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INTRODUCTION: International registries provide opportunities to describe use of biologics for treating severe asthma in current clinical practice. Our aims were to describe real-life global patterns of biologic use (continuation, switches, and discontinuations) for severe asthma, elucidate reasons underlying these patterns, and examine associated patient-level factors. METHODS: This was a historical cohort study including adults with severe asthma enrolled into the International Severe Asthma Registry (ISAR; http://isaregistries.org, 2015-2020) or the CHRONICLE Study (2018-2020) and treated with a biologic. Eleven countries were included (Bulgaria, Canada, Denmark, Greece, Italy, Japan, Kuwait, South Korea, Spain, UK, and USA). Biologic utilization patterns were defined: 1) continuing initial biologic; 2) stopping biologic treatment; or 3) switching to another biologic. Reasons for discontinuation/switching were recorded and comparisons drawn between groups. RESULTS: A total of 3531 patients were included. Omalizumab was the most common initial biologic in 2015 (88.2%) and benralizumab in 2019 (29.6%). Most patients (79%; 2791/3531) continued their first biologic; 10.2% (356/3531) stopped; 10.8% (384/3531) switched. The most frequent first switch was from omalizumab to an anti-IL-5/5R (49.6%; 187/377). The most common subsequent switch was from one anti-IL-5/5R to another (44.4%; 20/45). Insufficient efficacy and/or adverse effects were the most frequent reasons for stopping/switching. Patients who stopped/switched were more likely to have a higher baseline blood eosinophil count and exacerbation rate, lower lung function, and greater health care resource utilization. CONCLUSION: The description of real-life patterns of continuing, stopping, or switching biologics enhances our understanding of global biologic use. Prospective studies involving structured switching criteria could ascertain optimal strategies to identify patients who may benefit from switching.

BACKGROUND: Many severe asthma patients with high oral corticosteroid exposure (HOCS) often do not initiate biologics despite being eligible. This study aimed to compare the characteristics of severe asthma patients with HOCS who did and did not initiate biologics. METHODS: Baseline characteristics of patients with HOCS (long-term maintenance OCS therapy for at least 1 year, or ≥4 courses of steroid bursts in a year) from the International Severe Asthma Registry (ISAR; https://isaregistries.org/), who initiated or did not initiate biologics (anti-lgE, anti-IL5/5R or anti-IL4R), were described at the time of biologic initiation or registry enrolment. Statistical relationships were tested using Pearson's chi-squared tests for categorical variables, and t-tests for continuous variables, adjusting for potential errors in multiple comparisons. RESULTS: Between January 2015 and February 2021, we identified 1412 adult patients with severe asthma from 19 countries that met our inclusion criteria of HOCS, of whom 996 (70.5%) initiated a biologic and 416 (29.5%) did not. The frequency of biologic initiation varied across geographical regions. Those who initiated a biologic were more likely to have higher blood eosinophil count (483 vs 399 cells/µL, p=0.003), serious infections (49.0% vs 13.3%, p<0.001), nasal polyps (35.2% vs 23.6%, p<0.001), airflow limitation (56.8% vs 51.8%, p=0.013), and uncontrolled asthma (80.8% vs 73.2%, p=0.004) despite greater conventional treatment adherence than those who did not start a biologic. Both groups had similar annual asthma exacerbation rates in the previous 12 months (5.7 vs 5.3, p=0.147). CONCLUSION: Around one third of severe HOCS asthma patients did not receive biologics despite a similar high burden of asthma exacerbations as those who initiated a biologic therapy. Other disease characteristics such as eosinophilic phenotype, serious infectious events, nasal polyps, airflow limitation and lack of asthma control appear to dictate bio

