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12 results on '"Bolton, Timothy A."'

2. Evaluation of gallbladder motility assessed by ultrasonography in dogs with hyperlipidemia

Author

Villm, Jessica A., DeMonaco, Stefanie M., Panciera, David L., Larson, Martha M., Bolton, Timothy A., Villm, Jessica A., DeMonaco, Stefanie M., Panciera, David L., Larson, Martha M., and Bolton, Timothy A.

Abstract

Background: The pathogenesis of gallbladder (GB) mucoceles in dogs is unknown. It has been proposed that hyperlipidemia could impair GB motility and contribute to GB mucocele formation. Hypothesis/Objectives: The objective of this study was to compare GB motility in dogs with hyperlipidemia to control dogs using ultrasonography. We hypothesized that hyperlipidemic dogs will have decreased GB motility compared with controls. Animals: Twenty-six hyperlipidemic and 28 healthy, age-matched control dogs were prospectively enrolled. Methods: Cholesterol and triglyceride concentrations were measured in all dogs. Hyperlipidemia was defined as hypercholesterolemia (>332 mg/dL) and/or hypertriglyceridemia (>143 mg/dL) using a biochemical analyzer. Ultrasound was performed before feeding, and 60 and 120 minutes after ingestion of a high fat diet. Gallbladder volumes (GBV) and ejection fractions (EF) were calculated. Results: Hyperlipidemic dogs had significantly larger GBVs (ml/kg) before feeding and 60 minutes after feeding of 1.2 (0.4-7.5; P = .008) and 0.6 (0.1-7.2; P = .04) compared with controls 0.6 (0.2-2.6) and 0.4 (0.1-1.9), respectively. Severely hyperlipidemic dogs had significantly larger GBV at baseline, 60 minutes, and 120 minutes of 1.7 (0.6-7.5; P = .03), 1.3 (0.4-7.2; P = .02), and 1.3 (0.2-8.2; P = .04), respectively compared with mildly hyperlipidemic dogs. EFs at 60 and 120 minutes between controls, hyperlipidemic, and severely hyperlipidemic were all 0.3 at 60 minutes and 0.5, 0.3, and 0.3 at 120 minutes, respectively which were not statistically different. Conclusions and Clinical Importance: Hyperlipidemia leads to GB distention in dogs which could lead to retention of bile and gallbladder disease.

Published
2023

3. Clinical, Diagnostic, and Imaging Findings in Three Juvenile Dogs With Paraspinal Hyperesthesia or Myelopathy as a Consequence of Hemophilia A: A Case Report.

Author

Fowler, Kayla M, Fowler, Kayla M, Bolton, Timothy A, Rossmeisl, John H, Arendse, Avril U, Vernau, Karen M, Li, Ronald HL, Parker, Rell L, Fowler, Kayla M, Fowler, Kayla M, Bolton, Timothy A, Rossmeisl, John H, Arendse, Avril U, Vernau, Karen M, Li, Ronald HL, and Parker, Rell L

Abstract

Three juvenile dogs presented with an acute onset of paraspinal hyperesthesia and/or neurologic deficits. These dogs underwent anesthesia for MRI and additional diagnostics. The thoracolumbar MRI in Dog 1 revealed an accumulation of T2-weighted (T2W) hyperintense, T1-weighted (T1W) iso- to hyperintense, contrast enhancing extradural material. The differential diagnoses were meningitis with secondary hemorrhage or empyema or late subacute hemorrhage. The initial cervical MRI in Dog 2 revealed T1W meningeal contrast enhancement suspected to be secondary to meningitis. A repeat MRI following neurologic decline after CSF sampling revealed a large area of T2W and T1W hyperintensity between fascial planes of the cervical musculature as well as T2W iso- to hyperintense and T1W iso- to hypointense extradural material at the level of C1 consistent with hemorrhage. The cervical MRI in Dog 3 revealed T2W hyperintense and T1W iso- to hypointense extradural compressive material consistent with hemorrhage. Dogs 1 and 2 underwent CSF sampling and developed complications, including subcutaneous hematoma and vertebral canal hemorrhage. Dog 3 underwent surgical decompression, which revealed a compressive extradural hematoma. In each case, a hemophilia panel including factor VIII concentration confirmed the diagnosis of hemophilia A. Dog 1 had a resolution of clinical signs for ~5 months before being euthanized from gastrointestinal hemorrhage. Dog 2 was euthanized due to neurologic decompensation following CSF sampling. Dog 3 did well for 2 weeks after surgery but was then lost to follow-up. This case series provides information on clinical signs, MRI findings, and outcome in 3 juvenile dogs with hemophilia A that developed neurologic deficits or paraspinal hyperesthesia secondary to spontaneous or iatrogenic vertebral canal hemorrhage. Hemophilia A should be considered as a differential in any young dog presenting with an acute onset of hyperesthesia with or without neurologic defic

Published
2022

4. Probable paraneoplastic leukocytosis in a dog with a gastrointestinal stromal tumor

Author

Gidcumb, Emily M., Bolton, Timothy A., Trusiano, Brie, Zimmerman, Kurt L., Oakes, Vanessa J., Gidcumb, Emily M., Bolton, Timothy A., Trusiano, Brie, Zimmerman, Kurt L., and Oakes, Vanessa J.

Abstract

A 9-year-old female spayed Boston Terrier presented for diagnostic investigation of lethargy, poor appetite, weight loss, and a marked leukocytosis. Significant muscle wasting and a palpable abdominal mass were present on physical examination. Abdominal imaging revealed the mass to be of small intestinal origin; consequently, an intestinal resection and anastomosis were performed without complication. The histopathologic diagnosis was a gastrointestinal stromal tumor, verified by immunohistochemical positivity to CD117 (KIT). Two weeks after discharge, the leukocytosis had resolved. Though the exact molecular mediator of the severe leukocytosis was undetermined, resolution following tumor removal suggests a paraneoplastic cause. To the authors' knowledge, this is the first reported case of probable paraneoplastic leukocytosis secondary to a gastrointestinal stromal tumor in the dog. Gastrointestinal tract imaging should be performed when this uncommon hematologic abnormality is present.

