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Hypertension affects approximately one third of the world's adult population and is a major cause of premature death despite considerable advances in pharmacological treatments. Growing evidence supports the use of lifestyle interventions for the prevention and adjuvant treatment of hypertension. In this Review, we provide a summary of the epidemiological research supporting the preventive and antihypertensive effects of major lifestyle interventions (regular physical exercise, body weight management and healthy dietary patterns), as well as other less traditional recommendations such as stress management and the promotion of adequate sleep patterns coupled with circadian entrainment. We also discuss the physiological mechanisms underlying the beneficial effects of these lifestyle interventions on hypertension, which include not only the prevention of traditional risk factors (such as obesity and insulin resistance) and improvements in vascular health through an improved redox and inflammatory status, but also reduced sympathetic overactivation and non-traditional mechanisms such as increased secretion of myokines., Depto. de Bioquímica y Biología Molecular, Fac. de Farmacia, TRUE, pub

Importance: Atopic dermatitis onset usually occurs in childhood. Persistence of disease into adolescence and adulthood is common. It is important to evaluate new treatment options in adolescents because of the high unmet need in this population. Objective: To assess the efficacy and safety of upadacitinib to treat moderate-to-severe atopic dermatitis in adolescents. Design, Setting, and Participants: Prespecified analysis of adolescents enrolled in 3 randomized, double-blind, placebo-controlled phase 3 clinical trials in more than 20 countries across Europe, North and South America, Oceania, the Middle East, and the Asia-Pacific region from July 2018 through December 2020. Participants were adolescents aged 12 to 17 years with moderate-to-severe atopic dermatitis. Data analysis was performed from April to August 2021. Interventions: Patients were randomized (1:1:1) to once-daily oral upadacitinib 15 mg, upadacitinib 30 mg, or placebo alone (Measure Up 1 and Measure Up 2) or with topical corticosteroids (AD Up). Main Outcomes and Measures: Safety and efficacy, including at least a 75% improvement in the Eczema Area and Severity Index from baseline and validated Investigator Global Assessment for Atopic Dermatitis score of 0 (clear) or 1 (almost clear) at week 16 (coprimary end points). Results: A total of 552 adolescents (290 female; 262 male) were randomized. Mean (SD) age was 15.4 (1.8), 15.5 (1.7), and 15.3 (1.8) years for adolescents in Measure Up 1, Measure Up 2, and AD Up, respectively. In Measure Up 1, Measure Up 2, and AD Up, respectively, a greater proportion of adolescents (% [95% CI]) achieved at least 75% improvement in the Eczema Area and Severity Index at week 16 with upadacitinib 15 mg (73% [63%-84%], 69% [57%-81%], 63% [51%-76%]), and upadacitinib 30 mg (78% [68%-88%], 73% [62%-85%], 84% [75%-94%]), than with placebo (12% [4%-20%], 13% [5%-22%], 30% [19%-42%]; nominal P <.001 for all comparisons vs placebo). Similarly, a greater proportion of ad

O presente trabalho tem por objetivo relatar a vivência de discentes do curso de Ciência da Computação da Universidade do Estado do Mato Grosso (UNEMAT), membros do projeto de extensão: Reforço de Matemática por meio de jogos lúdicos. A proposta do projeto é de contribuir, de forma direta, para a melhoria do rendimento nos estudos na disciplina de Matemática. O que se pretende, não é repetir as explicações do conteúdo ministrado em sala de aula, mas perceber quais são as dificuldades dos alunos e, a partir disso, trabalhar para ajudá-los na evolução do aprendizado por meio de jogos lúdicos. O projeto atende quatro turmas com uma média de 20 alunos cada. As aulas de reforço são oferecidas aos alunos do 6º Ano do Ensino Fundamental de uma escola pública do município de Santa Rita do Araguaia – GO e ocorrem quinzenalmente. O projeto ainda está em andamento e os resultados obtidos até o momento levam a uma mudança de postura dos alunos com relação ao estudo da Matemática.

Importance: Atopic dermatitis onset usually occurs in childhood. Persistence of disease into adolescence and adulthood is common. It is important to evaluate new treatment options in adolescents because of the high unmet need in this population. Objective: To assess the efficacy and safety of upadacitinib to treat moderate-to-severe atopic dermatitis in adolescents. Design, Setting, and Participants: Prespecified analysis of adolescents enrolled in 3 randomized, double-blind, placebo-controlled phase 3 clinical trials in more than 20 countries across Europe, North and South America, Oceania, the Middle East, and the Asia-Pacific region from July 2018 through December 2020. Participants were adolescents aged 12 to 17 years with moderate-to-severe atopic dermatitis. Data analysis was performed from April to August 2021. Interventions: Patients were randomized (1:1:1) to once-daily oral upadacitinib 15 mg, upadacitinib 30 mg, or placebo alone (Measure Up 1 and Measure Up 2) or with topical corticosteroids (AD Up). Main Outcomes and Measures: Safety and efficacy, including at least a 75% improvement in the Eczema Area and Severity Index from baseline and validated Investigator Global Assessment for Atopic Dermatitis score of 0 (clear) or 1 (almost clear) at week 16 (coprimary end points). Results: A total of 552 adolescents (290 female; 262 male) were randomized. Mean (SD) age was 15.4 (1.8), 15.5 (1.7), and 15.3 (1.8) years for adolescents in Measure Up 1, Measure Up 2, and AD Up, respectively. In Measure Up 1, Measure Up 2, and AD Up, respectively, a greater proportion of adolescents (% [95% CI]) achieved at least 75% improvement in the Eczema Area and Severity Index at week 16 with upadacitinib 15 mg (73% [63%-84%], 69% [57%-81%], 63% [51%-76%]), and upadacitinib 30 mg (78% [68%-88%], 73% [62%-85%], 84% [75%-94%]), than with placebo (12% [4%-20%], 13% [5%-22%], 30% [19%-42%]; nominal P <.001 for all comparisons vs placebo). Similarly, a greater proportion of ad

The paper presents stylized facts about the two hundred years of Brazilian economic history according to classical liberals, nationalists, and Marxists. For this, some classic authors of each theoretical orientation are chosen according to the influence of their interpretations. While classical liberals praise economic dependence and criticize the political struggle to overcome the colonial and neo-colonial heritage, nationalists and Marxists, in different ways, criticize dependence and propose to overcome it politically. Marxists have never been in power in Brazil, but a pendulum between liberals and nationalists is clear. The relevance of the proposed classification is illustrated by recalling that, today, Brazil is governed by a leader in the Latin American authoritarian neoliberalism tradition inaugurated by Augusto Pinochet in 1973. However, shortly after commemorating 200 years of political independence on September 07th, 2022, the presidential elections in October 2022 may set a new swing in the pendulum toward a nationalist vision of the Brazilian past and future., El artículo presenta hechos estilizados sobre los doscientos años de historia económica brasileña según los liberales clásicos, nacionalistas y marxistas. Para ello se eligen algunos autores clásicos de cada orientación teórica por la influencia de sus interpretaciones. Mientras que los liberales clásicos alaban la dependencia económica y critican la lucha política por superar las herencias coloniales y neocoloniales, los nacionalistas y marxistas, de diferentes maneras, critican la dependencia y proponen superarla políticamente. En Brasil, los marxistas nunca han estado en el poder, pero es claro un péndulo entre liberales y nacionalistas. La relevancia de la clasificación propuesta se ilustra al recordar que, hoy, Brasil es gobernado por un líder en la tradición del neoliberalismo autoritario latinoamericano inaugurado por Augusto Pinochet en 1973. Sin embargo, poco después de conmemorarse los 200 años de la independencia política en 07 de septiembre de 2022, la elección presidencial de octubre de 2022 puede marcar un nuevo giro en el péndulo hacia una visión nacionalista del pasado y el futuro de Brasil.

