3 results on '"Bernardi, Guilherme"'
Search Results
2. Predictors and impact of myocardial injury after transcatheter aortic valve replacement : a multicenter registry.
- Author
-
Campelo-Parada, Francisco, Dumont, Éric, Muñoz, Antonio, Abdul-Jawad Altisent, Omar, Lemos, Pedro A., Côté, Mélanie, Nombela-Franco, Luis, Serra, Vicenç, Rodés-Cabau, Josep, Brito, Fabio Sandoli de, Amat Santos, Ignacio J., Abizaid, Alexandre, Del Trigo, Maria, Sarmento-Leite, Rogério, Urena Alcazar, Marina, Pibarot, Philippe, Cheema, Asim, Puri, Rishi, Ruel, Marc, Ribeiro, Henrique B., Nietlispach, Fabian, Maisano, Francesco, Moris, Cesar, Valle, Raquel del, Jiménez-Quevedo, Pilar, Alonso-Briales, Juan H., Gutiérrez, Hipólito, García del Blanco, Bruno, Perin, Marco Antonio, Siqueira, Dimytri, Bernardi, Guilherme, Campelo-Parada, Francisco, Dumont, Éric, Muñoz, Antonio, Abdul-Jawad Altisent, Omar, Lemos, Pedro A., Côté, Mélanie, Nombela-Franco, Luis, Serra, Vicenç, Rodés-Cabau, Josep, Brito, Fabio Sandoli de, Amat Santos, Ignacio J., Abizaid, Alexandre, Del Trigo, Maria, Sarmento-Leite, Rogério, Urena Alcazar, Marina, Pibarot, Philippe, Cheema, Asim, Puri, Rishi, Ruel, Marc, Ribeiro, Henrique B., Nietlispach, Fabian, Maisano, Francesco, Moris, Cesar, Valle, Raquel del, Jiménez-Quevedo, Pilar, Alonso-Briales, Juan H., Gutiérrez, Hipólito, García del Blanco, Bruno, Perin, Marco Antonio, Siqueira, Dimytri, and Bernardi, Guilherme
- Abstract
BACKGROUND : Cardiac biomarker release signifying myocardial injury post-transcatheter aortic valve replacement (TAVR) is common, yet its clinical impact within a large TAVR cohort receiving differing types of valve and procedural approaches is unknown. OBJECTIVES : This study sought to determine the incidence, clinical impact, and factors associated with cardiac biomarker elevation post TAVR. METHODS : This multicenter study included 1,131 consecutive patients undergoing TAVR with balloon-expandable (58%) or self-expandable (42%) valves. Transfemoral and transapical (TA) approaches were selected in 73.1% and 20.3% of patients, respectively. Creatine kinase-myocardial band (CK-MB) measurements were obtained at baseline and at several time points within the initial 72 h post TAVR. Echocardiography was performed at baseline and at 6- to 12-month follow-up. RESULTS : Overall, 66% of the TAVR population demonstrated some degree of myocardial injury as determined by a rise in CK-MB levels (peak value: 1.6-fold [interquartile range (IQR): 0.9 to 2.8-fold]). A TA approach and major procedural complications were independently associated with higher peak of CK-MB levels (p < 0.01 for all), which translated into impaired systolic left ventricular function at 6 to 12 months post TAVR (p < 0.01). A greater rise in CK-MB levels independently associated with an increased 30-day, late (median of 21 [IQR: 8 to 36] months) overall and cardiovascular mortality (p < 0.001 for all). Any increase in CK-MB levels was associated with poorer clinical outcomes, and there was a stepwise rise in late mortality according to the various degrees of CK-MB increase after TAVR (p < 0.001). CONCLUSIONS : Some degree of myocardial injury was detected in two-thirds of patients post TAVR, especially in those undergoing TA-TAVR or presenting with major procedural complications. A greater rise in CK-MB levels associated with greater acute and late mortality, imparting a negative impact on left ventricula