Published
2022
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5. Clinical, Diagnostic, and Imaging Findings in Three Juvenile Dogs With Paraspinal Hyperesthesia or Myelopathy as a Consequence of Hemophilia A: A Case Report

Author

Fowler, Kayla M., Bolton, Timothy A., Rossmeisl, John H. Jr., Arendse, Avril U., Vernau, Karen M., Li, Ronald H., Parker, Rell L., Fowler, Kayla M., Bolton, Timothy A., Rossmeisl, John H. Jr., Arendse, Avril U., Vernau, Karen M., Li, Ronald H., and Parker, Rell L.

Abstract

Three juvenile dogs presented with an acute onset of paraspinal hyperesthesia and/or neurologic deficits. These dogs underwent anesthesia forMRI and additional diagnostics. The thoracolumbar MRI in Dog 1 revealed an accumulation of T2-weighted (T2W) hyperintense, T1-weighted (T1W) iso- to hyperintense, contrast enhancing extradural material. The differential diagnoses were meningitis with secondary hemorrhage or empyema or late subacute hemorrhage. The initial cervical MRI in Dog 2 revealed T1W meningeal contrast enhancement suspected to be secondary to meningitis. A repeat MRI following neurologic decline after CSF sampling revealed a large area of T2W and T1W hyperintensity between fascial planes of the cervical musculature as well as T2W iso- to hyperintense and T1W iso- to hypointense extradural material at the level of C1 consistent with hemorrhage. The cervical MRI in Dog 3 revealed T2W hyperintense and T1W iso- to hypointense extradural compressive material consistent with hemorrhage. Dogs 1 and 2 underwent CSF sampling and developed complications, including subcutaneous hematoma and vertebral canal hemorrhage. Dog 3 underwent surgical decompression, which revealed a compressive extradural hematoma. In each case, a hemophilia panel including factor VIII concentration confirmed the diagnosis of hemophilia A. Dog 1 had a resolution of clinical signs for ~5 months before being euthanized from gastrointestinal hemorrhage. Dog 2 was euthanized due to neurologic decompensation following CSF sampling. Dog 3 did well for 2 weeks after surgery but was then lost to follow-up. This case series provides information on clinical signs, MRI findings, and outcome in 3 juvenile dogs with hemophilia A that developed neurologic deficits or paraspinal hyperesthesia secondary to spontaneous or iatrogenic vertebral canal hemorrhage. Hemophilia A should be considered as a differential in any young dog presenting with an acute onset of hyperesthesia with or without neurologic defici

Published
2022

6. Vasovagal reaction secondary to bladder overdistension in a dog undergoing a unique timeline of medical and surgical treatment for Corynebacterium urealyticum encrusting cystitis: a case report

Author

Peiffer, Ryan F., Iulo, Carly, LeCuyer, Tessa, Bolton, Timothy, Peiffer, Ryan F., Iulo, Carly, LeCuyer, Tessa, and Bolton, Timothy

Abstract

Background Corynebacterium urealyticum urinary tract infections can result in a rarely reported condition called encrusting cystitis whereby plaque lesions form on and within the urinary bladder mucosa. Chronic lower urinary tract signs manifest subsequent to the infection-induced cystitis and plaque-induced decreased bladder wall distensibility. Because of the organism’s multidrug resistance and plaque forming capability, infection eradication can be difficult. While systemic antimicrobial therapy is the mainstay of treatment, adjunctive surgical debridement of plaques has been used with relative paucity in such cases, thereby limiting our understanding of this modality’s indications and success rate. Consequently, this report describes the successful eradication of Corynebacterium urealyticum encrusting cystitis utilizing a unique timeline of medical and surgical treatments. Additionally, this represents the first reported veterinary case of a vasovagal reaction due to bladder overdistension. Case presentation A 6-year-old female spayed Miniature Schnauzer was evaluated for lower urinary tract clinical signs and diagnosed with Corynebacterium urealyticum encrusting cystitis. The infection was persistent despite prolonged courses of numerous oral antimicrobials and urinary acidification. A unique treatment timeline of intravenous vancomycin, intravesical gentamicin, and mid-course surgical debridement ultimately resulted in infection resolution. During surgery, while the urinary bladder was copiously flushed and distended with saline, the dog experienced an acute vasovagal reaction from which it fully recovered. Conclusions Surgical debridement of bladder wall plaques should be considered a viable adjunctive therapy for Corynebacterium urealyticum encrusting cystitis cases failing to respond to systemic antibiotic therapy. The timing in which surgery was employed in this case, relative to concurrent treatment modalities, may be applicable in future cases of this di

Published
2021
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7. A case of congenital ureteral atresia causing rare upper and lower urinary tract manifestations in a puppy: a case report

Author

Zalek, Megan, Shah, Rohan, Bolton, Timothy, Zalek, Megan, Shah, Rohan, and Bolton, Timothy