BACKGROUND: Phenotypic characteristics of patients with eosinophilic and noneosinophilic asthma are not well characterized in global, real-life severe asthma cohorts. RESEARCH QUESTION: What is the prevalence of eosinophilic and noneosinophilic phenotypes in the population with severe asthma, and can these phenotypes be differentiated by clinical and biomarker variables? STUDY DESIGN AND METHODS: This was an historical registry study. Adult patients with severe asthma and available blood eosinophil count (BEC) from 11 countries enrolled in the International Severe Asthma Registry (January 1, 2015-September 30, 2019) were categorized according to likelihood of eosinophilic phenotype using a predefined gradient eosinophilic algorithm based on highest BEC, long-term oral corticosteroid use, elevated fractional exhaled nitric oxide, nasal polyps, and adult-onset asthma. Demographic and clinical characteristics were defined at baseline (ie, 1 year before or closest to date of BEC). RESULTS: One thousand seven hundred sixteen patients with prospective data were included; 83.8% were identified as most likely (grade 3), 8.3% were identified as likely (grade 2), and 6.3% identified as least likely (grade 1) to have an eosinophilic phenotype, and 1.6% of patients showed a noneosinophilic phenotype (grade 0). Eosinophilic phenotype patients (ie, grades 2 or 3) showed later asthma onset (29.1 years vs 6.7 years; P < .001) and worse lung function (postbronchodilator % predicted FEV1, 76.1% vs 89.3%; P = .027) than those with a noneosinophilic phenotype. Patients with noneosinophilic phenotypes were more likely to be women (81.5% vs 62.9%; P = .047), to have eczema (20.8% vs 8.5%; P = .003), and to use anti-IgE (32.1% vs 13.4%; P = .004) and leukotriene receptor antagonists (50.0% vs 28.0%; P = .011) add-on therapy. INTERPRETATION: According to this multicomponent, consensus-driven, and evidence-based eosinophil gradient algorithm (using variables readily accessible in real life)

INTRODUCTION: Asthma morbidity and health-care utilization are known to exhibit a steep socioeconomic gradient. Further investigation into the modulators of this effect is required to identify potentially modifiable factors. METHODS: We identified a cohort of patients with asthma from the Optimum Patient Care Research Database (OPCRD). We compared demographics, clinical variables, and health-care utilization by quintile of the UK 2011 Indices of Multiple Deprivation based on the location of the patients' general practice. Multivariable analyses were conducted using generalized linear models adjusting for year, age, and sex. We conducted subgroup analyses and interaction tests to investigate the impact of deprivation by age, sex, ethnicity, and treatment step. RESULTS: Our analysis included 127,040 patients with asthma. Patients from the most deprived socio-economic status (SES) quintile were more likely to report uncontrolled disease (OR: 1.54, 95% CI: 1.16, 2.05) and to have an exacerbation during follow-up (OR: 1.27, 95% CI: 1.13, 1.42) than the least deprived quintile. They had higher blood eosinophils (ratio: 1.03; 95% CI: 1.00, 1.06) and decreased peak flow (ratio: 0.95, 95% CI: 0.94, 0.97) when compared to those in the least deprived quintile. The effect of deprivation on asthma control was greater among those aged over 75 years (OR = 1.81, 95% CI: 1.20, 2.73) compared to those aged less than 35 years (OR: 1.22, 95% CI: 0.85, 1.74; pinteraction=0.019). Similarly, socioeconomic disparities in exacerbations were larger among those from ethnic minority groups (OR: 1.94, 95% CI: 1.40, 2.68) than white patients (OR: 1.24, 95% CI: 1.10, 1.39; pinteraction=0.012). CONCLUSION: We found worse disease control and increased exacerbation rates among patients with asthma from more deprived areas. There was evidence that the magnitude of socioeconomic disparities was elevated among older patients and those from ethnic minority groups. The drivers of these differences requir

BACKGROUND: Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical features and outcomes of severe asthma in order to facilitate personalised and targeted care. The International Severe Asthma Registry (ISAR) is a multi-country registry project initiated to aid in this endeavour. METHODS: ISAR is a multi-disciplinary initiative benefitting from the combined experience of the ISAR Steering Committee (ISC; comprising 47 clinicians and researchers across 29 countries, who have a special interest and/or experience in severe asthma management or establishment and maintenance of severe asthma registries) in collaboration with scientists and experts in database management and communication. Patients (≥18 years old) receiving treatment according to the 2018 definitions of the Global Initiative for Asthma (GINA) Step 5 or uncontrolled on GINA Step 4 treatment will be included. Data will be collected on a core set of 95 variables identified using the Delphi method. Participating registries will agree to provide acces

Low temperature heat recovery, cooling and storage schemes, using abandoned flooded mine workings are a viable option for low carbon heating solutions within many abandoned British coalfields. The temperature of mine water is a useful parameter, coupled with depth to water, sustainable yield and recharge potential, to identify suitable locations and calculate the likely performance of heat recovery schemes. This paper aims to provide the first mapping and synthesis of the temperature of Britain's coalfields to support this emerging technology. Using the best available evidence, a median geothermal gradient of 24.1 °C/km was calculated for the British coalfields. However, geothermal gradients between separate coalfields can vary from 17.3 to 34.3 °C/km. The North East, Cumbria and Yorkshire coalfields all have mean geothermal gradients generally >30 °C/km, whilst geothermal gradients of generally <23 °C/km are measured in the Warwickshire, South Wales, Staffordshire, Douglas and Fife coalfields. Active dewatering schemes are shown to locally increase the apparent measured geothermal gradient by ingress and mixing of deeper water into the pumping shafts. This baseline spatial mapping and synthesis of coalfield temperatures offers significant benefit to those planning, designing and regulating heat recovery and storage in Britain's abandoned coalfields.

