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Background: Premenopausal risk-reducing salpingo-oophorectomy (RRSO) in women at high familial risk of ovarian cancer leads to immediate menopause. Although early natural menopause is associated with increased cardiovascular disease risk, evidence on long-term cardiovascular disease risk after early surgical menopause is scarce. Objectives: We sought to determine the long-term influence of the timing of RRSO on the development of coronary artery calcium (CAC), an established marker for cardiovascular disease risk. Methods: We conducted a cross-sectional study (N = 733) nested in a nationwide cohort of women at high familial risk of ovarian cancer. In women aged 60-70 years (n = 328), we compared CAC scores between women with a premenopausal RRSO (age ≤45 years) and women with a postmenopausal RRSO (age ≥54 years), using multivariable Poisson analyses. Within the premenopausal RRSO group (n = 498), we also examined the effect of age at RRSO. In addition, we compared the premenopausal RRSO group with an external reference cohort (n = 5,226). Results: Multivariable analyses showed that the prevalence rates of any CAC (CAC >0), at least moderate CAC (CAC >100), and severe CAC (CAC >400) were comparable between the premenopausal and postmenopausal RRSO groups (relative risk [RR]: 0.93; 95% CI: 0.75-1.15 for any CAC; RR: 0.71; 95% CI: 0.43-1.17 for at least moderate CAC; RR: 0.81; 95% CI: 0.30-2.13 for severe CAC). There was no difference in CAC between the premenopausal RRSO group and a similar aged reference cohort. Timing of premenopausal RRSO (early premenopausal RRSO [<41 years] vs late premenopausal RRSO [41-45 years]) did not affect the outcomes. Conclusions: Our results do not show a long-term adverse effect of surgical menopause on the development of CAC.

Nanoparticles are ultrafine particulate matter having considerable potential for treatment of central nervous system (CNS) disorders. Despite their tiny size, the blood-brain barrier (BBB) restricts their access to the CNS. Their direct cerebrospinal fluid (CSF) administration bypasses the BBB endothelium, but still fails to give adequate brain uptake. We present a novel approach for efficient CNS delivery of 111In-radiolabelled gold nanoparticles (AuNPs; 10–15 nm) via intra-cisterna magna administration, with tracking by SPECT imaging. To accelerate CSF brain influx, we administered AuNPs intracisternally in conjunction with systemic hypertonic saline, which dramatically increased the parenchymal AuNP uptake, especially in deep brain regions. AuNPs entered the CNS along periarterial spaces as visualized by MRI of gadolinium-labelled AuNPs and were cleared from brain within 24 h and excreted through the kidneys. Thus, the glymphatic-assisted perivascular network augment by systemic hypertonic saline is a pathway for highly efficient brain-wide distribution of small AuNPs., Nanoparticles are ultrafine particulate matter having considerable potential for treatment of central nervous system (CNS) disorders. Despite their tiny size, the blood-brain barrier (BBB) restricts their access to the CNS. Their direct cerebrospinal fluid (CSF) administration bypasses the BBB endothelium, but still fails to give adequate brain uptake. We present a novel approach for efficient CNS delivery of 111In-radiolabelled gold nanoparticles (AuNPs; 10–15 nm) via intra-cisterna magna administration, with tracking by SPECT imaging. To accelerate CSF brain influx, we administered AuNPs intracisternally in conjunction with systemic hypertonic saline, which dramatically increased the parenchymal AuNP uptake, especially in deep brain regions. AuNPs entered the CNS along periarterial spaces as visualized by MRI of gadolinium-labelled AuNPs and were cleared from brain within 24 h and excreted through the kidneys. Thus, the glymphatic-assisted perivascular network augment by systemic hypertonic saline is a pathway for highly efficient brain-wide distribution of small AuNPs.

