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Lucia Mangone,1 Isabella Bisceglia,1 Maria Michiara,2 Antonino Musolino,2 Guido Mazzoleni,3 Adele Caldarella,4 Sante Minerba,5 Giuseppe Cascone,6 Francesca Bella,7 Ylenia Dinaro,7 Loredana Pau,8 Carmine Pinto9 1Epidemiology Unit, Azienda Unità Sanitaria Locale–IRCCS di Reggio Emilia, Reggio Emilia, Italy; 2Medical Oncology and Breast Unit, University Hospital of Parma, Parma, Italy; 3Pathology Service South Tyrol Local Health Authority, Bolzano, 39100, Italy; 4Tuscany Cancer Registry, Clinical and Descriptive Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy; 5Local Health Service Taranto, Taranto, Italy; 6Cancer Registry, Provincial Health Department, Ragusa, Italy; 7Siracusa Cancer Registry, Azienda Sanitaria Provinciale Di Siracusa, Siracusa, Italy; 8Europa Donna, Italia, Milan, Italy; 9Medical Oncology Unit, Comprehensive Cancer Centre, Azienda Unità Sanitaria Locale -IRCCS Di Reggio Emilia, Reggio Emilia, ItalyCorrespondence: Isabella Bisceglia, Via Giovanni Amendola 2, Tel +39 0522/35075, Email isabella.bisceglia@ausl.re.itPurpose: Describe breast cancer in Italy by age, geographical area, stage and sites of metastases. In addition, incident and prevalent cases by region are provided.Patients and Methods: This population-based study included all female patients with histologically confirmed breast cancer diagnosed in Italy between 2013 and 2019 in the eight participating Cancer Registries. Cases were described by geographic area (north, center, south), age group (< 50, 50– 69 and 70+) and site of metastases. In addition, the study also provided an estimate of the cases of metastatic breast cancer per single region.Results: Of the total 5731 cases, the number of unknown stage cases (eliminated from our analyses) was 545 (10.5% of cases); therefore, the study was conducted on 5186 cases. Overall, 333 (6.5%) of tumors were metastatic at diagnosis but the distribution by geographical area was differ