The paper presents stylized facts about the two hundred years of Brazilian economic history according to classical liberals, nationalists, and Marxists. For this, some classic authors of each theoretical orientation are chosen according to the influence of their interpretations. While classical liberals praise economic dependence and criticize the political struggle to overcome the colonial and neo-colonial heritage, nationalists and Marxists, in different ways, criticize dependence and propose to overcome it politically. Marxists have never been in power in Brazil, but a pendulum between liberals and nationalists is clear. The relevance of the proposed classification is illustrated by recalling that, today, Brazil is governed by a leader in the Latin American authoritarian neoliberalism tradition inaugurated by Augusto Pinochet in 1973. However, shortly after commemorating 200 years of political independence on September 07th, 2022, the presidential elections in October 2022 may set a new swing in the pendulum toward a nationalist vision of the Brazilian past and future., El artículo presenta hechos estilizados sobre los doscientos años de historia económica brasileña según los liberales clásicos, nacionalistas y marxistas. Para ello se eligen algunos autores clásicos de cada orientación teórica por la influencia de sus interpretaciones. Mientras que los liberales clásicos alaban la dependencia económica y critican la lucha política por superar las herencias coloniales y neocoloniales, los nacionalistas y marxistas, de diferentes maneras, critican la dependencia y proponen superarla políticamente. En Brasil, los marxistas nunca han estado en el poder, pero es claro un péndulo entre liberales y nacionalistas. La relevancia de la clasificación propuesta se ilustra al recordar que, hoy, Brasil es gobernado por un líder en la tradición del neoliberalismo autoritario latinoamericano inaugurado por Augusto Pinochet en 1973. Sin embargo, poco después de conmemorarse los 200 años de la independencia política en 07 de septiembre de 2022, la elección presidencial de octubre de 2022 puede marcar un nuevo giro en el péndulo hacia una visión nacionalista del pasado y el futuro de Brasil.

The paper presents stylized facts about the two hundred years of Brazilian economic history according to classical liberals, nationalists, and Marxists. For this, some classic authors of each theoretical orientation are chosen according to the influence of their interpretations. While classical liberals praise economic dependence and criticize the political struggle to overcome the colonial and neo-colonial heritage, nationalists and Marxists, in different ways, criticize dependence and propose to overcome it politically. Marxists have never been in power in Brazil, but a pendulum between liberals and nationalists is clear. The relevance of the proposed classification is illustrated by recalling that, today, Brazil is governed by a leader in the Latin American authoritarian neoliberalism tradition inaugurated by Augusto Pinochet in 1973. However, shortly after commemorating 200 years of political independence on September 07th, 2022, the presidential elections in October 2022 may set a new swing in the pendulum toward a nationalist vision of the Brazilian past and future., El artículo presenta hechos estilizados sobre los doscientos años de historia económica brasileña según los liberales clásicos, nacionalistas y marxistas. Para ello se eligen algunos autores clásicos de cada orientación teórica por la influencia de sus interpretaciones. Mientras que los liberales clásicos alaban la dependencia económica y critican la lucha política por superar las herencias coloniales y neocoloniales, los nacionalistas y marxistas, de diferentes maneras, critican la dependencia y proponen superarla políticamente. En Brasil, los marxistas nunca han estado en el poder, pero es claro un péndulo entre liberales y nacionalistas. La relevancia de la clasificación propuesta se ilustra al recordar que, hoy, Brasil es gobernado por un líder en la tradición del neoliberalismo autoritario latinoamericano inaugurado por Augusto Pinochet en 1973. Sin embargo, poco después de conmemorarse los 200 años de la independencia política en 07 de septiembre de 2022, la elección presidencial de octubre de 2022 puede marcar un nuevo giro en el péndulo hacia una visión nacionalista del pasado y el futuro de Brasil.

The paper presents stylized facts about the two hundred years of Brazilian economic history according to classical liberals, nationalists, and Marxists. For this, some classic authors of each theoretical orientation are chosen according to the influence of their interpretations. While classical liberals praise economic dependence and criticize the political struggle to overcome the colonial and neo-colonial heritage, nationalists and Marxists, in different ways, criticize dependence and propose to overcome it politically. Marxists have never been in power in Brazil, but a pendulum between liberals and nationalists is clear. The relevance of the proposed classification is illustrated by recalling that, today, Brazil is governed by a leader in the Latin American authoritarian neoliberalism tradition inaugurated by Augusto Pinochet in 1973. However, shortly after commemorating 200 years of political independence on September 07th, 2022, the presidential elections in October 2022 may set a new swing in the pendulum toward a nationalist vision of the Brazilian past and future., El artículo presenta hechos estilizados sobre los doscientos años de historia económica brasileña según los liberales clásicos, nacionalistas y marxistas. Para ello se eligen algunos autores clásicos de cada orientación teórica por la influencia de sus interpretaciones. Mientras que los liberales clásicos alaban la dependencia económica y critican la lucha política por superar las herencias coloniales y neocoloniales, los nacionalistas y marxistas, de diferentes maneras, critican la dependencia y proponen superarla políticamente. En Brasil, los marxistas nunca han estado en el poder, pero es claro un péndulo entre liberales y nacionalistas. La relevancia de la clasificación propuesta se ilustra al recordar que, hoy, Brasil es gobernado por un líder en la tradición del neoliberalismo autoritario latinoamericano inaugurado por Augusto Pinochet en 1973. Sin embargo, poco después de conmemorarse los 200 años de la independencia política en 07 de septiembre de 2022, la elección presidencial de octubre de 2022 puede marcar un nuevo giro en el péndulo hacia una visión nacionalista del pasado y el futuro de Brasil.

The paper presents stylized facts about the two hundred years of Brazilian economic history according to classical liberals, nationalists, and Marxists. For this, some classic authors of each theoretical orientation are chosen according to the influence of their interpretations. While classical liberals praise economic dependence and criticize the political struggle to overcome the colonial and neo-colonial heritage, nationalists and Marxists, in different ways, criticize dependence and propose to overcome it politically. Marxists have never been in power in Brazil, but a pendulum between liberals and nationalists is clear. The relevance of the proposed classification is illustrated by recalling that, today, Brazil is governed by a leader in the Latin American authoritarian neoliberalism tradition inaugurated by Augusto Pinochet in 1973. However, shortly after commemorating 200 years of political independence on September 07th, 2022, the presidential elections in October 2022 may set a new swing in the pendulum toward a nationalist vision of the Brazilian past and future., El artículo presenta hechos estilizados sobre los doscientos años de historia económica brasileña según los liberales clásicos, nacionalistas y marxistas. Para ello se eligen algunos autores clásicos de cada orientación teórica por la influencia de sus interpretaciones. Mientras que los liberales clásicos alaban la dependencia económica y critican la lucha política por superar las herencias coloniales y neocoloniales, los nacionalistas y marxistas, de diferentes maneras, critican la dependencia y proponen superarla políticamente. En Brasil, los marxistas nunca han estado en el poder, pero es claro un péndulo entre liberales y nacionalistas. La relevancia de la clasificación propuesta se ilustra al recordar que, hoy, Brasil es gobernado por un líder en la tradición del neoliberalismo autoritario latinoamericano inaugurado por Augusto Pinochet en 1973. Sin embargo, poco después de conmemorarse los 200 años de la independencia política en 07 de septiembre de 2022, la elección presidencial de octubre de 2022 puede marcar un nuevo giro en el péndulo hacia una visión nacionalista del pasado y el futuro de Brasil.