Abstract

Background Ureteral atresia is the congenital absence of a ureteral opening, resulting in a blind-ended ureter that fails to terminate at the urinary bladder. Consequently, severe hydroureter and hydronephrosis occur ipsilateral to the atresic ureter. However, hydronephrosis contralateral to severe hydroureter, although reported in humans, is not documented in the dog. Additionally, ureteral atresia has not been reported as a cause for lower urinary tract signs directly related to extramural urinary bladder compression. This report aims to describe these unique manifestations of this congenital urinary tract disease, as well as follow-up findings after successful treatment. Case presentation A 4-month-old male Husky puppy was evaluated for pollakiuria, stranguria, and urine dribbling of 1-month duration. During the physical examination, a mass was palpated in the mid-abdomen. Diagnostic imaging and cystoscopy findings were diagnostic for right-sided ureteral atresia with secondary hydroureter and hydronephrosis. The severe right hydroureter caused lower urinary tract signs and contralateral hydronephrosis secondary to regional compression of the left distal ureter and urinary bladder. A right-sided ureteronephrectomy was performed, resolving the stranguria and pollakiuria. Significant reduction in the contralateral (left) hydronephrosis also occurred. Clinical Relevance Ureteral atresia should be considered as a differential diagnosis for lower urinary tract signs and/or bilateral hydronephrosis in a young dog. Reporting this case expands our knowledge of congenital lower urinary tract disease and the etiology of their manifestations in dogs. Surgical resolution of the congenital ureteral abnormality can result in preservation of renal function in the contralaterally obstructed kidney.

Published
2021
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8. Escherichia coli-associated granulomatous colitis in a cat

Author

Safian, Alexander M., Bolton, Timothy, Safian, Alexander M., and Bolton, Timothy

Abstract

A 6-year-old male castrated domestic shorthair cat was evaluated for a 6-month history of haematochezia, mucoid diarrhoea, tenesmus and rectal prolapse. Colonic histopathology revealed multifocal mucosal ulceration and lamina propria infiltration with large numbers of periodic acid-Schiff-positivemacrophages. Large clusters of intracellular Escherichia coli were confirmed with fluorescence in situ hybridization testing, similar to that seen in dogs with granulomatous colitis. An 8-week course of marbofloxacin resulted in resolution of clinical signs; however, recurrence occurred 4 weeks later. A 12-week course of marbofloxacin resulted in disease remission for which the cat still remains free of clinical signs (15 months). Escherichia coli-associated granulomatous colitis, although reported with rarity in this species, is an important infectious cause of chronic large intestinal disease in the cat.

Published
2021
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9. A case of congenital ureteral atresia causing rare upper and lower urinary tract manifestations in a puppy: a case report

Author

Small Animal Clinical Sciences, Zalek, Megan, Shah, Rohan, Bolton, Timothy, Small Animal Clinical Sciences, Zalek, Megan, Shah, Rohan, and Bolton, Timothy

Abstract

Background Ureteral atresia is the congenital absence of a ureteral opening, resulting in a blind-ended ureter that fails to terminate at the urinary bladder. Consequently, severe hydroureter and hydronephrosis occur ipsilateral to the atresic ureter. However, hydronephrosis contralateral to severe hydroureter, although reported in humans, is not documented in the dog. Additionally, ureteral atresia has not been reported as a cause for lower urinary tract signs directly related to extramural urinary bladder compression. This report aims to describe these unique manifestations of this congenital urinary tract disease, as well as follow-up findings after successful treatment. Case presentation A 4-month-old male Husky puppy was evaluated for pollakiuria, stranguria, and urine dribbling of 1-month duration. During the physical examination, a mass was palpated in the mid-abdomen. Diagnostic imaging and cystoscopy findings were diagnostic for right-sided ureteral atresia with secondary hydroureter and hydronephrosis. The severe right hydroureter caused lower urinary tract signs and contralateral hydronephrosis secondary to regional compression of the left distal ureter and urinary bladder. A right-sided ureteronephrectomy was performed, resolving the stranguria and pollakiuria. Significant reduction in the contralateral (left) hydronephrosis also occurred. Clinical Relevance Ureteral atresia should be considered as a differential diagnosis for lower urinary tract signs and/or bilateral hydronephrosis in a young dog. Reporting this case expands our knowledge of congenital lower urinary tract disease and the etiology of their manifestations in dogs. Surgical resolution of the congenital ureteral abnormality can result in preservation of renal function in the contralaterally obstructed kidney.

Published
2021

10. Research and Development for Near Detector Systems Towards Long Term Evolution of Ultra-precise Long-baseline Neutrino Experiments