Nanoparticles are ultrafine particulate matter having considerable potential for treatment of central nervous system (CNS) disorders. Despite their tiny size, the blood-brain barrier (BBB) restricts their access to the CNS. Their direct cerebrospinal fluid (CSF) administration bypasses the BBB endothelium, but still fails to give adequate brain uptake. We present a novel approach for efficient CNS delivery of 111In-radiolabelled gold nanoparticles (AuNPs; 10–15 nm) via intra-cisterna magna administration, with tracking by SPECT imaging. To accelerate CSF brain influx, we administered AuNPs intracisternally in conjunction with systemic hypertonic saline, which dramatically increased the parenchymal AuNP uptake, especially in deep brain regions. AuNPs entered the CNS along periarterial spaces as visualized by MRI of gadolinium-labelled AuNPs and were cleared from brain within 24 h and excreted through the kidneys. Thus, the glymphatic-assisted perivascular network augment by systemic hypertonic saline is a pathway for highly efficient brain-wide distribution of small AuNPs.

Background: Women with a BRCA1/2 pathogenic variant are advised to undergo premenopausal risk-reducing salpingo-oophorectomy after completion of childbearing, to reduce their risk of ovarian cancer. Several studies reported less sexual pleasure 1 to 3 years after a premenopausal oophorectomy. However, the long-term effects of premenopausal oophorectomy on sexual functioning are unknown. Objective: This study aimed to study long-term sexual functioning in women at increased familial risk of breast or ovarian cancer who underwent a risk-reducing salpingo-oophorectomy either before the age of 46 years (premenopausal group) or after the age of 54 years (postmenopausal group). Subgroup analyses were performed in the premenopausal group, comparing early (before the age of 41 years) and later (at ages 41–45 years) premenopausal risk-reducing salpingo-oophorectomy. Study Design: Between 2018 and 2021, 817 women with a high familial risk of breast or ovarian cancer from an ongoing cohort study were invited to participate in our study. Because of a large difference in age in the study between the premenopausal and postmenopausal salpingo-oophorectomy groups, we restricted the comparison of sexual functioning between the groups to 368 women who were 60 to 70 years old at completion of the questionnaire (226 in the premenopausal group and 142 in the postmenopausal group). In 496 women with a premenopausal risk-reducing salpingo-oophorectomy, we compared the sexual functioning between women in the early premenopausal group (n=151) and women in the later premenopausal group (n=345). Differences between groups were analyzed using multiple regression analyses, adjusting for current age, breast cancer history, use of hormone replacement therapy, body mass index, chronic medication use (yes or no), and body image. Results: Mean times since risk-reducing salpingo-oophorectomy were 20.6 years in the premenopausal group and 10.6 years in the postmenopausal group (P<.001). The mean

Nanoparticles are ultrafine particulate matter having considerable potential for treatment of central nervous system (CNS) disorders. Despite their tiny size, the blood-brain barrier (BBB) restricts their access to the CNS. Their direct cerebrospinal fluid (CSF) administration bypasses the BBB endothelium, but still fails to give adequate brain uptake. We present a novel approach for efficient CNS delivery of 111In-radiolabelled gold nanoparticles (AuNPs; 10–15 nm) via intra-cisterna magna administration, with tracking by SPECT imaging. To accelerate CSF brain influx, we administered AuNPs intracisternally in conjunction with systemic hypertonic saline, which dramatically increased the parenchymal AuNP uptake, especially in deep brain regions. AuNPs entered the CNS along periarterial spaces as visualized by MRI of gadolinium-labelled AuNPs and were cleared from brain within 24 h and excreted through the kidneys. Thus, the glymphatic-assisted perivascular network augment by systemic hypertonic saline is a pathway for highly efficient brain-wide distribution of small AuNPs., Nanoparticles are ultrafine particulate matter having considerable potential for treatment of central nervous system (CNS) disorders. Despite their tiny size, the blood-brain barrier (BBB) restricts their access to the CNS. Their direct cerebrospinal fluid (CSF) administration bypasses the BBB endothelium, but still fails to give adequate brain uptake. We present a novel approach for efficient CNS delivery of 111In-radiolabelled gold nanoparticles (AuNPs; 10–15 nm) via intra-cisterna magna administration, with tracking by SPECT imaging. To accelerate CSF brain influx, we administered AuNPs intracisternally in conjunction with systemic hypertonic saline, which dramatically increased the parenchymal AuNP uptake, especially in deep brain regions. AuNPs entered the CNS along periarterial spaces as visualized by MRI of gadolinium-labelled AuNPs and were cleared from brain within 24 h and excreted through the kidneys. Thus, the glymphatic-assisted perivascular network augment by systemic hypertonic saline is a pathway for highly efficient brain-wide distribution of small AuNPs.