BACKGROUND: Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical features and outcomes of severe asthma in order to facilitate personalised and targeted care. The International Severe Asthma Registry (ISAR) is a multi-country registry project initiated to aid in this endeavour. METHODS: ISAR is a multi-disciplinary initiative benefitting from the combined experience of the ISAR Steering Committee (ISC; comprising 47 clinicians and researchers across 29 countries, who have a special interest and/or experience in severe asthma management or establishment and maintenance of severe asthma registries) in collaboration with scientists and experts in database management and communication. Patients (≥18 years old) receiving treatment according to the 2018 definitions of the Global Initiative for Asthma (GINA) Step 5 or uncontrolled on GINA Step 4 treatment will be included. Data will be collected on a core set of 95 variables identified using the Delphi method. Participating registries will agree to provide access to and share standardised anonymous patient-level data with ISAR. ISAR is a registered data source on the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance. ISAR's collaborators include Optimum Patient Care, the Respiratory Effectiveness Group (REG) and AstraZeneca. ISAR is overseen by the ISC, REG, the Anonymised Data Ethics & Protocol Transparency Committee and the ISAR operational committee, ensuring the conduct of ethical, clinically relevant research that brings value to all key stakeholders. CONCLUSIONS: ISAR aims to offer a rich source of real-life data for scientific research to understand and improve disease burden, treatment patterns and patient outcomes in severe asthma. Furthermore, the registry will provide an international platform for research collaboration in respiratory medi

BACKGROUND: Clinical characteristics of the international population with severe asthma are unknown. Intercountry comparisons are hindered by variable data collection within regional and national severe asthma registries. We aimed to describe demographic and clinical characteristics of patients treated in severe asthma services in the United States, Europe, and the Asia-Pacific region. METHODS: The International Severe Asthma Registry retrospectively and prospectively collected data in patients with severe asthma (≥ 18 years old), receiving Global Initiative for Asthma (GINA) Step 5 treatment or with severe asthma remaining uncontrolled at GINA Step 4. Baseline demographic and clinical data were collected from the United States, United Kingdom, South Korea, Italy, and the Severe Asthma Web-based Database registry (including Australia, Singapore, and New Zealand) from December 2014 to December 2017. RESULTS: We included 4,990 patients. Mean (SD) age was 55.0 (15.9) years, and mean (SD) age at asthma onset was 30.7 (17.7) years. Patients were predominantly female (59.3%) and white (72.6%), had never smoked (60.5%), and were overweight or obese (70.4%); 34.9% were at GINA Step 5; and 57.2% had poorly controlled disease. A total of 51.1% of patients were receiving regular intermittent oral corticosteroids, and 25.4% were receiving biologics (72.6% for those at GINA Step 5). Mean (SD) exacerbation rate was 1.7 (2.7) per year. Intercountry variation was observed in clinical characteristics, prescribed treatments, and biomarker profiles. CONCLUSIONS: Using a common data set and definitions, this study describes severe asthma characteristics of a large patient cohort included in multiple severe asthma registries and identifies country differences. Whether these are related to underlying epidemiological factors, environmental factors, phenotypes, asthma management systems, treatment access, and/or cultural factors requires further study.

Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals.This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases.Analysis of data from 3236 patients showed many differences in characteristics and lifestyle factors. Current smokers ranged from 0% (Poland and Sweden) to 9.5% (Belgium), mean body mass index ranged from 26.2 (Italy) to 30.6 kg·m-2 (the UK) and the largest difference in mean pre-bronchodilator forced expiratory volume in 1 s % predicted was 20.9% (the Netherlands versus Hungary). Before starting biologicals patients were treated differently between countries: mean inhaled corticosteroid dose ranged from 700 to 1335 µg·day-1 between those from Slovenia versus Poland when starting anti-interleukin (IL)-5 antibody and from 772 to 1344 µg·day-1 in those starting anti-IgE (Slovenia versus Spain). Maintenance oral corticosteroid use ranged from 21.0% (Belgium) to 63.0% (Sweden) and from 9.1% (Denmark) to 56.1% (the UK) in patients starting anti-IL-5 and anti-IgE, respectively.The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current European Respiratory Society/American Thoracic Society guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries.

Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals.This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases.Analysis of data from 3236 patients showed many differences in characteristics and lifestyle factors. Current smokers ranged from 0% (Poland and Sweden) to 9.5% (Belgium), mean body mass index ranged from 26.2 (Italy) to 30.6 kg·m-2 (the UK) and the largest difference in mean pre-bronchodilator forced expiratory volume in 1 s % predicted was 20.9% (the Netherlands versus Hungary). Before starting biologicals patients were treated differently between countries: mean inhaled corticosteroid dose ranged from 700 to 1335 µg·day-1 between those from Slovenia versus Poland when starting anti-interleukin (IL)-5 antibody and from 772 to 1344 µg·day-1 in those starting anti-IgE (Slovenia versus Spain). Maintenance oral corticosteroid use ranged from 21.0% (Belgium) to 63.0% (Sweden) and from 9.1% (Denmark) to 56.1% (the UK) in patients starting anti-IL-5 and anti-IgE, respectively.The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current European Respiratory Society/American Thoracic Society guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries.

The influence has been studied of thermo-mechanical treatment, sensitization conditions, and neutron irradiation on the pitting corrosion resistance of austenitic 316LN stainless steel variants in 10% FeCl[subscript 3]·6H[subscript 2]O at 22 °C. Variants of this steel were modified with additions of nitrogen, manganese, copper, and tungsten, as well as testing cast, cold-rolled, grain boundary engineered (GBE), and as-received variants. It was found that the 316LN steel variant with additions of 0.2% N and 2% Mn had the best pitting corrosion resistance of all studied conditions. When irradiated in a light water reactor (LWR) to a maximum fluence of 3 × 1017 n/cm[superscript 2] (E > 1.1 meV, Tirr < 50 °C), neutron irradiation surprisingly increased the resistance of GBE steels to pitting corrosion. An anisotropy of corrosion resistance of GBE and cold rolled steels was observed. Keywords: Austenitic stainless steel, Alloying, Nitrogen, Tungsten, Copper, Sensitization, Pitting corrosion, Grain boundary engineering

This report is a published product of the ‘CHPM2030’ project - an EC - funded, Horizon2020 project which aims to develop a novel and potentially disruptive techn ology solution that can help satisfy the European needs for energy and strategic metals in a single interlinked process. Working at the frontiers of geothermal resources development, minerals extraction and electro - metallurgy, the project aims at convertin g ultra - deep metallic mineral formations into ‘orebody - engineered geothermal systems’ that will serve as a basis for the development of a new type of facility for ‘Combined Heat, Power and Metal extraction’ (CHPM). The project will help provide new impetus to geothermal development in Europe by investigating previously unexplored pathways at low - TRL. This will be achieved by developing a roadmap in support of the pilot implementation of such system before 2025, and full - scale commercial implementation befor e 2030. This will include detailed specifications of a new type of future engineered geothermal system (EGS) facility that is designed and operated from the very beginning as a combined heat, power and metal extraction system. In the technology envisioned , the metal - bearing geological formation will be manipulated in a way that the co - production of thermal energy and metals will be possible. As part of this, we will investigate how fluid chemical conditions can be optimised to facilitate recovery of specif ic metals, anticipating variable market demands at any given moment in the future. Four geographical areas have been chosen for detailed investigation based on pre - existing data and potential for CHPM development in mineralised areas in the United Kingdom (UK), Portugal, Romania and Sweden. This report summarises information relevant to the investigation area in the UK. The project aims to provide proof - of - concept for the following hypotheses: 1. The composition and structure of orebodies have certain advanta ges that could be us

Generation-integrated energy storage (GIES) systems store energy at some point along the transformation between the primary energy form and electricity. Instances exist already in natural hydro power, biomass generation, wave power, and concentrated solar power. GIES systems have been proposed for wind, nuclear power and they arise naturally in photocatalysis systems that are in development. GIES systems can compare very favourably in both performance and total cost against equivalent non-integrated systems comprising both generation and storage. Despite this, they have not hitherto been recognised as a discrete class of systems. Consequently policy decisions affecting development or demonstration projects and policy approaches concerning low-carbon generation are not fully informed. This paper highlights that policy structures exist militating against the development and introduction of GIES systems-probably to the detriment of overall system good.

