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4 results on '"Brown, Mollie"'

1. Electronic health records (EHRs) in clinical research and platform trials:Application of the innovative EHR-based methods developed by EU-PEARL

Author

Lombardo, Giulia, Couvert, Camille, Kose, Melisa, Begum, Amina, Spiertz, Cecile, Worrell, Courtney, Hasselbaink, Danny, Didden, Eva Maria, Sforzini, Luca, Todorovic, Marija, Lewi, Martine, Brown, Mollie, Vaterkowski, Morgan, Gullet, Nancy, Amasi-Hartoonian, Nare, Griffon, Nicolas, Pais, Raluca, Rodriguez Navarro, Sarai, Kremer, Andreas, Maes, Christophe, Tan, Eng Hooi, Moinat, Maxim, Ferrer, Joan Genescà, Pariante, Carmine M., Kalra, Dipak, Ammour, Nadir, Kalko, Susana, Lombardo, Giulia, Couvert, Camille, Kose, Melisa, Begum, Amina, Spiertz, Cecile, Worrell, Courtney, Hasselbaink, Danny, Didden, Eva Maria, Sforzini, Luca, Todorovic, Marija, Lewi, Martine, Brown, Mollie, Vaterkowski, Morgan, Gullet, Nancy, Amasi-Hartoonian, Nare, Griffon, Nicolas, Pais, Raluca, Rodriguez Navarro, Sarai, Kremer, Andreas, Maes, Christophe, Tan, Eng Hooi, Moinat, Maxim, Ferrer, Joan Genescà, Pariante, Carmine M., Kalra, Dipak, Ammour, Nadir, and Kalko, Susana

Abstract

Objective: Electronic Health Record (EHR) systems are digital platforms in clinical practice used to collect patients’ clinical information related to their health status and represents a useful storage of real-world data. EHRs have a potential role in research studies, in particular, in platform trials. Platform trials are innovative trial designs including multiple trial arms (conducted simultaneously and/or sequentially) on different treatments under a single master protocol. However, the use of EHRs in research comes with important challenges such as incompleteness of records and the need to translate trial eligibility criteria into interoperable queries. In this paper, we aim to review and to describe our proposed innovative methods to tackle some of the most important challenges identified. This work is part of the Innovative Medicines Initiative (IMI) EU Patient-cEntric clinicAl tRial pLatforms (EU-PEARL) project's work package 3 (WP3), whose objective is to deliver tools and guidance for EHR-based protocol feasibility assessment, clinical site selection, and patient pre-screening in platform trials, investing in the building of a data-driven clinical network framework that can execute these complex innovative designs for which feasibility assessments are critically important. Methods: ISO standards and relevant references informed a readiness survey, producing 354 criteria with corresponding questions selected and harmonised through a 7-round scoring process (0–1) in stakeholder meetings, with 85% of consensus being the threshold of acceptance for a criterium/question. ATLAS cohort definition and Cohort Diagnostics were mainly used to create the trial feasibility eligibility (I/E) criteria as executable interoperable queries. Results: The WP3/EU-PEARL group developed a readiness survey (eSurvey) for an efficient selection of clinical sites with suitable EHRs, consisting of yes-or-no questions, and a

Published
2023

2. Evaluation of minimally invasive sampling methods for detecting Avipoxvirus: Hummingbirds as a case example.

Author

Galvin, Aoife N, Galvin, Aoife N, Pandit, Pranav S, English, Simon G, Quock, Rachel C, Bandivadekar, Ruta R, Colwell, Rita R, Robinson, Barbara W, Ernest, Holly B, Brown, Mollie H, Sehgal, Ravinder NM, Tell, Lisa A, Galvin, Aoife N, Galvin, Aoife N, Pandit, Pranav S, English, Simon G, Quock, Rachel C, Bandivadekar, Ruta R, Colwell, Rita R, Robinson, Barbara W, Ernest, Holly B, Brown, Mollie H, Sehgal, Ravinder NM, and Tell, Lisa A