We address a subject that could have been analyzed century ago: how does the universe of general relativity look like when it would have been filled with solid matter? Solids break spontaneously the translations and rotations of space itself. Only rather recently it was realized in various context that the order parameter of the solid has a relation to Einsteins dynamical space time which is similar to the role of a Higgs field in a Yang-Mills gauge theory. Such a "crystal gravity" is therefore like the Higgs phase of gravity. The usual Higgs phases are characterized by a special phenomenology. A case in point is superconductivity exhibiting phenomena like the Type II phase, characterized by the emergence of an Abrikosov lattice of quantized magnetic fluxes absorbing the external magnetic field. What to expect in the gravitational setting? The theory of elasticity is the universal effective field theory associated with the breaking of space translations and rotations having a similar status as the phase action describing a neutral superfluid. A geometrical formulation appeared in its long history, similar in structure to general relativity, which greatly facilitates the marriage of both theories. With as main limitation that we focus entirely on stationary circumstances -- the dynamical theory is greatly complicated by the lack of Lorentz invariance -- we will present a first exploration of a remarkably rich and often simple physics of "Higgsed gravity"., Comment: 64 pages, 22 figures. The introduction has been revised compared to the first version

Recent insights suggest that the osteochondral interface plays a central role in maintaining healthy articulating joints. Uncovering the underlying transport mechanisms is key to the understanding of the cross-talk between articular cartilage and subchondral bone. Here, we describe the mechanisms that facilitate transport at the osteochondral interface. Using scanning electron microscopy (SEM), we found a continuous transition of mineralization architecture from the non-calcified cartilage towards the calcified cartilage. This refurbishes the classical picture of the so-called tidemark; a well-defined discontinuity at the osteochondral interface. Using focused-ion-beam SEM (FIB-SEM) on one osteochondral plug derived from a human cadaveric knee, we elucidated that the pore structure gradually varies from the calcified cartilage towards the subchondral bone plate. We identified nano-pores with radius of 10.71 ± 6.45 nm in calcified cartilage to 39.1 ± 26.17 nm in the subchondral bone plate. The extracted pore sizes were used to construct 3D pore-scale numerical models to explore the effect of pore sizes and connectivity among different pores. Results indicated that connectivity of nano-pores in calcified cartilage is highly compromised compared to the subchondral bone plate. Flow simulations showed a permeability decrease by about 2000-fold and solute transport simulations using a tracer (iodixanol, 1.5 kDa with a free diffusivity of 2.5 × 10-10 m2/s) showed diffusivity decrease by a factor of 1.5. Taken together, architecture of the nano-pores and the complex mineralization pattern in the osteochondral interface considerably impacts the cross-talk between cartilage and bone.

