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Nowadays, the selective introduction of fluorine into bioactive compounds is a mature strategy in the design of drugs allowing to increase efficiency, biological half-life and bio-absorption. On the other hand, amino acids (AAs) represent one of the most ubiquitious classes of naturally occurring organic compounds, which are found in over 40% of newly marked small-molecule pharmaceutical drugs and medical formulations. The primary goal of this work is to underscore two major trends in the design of modern pharmaceuticals. The first is dealing with the unique structural characteristics provided by the structure of amino acids featuring an abundance of functionality and the presence of a stereogenic center, all of which bodes well for the successful development of targeted bioactivity. The second is related to fine-tuning the desired activity and pharmacokinetics by selective introduction of fluorine. Historically, both trends were developed separately as innovative and prolific approaches in modern drug design. However, in recent decades, these approaches are clearly converging leading to an ever-increasing number of newly approved pharmaceuticals containing both structural features of amino acids and fluorine.

Nowadays, the selective introduction of fluorine into bioactive compounds is a mature strategy in the design of drugs allowing to increase efficiency, biological half-life and bio-absorption. On the other hand, amino acids (AAs) represent one of the most ubiquitious classes of naturally occurring organic compounds, which are found in over 40% of newly marked small-molecule pharmaceutical drugs and medical formulations. The primary goal of this work is to underscore two major trends in the design of modern pharmaceuticals. The first is dealing with the unique structural characteristics provided by the structure of amino acids featuring an abundance of functionality and the presence of a stereogenic center, all of which bodes well for the successful development of targeted bioactivity. The second is related to fine-tuning the desired activity and pharmacokinetics by selective introduction of fluorine. Historically, both trends were developed separately as innovative and prolific approaches in modern drug design. However, in recent decades, these approaches are clearly converging leading to an ever-increasing number of newly approved pharmaceuticals containing both structural features of amino acids and fluorine.

This review provides a short summary of the traditional methods for synthesis of CF3-O-containing compounds, followed by a critical overview of known trifluoromethoxylating reagents, focusing on their preparation, synthetic generality and limitations.

This review provides a short summary of the traditional methods for synthesis of CF3-O-containing compounds, followed by a critical overview of known trifluoromethoxylating reagents, focusing on their preparation, synthetic generality and limitations.

This review provides a short summary of the traditional methods for synthesis of CF3-O-containing compounds, followed by a critical overview of known trifluoromethoxylating reagents, focusing on their preparation, synthetic generality and limitations.

The composition of software units has been one of the main research topics in computer science. This paper addresses the composition validation problem evolving in this context. It focuses on the composition for a certain kind of units called aspects. Aspects are a new concept which is introduced by aspect-oriented programming aiming at a better separation of concerns. Cross-cutting code is captured and localised in these aspects. Some of the cross-cutting features which are expressed in aspects cannot be woven with other features into the same application since two features could be mutually exclusive. With a growing number of aspects, manual control of these dependencies becomes error-prone or even impossible. We show how assertions can be useful in this respect to support the software developer.

Over the recent years aspect-oriented programming (AOP) has found increasing interest among researchers in software engineering. Aspects are abstractions which capture and localise cross-cutting concerns. Although persistence has been considered as an aspect of a system, persistence of aspects has been largely ignored. This paper identifies several scenarios where aspect persistence is an essential requirement. A model for aspect persistence and an initial prototype based on AspectJ (0.6beta2) are presented. Various open issues are also pointed out.

Over the recent years aspect-oriented programming (AOP) has found increasing interest among researchers in software engineering. Aspects are abstractions which capture and localise cross-cutting concerns. Although persistence has been considered as an aspect of a system, persistence of aspects has been largely ignored. This paper identifies several scenarios where aspect persistence is an essential requirement. A model for aspect persistence and an initial prototype based on AspectJ (0.6beta2) are presented. Various open issues are also pointed out.

The composition of software units has been one of the main research topics in computer science. This paper addresses the composition validation problem evolving in this context. It focuses on the composition for a certain kind of units called aspects. Aspects are a new concept which is introduced by aspect-oriented programming aiming at a better separation of concerns. Cross-cutting code is captured and localised in these aspects. Some of the cross-cutting features which are expressed in aspects cannot be woven with other features into the same application since two features could be mutually exclusive. With a growing number of aspects, manual control of these dependencies becomes error-prone or even impossible. We show how assertions can be useful in this respect to support the software developer.