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25th IEEE Wireless Communications and Networking Conference, WCNC 2024 -- 21 April 2024 through 24 April 2024 -- Dubai -- 200793, Extremely large aperture arrays can enable unprecedented spatial multiplexing in beyond 5G systems due to their extremely narrow beamfocusing capabilities. However, acquiring the spatial correlation matrix to enable efficient channel estimation is a complex task due to the vast number of antenna dimensions. Recently, a new estimation method called the 'reduced-subspace least squares (RS-LS) estimator' has been proposed for densely packed arrays. This method relies solely on the geometry of the array to limit the estimation resources. In this paper, we address a gap in the existing literature by deriving the average spectral efficiency for a certain distribution of user equipments (UEs) and a lower bound on it when using the RS-LS estimator. This bound is determined by the channel gain and the statistics of the normalized spatial correlation matrices of potential UEs but, importantly, does not require knowledge of a specific UE's spatial correlation matrix. We establish that there exists a pilot length that maximizes this expression. Additionally, we derive an approximate expression for the optimal pilot length under low signal-to-noise ratio (SNR) conditions. Simulation results validate the tightness of the derived lower bound and the effectiveness of using the optimized pilot length. © 2024 IEEE., ASELSAN Inc.; Stiftelsen för Strategisk Forskning, SSF; Scientific and Technological Research Council of Türkiye, (FFL18-0277)

25th IEEE Wireless Communications and Networking Conference, WCNC 2024 -- 21 April 2024 through 24 April 2024 -- Dubai -- 200793, In this paper, we investigate how metasurfaces can be deployed to deliver high data rates in a millimeter-wave (mmWave) indoor dense space with many blocking objects. These surfaces can either be static metasurfaces (SMSs) that reflect with fixed phase-shifts or reconfigurable intelligent surfaces (RISs) that can reconfigure their phase-shifts to the currently served user. The latter comes with an increased power, cabling, and signaling cost. To see how reconfigurability affects the network performance, we propose an iterative algorithm based on the feasible point pursuit successive convex approximation method. We jointly optimize the types and phase-shifts of the surfaces and the time portion allocated to each user equipment to maximize the minimum data rate achieved by the network. Our numerical results demonstrate that the minimum data rate improves as more RISs are introduced but the gain diminishes after some point. Therefore, introducing more reconfigurability is not always necessary. Another result shows that to reach the same data rate achieved by using 22 SMSs, at least 18 RISs are needed. This suggests that when it is costly to deploy many RISs, as an inexpensive alternative solution, one can reach the same data rate just by densely deploying more SMSs. © 2024 IEEE., 6G; Horizon 2020; ECSEL, (876124); VINNOVA, (2020- 1.2.3-EUREKA-2021-000006)

2023 IEEE International Conference on Communications, ICC 2023 -- 28 May 2023 through 1 June 2023 -- 193943, In this work, we consider the deployment of reconfigurable intelligent surfaces (RISs) to extend the coverage of a millimeter-wave (mmWave) network in indoor dense spaces. We first integrate RIS into ray-tracing simulations to realistically capture the propagation characteristics, then formulate a non-convex optimization problem that minimizes the number of RISs under rate constraints. We propose a feasible point pursuit and successive convex approximation-based algorithm, which solves the problem by jointly selecting the RIS locations, optimizing the RIS phase-shifts, and allocating time resources to user equipments (UEs). The numerical results demonstrate substantial coverage extension by using at least four RISs, and a data rate of 130 Mbit/s is guaranteed for UEs in the considered area of an airplane cabin. © 2023 IEEE., Horizon 2020; Electronic Components and Systems for European Leadership, ECSEL: 876124

2023 IEEE International Conference on Communications, ICC 2023 -- 28 May 2023 through 1 June 2023 -- 193943, In this work, we consider the deployment of reconfigurable intelligent surfaces (RISs) to extend the coverage of a millimeter-wave (mmWave) network in indoor dense spaces. We first integrate RIS into ray-tracing simulations to realistically capture the propagation characteristics, then formulate a non-convex optimization problem that minimizes the number of RISs under rate constraints. We propose a feasible point pursuit and successive convex approximation-based algorithm, which solves the problem by jointly selecting the RIS locations, optimizing the RIS phase-shifts, and allocating time resources to user equipments (UEs). The numerical results demonstrate substantial coverage extension by using at least four RISs, and a data rate of 130 Mbit/s is guaranteed for UEs in the considered area of an airplane cabin. © 2023 IEEE., Horizon 2020; Electronic Components and Systems for European Leadership, ECSEL: 876124