BACKGROUND: Three-dimensional (3D)-printed saw guides are frequently used to optimize osteotomy results and are usually designed based on computed tomography (CT), despite the radiation burden, as radiation-less alternatives like magnetic resonance imaging (MRI) have inferior bone visualization capabilities. This study investigated the usability of MR-based synthetic-CT (sCT), a novel radiation-less bone visualization technique for 3D planning and design of patient-specific saw guides.METHODS: Eight human cadaveric lower arms (mean age: 78y) received MRI and CT scans as well as high-resolution micro-CT. From the MRI scans, sCT were generated using a conditional generative adversarial network. Digital 3D bone surface models based on the sCT and general CT were compared to the surface model from the micro-CT that was used as ground truth for image resolution. From both the sCT and CT digital bone models saw guides were designed and 3D-printed in nylon for one proximal and one distal bone position for each radius and ulna. Six blinded observers placed these saw guides as accurately as possible on dissected bones. The position of each guide was assessed by optical 3D-scanning of each bone with positioned saw guide and compared to the preplanning. Eight placement errors were evaluated: three translational errors (along each axis), three rotational errors (around each axis), a total translation (∆T) and a total rotation error (∆R).RESULTS: Surface models derived from micro-CT were on average smaller than sCT and CT-based models with average differences of 0.27 ± 0.30 mm for sCT and 0.24 ± 0.12 mm for CT. No statistically significant positioning differences on the bones were found between sCT- and CT-based saw guides for any axis specific translational or rotational errors nor between the ∆T (p = .284) and ∆R (p = .216). On Bland-Altman plots, the ∆T and ∆R limits of agreement (LoA) were within the inter-observer variability LoA.CONCLUSIONS: This re

We address a subject that could have been analyzed century ago: how does the universe of general relativity look like when it would have been filled with solid matter? Solids break spontaneously the translations and rotations of space itself. Only rather recently it was realized in various context that the order parameter of the solid has a relation to Einsteins dynamical space time which is similar to the role of a Higgs field in a Yang-Mills gauge theory. Such a "crystal gravity" is therefore like the Higgs phase of gravity. The usual Higgs phases are characterized by a special phenomenology. A case in point is superconductivity exhibiting phenomena like the Type II phase, characterized by the emergence of an Abrikosov lattice of quantized magnetic fluxes absorbing the external magnetic field. What to expect in the gravitational setting? The theory of elasticity is the universal effective field theory associated with the breaking of space translations and rotations having a similar status as the phase action describing a neutral superfluid. A geometrical formulation appeared in its long history, similar in structure to general relativity, which greatly facilitates the marriage of both theories. With as main limitation that we focus entirely on stationary circumstances -- the dynamical theory is greatly complicated by the lack of Lorentz invariance -- we will present a first exploration of a remarkably rich and often simple physics of "Higgsed gravity"., Comment: 64 pages, 22 figures. The introduction has been revised compared to the first version

Background: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imaging for the detection of these biomarkers. Methods: Human carotid plaque segments, obtained from endarterectomy, were incubated in [111In]In-DOTA-butylamino-NorBIRT ([111In]In-Danbirt), targeting Leukocyte Function-associated Antigen-1 (LFA-1) on leukocytes. By performing SPECT/CT, both inflammation from DANBIRT uptake and calcification from CT imaging were assessed. Plaque phenotype was classified using histology. Results: On a total plaque level, comparable levels of calcification volume existed with different degrees of inflammation and vice versa. On a segment level, an inverse relationship between calcification volume and inflammation was evident in highly calcified segments, which classify as fibrocalcific, stable plaque segments. In contrast, segments with little or no calcification presented with a moderate to high degree of inflammation, often coinciding with the more dangerous fibrous cap atheroma phenotype. Conclusion: Calcification imaging alone can only accurately identify highly calcified, stable, fibrocalcific plaques. To identify high-risk plaques, with little or no calcification, hybrid imaging of calcification and inflammation could provide diagnostic benefit.