Author

Topaksu, Aysel Kayis, Blucher, Edward, Andrieu, Bernard, Bian, Jianming, Roe, Byron, Horton-Smith, Glenn, Hayato, Yoshinari, Caballero, Juan Antonio, Sinclair, James, Kudenko, Yury, Patrizi, Laura, Stanco, Luca, Tenti, Matteo, Megias, Guilermo Daniel, Jachowicz, Natalie, Benhar, Omar, Ricciardi, Giulia, Roth, Stefan, Manly, Steven, Stipcevi, Mario, Meloni, Davide, Ruiz, Ignacio, Sobczyk, Jan, Alvarez-Ruso, Luis, Martini, Marco, Pallavicini, Marco, Barbaro, Maria Benedetta, Hartz, Mark, Mishra, Sanjib, Katori, Teppei, Ekelof, Tord, Mosel, Ulrich, Pandey, Vishvas, Blondel, Alain, Bonesini, Maurizio, Buescher, Volker, Catanesi, Gabriella, Collazuol, Gianmaria, De Roeck, Albert, Di Lodovico, Francesca, Diwan, Milind Vaman, Dracos, Marcos, Ekelof, Tord Johan Carl, Ereditato, Antonio, Sala, Paola, Gamazo, Maria Pilar Hernandez, Lokajicek, Milos, Long, Kenneth Richard, Nachtman, Jane, Nessi, Marzio, Onel, Yasar, Palladino, Vittorio, Patrizii, Laura, Penzo, Aldo, Petti, Roberto, Popov, Boris, Potekhin, Maxim, Radicioni, Emilio, Sanchez, Federico, Jermyn, Paul Soler, Surdo, Antonio, Terranova, Francesco, Thomson, Mark Andrew, Touramanis, Christos, Tsenov, Roumen, Weber, Alfons, Zeyrek, Mehmet, Zito, Marco, Benekos, Nectarios, Messomo, Etam Noah, Jung, Chang Kee, De Rosa, Gianfranca, Bernardini, Paolo, Lux, Thorsten, Masetti, Lucia, Bertolucci, Sergio, Simon, Frank Richard, Mermod, Philippe, Bhatnagar, Vipin, Longhin, Andrea, Kose, Umut, Bolton, Timothy Alan, Paolone, Vittorio, Salamanna, Giuseppe, Bolognesi, Sara, Arbuzov, Andrey, Yokoyama, Masashi, Maneira, Jose Carvalho, Nagai, Yoshikazu, Andreopoulos, Constantinos, Bordoni, Stefania, Hasegawa, Takuya, Bross, Alan David, Asaadi, Jonathan, Bilki, Burak, Giganti, Claudio, Whitehead, Leigh Howard, Christodoulou, Georgios, Diaz, Diego Gonzalez, Mauri, Nicoletta, Di Noto, Lea, Sgalaberna, Davide, Hallsjo, Sven-Patrik, Riccio, Ciro, Wurm, Michael, Roda, Marco, Fernandez, Pablo, Wilking, Michael Joseph, Dennis, Stephen Robert, Mariani, Camillo, Ferraro, Federico, Topaksu, Aysel Kayis, Blucher, Edward, Andrieu, Bernard, Bian, Jianming, Roe, Byron, Horton-Smith, Glenn, Hayato, Yoshinari, Caballero, Juan Antonio, Sinclair, James, Kudenko, Yury, Patrizi, Laura, Stanco, Luca, Tenti, Matteo, Megias, Guilermo Daniel, Jachowicz, Natalie, Benhar, Omar, Ricciardi, Giulia, Roth, Stefan, Manly, Steven, Stipcevi, Mario, Meloni, Davide, Ruiz, Ignacio, Sobczyk, Jan, Alvarez-Ruso, Luis, Martini, Marco, Pallavicini, Marco, Barbaro, Maria Benedetta, Hartz, Mark, Mishra, Sanjib, Katori, Teppei, Ekelof, Tord, Mosel, Ulrich, Pandey, Vishvas, Blondel, Alain, Bonesini, Maurizio, Buescher, Volker, Catanesi, Gabriella, Collazuol, Gianmaria, De Roeck, Albert, Di Lodovico, Francesca, Diwan, Milind Vaman, Dracos, Marcos, Ekelof, Tord Johan Carl, Ereditato, Antonio, Sala, Paola, Gamazo, Maria Pilar Hernandez, Lokajicek, Milos, Long, Kenneth Richard, Nachtman, Jane, Nessi, Marzio, Onel, Yasar, Palladino, Vittorio, Patrizii, Laura, Penzo, Aldo, Petti, Roberto, Popov, Boris, Potekhin, Maxim, Radicioni, Emilio, Sanchez, Federico, Jermyn, Paul Soler, Surdo, Antonio, Terranova, Francesco, Thomson, Mark Andrew, Touramanis, Christos, Tsenov, Roumen, Weber, Alfons, Zeyrek, Mehmet, Zito, Marco, Benekos, Nectarios, Messomo, Etam Noah, Jung, Chang Kee, De Rosa, Gianfranca, Bernardini, Paolo, Lux, Thorsten, Masetti, Lucia, Bertolucci, Sergio, Simon, Frank Richard, Mermod, Philippe, Bhatnagar, Vipin, Longhin, Andrea, Kose, Umut, Bolton, Timothy Alan, Paolone, Vittorio, Salamanna, Giuseppe, Bolognesi, Sara, Arbuzov, Andrey, Yokoyama, Masashi, Maneira, Jose Carvalho, Nagai, Yoshikazu, Andreopoulos, Constantinos, Bordoni, Stefania, Hasegawa, Takuya, Bross, Alan David, Asaadi, Jonathan, Bilki, Burak, Giganti, Claudio, Whitehead, Leigh Howard, Christodoulou, Georgios, Diaz, Diego Gonzalez, Mauri, Nicoletta, Di Noto, Lea, Sgalaberna, Davide, Hallsjo, Sven-Patrik, Riccio, Ciro, Wurm, Michael, Roda, Marco, Fernandez, Pablo, Wilking, Michael Joseph, Dennis, Stephen Robert, Mariani, Camillo, and Ferraro, Federico

Abstract

With the discovery of non-zero value of $\theta_{13}$ mixing angle, the next generation of long-baseline neutrino (LBN) experiments offers the possibility of obtaining statistically significant samples of muon and electron neutrinos and anti-neutrinos with large oscillation effects. In this document we intend to highlight the importance of Near Detector facilities in LBN experiments to both constrain the systematic uncertainties affecting oscillation analyses but also to perform, thanks to their close location, measurements of broad benefit for LBN physics goals. A strong European contribution to these efforts is possible., Comment: Document submitted to the European Strategy For European Particle Physics

