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This paper empirically analyses whether post-global financial crisis regulatory reforms have created appropriate incentives to voluntarily centrally clear over-the-counter (OTC) derivative contracts. We use confidential European trade repository data on single-name sovereign credit default swap (CDS) transactions and show that both seller and buyer manage counterparty exposures and capital costs, strategically choosing to clear when the counterparty is riskier. The clearing incentives seem particularly responsive to seller credit risk, which is in line with the notion that counterparty credit risk (CCR) is asymmetric in CDS contracts. The riskiness of the underlying reference entity also impacts the decision to clear as it affects both CCR capital charges for OTC contracts and central counterparty clearing house (CCP) margins for cleared contracts. Lastly, we find evidence that when a transaction helps netting positions with the CCP and hence lower margins, the likelihood of clearing is higher.

The link between pain severity, depressive symptomatology and catastrophizing among women with endometriosis is still under-investigated. The aim of this study was to (i) evaluate differences in depressive symptomatology between women with and without endometriosis; (ii) investigate if pain severity is associated with depressive symptoms; and (iii) test if catastrophizing moderates the link between these two variables. A total of 172 women with a diagnosis of endometriosis and 62 healthy controls volunteered for this cross-sectional study. Depressive symptomatology, pain severity, and catastrophizing were assessed. Compared to healthy controls, women with endometriosis were more likely to score above the cutoff for depressive symptomatology, with 60.5% of the latter being classified as having a subthreshold depression or minor depression and 15.7% as having moderate or severe major depression. Pain severity was significantly associated with depressive symptoms even after controlling for several covariates. Finally, the moderation model suggested that among patients with endometriosis, the relationship between pain severity and depressive symptomatology depended on the level of catastrophizing, with this association being stronger for high levels of the moderator. Mental health practitioners working with women with endometriosis may consider those who report high levels of pain severity and of catastrophizing at high risk of depression and are advised to promote adaptive coping strategies among patients to foster a better adaptation to this chronic disease.

Background & Aims: Obeticholic acid (OCA) has recently been restricted in patients with primary biliary cholangitis (PBC) with “advanced cirrhosis” because of its narrow therapeutic index. We aimed to better define the predicting factors of hepatic serious adverse events (SAEs) and non-response in cirrhotic patients undergoing OCA therapy. Methods: Safety and efficacy of treatment were evaluated in a cohort of consecutive PBC cirrhotic patients started with OCA. OCA response was evaluated according to the Poise criteria. Risk factors for hepatic SAEs and non-response were reported as risk ratios (RR) with 95% confidence intervals (CIs). Results: One hundred PBC cirrhotics were included, 97 Child-Pugh class A and 3 class B. Thirty-one had oesophageal varices and 5 had a history of ascites. Thirty-three per cent and 32% of patients achieved a biochemical response at 6 and 12 months respectively. Male sex (adjusted-RR 1.75, 95%CI 1.42–2.12), INR (1.37, 1.00–1.87), Child-Pugh score (1.79, 1.28–2.50), MELD (1.17, 1.04–1.30) and bilirubin (1.83, 1.11–3.01) were independently associated with non-response to OCA. Twenty-two patients discontinued OCA within 12 months: 10 for pruritus, 9 for hepatic SAEs (5 for jaundice and/or ascitic decompensation; 4 for upper digestive bleeding). INR (adjusted-RR 1.91, 95%CI 1.10–3.36), lower albumin levels (0.18, 0.06–0.51), Child-Pugh score (2.43, 1.50–4.04), history of ascites (3.5, 1.85–6.5) and bilirubin (1.30, 1.05–1.56), were associated with hepatic SAEs. A total bilirubin≥1.4 mg/dl at baseline was the most accurate biochemical predictor of hepatic SAEs under OCA. Conclusions: An accurate baseline assessment is crucial to select cirrhotic patients who can benefit from OCA. Although OCA is effective in one third of cirrhotics, bilirubin level ≥1.4 mg/dl should discourage from its use.

Sixty women with a diagnosis of endometriosis (30 with low pain severity - LP; 30 with high pain severity - HP) were evaluated at study entry (T0) and after three months (T1). At T0 they were compared for different psychological dimensions to sixty-two age-paired healthy women (CG). HP group had significantly higher scores on depressive symptomatology, sexual distress, and catastrophizing than CG, and higher scores on worry traits than LP. Metacognitive beliefs predicted sexual distress at T1, over and above pain severity. Pain affects different domains of mental health in this population. Coping strategies, metacognitive beliefs, and worry traits may modulate pain experience and psychological distress.