BACKGROUND: Three-dimensional (3D)-printed saw guides are frequently used to optimize osteotomy results and are usually designed based on computed tomography (CT), despite the radiation burden, as radiation-less alternatives like magnetic resonance imaging (MRI) have inferior bone visualization capabilities. This study investigated the usability of MR-based synthetic-CT (sCT), a novel radiation-less bone visualization technique for 3D planning and design of patient-specific saw guides.METHODS: Eight human cadaveric lower arms (mean age: 78y) received MRI and CT scans as well as high-resolution micro-CT. From the MRI scans, sCT were generated using a conditional generative adversarial network. Digital 3D bone surface models based on the sCT and general CT were compared to the surface model from the micro-CT that was used as ground truth for image resolution. From both the sCT and CT digital bone models saw guides were designed and 3D-printed in nylon for one proximal and one distal bone position for each radius and ulna. Six blinded observers placed these saw guides as accurately as possible on dissected bones. The position of each guide was assessed by optical 3D-scanning of each bone with positioned saw guide and compared to the preplanning. Eight placement errors were evaluated: three translational errors (along each axis), three rotational errors (around each axis), a total translation (∆T) and a total rotation error (∆R).RESULTS: Surface models derived from micro-CT were on average smaller than sCT and CT-based models with average differences of 0.27 ± 0.30 mm for sCT and 0.24 ± 0.12 mm for CT. No statistically significant positioning differences on the bones were found between sCT- and CT-based saw guides for any axis specific translational or rotational errors nor between the ∆T (p = .284) and ∆R (p = .216). On Bland-Altman plots, the ∆T and ∆R limits of agreement (LoA) were within the inter-observer variability LoA.CONCLUSIONS: This re

Purpose: Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer’s capability to identify plaque phenotype and inflammation levels pertaining to leukocytes expressing leukocyte function-associated antigen-1 (LFA-1) and the leukocyte subset of proinflammatory macrophages expressing somatostatin receptor subtype-2 (SST2). Individual radiotracer uptake was quantified and the presence of corresponding immunohistological cell markers was assessed. Methods: Human symptomatic carotid plaque segments were obtained from endarterectomy. Segments were incubated in dual-isotope radiotracers [111In]In-DOTA-butylamino-NorBIRT ([111In]In-Danbirt) and [99mTc]Tc-[N0–14,Asp0,Tyr3]-octreotate ([99mTc]Tc-Demotate 2) before scanning with SPECT/CT. Plaque phenotype was classified as pathological intimal thickening, fibrous cap atheroma or fibrocalcific using histology sections based on distinct morphological characteristics. Plaque segments were subsequently immuno-stained with LFA-1 and SST2 and quantified in terms of positive area fraction and compared against the corresponding SPECT images. Results: Focal uptake of co-localising dual-radiotracers identified the heterogeneous distribution of inflamed regions in the plaques which co-localised with positive immuno-stained regions of LFA-1 and SST2. [111In]In-Danbirt and [99mTc]Tc-Demotate 2 uptake demonstrated a significant positive correlation (r = 0.651; p = 0.001). Fibrous cap atheroma plaque phenotype correlated with the highest [111In]In-Danbirt and [99mTc]Tc-Demotate 2 uptake compared with fib

The DC Josephson effect is the flow of supercurrent across a weak link between two superconductors with a different value of their order parameter, the phase. We generalize this notion to any kind of spontaneous continuous symmetry breaking. The quantity that flows between the two systems is identified as the Noether current associated with the broken symmetry. The AC Josephson effect is identified as the oscillations due to the energy difference between the two systems caused by an imposed asymmetric chemical potential. As an example of novel physics, a Josephson effect is predicted between two crystalline solids, potentially measurable as a force periodic in the separation distance., Comment: RevTeX, 5 pages, 2 figures

In the Abelian-Higgs model, or Ginzburg-Landau model of superconductivity, the existence of an infrared stable charged fixed point ensures that there is a parameter range where the superconducting phase transition is second order, as opposed to fluctuation-induced first order as one would infer from the Coleman-Weinberg mechanism. We study the charged and neutral fixed points of a two-field generalization of the Abelian-Higgs model, where two N-component fields are coupled to two gauge fields and to each other, using the functional renormalization group. Focusing mostly on three dimensions, in the neutral case, this is a model for two-component Bose-Einstein condensation, and we confirm the fixed-point structure established in earlier works using different methods. The charged model is a dual theory of two-dimensional dislocation-mediated quantum melting. We find the existence of three charged fixed points for all N>2, while there are additional fixed points for N=2., Comment: RevTeX. 14 pages, 4 figures. Matches published version