Published
2019

12. The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

Author

LBNE Collaboration, Adams, Corey, Adams, David, Akiri, Tarek, Alion, Tyler, Anderson, Kris, Andreopoulos, Costas, Andrews, Mike, Anghel, Ioana, Anjos, João Carlos Costa dos, Antonello, Maddalena, Arrieta-Diaz, Enrique, Artuso, Marina, Asaadi, Jonathan, Bai, Xinhua, Baibussinov, Bagdat, Baird, Michael, Balantekin, Baha, Baller, Bruce, Baptista, Brian, Barker, D'Ann, Barker, Gary, Barletta, William A., Barr, Giles, Bartoszek, Larry, Bashyal, Amit, Bass, Matt, Bellini, Vincenzo, Benetti, Pietro Angelo, Berger, Bruce E., Bergevin, Marc, Berman, Eileen, Berns, Hans-Gerd, Bernstein, Adam, Bernstein, Robert, Bhandari, Babu, Bhatnagar, Vipin, Bhuyan, Bipul, Bian, Jianming, Bishai, Mary, Blake, Andrew, Blaszczyk, Flor, Blaufuss, Erik, Bleakley, Bruce, Blucher, Edward, Blusk, Steve, Bocean, Virgil, Boffelli, F., Boissevain, Jan, Bolton, Timothy, Bonesini, Maurizio, Boyd, Steve, Brandt, Andrew, Breedon, Richard, Bromberg, Carl, Brown, Ralph, Brunetti, Giullia, Buchanan, Norman, Bugg, Bill, Busenitz, Jerome, Calligarich, E., Camilleri, Leslie, Carminati, Giada, Carr, Rachel, Castromonte, Cesar, Cavanna, Flavio, Centro, Sandro, Chen, Alex, Chen, Hucheng, Chen, Kai, Cherdack, Daniel, Chi, Cheng-Yi, Childress, Sam, Choudhary, Brajesh Chandra, Christodoulou, Georgios, Christofferson, Cabot-Ann, Church, Eric, Cline, David, Coan, Thomas, Cocco, Alfredo, Coelho, Joao, Coleman, Stephen, Conrad, Janet M., Convery, Mark, Corey, Robert, Corwin, Luke, Cranshaw, Jack, Cronin-Hennessy, Daniel, Curioni, A., da Motta, Helio, Davenne, Tristan, Davies, Gavin S., Dazeley, Steven, De, Kaushik, de Gouvea, Andre, de Jong, Jeffrey K., Demuth, David, Densham, Chris, Diwan, Milind, Djurcic, Zelimir, Dolfini, R., Dolph, Jeffrey, Drake, Gary, Dye, Stephen, Dyuang, Hongue, Edmunds, Daniel, Elliott, Steven, Elnimr, Muhammad, Eno, Sarah, Enomoto, Sanshiro, Escobar, Carlos O., Evans, Justin, Falcone, A., Falk, Lisa, Farbin, Amir, Farnese, Christian, Fava, Angela, Felde, John, Fernandes, S., Ferroni, Fernando, Feyzi, Farshid, Fields, Laura, Finch, Alex, Fitton, Mike, Fleming, Bonnie, Fowler, Jack, Fox, Walt, Friedland, Alex, Fuess, Stu, Fujikawa, Brian, Gallagher, Hugh, Gandhi, Raj, Garvey, Gerald, Gehman, Victor M., de Geronimo, Gianluigi, Gibin, Daniele, Gill, Ronald, Gomes, Ricardo A., Goodman, Maury C., Goon, Jason, Graf, Nicholas, Graham, Mathew, Gran, Rik, Grant, Christopher, Grant, Nick, Greenlee, Herbert, Greenler, Leland, Grullon, Sean, Guardincerri, Elena, Guarino, Victor, Guarnaccia, Evan, Guedes, Germano, Guenette, Roxanne, Guglielmi, Alberto, Guzzo, Marcelo M., Habig, Alec T., Hackenburg, Robert W., Hadavand, Haleh, Hahn, Alan, Haigh, Martin, Haines, Todd, Handler, Thomas, Hans, Sunej, Hartnell, Jeff, Harton, John, Hatcher, Robert, Hatzikoutelis, Athans, Hays, Steven, Hazen, Eric, Headley, Mike, Heavey, Anne, Heeger, Karsten, Heise, Jaret, Hellauer, Robert, Hewes, V, Himmel, Alexander, Hogan, Matthew, Holanda, Pedro, Holin, Anna, Horton-Smith, Glenn, Howell, Joe, Hurh, Patrick, Huston, Joey, Hylen, James, Imlay, Richard, Insler, Jonathan, Introzzi, G., Isvan, Zeynep, Jackson, Chris, Jacobsen, John, Jaffe, David E., James, Cat, Jen, Chun-Min, Johnson, Marvin, Johnson, Randy, Johnson, Robert, Johnson, Scott, Johnston, William, Johnstone, John, Jones, Ben J. P., Jostlein, H., Junk, Thomas, Kadel, Richard, Kaess, Karl, Karagiorgi, Georgia, Kaspar, Jarek, Katori, Teppei, Kayser, Boris, Kearns, Edward, Keener, Paul, Kemp, Ernesto, Kettell, Steve H., Kirby, Mike, Klein, Joshua, Koizumi, Gordon, Kopp, Sacha, Kormos, Laura, Kropp, William, Kudryavtsev, Vitaly A., Kumar, Ashok, Kumar, Jason, Kutter, Thomas, La Zia, Franco, Lande, Kenneth, Lane, Charles, Lang, Karol, Lanni, Francesco, Lanza, Richard, Latorre, Tony, Learned, John, Lee, David, Lee, Kevin, Li, Qizhong, Li, Shaorui, Li, Yichen, Li, Zepeng, Libo, Jiang, Linden, Steve, Ling, Jiajie, Link, Jonathan, Littenberg, Laurence, Liu, Hu, Liu, Qiuguang, Liu, Tiankuan, Losecco, John, Louis, William, Lundberg, Byron, Lundin, Tracy, Lundy, Jay, Machado, Ana