Literature about the impact of infertility and endometriosis on Quality of Life (QoL) is scarce and needs further investigation. Our aim was to deeply investigate the QoL of women with diagnoses of both endometriosis and infertility with failed Assisted Reproductive Treatments (ART). We conducted a concurrent mixed-method study composed of both quantitative and qualitative surveys. The quantitative survey included 22 women who completed the FertiQoL. The qualitative survey included 15 of them who provided written answers to open-ended questions aimed at deeply exploring their QoL. Data were initially analyzed separately and then combined in a meta-matrix. From the quantitative survey emerged that women at higher risk for low QoL were those who have experienced previous spontaneous miscarriages and that the domains of the FertiQoL related to fertility treatment (i.e. increased pain severity, disturbed daily life routine, and dissatisfaction with services) were the most critical. From the Interpretative Phenomenological Analysis (IPA) of qualitative survey, narrations about the physical, relational, social, emotional-cognitive, and behavioural impact of the diseases emerged. Mixed findings showed that the QoL of this population was scarce and that different levels (the inner world, the behaviours, the relational context, and the environmental context) are strictly connected and interact between them in influencing QoL. Multi-level preventive or supportive programs (with specific attention to pain experience, coping strategies, quality of services and governmental support) are required for this population.

The current socio-economic scenario has promoted telecommuting at home for a significant number of workers, mainly due to the sanitary situation experienced and the improvement in communication technologies. However, the work context at home is often not suitable for teleworking since the environmental conditions are not usually adequate for good performance and the wellness of workers. The received light, both in quantity and in spectrum, affects the visual comfort and performance of the worker through the regulation of the circadian stimulus. Accordingly, the objective of the present study is to ascertain the influence of natural daylight on the performance and health of teleworkers, considering a room at home analyzed in three different locations, two orientations, two-time schedules, and two window shapes. The impact of natural light on health was assessed using the Circadian Stimulus Autonomy (CSA) produced by daylight during the morning, while the illuminance requirement was defined in accordance with the Daylight Autonomy (DA). The results obtained were contrasted with a real test cell under real daylight conditions. The conclusions of this study serve to determine the suitable windowed areas of the analyzed room where teleworkers obtain the appropriate lighting performance and well-being.

Background & aims: Obeticholic acid (OCA) is the second-line treatment approved for patients with primary biliary cholangitis (PBC) and an inadequate response or intolerance to ursodeoxycholic acid. We aimed to evaluate the effectiveness and safety of OCA under real-world conditions. Methods: Patients were recruited into the Italian PBC Registry, a multicentre, observational cohort study that monitors patients with PBC at national level. The primary endpoint was the biochemical response according to Poise criteria; the secondary endpoint was the biochemical response according to normal range criteria, defined as normal levels of bilirubin, alkaline phosphatase (ALP), and alanine aminotransferase (ALT) at 12 months. Safety and tolerability were also assessed. Results: We analysed 191 patients until at least 12 months of follow-up. Median age was 57 years, 94% female, 61 (32%) had cirrhosis, 28 (15%) had histologically proven overlap with autoimmune hepatitis (PBC-AIH). At 12 months, significant median reductions of ALP (-32.3%), ALT (-31.4%), and bilirubin (-11.2%) were observed. Response rates were 42.9% according to Poise criteria, and 11% by normal range criteria. Patients with cirrhosis had lower response than patients without cirrhosis (29.5% vs. 49.2%, p = 0.01), owing to a higher rate of OCA discontinuation (30% vs. 12%, p = 0.004), although with similar ALP reduction (29.4% vs. 34%, p = 0.53). Overlap PBC-AIH had a similar response to pure PBC (46.4% vs. 42.3%, p = 0.68), with higher ALT reduction at 6 months (-38% vs. -29%, p = 0.04). Thirty-three patients (17%) prematurely discontinued OCA because of adverse events, of whom 11 experienced serious adverse events. Treatment-induced pruritus was the leading cause of OCA discontinuation (67%). Conclusions: Effectiveness and safety of OCA under real-world conditions mirror those in the Poise trial. Patients with cirrhosis had lower tolerability. Overlap PBC-AIH showed higher ALT reduction at 6 months compare

