vez subdivididas. Las principales diferencias significativas se encontraron en las parcelas de las clases CL1, sobre albarizas del Mioceno, y las de la clase CL5, sobre arenas y arcillas del Plioceno-Cuaternario. La clase CL1 presenta el contenido más elevado de cenizas (mean ± sd CL1; CL5) (15,36 ± 1,73; 12,36 ± 1,77) y calcio (3,42 ± 0,90; 2,65 ± 0,72), el menor peso de grano de uva (2,10 ± 0,30; 2,47 ± 0,50) y un mayor grado Baumé (10,55 ± 0,86; 9,63 ± 0,98) que la CL5. Esta nueva aproximación tiene en cuenta otros factores esenciales para la calidad de la producción como son el clima y la geomorfología (altitud, pendiente, fisiografía)

The Appellations of Origin "Jerez-Xérès-Sherry" and "Manzanilla-Sanlúcar de Barrameda" occupy one of the oldest and most world renowned viticultural areas in the peninsula, but it is not exempt from the serious problems that are to be found throughout the sector. In order to try to adapt to the present situation, zoning plans are being promoted whereby priority is given to the quality of the product, sustainable development and the economic interests. This work undertakes an approach to the viticultural zoning. The nutritional state of the grapevines is studied by means of foliage analysis at veraison. The quality of production was measured by means of the berry weight and the analysis of the most usual variables of the must at the time of harvest (°Baumé, pH and titratable acidity) over five seasons, in the 21 plots where the soil profiles were opened for analysis. As a result of applying statistical analysis, the plots are grouped into five classes, two of which are subdivided. The most significant differences were established between the plots of class CL1, on Miocene limestone, and those of class CL5, on Pliocene-Quaternary sands and clays. Class CL1 presented the highest content of ash (mean ± sd CL1; CL5) (15.36 ± 1.73; 12.36 ± 1.77) and calcium (3.42 ± 0.90; 2.65 ± 0.72), the lowest berry weight (2.10 ± 0.30; 2.47 ± 0.50) and a greater Baumé degree (10.55 ± 0.86; 9.63 ± 0.98) than the CL5. This new approach takes other essential factors for the quality of the production into account such as the climate and the geomorphology (altitude, slope, and physiography).

The Appellations of Origin “Jerez-Xérès-Sherry” and “Manzanilla-Sanlúcar de Barrameda” occupy one of the oldest and most world renowned viticultural areas in the peninsula, but it is not exempt from the serious problems that are to be found throughout the sector. In order to try to adapt to the present situation, zoning plans are being promoted whereby priority is given to the quality of the product, sustainable development and the economic interests. This work undertakes an approach to the viticultural zoning. The nutritional state of the grapevines is studied by means of foliage analysis at veraison. The quality of production was measured by means of the berry weight and the analysis of the most usual variables of the must at the time of harvest (°Baumé, pH and titratable acidity) over five seasons, in the 21 plots where the soil profiles were opened for analysis. As a result of applying statistical analysis, the plots are grouped into five classes, two of which are subdivided. The most significant differences were established between the plots of class CL1, on Miocene limestone, and those of class CL5, on Pliocene-Quaternary sands and clays. Class CL1 presented the highest content of ash (mean ± sd CL1; CL5) (15.36 ± 1.73; 12.36 ± 1.77) and calcium (3.42 ± 0.90; 2.65 ± 0.72), the lowest berry weight (2.10 ± 0.30; 2.47 ± 0.50) and a greater Baumé degree (10.55 ± 0.86; 9.63 ± 0.98) than the CL5. This new approach takes other essential factors for the quality of the production into account such as the climate and the geomorphology (altitude, slope, and physiography), Las Denominaciones de Origen Jerez-Xérès-Sherry y Manzanilla-Sanlúcar de Barrameda ocupan una de las zonas de producción más antiguas de la península y de mayor reconocimiento a nivel mundial, aunque no están exentas de la grave problemática por la que atraviesa el sector. Para intentar adaptarse a la situación actual se están promoviendo planes de zonificación en donde prima la calidad del producto, el desarrollo sostenible y los intereses económicos. En este trabajo se realiza una aproximación a la zonificación vitícola. Para ello, se estudia el estado nutricional de las vides mediante el análisis foliar en el envero, la calidad de producción mediante el peso de los granos de uva y el análisis de las variables más usuales del mosto en la época de vendimia (°Baumé, pH y acidez total) durante 5 campañas, en 21 parcelas coincidentes con la apertura de los perfiles. Como resultado de aplicar el análisis estadístico, se han agrupado las parcelas en cinco clases, dos de ellas a su vez subdivididas. Las principales diferencias significativas se encontraron en las parcelas de las clases CL1, sobre albarizas del Mioceno, y las de la clase CL5, sobre arenas y arcillas del Plioceno-Cuaternario. La clase CL1 presenta el contenido más elevado de cenizas (mean ± sd CL1; CL5) (15,36 ± 1,73; 12,36 ± 1,77) y calcio (3,42 ± 0,90; 2,65 ± 0,72), el menor peso de grano de uva (2,10 ± 0,30; 2,47 ± 0,50) y un mayor grado Baumé (10,55 ± 0,86; 9,63 ± 0,98) que la CL5. Esta nueva aproximación tiene en cuenta otros factores esenciales para la calidad de la producción como son el clima y la geomorfología (altitud, pendiente, fisiografía)