Background: Comprehensive proteomics profiling may offer new insights into the dysregulated metabolic milieu of type 2 diabetes, and in the future, serve as a useful tool for personalized medicine. This calls for a better understanding of circulating protein patterns at the early stage of type 2 diabetes as well as the dynamics of protein patterns during changes in metabolic status. Methods: To elucidate the systemic alterations in early-stage diabetes and to investigate the effects on the proteome during metabolic improvement, we measured 974 circulating proteins in 52 newly diagnosed, treatment-naïve type 2 diabetes subjects at baseline and after 1 and 3 months of guideline-based diabetes treatment, while comparing their protein profiles to that of 94 subjects without diabetes. Findings: Early stage type 2 diabetes was associated with distinct protein patterns, reflecting key metabolic syndrome features including insulin resistance, adiposity, hyperglycemia and liver steatosis. The protein profiles at baseline were attenuated during guideline-based diabetes treatment and several plasma proteins associated with metformin medication independently of metabolic variables, such as circulating EPCAM. Interpretation: The results advance our knowledge about the biochemical manifestations of type 2 diabetes and suggest that comprehensive protein profiling may serve as a useful tool for metabolic phenotyping and for elucidating the biological effects of diabetes treatments. Funding: This work was supported by the Swedish Heart and Lung Foundation, the Swedish Research Council, the Erling Persson Foundation, the Knut and Alice Wallenberg Foundation, and the Swedish state under the agreement between the Swedish government and the county councils (ALF-agreement)., QC 20210217

Executive Summary This white paper explores the road to implementing broadband connectivity in future 6G wireless systems. Different categories of use cases are considered, from extreme capacity with peak data rates up to 1 Tbps, to raising the typical data rates by orders-of-magnitude, to support broadband connectivity at railway speeds up to 1000 km/h. To achieve these goals, not only the terrestrial networks will be evolved but they will also be integrated with satellite networks, all facilitating autonomous systems and various interconnected structures. We believe that several categories of enablers at the infrastructure, spectrum, and protocol/algorithmic levels are required to realize the intended broadband connectivity goals in 6G. At the infrastructure level, we consider ultra-massive MIMO technology (possibly implemented using holographic radio), intelligent reflecting surfaces, user-centric and scalable cell-free networking, integrated access and backhaul, and integrated space and terrestrial networks. At the spectrum level, the network must seamlessly utilize sub-6 GHz bands for coverage and spatial multiplexing of many devices, while higher bands will be used for pushing the peak rates of point-to-point links. The latter path will lead to THz communications complemented by visible light communications in specific scenarios. At the protocol/algorithmic level, the enablers include improved coding, modulation, and waveforms to achieve lower latencies, higher reliability, and reduced complexity. Different options will be needed to optimally support different use cases. The resource efficiency can be further improved by using various combinations of full-duplex radios, interference management based on rate-splitting, machine-learning-based optimization, coded caching, and broadcasting. Finally, the three levels of enablers must be utilized not only to deliver better broadband services in urban areas, but also to provide full-coverage broadband connectivity mu

BACKGROUND AND AIMS: Incretin hormones glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP) are affected early on in the pathogenesis of metabolic syndrome and type 2 diabetes. Epidemiologic studies consistently link high fructose consumption to insulin resistance but whether fructose consumption impairs the incretin response remains unknown.METHODS AND RESULTS: As many as 66 obese (BMI 26-40 kg/m(2)) male subjects consumed fructose-sweetened beverages containing 75 g fructose/day for 12 weeks while continuing their usual lifestyle. Glucose, insulin, GLP-1 and GIP were measured during oral glucose tolerance test (OGTT) and triglycerides (TG), GLP-1, GIP and PYY during a mixed meal test before and after fructose intervention. Fructose intervention did not worsen glucose and insulin responses during OGTT, and GLP-1 and GIP responses during OGTT and fat-rich meal were unchanged. Postprandial TG response increased significantly, p = 0.004, and we observed small but significant increases in weight and liver fat content, but not in visceral or subcutaneous fat depots. However, even the subgroups who gained weight or liver fat during fructose intervention did not worsen their glucose, insulin, GLP-1 or PYY responses. A minor increase in GIP response during OGTT occurred in subjects who gained liver fat (p = 0.049).CONCLUSION: In obese males with features of metabolic syndrome, 12 weeks fructose intervention 75 g/day did not change glucose, insulin, GLP-1 or GIP responses during OGTT or GLP-1, GIP or PYY responses during a mixed meal. Therefore, fructose intake, even accompanied with mild weight gain, increases in liver fat and worsening of postprandial TG profile, does not impair glucose tolerance or gut incretin response to oral glucose or mixed meal challenge.

Hardware non-idealities in wireless transmitter electronics cause distortion that is not captured by conventional linear channel models; in fact, error-vector magnitude (EVM) measurements in conformance testing conceptually reduce their collective effect to an additive noise component at each subcarrier. Motivated by the EVM, the present paper considers a 'binoisy' multiple-input multiple-output (MIMO) channel model where the additional non-idealities manifest themselves as an additive distortion noise term at the transmit side. Through this extended MIMO relation, the effects of hardware impairments on the achievable rates of different digital modulation schemes are studied via large system analysis. The numerical results illustrate how tolerable EVM levels depend non-trivially on various factors, including the signal-to-noise ratio, modulation order and the level of asymmetry in antenna array configurations., QC 20160216, QC 20160421