A recent Climatic Change review article reports a remarkable convergence of scientific evidence for a link between climatic events and violent intergroup conflict, thus departing markedly from other contemporary assessments of the empirical literature. This commentary revisits the review in order to understand the discrepancy. We believe the origins of the disagreement can be traced back to the review article's underlying quantitative meta-analysis, which suffers from shortcomings with respect to sample selection and analytical coherence. A modified assessment that addresses some of these problems suggests that scientific research on climate and conflict to date has produced mixed and inconclusive results.

There is a requirement to understand the electrical resistivity structure of the near subsurface (i.e. the upper 10 m). This is the zone into which infrastructure is buried and electrical systems are earthed. Detailed resistivity surveys are carried out for site-specific purposes, but there is a lack of regional data. A synthetic resistivity map has been generated by assigning average intrinsic resistivity values to the superficial and bedrock geology and producing an average resistivity for the top 10 m using the superficial thickness as the weight. To test this approach the synthetic map has been compared with the measured resistivity arising from a high-frequency airborne electromagnetic survey over the Isle of Wight. Many general features of the synthetic and measured maps are in agreement, but some of the resistivity assignments are oversimplified. A revised synthetic map that takes into account the position in the landscape of the geological units and with revised resistivity ranges informed from the airborne survey has been generated that represents a good first approximation of the near-surface resistivity structure. A scheme for generating synthetic maps in the absence of measured airborne data is indicated.

The move towards a lower carbon society is likely to lead to a greater utilization of geothermal heat as the UK meets the challenge of its EU renewable obligation to source 15% of its energy from renewables by 2020. The shallow temperature field can be estimated, but measured temperatures are the most accurate approach for defining the shallow heat resource. Available measured temperature data have been used to compile maps of temperatures at depths below ground level of 100, 200, 500 and 1000 m. From these data regional trends and anomalies have been defined. From a consideration of all of the data a geothermal gradient of 28 °C km–1 has been calculated for the upper 1 km of the sedimentary crust, which is slightly above the previously quoted value of 26 °C km–1. Elevated temperatures have been mainly observed in eastern and southern England and have been attributed to convection within some of the thicker Permo-Triassic sandstones and the thermal blanketing effect of Triassic and Jurassic argillaceous rocks. Some of the depressed temperatures are associated with thick sequences of Carboniferous arenaceous rocks.

The redistribution of risk across social groups is an important aspect of risk analysis. This article argues for a more general concept of risk redistribution across any significant categorisation, however, not just social groups. This includes the redistribution of risk across different kinds of harm, different kinds of failure mode and so on. These redistributions are connected by the way in which they all somehow threaten coping capacities that are adapted to specific past distributions: for example redistributions across failure modes threaten technological and organisational risk controls, whereas redistributions across social groups can threaten notions of fairness and social order. The purpose of the study described here was to investigate this general concept of risk redistribution as a managerial problem. It involved interviews with regulatory and consultancy staff, predominantly in offshore, maritime and railroad operations. These indicated that redistribution was a ubiquitous outcome of activity – and not one confined to discontinuous changes in technology or organisation. Yet, the management of this redistribution was not strongly institutionalised. It was mostly not embodied as an important concept in regulations, codes and procedures and it was not a product of risk assessment processes. But there was a considerable sensitivity to how both technological change and the practice of risk management itself produced redistributions, and extensive efforts were often made to deal with them in the informal domain.

One of the main approaches we have for studying the progressive divergence of understandings around a risk issue is that of social risk amplification. This article describes a case study of a particular environmental contaminant, a chemical flame retardant that could be interpreted as having produced a risk amplifying process. It describes in particular how a group of industrial organizations acted collectively to reduce emissions of this contaminant, in an apparent attempt to avert regulation and boycotts—that is, to intercept the social amplification process and avoid its secondary effects. The aim of the study was to investigate the constitutive qualities of this collective action: the qualities that defined it and made it effective in the eyes of those involved. These include institutionalisation and independence, the ability to confer individual as well as collective benefit, the capacity to attract (rather than avoid) criticism, and the ‘branding’ that helps communicate what otherwise appear to be a set of unconnected, local actions. Although the risk amplification framework has been criticised for implying that there is some externally given risk level that is subsequently amplified, it does appear to capture the mentality of actors involved in issues of this kind. They talk and act as though they believe they are participants in a risk amplification process.