Amelia, Maesano, Cara, Magill, Steve, Mahler, George, Malon, David, Malys, Stephen, Mammoliti, Francesco, Mandal, Samit Kumar, Mann, Anthony, Mantsch, Paul, Marchionni, Alberto, Marciano, William, Mariani, Camillo, Maricic, Jelena, Marino, Alysia, Marshak, Marvin, Marshall, John, Matsuno, Shiegenobu, Mauger, Christopher, Mavrokoridis, Konstantinos, Mayer, Nate, McCauley, Neil, McCluskey, Elaine, McDonald, Kirk, McFarland, Kevin, McKee, David, McKeown, Robert, McTaggart, Robert, Mehdiyev, Rashid, Mei, Dongming, Menegolli, A., Meng, Guang, Meng, Yixiong, Mertins, David, Messier, Mark, Metcalf, William, Milincic, Radovan, Miller, William, Mills, Geoff, Mishra, Sanjib R., Mokhov, Nikolai, Montanari, Claudio, Montanari, David, Moore, Craig, Morfin, Jorge, Morgan, Ben, Morse, William, Moss, Zander, Moura, Célio A., Mufson, Stuart, Muller, David, Musser, Jim, Naples, Donna, Napolitano, Jim, Newcomer, Mitch, Nichol, Ryan, Nicholls, Tim, Niner, Evan, Norris, Barry, Nowak, Jaroslaw, O'Keeffe, Helen, Oliveira, Roberto, Olson, Travis, Page, Brian, Pakvasa, Sandip, Palamara, Ornella, Paley, Jon, Paolone, Vittorio, Papadimitriou, Vaia, Park, Seongtae, Parsa, Zohreh, Partyka, Kinga, Paulos, Bob, Pavlovic, Zarko, Peeters, Simon, Perch, Andy, Perkin, Jon D., Petti, Roberto, Petukhov, Andre, Pietropaolo, Francesco, Plunkett, Robert, Polly, Chris, Pordes, Stephen, Potekhin, Maxim, Potenza, Renato, Prakash, Arati, Prokofiev, Oleg, Qian, Xin, Raaf, Jennifer L., Radeka, Veljko, Rakhno, Igor, Ramachers, Yorck, Rameika, Regina, Ramsey, John, Rappoldi, A., Raselli, G. L., Ratoff, Peter, Ravindra, Shreyas, Rebel, Brian, Reichenbacher, Juergen, Reitzner, Dianne, Rescia, Sergio, Richardson, Martin, Rielage, Kieth, Riesselmann, Kurt, Robinson, Matt, Rochester, Leon, Ronquest, Michael, Rosen, Marc, Rossella, M., Rubbia, Carlo, Rucinski, Russ, Sahijpal, Sandeep, Sahoo, Himansu, Sala, Paola, Salmiera, Delia, Samios, Nicholas, Sanchez, Mayly, Scaramelli, Alberto, Schellman, Heidi, Schmitt, Richard, Schmitz, David, Schneps, Jack, Scholberg, Kate, Segreto, Ettore, Seibert, Stanley, Sexton-Kennedy, Liz, Shaevitz, Mike, Shanahan, Peter, Sharma, Rahul, Shaw, Terri, Simos, Nikolaos, Singh, Venktesh, Sinnis, Gus, Sippach, William, Skwarnicki, Tomasz, Smy, Michael, Sobel, Henry, Soderberg, Mitch, Sondericker, John, Sondheim, Walter, Sousa, Alexandre, Spooner, Neil J. C., Stancari, Michelle, Stancu, Ion, Stefan, Dorota, Stefanik, Andy, Stewart, James, Stone, Sheldon, Strait, James, Strait, Matthew, Striganov, Sergei, Sullivan, Gregory, Sun, Yujing, Suter, Louise, Svenson, Andrew, Svoboda, Robert, Szczerbinska, Barbara, Szelc, Andrzej, Szydagis, Matthew, Söldner-Rembold, Stefan, Talaga, Richard, Tamsett, Matthew, Tariq, Salman, Tayloe, Rex, Taylor, Charles, Taylor, David, Teymourian, Artin, Themann, Harry, Thiesse, Matthew, Thomas, Jenny, Thompson, Lee F., Thomson, Mark, Thorn, Craig, Thorpe, Matt, Tian, Xinchun, Tiedt, Doug, Toki, Walter, Tolich, Nikolai, Torti, M., Toups, Matt, Touramanis, Christos, Tripathi, Mani, Tropin, Igor, Tsai, Yun-Tse, Tull, Craig, Tzanov, Martin, Urheim, Jon, Usman, Shawn, Vagins, Mark, Valdiviesso, Gustavo, Van Berg, Rick, Van de Water, Richard, Van Gemmeren, Peter, Varanini, Filippo, Varner, Gary, Vaziri, Kamran, Velev, Gueorgui, Ventura, Sandro, Vignoli, Chiara, Viren, Brett, Wahl, Dan, Waldron, Abby, Walter, Christopher W., Wang, Hanguo, Wang, Wei, Warburton, Karl, Warner, David, Wasserman, Ryan, Watson, Blake, Weber, Alfons, Wei, Wenzhao, Wells, Douglas, Wetstein, Matthew, White, Andy, White, Hywel, Whitehead, Lisa, Whittington, Denver, Willhite, Joshua, Wilson, Robert J., Winslow, Lindley, Wood, Kevin, Worcester, Elizabeth, Worcester, Matthew, Xin, Tian, Yarritu, Kevin, Ye, Jingbo, Yeh, Minfang, Yu, Bo, Yu, Jae, Yuan, Tianlu, Zani, A., Zeller, Geralyn P., Zhang, Chao, Zimmerman, Eric D., Zwaska, Robert, LBNE