Background: Drug survival, defined as the length of time from initiation to discontinuation of a given therapy, allows comparisons between drugs, helps to predict patient's likelihood of remaining on a specific treatment, and achieving the best decision for each patient in daily clinical practice. Objective: The aim of this study was to provide data on drug survival of secukinumab, ixekizumab, brodalumab, guselkumab, tildrakizumab, and risankizumab in a large international cohort, and to identify clinical predictors that might have an impact on the drug survival of these drugs. Methods: This was a retrospective, multicentric, multi-country study that provides data of adult patients with moderate to severe psoriasis who started treatment with an interleukin (IL)-17 or IL-23 inhibitor between 1 February 2015 and 31 October 2021. Data were collected from 19 distinct hospital and non-hospital-based dermatology centers from Canada, Czech Republic, Italy, Greece, Portugal, Spain, and Switzerland. Kaplan-Meier estimator and proportional hazard Cox regression models were used for drug survival analysis. Results: A total of 4866 treatment courses (4178 patients)-overall time of exposure of 9500 patient-years-were included in this study, with 3164 corresponding to an IL-17 inhibitor (secukinumab, ixekizumab, brodalumab) and 1702 corresponding to an IL-23 inhibitor (guselkumab, risankizumab, tildrakizumab). IL-23 inhibitors had the highest drug survival rates during the entire study period. After 24 months of treatment, the cumulative probabilities of drug survival were 0.92 (95% confidence interval [CI] 0.89-0.95) for risankizumab, 0.90 (95% CI 0.88-0.92) for guselkumab, 0.80 (95% CI 0.76-0.84) for brodalumab, 0.79 (95% CI 0.76-0.82) for ixekizumab, and 0.75 (95% CI 0.73-0.77) for secukinumab. At 36 months, only guselkumab [0.88 (95% CI 0.85-0.91)], ixekizumab [0.73 (95% CI 0.70-0.76)], and secukinumab [0.67 (95% CI 0.65-0.70)] had more than 40 patients at risk of drug discon

Healthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of proteins/pathways that reflect a healthy immune function, including a lower pro-inflammatory status (less 'inflammaging' and autoimmunity) and a preserved humoral immune response (increased B cell-mediated immune response). Compared with controls, healthy centenarians also presented with a higher expression of proteins involved in angiogenesis and related to enhanced intercellular junctions, as well as a lower expression of proteins involved in cardiovascular abnormalities. The identification of these proteins/pathways might provide new insights into the biological mechanisms underlying the paradigm of healthy aging., Universidad Europea de Madrid (#2017/UEM05)., Universidad de Alcalá de Henares, Ministerio de Ciencia, Innovación y Universidades, Fundació Marató TV3, Fundacion "La Caixa", Depto. de Bioquímica y Biología Molecular, Fac. de Farmacia, TRUE, pub

Hypertension affects approximately one third of the world's adult population and is a major cause of premature death despite considerable advances in pharmacological treatments. Growing evidence supports the use of lifestyle interventions for the prevention and adjuvant treatment of hypertension. In this Review, we provide a summary of the epidemiological research supporting the preventive and antihypertensive effects of major lifestyle interventions (regular physical exercise, body weight management and healthy dietary patterns), as well as other less traditional recommendations such as stress management and the promotion of adequate sleep patterns coupled with circadian entrainment. We also discuss the physiological mechanisms underlying the beneficial effects of these lifestyle interventions on hypertension, which include not only the prevention of traditional risk factors (such as obesity and insulin resistance) and improvements in vascular health through an improved redox and inflammatory status, but also reduced sympathetic overactivation and non-traditional mechanisms such as increased secretion of myokines., Depto. de Bioquímica y Biología Molecular, Fac. de Farmacia, TRUE, pub

Healthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of proteins/pathways that reflect a healthy immune function, including a lower pro-inflammatory status (less 'inflammaging' and autoimmunity) and a preserved humoral immune response (increased B cell-mediated immune response). Compared with controls, healthy centenarians also presented with a higher expression of proteins involved in angiogenesis and related to enhanced intercellular junctions, as well as a lower expression of proteins involved in cardiovascular abnormalities. The identification of these proteins/pathways might provide new insights into the biological mechanisms underlying the paradigm of healthy aging., Universidad Europea de Madrid (#2017/UEM05)., Universidad de Alcalá de Henares, Ministerio de Ciencia, Innovación y Universidades, Fundació Marató TV3, Fundacion "La Caixa", Depto. de Bioquímica y Biología Molecular, Fac. de Farmacia, TRUE, pub

BACKGROUND: Population-based levels of the chronic low-grade systemic inflammation biomarker, C-reactive protein (CRP), vary widely among traditional populations, despite their apparent absence of chronic conditions associated with chronic low-grade systemic inflammation, such as type 2 diabetes, metabolic syndrome and cardiovascular disease. We have previously reported an apparent absence of aforementioned conditions amongst the traditional Melanesian horticulturalists of Kitava, Trobriand Islands, Papua New Guinea. Our objective in this study was to clarify associations between chronic low-grade systemic inflammation and chronic cardiometabolic conditions by measuring CRP in a Kitava population sample. For comparison purposes, CRP was also measured in Swedish controls matched for age and gender. METHODS: Fasting levels of serum CRP were measured cross-sectionally in ≥ 40-year-old Kitavans (N = 79) and Swedish controls (N = 83). RESULTS: CRP was lower for Kitavans compared to Swedish controls (Mdn 0.5 mg/L range 0.1-48 mg/L and Mdn 1.1 mg/L range 0.1-33 mg/L, respectively, r = .18 p = .02). Among Kitavans, there were small negative associations between lnCRP for CRP values < 10 and total, low-density lipoprotein (LDL) and non-high-density lipoprotein (non-HDL) cholesterol. Among Swedish controls, associations of lnCRP for CRP values < 10 were medium positive with weight, body mass index, waist circumference, hip circumference and waist-hip ratio and low positive with triglyceride, total cholesterol-HDL cholesterol ratio, triglyceride-HDL cholesterol ratio and serum insulin. CONCLUSIONS: Chronic low-grade systemic inflammation, measured as CRP, was lower among Kitavans compared to Swedish controls, indicating a lower and average cardiovascular risk, respectively, for these populations.

BACKGROUND: Population-based levels of the chronic low-grade systemic inflammation biomarker, C-reactive protein (CRP), vary widely among traditional populations, despite their apparent absence of chronic conditions associated with chronic low-grade systemic inflammation, such as type 2 diabetes, metabolic syndrome and cardiovascular disease. We have previously reported an apparent absence of aforementioned conditions amongst the traditional Melanesian horticulturalists of Kitava, Trobriand Islands, Papua New Guinea. Our objective in this study was to clarify associations between chronic low-grade systemic inflammation and chronic cardiometabolic conditions by measuring CRP in a Kitava population sample. For comparison purposes, CRP was also measured in Swedish controls matched for age and gender. METHODS: Fasting levels of serum CRP were measured cross-sectionally in ≥ 40-year-old Kitavans (N = 79) and Swedish controls (N = 83). RESULTS: CRP was lower for Kitavans compared to Swedish controls (Mdn 0.5 mg/L range 0.1-48 mg/L and Mdn 1.1 mg/L range 0.1-33 mg/L, respectively, r = .18 p = .02). Among Kitavans, there were small negative associations between lnCRP for CRP values < 10 and total, low-density lipoprotein (LDL) and non-high-density lipoprotein (non-HDL) cholesterol. Among Swedish controls, associations of lnCRP for CRP values < 10 were medium positive with weight, body mass index, waist circumference, hip circumference and waist-hip ratio and low positive with triglyceride, total cholesterol-HDL cholesterol ratio, triglyceride-HDL cholesterol ratio and serum insulin. CONCLUSIONS: Chronic low-grade systemic inflammation, measured as CRP, was lower among Kitavans compared to Swedish controls, indicating a lower and average cardiovascular risk, respectively, for these populations.