Project risk analysis has traditionally emphasized the analysis of external threats. Here we argue that internal decisions and structures are more fundamental, because they determine which external events pose risks to project management. A “pathogen” metaphor is used to understand these internal sources of risk, in an analysis of failure in two sets of projects that lie on the border between the private and public sectors. This analysis goes beyond earlier work on organizational pathogens by treating them as subjective interpretations, not objective conditions. The study suggests that the more insidious risks to which a project is exposed involve different project members holding contradictory beliefs about what is pathogenic and what is protective.

When risks generate anger rather than fear, there is at least someone who regards the imposition of those risks as wrongdoing; and it then makes sense to speak of the involvement in producing those risks as complicity. It is particularly relevant to examine the complicity of risk bearers, because this is likely to have a strong influence on how far other actors should go in providing them with protection. This article makes a case for analyzing complicity explicitly, in parallel with normal processes of risk assessment, and proposes a framework for this analysis. It shows how it can be applied in a case study of maritime transportation, and examines the practical and theoretical difficulties of this kind of analysis. The conclusion is that the analysis has to be formative rather than summative, but that it could provide a useful way of exposing differences in the assumptions of different actors about agency and responsibility.

The risk assessment of complex systems often seems to neglect the way in which intentions, collective and individual, are central to our explanations of how risk arises in such systems. Contradictions among the intentions of different actors, for example, are typically an important part of our understanding of how organizations break down. Moreover, risk assessment practice pays little attention to the reflexive problem of how intentions for the risk assessment itself can themselves become problematic. This study was an attempt to develop a framework to support reasoning about intentionality, both individual and collective, during risk assessment. The framework broadly follows a process of 1) identifying the main social objects in a system, 2) asking what are the collective intentions for these objects in terms of the functions that are conferred on them, 3) asking what obligations and powers these create, and 4) asking what risks of organizational dysfunction can then arise. The approach was applied in a case study of aviation ramp operations. Its main value is as a formative rather than a summative kind of analysis.

Ubiquitous computing is a new kind of computing where devices enhance everyday artefacts and open up previously inaccessible situations for data capture. ‘Technology paternalism’ has been suggested by Spiekermann and Pallas (Poiesis & Praxis: Int J Technol Assess Ethics Sci 4(1):6–18, 2006) as a concept to gauge the social and ethical impact of these new technologies. In this article we explore this concept in the specific setting of UK road maintenance and construction. Drawing on examples from our qualitative fieldwork we suggest that cultural logics such as those reflected in paternalistic health and safety discourse are central in legitimising the introduction of ubiquitous computing technologies. As such, there is little doubt that paternalism plays an essential role in people’s reasoning about ubiquitous computing in this setting. We argue, however, that since discourses such as health and safety are used by everyone (including both managers and workers) in the organisation to further their own aims, technologies transcend purely paternalistic conceptualisations and instead become a focal point for ongoing struggles for control between those deploying and using them. This means that the benefits and costs of such new technologies become harder to define from an ethical and social perspective.

Beaches provide sediment stores and have an important role in the development of the coastline in response to climate change. Quantification of beach thickness and volume is required to assess coastal sediment transport budgets. Therefore, portable, rapid, non-invasive techniques are required to evaluate thickness where environmental sensitivities exclude invasive methods. Site methods and data are described for a toolbox of electrical, electromagnetic, seismic and mechanical based techniques that were evaluated at a coastal site at Easington, Yorkshire. Geophysical and geotechnical properties are shown to be dependent upon moisture content, porosity and lithology of the beach and the morphology of the beach–platform interface. Thickness interpretation, using an inexpensive geographic information system to integrate data, allowed these controls and relationships to be understood. Guidelines for efficient site practices, based upon this case history including procedures and techniques, are presented using a systematic approach. Field results indicated that a mixed sand and gravel beach is highly variable and cannot be represented in models as a homogeneous layer of variable thickness overlying a bedrock half-space.

A study has been conducted to characterise the coordination that is required in systems of distributed cognition in the maritime industry. This concentrated particularly on the role of organisational artefacts -entities such as rules, procedures, authority structures, records and so on that have organisational functions rather than physical ones. These artefacts work by providing constraints. Such constraints make the coordination of distributed cognitions more tractable, and they provide other organisational functions in parallel -such as encoding historical learning. An analysis of accidents provided the empirical basis of the study, in an attempt to reveal what was commonly taken for granted in normal operations. The results provide a characterisation of the kind of artefacts involved, the kind of coordinations that are required, and the ways in which this coordination sometimes fails.