The Appellations of Origin “Jerez-Xérès-Sherry” and “Manzanilla-Sanlúcar de Barrameda” occupy one of the oldest and most world renowned viticultural areas in the peninsula, but it is not exempt from the serious problems that are to be found throughout the sector. In order to try to adapt to the present situation, zoning plans are being promoted whereby priority is given to the quality of the product, sustainable development and the economic interests. This work undertakes an approach to the viticultural zoning. The nutritional state of the grapevines is studied by means of foliage analysis at veraison. The quality of production was measured by means of the berry weight and the analysis of the most usual variables of the must at the time of harvest (°Baumé, pH and titratable acidity) over five seasons, in the 21 plots where the soil profiles were opened for analysis. As a result of applying statistical analysis, the plots are grouped into five classes, two of which are subdivided. The most significant differences were established between the plots of class CL1, on Miocene limestone, and those of class CL5, on Pliocene-Quaternary sands and clays. Class CL1 presented the highest content of ash (mean ± sd CL1; CL5) (15.36 ± 1.73; 12.36 ± 1.77) and calcium (3.42 ± 0.90; 2.65 ± 0.72), the lowest berry weight (2.10 ± 0.30; 2.47 ± 0.50) and a greater Baumé degree (10.55 ± 0.86; 9.63 ± 0.98) than the CL5. This new approach takes other essential factors for the quality of the production into account such as the climate and the geomorphology (altitude, slope, and physiography), Las Denominaciones de Origen Jerez-Xérès-Sherry y Manzanilla-Sanlúcar de Barrameda ocupan una de las zonas de producción más antiguas de la península y de mayor reconocimiento a nivel mundial, aunque no están exentas de la grave problemática por la que atraviesa el sector. Para intentar adaptarse a la situación actual se están promoviendo planes de zonificación en donde prima la calidad del producto, el desarrollo sostenible y los intereses económicos. En este trabajo se realiza una aproximación a la zonificación vitícola. Para ello, se estudia el estado nutricional de las vides mediante el análisis foliar en el envero, la calidad de producción mediante el peso de los granos de uva y el análisis de las variables más usuales del mosto en la época de vendimia (°Baumé, pH y acidez total) durante 5 campañas, en 21 parcelas coincidentes con la apertura de los perfiles. Como resultado de aplicar el análisis estadístico, se han agrupado las parcelas en cinco clases, dos de ellas a su vez subdivididas. Las principales diferencias significativas se encontraron en las parcelas de las clases CL1, sobre albarizas del Mioceno, y las de la clase CL5, sobre arenas y arcillas del Plioceno-Cuaternario. La clase CL1 presenta el contenido más elevado de cenizas (mean ± sd CL1; CL5) (15,36 ± 1,73; 12,36 ± 1,77) y calcio (3,42 ± 0,90; 2,65 ± 0,72), el menor peso de grano de uva (2,10 ± 0,30; 2,47 ± 0,50) y un mayor grado Baumé (10,55 ± 0,86; 9,63 ± 0,98) que la CL5. Esta nueva aproximación tiene en cuenta otros factores esenciales para la calidad de la producción como son el clima y la geomorfología (altitud, pendiente, fisiografía)