Abstract

Avian pox is a common avian virus that in its cutaneous form can cause characteristic lesions on a bird's dermal surfaces. Detection of avian pox in free-ranging birds historically relied on observations of visual lesions and/or histopathology, both which can underestimate avian pox prevalence. We compared traditional visual observation methods for avian pox with molecular methods that utilize minimally invasive samples (blood, toenail clipping, feathers, and dermal swabs) in an ecologically important group of birds, hummingbirds. Specifically, avian pox prevalence in several species of hummingbirds were examined across multiple locations using three different methods: (1) visual inspection of hummingbirds for pox-like lesions from a long-term banding data set, (2) qPCR assay of samples from hummingbird carcasses from wildlife rehabilitation centers, and (3) qPCR assay of samples from live-caught hummingbirds. A stark difference in prevalences among these three methods was identified, with an avian pox prevalence of 1.5% from banding data, 20.4% from hummingbird carcasses, and 32.5% from live-caught hummingbirds in California. This difference in detection rates underlines the necessity of a molecular method to survey for avian pox, and this study establishes one such method that could be applied to other wild bird species. Across all three methods, Anna's hummingbirds harbored significantly higher avian pox prevalence than other species examined, as did males compared with females and birds caught in Southern California compared with Northern California. After hatch-year hummingbirds also harbored higher avian pox prevalences than hatch-year hummingbirds in the California banding data set and the carcass data set. This is the first study to estimate the prevalence of avian pox in hummingbirds and address the ecology of this hummingbird-specific strain of avian pox virus, providing vital information to inform future studies on this charismatic and ecologically import

Published
2022

3. Local history cards for the Woodring family

Author

Woodring, Andrew; Woodring, Anna, 1805-; Woodring, Benjamin, 1825-; Woodring, Ezra, 1832-; Woodring, Frank; Woodring, George M., 1857-; Janney, Jane; Depoy, Lucinda; Woodring, Martha; Woodring, Martha A., 1861-; Brown, Mollie, 1855-; Woodring, Noah, 1833-; Woodring, Philip; Woodring, Philip W., 1805-; Woodring, Rhoda, 1836-; Woodring, Richard, 1875-; Woodring, Silva, 1873-; Woodwring, Valentine, 1828-; Woodring, Valentine, 1848-; Woodring, William, 1830, Bennett, Elaine C., Woodring, Andrew; Woodring, Anna, 1805-; Woodring, Benjamin, 1825-; Woodring, Ezra, 1832-; Woodring, Frank; Woodring, George M., 1857-; Janney, Jane; Depoy, Lucinda; Woodring, Martha; Woodring, Martha A., 1861-; Brown, Mollie, 1855-; Woodring, Noah, 1833-; Woodring, Philip; Woodring, Philip W., 1805-; Woodring, Rhoda, 1836-; Woodring, Richard, 1875-; Woodring, Silva, 1873-; Woodwring, Valentine, 1828-; Woodring, Valentine, 1848-; Woodring, William, 1830, and Bennett, Elaine C.

Abstract

This archival material has been provided for educational purposes. Ball State University Libraries recognizes that some historic items may include offensive content. Our statement regarding objectionable content is available at: https://dmr.bsu.edu/digital/about