BACKGROUND: Population-based levels of the chronic low-grade systemic inflammation biomarker, C-reactive protein (CRP), vary widely among traditional populations, despite their apparent absence of chronic conditions associated with chronic low-grade systemic inflammation, such as type 2 diabetes, metabolic syndrome and cardiovascular disease. We have previously reported an apparent absence of aforementioned conditions amongst the traditional Melanesian horticulturalists of Kitava, Trobriand Islands, Papua New Guinea. Our objective in this study was to clarify associations between chronic low-grade systemic inflammation and chronic cardiometabolic conditions by measuring CRP in a Kitava population sample. For comparison purposes, CRP was also measured in Swedish controls matched for age and gender. METHODS: Fasting levels of serum CRP were measured cross-sectionally in ≥ 40-year-old Kitavans (N = 79) and Swedish controls (N = 83). RESULTS: CRP was lower for Kitavans compared to Swedish controls (Mdn 0.5 mg/L range 0.1-48 mg/L and Mdn 1.1 mg/L range 0.1-33 mg/L, respectively, r = .18 p = .02). Among Kitavans, there were small negative associations between lnCRP for CRP values < 10 and total, low-density lipoprotein (LDL) and non-high-density lipoprotein (non-HDL) cholesterol. Among Swedish controls, associations of lnCRP for CRP values < 10 were medium positive with weight, body mass index, waist circumference, hip circumference and waist-hip ratio and low positive with triglyceride, total cholesterol-HDL cholesterol ratio, triglyceride-HDL cholesterol ratio and serum insulin. CONCLUSIONS: Chronic low-grade systemic inflammation, measured as CRP, was lower among Kitavans compared to Swedish controls, indicating a lower and average cardiovascular risk, respectively, for these populations.

Reflectance confocal microscopy (RCM) is a noninvasive real-time imaging technique that has been widely used for the diagnosis of skin cancer. More recently, it has been reported as a useful tool for the diagnosis and management of several inflammatory and infectious skin disorders. This article provides an overview of the current available applications of RCM use in cutaneous infections and infestations. PubMed was used to search the following terms in various combinations: reflectance confocal microscopy, skin, hair, nail, infection, parasitosis, mycosis, virus, bacteria. All papers were accordingly reviewed. In most cutaneous infections or infestations, the main alterations are found in the epidermis and upper dermis, where the accuracy of confocal microscopy is nearly similar to that of histopathology. The high resolution of this technique allows the visualization of most skin parasites, fungi, and a few bacteria. Although viruses cannot be identified because of their small size, viral cytopathic effects can be observed on keratinocytes. In addition, RCM can be used to monitor the response to treatment, thereby reducing unnecessary treatments.

BACKGROUND: Population-based levels of the chronic low-grade systemic inflammation biomarker, C-reactive protein (CRP), vary widely among traditional populations, despite their apparent absence of chronic conditions associated with chronic low-grade systemic inflammation, such as type 2 diabetes, metabolic syndrome and cardiovascular disease. We have previously reported an apparent absence of aforementioned conditions amongst the traditional Melanesian horticulturalists of Kitava, Trobriand Islands, Papua New Guinea. Our objective in this study was to clarify associations between chronic low-grade systemic inflammation and chronic cardiometabolic conditions by measuring CRP in a Kitava population sample. For comparison purposes, CRP was also measured in Swedish controls matched for age and gender. METHODS: Fasting levels of serum CRP were measured cross-sectionally in ≥ 40-year-old Kitavans (N = 79) and Swedish controls (N = 83). RESULTS: CRP was lower for Kitavans compared to Swedish controls (Mdn 0.5 mg/L range 0.1-48 mg/L and Mdn 1.1 mg/L range 0.1-33 mg/L, respectively, r = .18 p = .02). Among Kitavans, there were small negative associations between lnCRP for CRP values < 10 and total, low-density lipoprotein (LDL) and non-high-density lipoprotein (non-HDL) cholesterol. Among Swedish controls, associations of lnCRP for CRP values < 10 were medium positive with weight, body mass index, waist circumference, hip circumference and waist-hip ratio and low positive with triglyceride, total cholesterol-HDL cholesterol ratio, triglyceride-HDL cholesterol ratio and serum insulin. CONCLUSIONS: Chronic low-grade systemic inflammation, measured as CRP, was lower among Kitavans compared to Swedish controls, indicating a lower and average cardiovascular risk, respectively, for these populations.

Reflectance confocal microscopy (RCM) is a noninvasive real-time imaging technique that has been widely used for the diagnosis of skin cancer. More recently, it has been reported as a useful tool for the diagnosis and management of several inflammatory and infectious skin disorders. This article provides an overview of the current available applications of RCM use in cutaneous infections and infestations. PubMed was used to search the following terms in various combinations: reflectance confocal microscopy, skin, hair, nail, infection, parasitosis, mycosis, virus, bacteria. All papers were accordingly reviewed. In most cutaneous infections or infestations, the main alterations are found in the epidermis and upper dermis, where the accuracy of confocal microscopy is nearly similar to that of histopathology. The high resolution of this technique allows the visualization of most skin parasites, fungi, and a few bacteria. Although viruses cannot be identified because of their small size, viral cytopathic effects can be observed on keratinocytes. In addition, RCM can be used to monitor the response to treatment, thereby reducing unnecessary treatments.

BACKGROUND: Population-based levels of the chronic low-grade systemic inflammation biomarker, C-reactive protein (CRP), vary widely among traditional populations, despite their apparent absence of chronic conditions associated with chronic low-grade systemic inflammation, such as type 2 diabetes, metabolic syndrome and cardiovascular disease. We have previously reported an apparent absence of aforementioned conditions amongst the traditional Melanesian horticulturalists of Kitava, Trobriand Islands, Papua New Guinea. Our objective in this study was to clarify associations between chronic low-grade systemic inflammation and chronic cardiometabolic conditions by measuring CRP in a Kitava population sample. For comparison purposes, CRP was also measured in Swedish controls matched for age and gender. METHODS: Fasting levels of serum CRP were measured cross-sectionally in ≥ 40-year-old Kitavans (N = 79) and Swedish controls (N = 83). RESULTS: CRP was lower for Kitavans compared to Swedish controls (Mdn 0.5 mg/L range 0.1-48 mg/L and Mdn 1.1 mg/L range 0.1-33 mg/L, respectively, r = .18 p = .02). Among Kitavans, there were small negative associations between lnCRP for CRP values < 10 and total, low-density lipoprotein (LDL) and non-high-density lipoprotein (non-HDL) cholesterol. Among Swedish controls, associations of lnCRP for CRP values < 10 were medium positive with weight, body mass index, waist circumference, hip circumference and waist-hip ratio and low positive with triglyceride, total cholesterol-HDL cholesterol ratio, triglyceride-HDL cholesterol ratio and serum insulin. CONCLUSIONS: Chronic low-grade systemic inflammation, measured as CRP, was lower among Kitavans compared to Swedish controls, indicating a lower and average cardiovascular risk, respectively, for these populations.

BACKGROUND: Population-based levels of the chronic low-grade systemic inflammation biomarker, C-reactive protein (CRP), vary widely among traditional populations, despite their apparent absence of chronic conditions associated with chronic low-grade systemic inflammation, such as type 2 diabetes, metabolic syndrome and cardiovascular disease. We have previously reported an apparent absence of aforementioned conditions amongst the traditional Melanesian horticulturalists of Kitava, Trobriand Islands, Papua New Guinea. Our objective in this study was to clarify associations between chronic low-grade systemic inflammation and chronic cardiometabolic conditions by measuring CRP in a Kitava population sample. For comparison purposes, CRP was also measured in Swedish controls matched for age and gender. METHODS: Fasting levels of serum CRP were measured cross-sectionally in ≥ 40-year-old Kitavans (N = 79) and Swedish controls (N = 83). RESULTS: CRP was lower for Kitavans compared to Swedish controls (Mdn 0.5 mg/L range 0.1-48 mg/L and Mdn 1.1 mg/L range 0.1-33 mg/L, respectively, r = .18 p = .02). Among Kitavans, there were small negative associations between lnCRP for CRP values < 10 and total, low-density lipoprotein (LDL) and non-high-density lipoprotein (non-HDL) cholesterol. Among Swedish controls, associations of lnCRP for CRP values < 10 were medium positive with weight, body mass index, waist circumference, hip circumference and waist-hip ratio and low positive with triglyceride, total cholesterol-HDL cholesterol ratio, triglyceride-HDL cholesterol ratio and serum insulin. CONCLUSIONS: Chronic low-grade systemic inflammation, measured as CRP, was lower among Kitavans compared to Swedish controls, indicating a lower and average cardiovascular risk, respectively, for these populations.