- Published
- 2016
3. Predictors and impact of myocardial injury after transcatheter aortic valve replacement : a multicenter registry.
- Author
-
Barbosa Ribeiro, Henrique, Nombela-Franco, Luis, Muñoz, Antonio, Lemos, Pedro A., Amat Santos, Ignacio J., Serra, Vicenç, Brito, Fabio Sandoli de, Abizaid, Alexandre, Sarmento-Leite, Rogério, Puri, Rishi, Cheema, Asim, Ruel, Marc, Nietlispach, Fabian, Maisano, Francesco, Moris, Cesar, Valle, Raquel del, Urena Alcazar, Marina, Abdul-Jawad Altisent, Omar, Del Trigo, Maria, Campelo-Parada, Francisco, Jiménez-Quevedo, Pilar, Alonso-Briales, Juan H., Gutiérrez, Hipólito, García del Blanco, Bruno, Perin, Marco Antonio, Siqueira, Dimytri, Bernardi, Guilherme, Dumont, Éric, Côté, Mélanie, Pibarot, Philippe, Rodés-Cabau, Josep, Barbosa Ribeiro, Henrique, Nombela-Franco, Luis, Muñoz, Antonio, Lemos, Pedro A., Amat Santos, Ignacio J., Serra, Vicenç, Brito, Fabio Sandoli de, Abizaid, Alexandre, Sarmento-Leite, Rogério, Puri, Rishi, Cheema, Asim, Ruel, Marc, Nietlispach, Fabian, Maisano, Francesco, Moris, Cesar, Valle, Raquel del, Urena Alcazar, Marina, Abdul-Jawad Altisent, Omar, Del Trigo, Maria, Campelo-Parada, Francisco, Jiménez-Quevedo, Pilar, Alonso-Briales, Juan H., Gutiérrez, Hipólito, García del Blanco, Bruno, Perin, Marco Antonio, Siqueira, Dimytri, Bernardi, Guilherme, Dumont, Éric, Côté, Mélanie, Pibarot, Philippe, and Rodés-Cabau, Josep
- Abstract
BACKGROUND : Cardiac biomarker release signifying myocardial injury post-transcatheter aortic valve replacement (TAVR) is common, yet its clinical impact within a large TAVR cohort receiving differing types of valve and procedural approaches is unknown. OBJECTIVES : This study sought to determine the incidence, clinical impact, and factors associated with cardiac biomarker elevation post TAVR. METHODS : This multicenter study included 1,131 consecutive patients undergoing TAVR with balloon-expandable (58%) or self-expandable (42%) valves. Transfemoral and transapical (TA) approaches were selected in 73.1% and 20.3% of patients, respectively. Creatine kinase-myocardial band (CK-MB) measurements were obtained at baseline and at several time points within the initial 72 h post TAVR. Echocardiography was performed at baseline and at 6- to 12-month follow-up. RESULTS : Overall, 66% of the TAVR population demonstrated some degree of myocardial injury as determined by a rise in CK-MB levels (peak value: 1.6-fold [interquartile range (IQR): 0.9 to 2.8-fold]). A TA approach and major procedural complications were independently associated with higher peak of CK-MB levels (p < 0.01 for all), which translated into impaired systolic left ventricular function at 6 to 12 months post TAVR (p < 0.01). A greater rise in CK-MB levels independently associated with an increased 30-day, late (median of 21 [IQR: 8 to 36] months) overall and cardiovascular mortality (p < 0.001 for all). Any increase in CK-MB levels was associated with poorer clinical outcomes, and there was a stepwise rise in late mortality according to the various degrees of CK-MB increase after TAVR (p < 0.001). CONCLUSIONS : Some degree of myocardial injury was detected in two-thirds of patients post TAVR, especially in those undergoing TA-TAVR or presenting with major procedural complications. A greater rise in CK-MB levels associated with greater acute and late mortality, imparting a negative impact on left ventricula
- Published
- 2015
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