4. Local history cards for the Brown family

Author

Brown, Absalom, 1841-; Brown, Andrew; Brown, Andrew, 1832-; Brown, Andrew, 1834-; Brown, Anna, -1855; Brown, Arch; Brown, B. A.; Brown, Benjamin, 1819-; Brown, Benjamin; Brown, Caroline; Brown, Catherine, 1828-1886; Brown, Charles; Brown, Charles, 1827-; Brown, Charles C.; Brown, Cora Eddie; Brown, David; Brown, David S.; Brown, David, 1826-; Brown, Eddie; Brown, Eliza Jane; Brown, Eliza; Brown, Elizabeth, 1803-; Brown, Elizabeth; Brown, Emeline; Brown, Emaline, 1845-; Brown, Esther; Brown, Frank A.; Brown, Frank M.; Brown, Garret; Brown, George, 1825-; Brown, George A., 1852-; Brown, George W., 1861-; Brown, H.; Brown, Hannah, 1832-; Brown, Harvey, 1849-; Brown, Harvey, 1860-; Brown, Henry, 1857-; Brown, Henry; Brown, Henry, 1798-; Brown, Hugh; Brown, Isaac; Brown, James Washington; Brown, James, 1862-; Brown, James H.; Brown, Jeremiah, -1875; Brown, Jerry, -1875; Brown, Joel, 1818-; Brown, John; Brown, John B.; Brown, John D.; Brown, John C.; Brown, John A., 1831-; Brown, John, 1857-; Brown, Jonathan, 1823-; Brown, Joseph; Brown, Joseph S., 1819-; Brown, Joseph, 1843-; Brown, Joshua, 1838-; Brown, Manda L., 1878-; Brown, Louisa; Brown, Mary; Brown, Mary J., 1846-; Brown, Millie; Brown, Mollie, 1855-; Brown, Nancy; Brown, Nancy, 1815-; Brown, Nathan; Brown, Polly; Brown, Rebecca Leona; Brown, Richard, 1875-; Brown, Samuel; Brown, Samuel, 1797-; Brown, Samuel, 1800-; Brown, Samuel, 1829-; Brown, Sarah Jane; Brown, Sarah, 1829-; Brown, Sarah Catherine; Brown, Silva, 1873-; Brown, Susan; Brown, Thomas, 1799-1871; Brown, Thomas, 1820-; Brown, Thomas; Brown, W. W.; Brown, William; Brown, William, 1855-; Brown, William H., 1846-; Brown, William Henry; Brown, Washington, 1811-; Brown, William, 1823-; Brown, William, 1822-; Brown, William, 1831-; Brown, William R., 1832-; Brown, W. M.; Brown, William, 1810, Bennett, Elaine C., Brown, Absalom, 1841-; Brown, Andrew; Brown, Andrew, 1832-; Brown, Andrew, 1834-; Brown, Anna, -1855; Brown, Arch; Brown, B. A.; Brown, Benjamin, 1819-; Brown, Benjamin; Brown, Caroline; Brown, Catherine, 1828-1886; Brown, Charles; Brown, Charles, 1827-; Brown, Charles C.; Brown, Cora Eddie; Brown, David; Brown, David S.; Brown, David, 1826-; Brown, Eddie; Brown, Eliza Jane; Brown, Eliza; Brown, Elizabeth, 1803-; Brown, Elizabeth; Brown, Emeline; Brown, Emaline, 1845-; Brown, Esther; Brown, Frank A.; Brown, Frank M.; Brown, Garret; Brown, George, 1825-; Brown, George A., 1852-; Brown, George W., 1861-; Brown, H.; Brown, Hannah, 1832-; Brown, Harvey, 1849-; Brown, Harvey, 1860-; Brown, Henry, 1857-; Brown, Henry; Brown, Henry, 1798-; Brown, Hugh; Brown, Isaac; Brown, James Washington; Brown, James, 1862-; Brown, James H.; Brown, Jeremiah, -1875; Brown, Jerry, -1875; Brown, Joel, 1818-; Brown, John; Brown, John B.; Brown, John D.; Brown, John C.; Brown, John A., 1831-; Brown, John, 1857-; Brown, Jonathan, 1823-; Brown, Joseph; Brown, Joseph S., 1819-; Brown, Joseph, 1843-; Brown, Joshua, 1838-; Brown, Manda L., 1878-; Brown, Louisa; Brown, Mary; Brown, Mary J., 1846-; Brown, Millie; Brown, Mollie, 1855-; Brown, Nancy; Brown, Nancy, 1815-; Brown, Nathan; Brown, Polly; Brown, Rebecca Leona; Brown, Richard, 1875-; Brown, Samuel; Brown, Samuel, 1797-; Brown, Samuel, 1800-; Brown, Samuel, 1829-; Brown, Sarah Jane; Brown, Sarah, 1829-; Brown, Sarah Catherine; Brown, Silva, 1873-; Brown, Susan; Brown, Thomas, 1799-1871; Brown, Thomas, 1820-; Brown, Thomas; Brown, W. W.; Brown, William; Brown, William, 1855-; Brown, William H., 1846-; Brown, William Henry; Brown, Washington, 1811-; Brown, William, 1823-; Brown, William, 1822-; Brown, William, 1831-; Brown, William R., 1832-; Brown, W. M.; Brown, William, 1810, and Bennett, Elaine C.

Abstract

This archival material has been provided for educational purposes. Ball State University Libraries recognizes that some historic items may include offensive content. Our statement regarding objectionable content is available at: https://dmr.bsu.edu/digital/about

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