Collaboration, Adams, Corey, Adams, David, Akiri, Tarek, Alion, Tyler, Anderson, Kris, Andreopoulos, Costas, Andrews, Mike, Anghel, Ioana, Anjos, João Carlos Costa dos, Antonello, Maddalena, Arrieta-Diaz, Enrique, Artuso, Marina, Asaadi, Jonathan, Bai, Xinhua, Baibussinov, Bagdat, Baird, Michael, Balantekin, Baha, Baller, Bruce, Baptista, Brian, Barker, D'Ann, Barker, Gary, Barletta, William A., Barr, Giles, Bartoszek, Larry, Bashyal, Amit, Bass, Matt, Bellini, Vincenzo, Benetti, Pietro Angelo, Berger, Bruce E., Bergevin, Marc, Berman, Eileen, Berns, Hans-Gerd, Bernstein, Adam, Bernstein, Robert, Bhandari, Babu, Bhatnagar, Vipin, Bhuyan, Bipul, Bian, Jianming, Bishai, Mary, Blake, Andrew, Blaszczyk, Flor, Blaufuss, Erik, Bleakley, Bruce, Blucher, Edward, Blusk, Steve, Bocean, Virgil, Boffelli, F., Boissevain, Jan, Bolton, Timothy, Bonesini, Maurizio, Boyd, Steve, Brandt, Andrew, Breedon, Richard, Bromberg, Carl, Brown, Ralph, Brunetti, Giullia, Buchanan, Norman, Bugg, Bill, Busenitz, Jerome, Calligarich, E., Camilleri, Leslie, Carminati, Giada, Carr, Rachel, Castromonte, Cesar, Cavanna, Flavio, Centro, Sandro, Chen, Alex, Chen, Hucheng, Chen, Kai, Cherdack, Daniel, Chi, Cheng-Yi, Childress, Sam, Choudhary, Brajesh Chandra, Christodoulou, Georgios, Christofferson, Cabot-Ann, Church, Eric, Cline, David, Coan, Thomas, Cocco, Alfredo, Coelho, Joao, Coleman, Stephen, Conrad, Janet M., Convery, Mark, Corey, Robert, Corwin, Luke, Cranshaw, Jack, Cronin-Hennessy, Daniel, Curioni, A., da Motta, Helio, Davenne, Tristan, Davies, Gavin S., Dazeley, Steven, De, Kaushik, de Gouvea, Andre, de Jong, Jeffrey K., Demuth, David, Densham, Chris, Diwan, Milind, Djurcic, Zelimir, Dolfini, R., Dolph, Jeffrey, Drake, Gary, Dye, Stephen, Dyuang, Hongue, Edmunds, Daniel, Elliott, Steven, Elnimr, Muhammad, Eno, Sarah, Enomoto, Sanshiro, Escobar, Carlos O., Evans, Justin, Falcone, A., Falk, Lisa, Farbin, Amir, Farnese, Christian, Fava, Angela, Felde, John, Fernandes, S., Ferroni, Fernando, Feyzi, Farshid, Fields, Laura, Finch, Alex, Fitton, Mike, Fleming, Bonnie, Fowler, Jack, Fox, Walt, Friedland, Alex, Fuess, Stu, Fujikawa, Brian, Gallagher, Hugh, Gandhi, Raj, Garvey, Gerald, Gehman, Victor M., de Geronimo, Gianluigi, Gibin, Daniele, Gill, Ronald, Gomes, Ricardo A., Goodman, Maury C., Goon, Jason, Graf, Nicholas, Graham, Mathew, Gran, Rik, Grant, Christopher, Grant, Nick, Greenlee, Herbert, Greenler, Leland, Grullon, Sean, Guardincerri, Elena, Guarino, Victor, Guarnaccia, Evan, Guedes, Germano, Guenette, Roxanne, Guglielmi, Alberto, Guzzo, Marcelo M., Habig, Alec T., Hackenburg, Robert W., Hadavand, Haleh, Hahn, Alan, Haigh, Martin, Haines, Todd, Handler, Thomas, Hans, Sunej, Hartnell, Jeff, Harton, John, Hatcher, Robert, Hatzikoutelis, Athans, Hays, Steven, Hazen, Eric, Headley, Mike, Heavey, Anne, Heeger, Karsten, Heise, Jaret, Hellauer, Robert, Hewes, V, Himmel, Alexander, Hogan, Matthew, Holanda, Pedro, Holin, Anna, Horton-Smith, Glenn, Howell, Joe, Hurh, Patrick, Huston, Joey, Hylen, James, Imlay, Richard, Insler, Jonathan, Introzzi, G., Isvan, Zeynep, Jackson, Chris, Jacobsen, John, Jaffe, David E., James, Cat, Jen, Chun-Min, Johnson, Marvin, Johnson, Randy, Johnson, Robert, Johnson, Scott, Johnston, William, Johnstone, John, Jones, Ben J. P., Jostlein, H., Junk, Thomas, Kadel, Richard, Kaess, Karl, Karagiorgi, Georgia, Kaspar, Jarek, Katori, Teppei, Kayser, Boris, Kearns, Edward, Keener, Paul, Kemp, Ernesto, Kettell, Steve H., Kirby, Mike, Klein, Joshua, Koizumi, Gordon, Kopp, Sacha, Kormos, Laura, Kropp, William, Kudryavtsev, Vitaly A., Kumar, Ashok, Kumar, Jason, Kutter, Thomas, La Zia, Franco, Lande, Kenneth, Lane, Charles, Lang, Karol, Lanni, Francesco, Lanza, Richard, Latorre, Tony, Learned, John, Lee, David, Lee, Kevin, Li, Qizhong, Li, Shaorui, Li, Yichen, Li, Zepeng, Libo, Jiang, Linden, Steve, Ling, Jiajie, Link, Jonathan, Littenberg, Laurence, Liu, Hu, Liu, Qiuguang, Liu, Tiankuan, Losecco, John, Louis, William, Lundberg, Byron, Lundin, Tracy, Lundy, Jay, Machado, Ana