Purpose: To investigate the glycated albumin (GA) introduction implications, as an add-on strategy to traditional glycemic control (Hb1Ac and fasting plasma glucose – FPG) instruments, considering insulin-naïve individuals with type 2 diabetes mellitus (T2DM), treated with oral therapies. Methods: A Health Technology Assessment was conducted in Italy, as a multi-dimensional approach useful to validate any innovative technology. The HTA dimensions, derived from the EUnetHTA Core Model, were deployed by means of literature evidence, health economics tools and qualitative questionnaires, filled-in by 15 professionals. Results: Literature stated that the GA introduction could lead to a higher number of individuals achieving therapeutic success after 3 months of therapy (97.0% vs 71.6% without GA). From an economic point of view, considering a projection of 1,955,447 T2DM insulin-naïve individuals, potentially treated with oral therapy, GA introduction would imply fewer individuals requiring a therapy switch (− 89.44%), with a 1.06% in costs reduction, on annual basis, thus being also the preferable solution from a cost-effectiveness perspective (cost-effectiveness value: 237.74 vs 325.53). According to experts opinions, lower perceptions on GA emerged with regard to equity aspects (0.13 vs 0.72, p-value> 0.05), whereas it would improve both individuals (2.17 vs 1.33, p-value=0.000) and caregivers quality of life (1.50 vs 0.83, p-value=0.000). Even if in the short term, GA required additional investments in training courses (− 0.80 vs 0.10, p-value = 0.036), in the long run, GA could become the preferable technology (0.30 vs 0.01, p-value=0.018) from an organisational perspective. Conclusion: Adding GA to traditional glycaemic control instruments could improve the clinical pathway of individuals with T2DM, leading to economic and organisational advantages for both hospitals and National Healthcare Systems.

Insuline-Naaïve type 2 diabetic patients: a multidimensional evaluation on the role of glycated albumin Introduction: glycated Albumin (GA) is an innovative glycemic marker, that could be used in the clinical practice, as an add-on strategy, to the traditional glycemic monitoring systems, such as glycated haemoglobin (Hb1Ac) and fasting plasma glucose (FPG). The study aims at presenting the results of a multidimensional analysis conducted in Italy, exploring the main clinical, economic, ethical, social and organizational implications, related to the introduction of GA. Methods: an Health Technology Assessment (HTA) approach was implemented. The analysis considered the Italian National Healthcare Service (NHS) perspective, and assumed a 12-month time horizon, focusing on type 2 diabetes patients insulin-naïve, assuming oral therapy. The 9 HTA dimensions (derived from the Core Model developed by the European Network of HTA – EUnetHTA) were deployed, considering scientific evidence, health economics tools and qualitative approaches, through the administration of specific questionnaires to 15 diabetes experts. Results: literature reported better GA safety and efficacy profiles, thus being a predictor of the relative risk for diabetes complications development, and increasing the therapeutic success after 3 months of therapy (97.0% versus 71.6%). From an economic point of view, GA introduction resulted in an economic advantage of 1.06% and in a better tradeoff between costs sustained and efficacy gained. Considering a 7-item Likert Scale (ranging from -3 to +3), negative perceptions emerged with regard to equity aspects (0.13 versus 0.72) due to GA limited accessibility, whereas it would improve both patients (2.17 versus 1.33) and care givers (1.50 versus 0.83) quality of life. In the short term, GA required training courses and equipment update, whereas, in the long term, it could be considered the preferable solution from an organizational perspective (0.30 Conclusi