Perhaps the most important aspect of symmetry in physics is the idea that a state does not need to have the same symmetries as the theory that describes it. This phenomenon is known as spontaneous symmetry breaking. In these lecture notes, starting from a careful definition of symmetry in physics, we introduce symmetry breaking and its consequences. Emphasis is placed on the physics of singular limits, showing the reality of symmetry breaking even in small-sized systems. Topics covered include Nambu-Goldstone modes, quantum corrections, phase transitions, topological defects and gauge fields. We provide many examples from both high energy and condensed matter physics. These notes are suitable for graduate students., Comment: 149 pages; matches published version

Perhaps the most important aspect of symmetry in physics is the idea that a state does not need to have the same symmetries as the theory that describes it. This phenomenon is known as spontaneous symmetry breaking. In these lecture notes, starting from a careful definition of symmetry in physics, we introduce symmetry breaking and its consequences. Emphasis is placed on the physics of singular limits, showing the reality of symmetry breaking even in small-sized systems. Topics covered include Nambu-Goldstone modes, quantum corrections, phase transitions, topological defects and gauge fields. We provide many examples from both high energy and condensed matter physics. These notes are suitable for graduate students., Comment: 149 pages; matches published version

In the Abelian-Higgs model, or Ginzburg-Landau model of superconductivity, the existence of an infrared stable charged fixed point ensures that there is a parameter range where the superconducting phase transition is second order, as opposed to fluctuation-induced first order as one would infer from the Coleman-Weinberg mechanism. We study the charged and neutral fixed points of a two-field generalization of the Abelian-Higgs model, where two N-component fields are coupled to two gauge fields and to each other, using the functional renormalization group. Focusing mostly on three dimensions, in the neutral case, this is a model for two-component Bose-Einstein condensation, and we confirm the fixed-point structure established in earlier works using different methods. The charged model is a dual theory of two-dimensional dislocation-mediated quantum melting. We find the existence of three charged fixed points for all N>2, while there are additional fixed points for N=2., Comment: RevTeX. 14 pages, 4 figures. Matches published version

In the Abelian-Higgs model, or Ginzburg-Landau model of superconductivity, the existence of an infrared stable charged fixed point ensures that there is a parameter range where the superconducting phase transition is second order, as opposed to fluctuation-induced first order as one would infer from the Coleman-Weinberg mechanism. We study the charged and neutral fixed points of a two-field generalization of the Abelian-Higgs model, where two N-component fields are coupled to two gauge fields and to each other, using the functional renormalization group. Focusing mostly on three dimensions, in the neutral case, this is a model for two-component Bose-Einstein condensation, and we confirm the fixed-point structure established in earlier works using different methods. The charged model is a dual theory of two-dimensional dislocation-mediated quantum melting. We find the existence of three charged fixed points for all N>2, while there are additional fixed points for N=2., Comment: RevTeX. 14 pages, 4 figures. Matches published version

The DC Josephson effect is the flow of supercurrent across a weak link between two superconductors with a different value of their order parameter, the phase. We generalize this notion to any kind of spontaneous continuous symmetry breaking. The quantity that flows between the two systems is identified as the Noether current associated with the broken symmetry. The AC Josephson effect is identified as the oscillations due to the energy difference between the two systems caused by an imposed asymmetric chemical potential. As an example of novel physics, a Josephson effect is predicted between two crystalline solids, potentially measurable as a force periodic in the separation distance., Comment: RevTeX, 5 pages, 2 figures