Amelia, Maesano, Cara, Magill, Steve, Mahler, George, Malon, David, Malys, Stephen, Mammoliti, Francesco, Mandal, Samit Kumar, Mann, Anthony, Mantsch, Paul, Marchionni, Alberto, Marciano, William, Mariani, Camillo, Maricic, Jelena, Marino, Alysia, Marshak, Marvin, Marshall, John, Matsuno, Shiegenobu, Mauger, Christopher, Mavrokoridis, Konstantinos, Mayer, Nate, McCauley, Neil, McCluskey, Elaine, McDonald, Kirk, McFarland, Kevin, McKee, David, McKeown, Robert, McTaggart, Robert, Mehdiyev, Rashid, Mei, Dongming, Menegolli, A., Meng, Guang, Meng, Yixiong, Mertins, David, Messier, Mark, Metcalf, William, Milincic, Radovan, Miller, William, Mills, Geoff, Mishra, Sanjib R., Mokhov, Nikolai, Montanari, Claudio, Montanari, David, Moore, Craig, Morfin, Jorge, Morgan, Ben, Morse, William, Moss, Zander, Moura, Célio A., Mufson, Stuart, Muller, David, Musser, Jim, Naples, Donna, Napolitano, Jim, Newcomer, Mitch, Nichol, Ryan, Nicholls, Tim, Niner, Evan, Norris, Barry, Nowak, Jaroslaw, O'Keeffe, Helen, Oliveira, Roberto, Olson, Travis, Page, Brian, Pakvasa, Sandip, Palamara, Ornella, Paley, Jon, Paolone, Vittorio, Papadimitriou, Vaia, Park, Seongtae, Parsa, Zohreh, Partyka, Kinga, Paulos, Bob, Pavlovic, Zarko, Peeters, Simon, Perch, Andy, Perkin, Jon D., Petti, Roberto, Petukhov, Andre, Pietropaolo, Francesco, Plunkett, Robert, Polly, Chris, Pordes, Stephen, Potekhin, Maxim, Potenza, Renato, Prakash, Arati, Prokofiev, Oleg, Qian, Xin, Raaf, Jennifer L., Radeka, Veljko, Rakhno, Igor, Ramachers, Yorck, Rameika, Regina, Ramsey, John, Rappoldi, A., Raselli, G. L., Ratoff, Peter, Ravindra, Shreyas, Rebel, Brian, Reichenbacher, Juergen, Reitzner, Dianne, Rescia, Sergio, Richardson, Martin, Rielage, Kieth, Riesselmann, Kurt, Robinson, Matt, Rochester, Leon, Ronquest, Michael, Rosen, Marc, Rossella, M., Rubbia, Carlo, Rucinski, Russ, Sahijpal, Sandeep, Sahoo, Himansu, Sala, Paola, Salmiera, Delia, Samios, Nicholas, Sanchez, Mayly, Scaramelli, Alberto, Schellman, Heidi, Schmitt, Richard, Schmitz, David, Schneps, Jack, Scholberg, Kate, Segreto, Ettore, Seibert, Stanley, Sexton-Kennedy, Liz, Shaevitz, Mike, Shanahan, Peter, Sharma, Rahul, Shaw, Terri, Simos, Nikolaos, Singh, Venktesh, Sinnis, Gus, Sippach, William, Skwarnicki, Tomasz, Smy, Michael, Sobel, Henry, Soderberg, Mitch, Sondericker, John, Sondheim, Walter, Sousa, Alexandre, Spooner, Neil J. C., Stancari, Michelle, Stancu, Ion, Stefan, Dorota, Stefanik, Andy, Stewart, James, Stone, Sheldon, Strait, James, Strait, Matthew, Striganov, Sergei, Sullivan, Gregory, Sun, Yujing, Suter, Louise, Svenson, Andrew, Svoboda, Robert, Szczerbinska, Barbara, Szelc, Andrzej, Szydagis, Matthew, Söldner-Rembold, Stefan, Talaga, Richard, Tamsett, Matthew, Tariq, Salman, Tayloe, Rex, Taylor, Charles, Taylor, David, Teymourian, Artin, Themann, Harry, Thiesse, Matthew, Thomas, Jenny, Thompson, Lee F., Thomson, Mark, Thorn, Craig, Thorpe, Matt, Tian, Xinchun, Tiedt, Doug, Toki, Walter, Tolich, Nikolai, Torti, M., Toups, Matt, Touramanis, Christos, Tripathi, Mani, Tropin, Igor, Tsai, Yun-Tse, Tull, Craig, Tzanov, Martin, Urheim, Jon, Usman, Shawn, Vagins, Mark, Valdiviesso, Gustavo, Van Berg, Rick, Van de Water, Richard, Van Gemmeren, Peter, Varanini, Filippo, Varner, Gary, Vaziri, Kamran, Velev, Gueorgui, Ventura, Sandro, Vignoli, Chiara, Viren, Brett, Wahl, Dan, Waldron, Abby, Walter, Christopher W., Wang, Hanguo, Wang, Wei, Warburton, Karl, Warner, David, Wasserman, Ryan, Watson, Blake, Weber, Alfons, Wei, Wenzhao, Wells, Douglas, Wetstein, Matthew, White, Andy, White, Hywel, Whitehead, Lisa, Whittington, Denver, Willhite, Joshua, Wilson, Robert J., Winslow, Lindley, Wood, Kevin, Worcester, Elizabeth, Worcester, Matthew, Xin, Tian, Yarritu, Kevin, Ye, Jingbo, Yeh, Minfang, Yu, Bo, Yu, Jae, Yuan, Tianlu, Zani, A., Zeller, Geralyn P., Zhang, Chao, Zimmerman, Eric D., and Zwaska, Robert

Abstract

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess., Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figures

Published
2013

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