The Appellations of Origin “Jerez-Xérès-Sherry” and “Manzanilla-Sanlúcar de Barrameda” occupy one of the oldest and most world renowned viticultural areas in the peninsula, but it is not exempt from the serious problems that are to be found throughout the sector. In order to try to adapt to the present situation, zoning plans are being promoted whereby priority is given to the quality of the product, sustainable development and the economic interests. This work undertakes an approach to the viticultural zoning. The nutritional state of the grapevines is studied by means of foliage analysis at veraison. The quality of production was measured by means of the berry weight and the analysis of the most usual variables of the must at the time of harvest (°Baumé, pH and titratable acidity) over five seasons, in the 21 plots where the soil profiles were opened for analysis. As a result of applying statistical analysis, the plots are grouped into five classes, two of which are subdivided. The most significant differences were established between the plots of class CL1, on Miocene limestone, and those of class CL5, on Pliocene-Quaternary sands and clays. Class CL1 presented the highest content of ash (mean ± sd CL1; CL5) (15.36 ± 1.73; 12.36 ± 1.77) and calcium (3.42 ± 0.90; 2.65 ± 0.72), the lowest berry weight (2.10 ± 0.30; 2.47 ± 0.50) and a greater Baumé degree (10.55 ± 0.86; 9.63 ± 0.98) than the CL5. This new approach takes other essential factors for the quality of the production into account such as the climate and the geomorphology (altitude, slope, and physiography), Las Denominaciones de Origen Jerez-Xérès-Sherry y Manzanilla-Sanlúcar de Barrameda ocupan una de las zonas de producción más antiguas de la península y de mayor reconocimiento a nivel mundial, aunque no están exentas de la grave problemática por la que atraviesa el sector. Para intentar adaptarse a la situación actual se están promoviendo planes de zonificación en donde prima la calidad del producto, el desarrollo sostenible y los intereses económicos. En este trabajo se realiza una aproximación a la zonificación vitícola. Para ello, se estudia el estado nutricional de las vides mediante el análisis foliar en el envero, la calidad de producción mediante el peso de los granos de uva y el análisis de las variables más usuales del mosto en la época de vendimia (°Baumé, pH y acidez total) durante 5 campañas, en 21 parcelas coincidentes con la apertura de los perfiles. Como resultado de aplicar el análisis estadístico, se han agrupado las parcelas en cinco clases, dos de ellas a su vez subdivididas. Las principales diferencias significativas se encontraron en las parcelas de las clases CL1, sobre albarizas del Mioceno, y las de la clase CL5, sobre arenas y arcillas del Plioceno-Cuaternario. La clase CL1 presenta el contenido más elevado de cenizas (mean ± sd CL1; CL5) (15,36 ± 1,73; 12,36 ± 1,77) y calcio (3,42 ± 0,90; 2,65 ± 0,72), el menor peso de grano de uva (2,10 ± 0,30; 2,47 ± 0,50) y un mayor grado Baumé (10,55 ± 0,86; 9,63 ± 0,98) que la CL5. Esta nueva aproximación tiene en cuenta otros factores esenciales para la calidad de la producción como son el clima y la geomorfología (altitud, pendiente, fisiografía)

The quasi-one-dimensional cobalt oxide Sr6Co5O15 is studied using first-principles electronic-structure calculations and Boltzmann transport theory. We have been able to describe the electronic structure, characterized by the structural one-dimensionality and a particular type of charge ordering, with unexpected electronic structure of the different Co atoms. The origin of the large unquenched misaligned orbital angular momenta comes out naturally from a correct description of the different crystal-field environments. The evolution with the on-site Coulomb repulsion (U) of the electronic structure and the transport properties is discussed, with a best agreement with experiment found for the smallest value of U that allows to converge the correct in-chain ferrimagnetic ground state

The Appellations of Origin "Jerez-Xérès-Sherry" and "Manzanilla-Sanlúcar de Barrameda" occupy one of the oldest and most world renowned viticultural areas in the peninsula, but it is not exempt from the serious problems that are to be found throughout the sector. In order to try to adapt to the present situation, zoning plans are being promoted whereby priority is given to the quality of the product, sustainable development and the economic interests. This work undertakes an approach to the viticultural zoning. The nutritional state of the grapevines is studied by means of foliage analysis at veraison. The quality of production was measured by means of the berry weight and the analysis of the most usual variables of the must at the time of harvest (°Baumé, pH and titratable acidity) over five seasons, in the 21 plots where the soil profiles were opened for analysis. As a result of applying statistical analysis, the plots are grouped into five classes, two of which are subdivided. The most significant differences were established between the plots of class CL1, on Miocene limestone, and those of class CL5, on Pliocene-Quaternary sands and clays. Class CL1 presented the highest content of ash (mean ± sd CL1; CL5) (15.36 ± 1.73; 12.36 ± 1.77) and calcium (3.42 ± 0.90; 2.65 ± 0.72), the lowest berry weight (2.10 ± 0.30; 2.47 ± 0.50) and a greater Baumé degree (10.55 ± 0.86; 9.63 ± 0.98) than the CL5. This new approach takes other essential factors for the quality of the production into account such as the climate and the geomorphology (altitude, slope, and physiography).