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Ranjan Parajuli,1 Eivind Bjerkaas,1 Aage Tverdal,2 Loïc Le Marchand,3 Elisabete Weiderpass1,4–6 Inger T Gram1,7 1Department of Community Medicine, Faculty of Health Sciences UiT, The Arctic University of Norway, Tromsø, Norway; 2Division of Epidemiology, Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Oslo, Norway; 3Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA; 4Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 5Department of Genetic Epidemiology, Samfundet Folkhälsan, Helsinki, Finland; 6Department of Research, Cancer Registry of Norway, Oslo, Norway; 7Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, Tromsø, Norway Background: Colorectal cancer (CRC) is one of the main cancer types, with high incidence and mortality in Norway. We examined the association between different measures of smoking exposure and CRC mortality overall and by subsite in a large Norwegian cohort. Methods: We followed 602,242 participants from four Norwegian health surveys, aged 19–67 years at enrollment between 1972 and 2003 by linkage to the national registries through December 2007. We used Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) by smoking categories for different CRC endpoints. Results: During a mean follow-up of 14 years, 2,333 Norwegian males and females died of CRC (60% men). Male and female ever smokers had a 20% (HR 1.23, CI 1.08–1.40 and HR 1.22, 95% CI 1.06–1.40, respectively) increased risk of death from CRC compared with sex-specific never smokers. For proximal colon cancer mortality, female ever smokers had a 50% (HR 1.49, 95% CI 1.20–1.87) increased risk compared with female never smokers. The increased risk of rectal cancer mortality was about 40% higher for male ever smokers (HR 1.43, 95