Introduction: Hidradenitis suppurativa (HS) is a chronic dermatosis with a large impact in patients’ quality of life and an estimated 7-year delay in diagnosis. The General Practitioner (GP) is usually the first doctor to assist the HS patient. The primary objective of this study is to describe the knowledge and clinical approach of HS by GPs.Material and Methods: A cross-sectional study was conducted, based on the GPs answers to a questionnaire designed to evaluate their knowledge on HS.Results: One hundred eighty seven questionnaires were considered valid for inclusion in the study. The majority (97.3%) of GPs correctly identified HS as the most likely diagnosis when confronted with a typical clinical history of the disease, and 84.5% associated HS with chronicity. The majority (84.0%) of GPs refers these patients, mostly to Dermatology (89.3%). The majority of GPs also considered that a surgical approach may not be curative (94.1%) and 15.0% considered that biological agents might be indicated. We compared the answers of 2 groups: group A, n=100, with <5 years of clinical practice and group B, n=84, with ≥5 years. Group A associated more HS with tobacco use and obesity than group B (p=0.013 and p=0.006, respectively). A multidisciplinary approach was also more frequently selected by group A (p=0.004).Conclusion: This pilot study shows that the view of Portuguese GPs about HS can be improved. There are significant differences concerning knowledge on HS between GPs with less than 5 years of clinical practice and the more experienced ones. This study can help to direct differential future educational actions., info:eu-repo/semantics/published

The present paper refers to the work carried out by the educational team during the exhibition of "Folhetos de Cordel Portugueses - Arnaldo Saraiva Collection", held at Academia Mineira de Letras between November 7 and November 26, 2017. During the exhibition guided visits and workshops were conducted by the team for students of Belo Horizonte public and private schools, as well as visits from the general public and accessibility, however, in this paper we will focus on the visits related to accessibility. We will reflect on how these workshops promote literary literacy and the empowerment of visitors through the appreciation of the popular culture present in the cordeis. It will also raise the question of the performance of professionals from various areas as mediators of art and promoters of accessibility promoters, as well as educational wage initiatives beyond schoolar discourse, also the role played by the cultural mediators in this paper. To do so, we will use Michelle Pettit's concepts regarding reading mediation, Rezende and Mayer in the scope of the audio description and accessibility, regarding the theme of the exhibition itself, the cordeis, we will use the texts of Arnaldo Saraiva himself, who besides being a collector is a relevant scholar of the subject and, carried out part of the training of the team., O presente relato refere-se ao trabalho realizado pela equipe do educativo durante a exposição “Folhetos de Cordéis Portugueses – Coleção Arnaldo Saraiva”, realizada na Academia Mineira de Letras entre os dias 07 de novembro e 26 de novembro de 2017. Durante a exposição foram realizadas visitas guiadas e oficinas com alunos da rede pública e privada da grande Belo Horizonte e também visitas do público geral, e de acessibilidade, no entanto, nesse relato focaremos nas visitas relacionadas a acessibilidade. Refletiremos o como essas oficinas promovem o letramento literário e o empoderamento dos visitantes por meio da valorização da cultura popular presente nos cordéis. Será também levantada a questão da atuação dos profissionais de diversas áreas como mediadores de arte e promotores de acessibilidade, assim como a promoção de iniciativas de cunho educacional além do discurso escolar, papel exercido como mediador cultural neste relato. Para tanto, usaremos os conceitos de Michelle Pettit no que tange a mediação de leitura, de Rezende e Mayer no âmbito da áudio descrição e acerca do objeto da exposição, os cordéis, faremos uso dos textos do próprio Arnaldo Saraiva, que além de colecionador é um relevante estudioso do tema e, este, realizou parte do treinamento da equipe.

The present paper refers to the work carried out by the educational team during the exhibition of "Folhetos de Cordel Portugueses - Arnaldo Saraiva Collection", held at Academia Mineira de Letras between November 7 and November 26, 2017. During the exhibition guided visits and workshops were conducted by the team for students of Belo Horizonte public and private schools, as well as visits from the general public and accessibility, however, in this paper we will focus on the visits related to accessibility. We will reflect on how these workshops promote literary literacy and the empowerment of visitors through the appreciation of the popular culture present in the cordeis. It will also raise the question of the performance of professionals from various areas as mediators of art and promoters of accessibility promoters, as well as educational wage initiatives beyond schoolar discourse, also the role played by the cultural mediators in this paper. To do so, we will use Michelle Pettit's concepts regarding reading mediation, Rezende and Mayer in the scope of the audio description and accessibility, regarding the theme of the exhibition itself, the cordeis, we will use the texts of Arnaldo Saraiva himself, who besides being a collector is a relevant scholar of the subject and, carried out part of the training of the team., O presente relato refere-se ao trabalho realizado pela equipe do educativo durante a exposição “Folhetos de Cordéis Portugueses – Coleção Arnaldo Saraiva”, realizada na Academia Mineira de Letras entre os dias 07 de novembro e 26 de novembro de 2017. Durante a exposição foram realizadas visitas guiadas e oficinas com alunos da rede pública e privada da grande Belo Horizonte e também visitas do público geral, e de acessibilidade, no entanto, nesse relato focaremos nas visitas relacionadas a acessibilidade. Refletiremos o como essas oficinas promovem o letramento literário e o empoderamento dos visitantes por meio da valorização da cultura popular presente nos cordéis. Será também levantada a questão da atuação dos profissionais de diversas áreas como mediadores de arte e promotores de acessibilidade, assim como a promoção de iniciativas de cunho educacional além do discurso escolar, papel exercido como mediador cultural neste relato. Para tanto, usaremos os conceitos de Michelle Pettit no que tange a mediação de leitura, de Rezende e Mayer no âmbito da áudio descrição e acerca do objeto da exposição, os cordéis, faremos uso dos textos do próprio Arnaldo Saraiva, que além de colecionador é um relevante estudioso do tema e, este, realizou parte do treinamento da equipe.

El sueño es un determinante fundamental en el rendimiento y la salud del deportista. En la actualidad algunos expertos la definen como la mejor estrategia de recuperación debido a sus efectos fisiológicos y restaurativos. Los deportistas deben ser alentados a dormir más horas que la población general, debido a las demandas de recuperación impuestas por el ejercicio. La presente revisión teórica busca esclarecer los factores que afectan al sueño, los efectos de éste sobre el rendimiento deportivo y la salud, así como explicar las estrategias más determinantes para mejorar la cantidad y calidad del sueño del deportista. Para ello es importante tener en cuenta los horarios de los eventos deportivos, el estrés psicosocial del deportista, el uso de dispositivos electrónicos, los viajes, el uso de sustancias estimulantes como la cafeína o la ingesta de alcohol, entre otros. Diferentes estrategias como la extensión del sueño, las siestas, estrategias de higiene del sueño y nutricionales deben ser consideradas en la mejora del sueño del deportista, Sleep is a fundamental determinant in the performance and health of the athlete. At present, some experts define it as the best recovery strategy due to its physiological and restorative effects. Athletes should be encouraged to sleep longer than the general population, due to the recovery demands imposed by the exercise. The present review looks for to clarify the factors that affect, the effects of these on sports performance and health, as well as describe the most decisive strategies to improve the quantity and quality of the athlete's sleep. Consequently, it is important the schedules of sporting events, the psychosocial stress of the athlete, the use of electronic devices, travel to compete, the use of stimulating substances such as caffeine or alcohol intake, among others. Different strategies such as sleep extension, naps, sleep hygiene and nutritional strategies should be considered in improving the athlete's sleep.