Objective To evaluate the presence and localization of folate receptor expressing macrophages in the rat groove model of osteoarthritis and determine the suitability of a new folate conjugate with albumin-binding entity (cm09) for in vivo SPECT (single-photon emission computed tomography) analysis. Design In male Wistar rats, local cartilage damage was induced in addition to a standard ( n = 10) or high-fat diet ( n = 6). After 12 weeks, (111)In labeled folate conjugates were administered, and SPECT/CT (computed tomography) imaging was performed after 24 hours. Subsequently, osteoarthritis severity and folate receptor expression were assessed using (immuno)-histological sections. Results In vivo SPECT/CT imaging of the new folate conjugate (cm09) was as useful as a folate conjugate without albumin-binding entity in the groove model of osteoarthritis with less renal accumulation. Induction of cartilage damage on a standard diet resulted in no effect on the amount of folate receptor expressing macrophages compared with the contralateral sham operated joints. In contrast, inducing cartilage damage in the high-fat diet group resulted in 28.4% increase of folate receptor expression as compared with the nondamaged control joints. Folate receptor expressing cells were predominantly present in the synovial lining and in subchondral bone as confirmed by immunohistochemistry. Conclusions Folate receptor expression, and thus macrophage activation, can clearly be demonstrated in vivo, in small animal models of osteoarthritis using the new (111)In-folate conjugate with specific binding to the folate receptor. Increased macrophage activity only plays a role in the groove model of osteoarthritis when applied in a high-fat diet induced dysmetabolic condition, which is in line with the higher inflammatory state of that specific model.

The lowest-energy state of a macroscopic in which symmetry is spontaneously broken, is a very stable wavepacket centered around a spontaneously chosen, classical direction in symmetry space. However, for a Heisenberg ferromagnet the quantum groundstate is exactly the classical groundstate. This coincides with other exceptional properties of the ferromagnet, including spontaneous time-reversal symmetry breaking, a reduced number of Nambu-Goldstone modes and the absence of a thin spectrum (Anderson tower of states). Recent discoveries of other non-relativistic systems with fewer Nambu-Goldstone modes suggest these specialties apply there as well. I establish precise criteria for the absence of quantum fluctuations and all the other features. In particular, it is not sufficient that the order parameter commute with the Hamiltonian. It leads to a measurably larger coherence time of superpositions in small but macroscopic systems., Comment: 41 pages, 3 figures, published version

The lowest-energy state of a macroscopic in which symmetry is spontaneously broken, is a very stable wavepacket centered around a spontaneously chosen, classical direction in symmetry space. However, for a Heisenberg ferromagnet the quantum groundstate is exactly the classical groundstate. This coincides with other exceptional properties of the ferromagnet, including spontaneous time-reversal symmetry breaking, a reduced number of Nambu-Goldstone modes and the absence of a thin spectrum (Anderson tower of states). Recent discoveries of other non-relativistic systems with fewer Nambu-Goldstone modes suggest these specialties apply there as well. I establish precise criteria for the absence of quantum fluctuations and all the other features. In particular, it is not sufficient that the order parameter commute with the Hamiltonian. It leads to a measurably larger coherence time of superpositions in small but macroscopic systems., Comment: 41 pages, 3 figures, published version

The vortex-boson (or Abelian-Higgs, XY) duality in 2+1 dimensions demonstrates that the quantum disordered superfluid is equivalent to an ordered superconductor and the other way around. Such a duality structure should be ubiquitous but in 3+1 (and higher) dimensions a precise formulation of the duality is lacking. The problem is that the topological defects become extended objects, strings in 3+1D. We argue how the condensate of such vortex strings must behave from the known physics of the disordered superfluid, namely the Bose-Mott insulator. A flaw in earlier proposals is repaired, and a more direct viewpoint, avoiding gauge fields, in terms of the physical supercurrent is laid out, that also easily generalizes to higher-dimensional and more complicated systems. Furthermore topological defects are readily identified; we demonstrate that the Bose-Mott insulator supports line defects, which may be seen in cold atom experiments., Comment: LaTeX, 25 pages, 5 figures; several revisions and additions

The Princeton review. / Volume 6, Issue 24, Page(s) 603-608, (dlps) volume: acf4325.2-06.024, (dlps) article: acf4325.2-06.024:2, http://quod.lib.umich.edu/t/text/accesspolicy.html