El sueño es un determinante fundamental en el rendimiento y la salud del deportista. En la actualidad algunos expertos la definen como la mejor estrategia de recuperación debido a sus efectos fisiológicos y restaurativos. Los deportistas deben ser alentados a dormir más horas que la población general, debido a las demandas de recuperación impuestas por el ejercicio. La presente revisión teórica busca esclarecer los factores que afectan al sueño, los efectos de éste sobre el rendimiento deportivo y la salud, así como explicar las estrategias más determinantes para mejorar la cantidad y calidad del sueño del deportista. Para ello es importante tener en cuenta los horarios de los eventos deportivos, el estrés psicosocial del deportista, el uso de dispositivos electrónicos, los viajes, el uso de sustancias estimulantes como la cafeína o la ingesta de alcohol, entre otros. Diferentes estrategias como la extensión del sueño, las siestas, estrategias de higiene del sueño y nutricionales deben ser consideradas en la mejora del sueño del deportista, Sleep is a fundamental determinant in the performance and health of the athlete. At present, some experts define it as the best recovery strategy due to its physiological and restorative effects. Athletes should be encouraged to sleep longer than the general population, due to the recovery demands imposed by the exercise. The present review looks for to clarify the factors that affect, the effects of these on sports performance and health, as well as describe the most decisive strategies to improve the quantity and quality of the athlete's sleep. Consequently, it is important the schedules of sporting events, the psychosocial stress of the athlete, the use of electronic devices, travel to compete, the use of stimulating substances such as caffeine or alcohol intake, among others. Different strategies such as sleep extension, naps, sleep hygiene and nutritional strategies should be considered in improving the athlete's sleep.

El sueño es un determinante fundamental en el rendimiento y la salud del deportista. En la actualidad algunos expertos la definen como la mejor estrategia de recuperación debido a sus efectos fisiológicos y restaurativos. Los deportistas deben ser alentados a dormir más horas que la población general, debido a las demandas de recuperación impuestas por el ejercicio. La presente revisión teórica busca esclarecer los factores que afectan al sueño, los efectos de éste sobre el rendimiento deportivo y la salud, así como explicar las estrategias más determinantes para mejorar la cantidad y calidad del sueño del deportista. Para ello es importante tener en cuenta los horarios de los eventos deportivos, el estrés psicosocial del deportista, el uso de dispositivos electrónicos, los viajes, el uso de sustancias estimulantes como la cafeína o la ingesta de alcohol, entre otros. Diferentes estrategias como la extensión del sueño, las siestas, estrategias de higiene del sueño y nutricionales deben ser consideradas en la mejora del sueño del deportista, Sleep is a fundamental determinant in the performance and health of the athlete. At present, some experts define it as the best recovery strategy due to its physiological and restorative effects. Athletes should be encouraged to sleep longer than the general population, due to the recovery demands imposed by the exercise. The present review looks for to clarify the factors that affect, the effects of these on sports performance and health, as well as describe the most decisive strategies to improve the quantity and quality of the athlete's sleep. Consequently, it is important the schedules of sporting events, the psychosocial stress of the athlete, the use of electronic devices, travel to compete, the use of stimulating substances such as caffeine or alcohol intake, among others. Different strategies such as sleep extension, naps, sleep hygiene and nutritional strategies should be considered in improving the athlete's sleep.

El sueño es un determinante fundamental en el rendimiento y la salud del deportista. En la actualidad algunos expertos la definen como la mejor estrategia de recuperación debido a sus efectos fisiológicos y restaurativos. Los deportistas deben ser alentados a dormir más horas que la población general, debido a las demandas de recuperación impuestas por el ejercicio. La presente revisión teórica busca esclarecer los factores que afectan al sueño, los efectos de éste sobre el rendimiento deportivo y la salud, así como explicar las estrategias más determinantes para mejorar la cantidad y calidad del sueño del deportista. Para ello es importante tener en cuenta los horarios de los eventos deportivos, el estrés psicosocial del deportista, el uso de dispositivos electrónicos, los viajes, el uso de sustancias estimulantes como la cafeína o la ingesta de alcohol, entre otros. Diferentes estrategias como la extensión del sueño, las siestas, estrategias de higiene del sueño y nutricionales deben ser consideradas en la mejora del sueño del deportista, Sleep is a fundamental determinant in the performance and health of the athlete. At present, some experts define it as the best recovery strategy due to its physiological and restorative effects. Athletes should be encouraged to sleep longer than the general population, due to the recovery demands imposed by the exercise. The present review looks for to clarify the factors that affect, the effects of these on sports performance and health, as well as describe the most decisive strategies to improve the quantity and quality of the athlete's sleep. Consequently, it is important the schedules of sporting events, the psychosocial stress of the athlete, the use of electronic devices, travel to compete, the use of stimulating substances such as caffeine or alcohol intake, among others. Different strategies such as sleep extension, naps, sleep hygiene and nutritional strategies should be considered in improving the athlete's sleep.

El sueño es un determinante fundamental en el rendimiento y la salud del deportista. En la actualidad algunos expertos la definen como la mejor estrategia de recuperación debido a sus efectos fisiológicos y restaurativos. Los deportistas deben ser alentados a dormir más horas que la población general, debido a las demandas de recuperación impuestas por el ejercicio. La presente revisión teórica busca esclarecer los factores que afectan al sueño, los efectos de éste sobre el rendimiento deportivo y la salud, así como explicar las estrategias más determinantes para mejorar la cantidad y calidad del sueño del deportista. Para ello es importante tener en cuenta los horarios de los eventos deportivos, el estrés psicosocial del deportista, el uso de dispositivos electrónicos, los viajes, el uso de sustancias estimulantes como la cafeína o la ingesta de alcohol, entre otros. Diferentes estrategias como la extensión del sueño, las siestas, estrategias de higiene del sueño y nutricionales deben ser consideradas en la mejora del sueño del deportista, Sleep is a fundamental determinant in the performance and health of the athlete. At present, some experts define it as the best recovery strategy due to its physiological and restorative effects. Athletes should be encouraged to sleep longer than the general population, due to the recovery demands imposed by the exercise. The present review looks for to clarify the factors that affect, the effects of these on sports performance and health, as well as describe the most decisive strategies to improve the quantity and quality of the athlete's sleep. Consequently, it is important the schedules of sporting events, the psychosocial stress of the athlete, the use of electronic devices, travel to compete, the use of stimulating substances such as caffeine or alcohol intake, among others. Different strategies such as sleep extension, naps, sleep hygiene and nutritional strategies should be considered in improving the athlete's sleep.

El sueño es un determinante fundamental en el rendimiento y la salud del deportista. En la actualidad algunos expertos la definen como la mejor estrategia de recuperación debido a sus efectos fisiológicos y restaurativos. Los deportistas deben ser alentados a dormir más horas que la población general, debido a las demandas de recuperación impuestas por el ejercicio. La presente revisión teórica busca esclarecer los factores que afectan al sueño, los efectos de éste sobre el rendimiento deportivo y la salud, así como explicar las estrategias más determinantes para mejorar la cantidad y calidad del sueño del deportista. Para ello es importante tener en cuenta los horarios de los eventos deportivos, el estrés psicosocial del deportista, el uso de dispositivos electrónicos, los viajes, el uso de sustancias estimulantes como la cafeína o la ingesta de alcohol, entre otros. Diferentes estrategias como la extensión del sueño, las siestas, estrategias de higiene del sueño y nutricionales deben ser consideradas en la mejora del sueño del deportista, Sleep is a fundamental determinant in the performance and health of the athlete. At present, some experts define it as the best recovery strategy due to its physiological and restorative effects. Athletes should be encouraged to sleep longer than the general population, due to the recovery demands imposed by the exercise. The present review looks for to clarify the factors that affect, the effects of these on sports performance and health, as well as describe the most decisive strategies to improve the quantity and quality of the athlete's sleep. Consequently, it is important the schedules of sporting events, the psychosocial stress of the athlete, the use of electronic devices, travel to compete, the use of stimulating substances such as caffeine or alcohol intake, among others. Different strategies such as sleep extension, naps, sleep hygiene and nutritional strategies should be considered in improving the athlete's sleep.

For pancreatic solid lesions, ESGE recommends performing endoscopic ultrasound (EUS)-guided sampling as first-line procedure when a pathological diagnosis is required. Alternatively, percutaneous sampling may be considered in metastatic disease.Strong recommendation, moderate quality evidence.In the case of negative or inconclusive results and a high degree of suspicion of malignant disease, ESGE suggests re-evaluating the pathology slides, repeating EUS-guided sampling, or surgery.Weak recommendation, low quality evidence.In patients with chronic pancreatitis associated with a pancreatic mass, EUS-guided sampling results that do not confirm cancer should be interpreted with caution.Strong recommendation, low quality evidence.For pancreatic cystic lesions (PCLs), ESGE recommends EUS-guided sampling for biochemical analyses plus cytopathological examination if a precise diagnosis may change patient management, except for lesions ≤ 10 mm in diameter with no high risk stigmata. If the volume of PCL aspirate is small, it is recommended that carcinoembryonic antigen (CEA) level determination be done as the first analysis.Strong recommendation, low quality evidence.For esophageal cancer, ESGE suggests performing EUS-guided sampling for the assessment of regional lymph nodes (LNs) in T1 (and, depending on local treatment policy, T2) adenocarcinoma and of lesions suspicious for metastasis such as distant LNs, left liver lobe lesions, and suspected peritoneal carcinomatosis.Weak recommendation, low quality evidence.For lymphadenopathy of unknown origin, ESGE recommends performing EUS-guided (or alternatively endobronchial ultrasound [EBUS]-guided) sampling if the pathological result is likely to affect patient management and no superficial lymphadenopathy is easily accessible.Strong recommendation, moderate quality evidence.In the case of solid liver masses suspicious for metastasis, ESGE suggests performing EUS-guided sampling if the pathological result is likely to affe

SCOPUS: ar.j, info:eu-repo/semantics/published

Background: We have previously shown that a Palaeolithic diet consisting of the typical food groups that our ancestors ate during the Palaeolithic era, improves cardiovascular disease risk factors and glucose control compared to the currently recommended diabetes diet in patients with type 2 diabetes. To elucidate the mechanisms behind these effects, we evaluated fasting plasma concentrations of glucagon, insulin, incretins, ghrelin, C-peptide and adipokines from the same study. Methods: In a randomised, open-label, cross-over study, 13 patients with type 2 diabetes were randomly assigned to eat a Palaeolithic diet based on lean meat, fish, fruits, vegetables, root vegetables, eggs and nuts, or a diabetes diet designed in accordance with current diabetes dietary guidelines during two consecutive 3-month periods. The patients were recruited from primary health-care units and included three women and 10 men [age (mean ± SD) 64 ± 6 years; BMI 30 ± 7 kg/m2; diabetes duration 8 ± 5 years; glycated haemoglobin 6.6 ± 0.6 % (57.3 ± 6 mmol/mol)] with unaltered diabetes treatment and stable body weight for 3 months prior to the start of the study. Outcome variables included fasting plasma concentrations of leptin, adiponectin, adipsin, visfatin, resistin, glucagon, insulin, C-peptide, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and ghrelin. Dietary intake was evaluated by use of 4-day weighed food records. Results: Seven participants started with the Palaeolithic diet and six with the diabetes diet. The Palaeolithic diet resulted in a large effect size (Cohen's d = -1.26) at lowering fasting plasma leptin levels compared to the diabetes diet [mean difference (95 % CI), -2.3 (-5.1 to 0.4) ng/ml, p = 0.023]. No statistically significant differences between the diets for the other variables, analysed in this study, were observed. Conclusions: Over a 3-month study period, a Palaeolithic diet resulted in reduced fasting plasma leptin levels

Background: We have previously shown that a Palaeolithic diet consisting of the typical food groups that our ancestors ate during the Palaeolithic era, improves cardiovascular disease risk factors and glucose control compared to the currently recommended diabetes diet in patients with type 2 diabetes. To elucidate the mechanisms behind these effects, we evaluated fasting plasma concentrations of glucagon, insulin, incretins, ghrelin, C-peptide and adipokines from the same study. Methods: In a randomised, open-label, cross-over study, 13 patients with type 2 diabetes were randomly assigned to eat a Palaeolithic diet based on lean meat, fish, fruits, vegetables, root vegetables, eggs and nuts, or a diabetes diet designed in accordance with current diabetes dietary guidelines during two consecutive 3-month periods. The patients were recruited from primary health-care units and included three women and 10 men [age (mean ± SD) 64 ± 6 years; BMI 30 ± 7 kg/m2; diabetes duration 8 ± 5 years; glycated haemoglobin 6.6 ± 0.6 % (57.3 ± 6 mmol/mol)] with unaltered diabetes treatment and stable body weight for 3 months prior to the start of the study. Outcome variables included fasting plasma concentrations of leptin, adiponectin, adipsin, visfatin, resistin, glucagon, insulin, C-peptide, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and ghrelin. Dietary intake was evaluated by use of 4-day weighed food records. Results: Seven participants started with the Palaeolithic diet and six with the diabetes diet. The Palaeolithic diet resulted in a large effect size (Cohen's d = -1.26) at lowering fasting plasma leptin levels compared to the diabetes diet [mean difference (95 % CI), -2.3 (-5.1 to 0.4) ng/ml, p = 0.023]. No statistically significant differences between the diets for the other variables, analysed in this study, were observed. Conclusions: Over a 3-month study period, a Palaeolithic diet resulted in reduced fasting plasma leptin levels

Background Research on the role of nutrition in type 2 diabetes has largely focused on macro/micronutrient composition and dietary fiber intake, while fewer studies have tested the effects of differing food choice. Some observational studies and short-term intervention studies suggest that a food pattern mimicking the diet with which humans evolved positively influences glucose control and associated endocrine systems. Such a food pattern mainly differs from other common healthy food patterns in its absence of cereal grains and dairy products. The primary aim of this pilot study is to determine the effect of two healthy diets with or without cereal grains and dairy products on glucose control, while keeping participants’ weight stable and other food parameters, such as macro/micronutrient composition, dietary fiber and glycemic load, the same in both diets. Methods/Design We intend to include 15 adult patients with a medical diagnosis of type 2 diabetes mellitus with or without medication and with an increased waist circumference (≥ 80 cm for women and ≥ 94 cm for men) in a random-order cross-over diet intervention study during two periods of four-weeks separated by a six-week washout period. Patients will be instructed to eat two healthy diets according to official dietary guidelines with respect to macro/micronutrient composition and fiber content, but differing in the type of food included, with one diet being without cereal grains and dairy products. Lunch will be served in a hospital kitchen for control of nutrient intake, while the rest of the meals will be eaten at home according to specific directions. The energy content of the diets will be individually adjusted to maintain a stable body weight during the two four-week intervention periods. Primary outcomes will be change in fasting plasma glucagon and fructosamine, while secondary outcomes include change in fasting glucose and glycated hemoglobin, glucose and glucagon response during oral glucose

Due to the necessity of extending the season to root peach herbaceous cuttings and optimize plant nurseries facilities, the present research had as goal to study technical viability of late summer rooting on four peach rootstocks. Distal portion (last growth) was used of branches of ‘Tsukuba-1’, ‘Tsukuba-2’, ‘Tsukuba-3’ and ‘Okinawa’ peach rootstocks and tested with different indolbutyric acid (IBA) concentrations (0; 3,000; and 6,000 mg.L-¹) by fast immersion. Sixty days after the treatments, rooting and root quality were measured. We conclude that using herbaceous branches from the last growth on March provides satisfactory results for ‘Tsukuba-1’ and ‘Okinawa’ rootstocks. The three Tsukuba rootstocks showed differences in rooting percentage, percentage of suitable and unsuitable cuttings for planting, root length and mortality percentage. IBA at 6,000 m.L-¹ on March can be recommended for herbaceous cutting treatment of the studied peach rootstocks., Diante da necessidade de ampliar o período de realização da estaquia herbácea de porta-enxertos de pessegueiro, visando otimização da infra-estrutura instalada nos viveiros, idealizou-se o presente trabalho, que teve por objetivo estudar sua viabilidade técnica em quatro cultivares, no final do verão. Utilizou-se da extremidade distal (último fluxo de crescimento) dos ramos de pessegueiros ‘Tsukuba-1’, ‘Tsukuba-2’, ‘Tsukuba-3’ e ‘Okinawa’, testando-se também as doses 0; 3.000 e 6.000 mg.L-1 de ácido indolbutírico, em imersão rápida. Transcorridos 60 dias após a estaquia, foram avaliadas variáveis relativas ao enraizamento e à qualidade das raízes. Conclui-se que o uso de ramos herbáceos, oriundos do ultimo fluxo de crescimento, para a estaquia em março, proporciona resultados satisfatórios para os porta-exertos ‘Okinawa’ e ‘Tsukuba 1’. Os três porta-enxertos da série ‘Tsukuba’ testados apresentam diferenças nas porcentagens de enraizamento, de estacas aptas e inaptas ao transplantio, no comprimento das raízes e na porcentagem de mortalidade. Recomenda-se o ácido indolbutírico a 6.000 mg.L-1 para o tratamento das estacas herbáceas dos porta-enxertos testados, para estaquia em março.

Background Research on the role of nutrition in type 2 diabetes has largely focused on macro/micronutrient composition and dietary fiber intake, while fewer studies have tested the effects of differing food choice. Some observational studies and short-term intervention studies suggest that a food pattern mimicking the diet with which humans evolved positively influences glucose control and associated endocrine systems. Such a food pattern mainly differs from other common healthy food patterns in its absence of cereal grains and dairy products. The primary aim of this pilot study is to determine the effect of two healthy diets with or without cereal grains and dairy products on glucose control, while keeping participants’ weight stable and other food parameters, such as macro/micronutrient composition, dietary fiber and glycemic load, the same in both diets. Methods/Design We intend to include 15 adult patients with a medical diagnosis of type 2 diabetes mellitus with or without medication and with an increased waist circumference (≥ 80 cm for women and ≥ 94 cm for men) in a random-order cross-over diet intervention study during two periods of four-weeks separated by a six-week washout period. Patients will be instructed to eat two healthy diets according to official dietary guidelines with respect to macro/micronutrient composition and fiber content, but differing in the type of food included, with one diet being without cereal grains and dairy products. Lunch will be served in a hospital kitchen for control of nutrient intake, while the rest of the meals will be eaten at home according to specific directions. The energy content of the diets will be individually adjusted to maintain a stable body weight during the two four-week intervention periods. Primary outcomes will be change in fasting plasma glucagon and fructosamine, while secondary outcomes include change in fasting glucose and glycated hemoglobin, glucose and glucagon response during oral glucose

Research on the role of nutrition in type 2 diabetes has largely focused on macro/micronutrient composition and dietary fiber intake, while fewer studies have tested the effects of differing food choice. Some observational studies and short-term intervention studies suggest that a food pattern mimicking the diet with which humans evolved positively influences glucose control and associated endocrine systems. Such a food pattern mainly differs from other common healthy food patterns in its absence of cereal grains and dairy products. The primary aim of this pilot study is to determine the effect of two healthy diets with or without cereal grains and dairy products on glucose control, while keeping participants' weight stable and other food parameters, such as macro/micronutrient composition, dietary fiber and glycemic load, the same in both diets.

Milk protein intake has recently been suggested to improve metabolic health. This Perspective provides evidence that metabolic effects of milk protein intake have to be regarded in the context of the individual's pre-existing metabolic and exercise status. Milk proteins provide abundant branched-chain amino acids (BCAAs) and glutamine. Plasma BCAAs and glutamine are increased in obesity and insulin resistance, but decrease after gastric bypass surgery resulting in weight loss and improved insulin sensitivity. Milk protein consumption results in postprandial hyperinsulinemia in obese subjects, increases body weight of overweight adolescents and may thus deteriorate pre-existing metabolic disturbances of obese, insulin resistant individuals.

Prostate cancer (PCa) is dependent on androgen receptor signaling and aberrations of the PI3K-Akt-mTORC1 pathway mediating excessive and sustained growth signaling. The nutrient-sensitive kinase mTORC1 is upregulated in nearly 100% of advanced human PCas. Oncogenic mTORC1 signaling activates key subsets of mRNAs that cooperate in distinct steps of PCa initiation and progression. Epidemiological evidence points to increased dairy protein consumption as a major dietary risk factor for the development of PCa. mTORC1 is a master regulator of protein synthesis, lipid synthesis and autophagy pathways that couple nutrient sensing to cell growth and cancer. This review provides evidence that PCa initiation and progression are promoted by cow's milk, but not human milk, stimulation of mTORC1 signaling. Mammalian milk is presented as an endocrine signaling system, which activates mTORC1, promotes cell growth and proliferation and suppresses autophagy. Naturally, milk-mediated mTORC1 signaling is restricted only to the postnatal growth phase of mammals. However, persistent consumption of cow's milk proteins in humans provide highly insulinotropic branched-chain amino acids (BCAAs) provided by milk's fast hydrolysable whey proteins, which elevate postprandial plasma insulin levels, and increase hepatic IGF-1 plasma concentrations by casein-derived amino acids. BCAAs, insulin and IGF-1 are pivotal activating signals of mTORC1. Increased cow's milk protein-mediated mTORC1 signaling along with constant exposure to commercial cow's milk estrogens derived from pregnant cows may explain the observed association between high dairy consumption and increased risk of PCa in Westernized societies. As well-balanced mTORC1-signaling plays an important role in appropriate prostate morphogenesis and differentiation, exaggerated mTORC1-signaling by high cow's milk consumption predominantly during critical growth phases of prostate development and differentiation may exert long-term adverse eff

This research discusses shrinkage and the development of mechanical properties in mortars made of cement, lime and sand 1:1:6 (volume), and in compositions with varying content of lime. Technology innovation was sought for in what concerns laboratory tests similar to real rendering conditions. The tests have been carried out in plaque specimens 15 and 25 mm thick. Factors such as mortar composition, water absorption through the basis and mortar/basis adherence, have been taken into account when analysing shrinkage in 400 mm x 150 mm specimens, as well as flexural strength and elasticity modulus. The mechanical tests have been carried out in plaques 200 mm x 75 mm, and the displacement in the centre of the specimen has been measured during loading for calculating elasticity modulus. The porosity of mortars has also been observed through the technique of mercury intrusion. The set of tests in the research showed the importance of laboratory simulation of real rendering conditions., A presente pesquisa aborda a retração e o desenvolvimento de propriedades mecânicas em argamassas mistas de revestimento de cimento, cal e areia, na proporção 1:1:6 em volume e em composições onde é variado o teor de cal. Procurando-se inovar na metodologia adotada, a retração foi observada nos estados fresco e endurecido, em corpos-de-prova de dimensões 400 mm x 150 mm, de espessuras 15 e 25 mm. Os ensaios mecânicos de flexão foram realizados em placas de dimensões 200 mm x 75 mm, espessura 15 mm, medindo-se o deslocamento no meio do corpo-de-prova, durante o carregamento, para o cálculo do módulo de deformação. Sobre os resultados dos ensaios foi analisada a influência dos fatores composição da argamassa, sucção de água pelo substrato e aderência argamassa/substrato. Observou-se também a porosimetria das argamassas com a técnica de intrusão de mercúrio. O conjunto de ensaios da pesquisa mostrou a importância da simulação em laboratório de condições de aplicação da argamassa de revestimento existentes em obra.

Partial view of exterior, from adjacent street, http://name.umdl.umich.edu/IC-UMMU-X-09-02871%5D09_02871, https://quod.lib.umich.edu/cgi/i/image/api/thumb/ummu/09-02871/09_02871/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. These materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Library Information Technology.; William Muschenheim, https://www.lib.umich.edu/about-us/policies/copyright-policy

Partial view of exterior, from adjacent street, http://name.umdl.umich.edu/IC-UMMU-X-09-02871%5D09_02871, https://quod.lib.umich.edu/cgi/i/image/api/thumb/ummu/09-02871/09_02871/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. These materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Library Information Technology.; William Muschenheim, https://www.lib.umich.edu/about-us/policies/copyright-policy