Lesi karies dan lesi non karies merupakan salah satu bentuk kerusakan pada jaringan keras gigi. Erosi gigi merupakan salah satu lesi non karies yang dapat disebabkan oleh minuman ringan (softdrink). Lesi karies dan erosi gigi terjadi karena adanya proses demineralisasi. Demineralisasi menyebabkan mineral yang terdapat pada struktur gigi larut dan jika keadaan ini terjadi secara berkelanjutan tanpa adanya proses remineralisasi akan menyebabkan mikroporositas pada permukaan gigi dan menurunnya kekerasan permukaan email gigi. Upaya untuk mencegah terjadinya kerusakan yang berlanjut pada struktur gigi dapat dilakukan dengan memberikan bahan yang berpotensi untuk membantu terjadinya proses remineralisasi gigi. Salah satu bahan yang dapat membantu terjadinya remineralisasi gigi yaitu susu kedelai (Glycine max (L.) Merill). Susu kedelai merupakan salah satu bentuk olahan dari kacang kedelai yang memiliki protein cukup tinggi dan harga relatif murah. Kandungan utama dari susu kedelai yaitu kalsium dan fosfor. Tujuan penulisan literatur riview ini adalah untuk mengetahui efektivitas susu kedelai murni (Glycine max (L.) Merill) sebagai alternatif bahan remineralisasi gigi. Metode studi dilakukan dengan cara mengumpulkan dan menelaah berbagai jurnal, literatur riview, dan buku mengenai susu kedelai, kalsium, remineralisasi, dan demineralisasi gigi. Literatur riview dilakukan dengan mencari kesamaan, ketidaksamaan, memberikan pandangan, membandingkan, dan menyimpulkan dari jurnal yang didapatkan. Remineralisasi salah satunya dapat terjadi karena adanya ion Ca2+ dan PO43- yang cukup sehingga ion ini dapat berdifusi kedalam permukaan gigi dan terjadi rebuilding kristal hidroksiapatit yang larut sehingga dapat meningkatkan kekerasan permukaan gigi. Kesimpulan dari skripsi ini yaitu kalsium dan fosfor yang terdapat pada susu kedelai (Glycine max (L.) Merill) efektif untuk meningkatkan remineralisasi gigi dengan indikator terjadinya peningkatan kekerasan permukaan email gigi.

L’industria, con il suo ideale di progresso scientifico-tecnologico, obbliga i letterati del Novecento ad abbattere i tradizionali steccati tra le «due culture» e riflettere sul significato della modernità. La storia dell’Italia passa per la progettualità di aziende come Eni, Olivetti e Pirelli, che con i loro house organs hanno elaborato una cultura dell’innovazione e creato una sinergia tra capitale e umanesimo. Accanto agli intellettuali «apocalittici», per dirla con Umberto Eco, che evidenziano le criticità dell’oltranza produttiva e delle nuove forme di colonialismo, si distingue una schiera di «integrati» in dialogo con le possibilità offerte dallo sviluppo tecnologico. Persino la veste dell’oggetto letterario ne risulta modificata: editoria, design e ricerca grafica si alleano all’incrocio tra sperimentazioni d’avanguardia, contestazione politica e cultura pop. I contributi del volume Fabrica in fabula si propongono di scandagliare le diverse questioni in gioco, aggiornando il dibattito intorno a un tema nevralgico del mondo contemporaneo.

Tanaman Johar (Cassia siamea Lamk.) merupakan salah satu tanaman yang diketahui berkhasiat sebagai antimikroba dan antioksidan karena memiliki kandungan senyawa flavonoid, alkaloid, tannin, saponin, dan terpenoid. Tanaman Johar telah banyak dimanfaatkan sebagai obat tradisional seperti anti kanker, luka, diare dan penyakit infeksi lainnya. Penelitian terdahulu mengenai ekstrak etanol daun Johar menunjukkan adanya aktivitas antimikroba dan antioksidan, sedangkan penelitian tentang daun muda dan bunga dari Johar dengan cara ekstraksi segar dan seduhan belum pernah dilaporkan. Penelitian ini bertujuan untuk mengetahui potensi antimikroba dan aktivitas antioksidan ekstrak daun muda dan bunga Johar. Metode yang digunakan pada penelitian adalah eksperimen pola nested 2 faktor dengan 3 kali pengulangan. Hasil penelitian menunjukkan bahwa zona hambat terbesar terhadap Staphylococcus aureus dan Escherichia coli diperoleh dari perlakuan ekstrak segar daun muda dengan rata-rata zona hambat (13.3 mm) dan (7.7 mm). KHM Johar terhadap E. coli dan S. aureus yaitu 12,5%, sedangkan KHM untuk C. albicans dan nilai KBM untuk semua mikroba uji tidak ditemukan. Aktivitas antioksidan dan polifenol tertinggi Johar terdapat pada ekstrak segar daun muda dengan nilai IC50 31.09 dan 73.57 mgGAE/G.

Objective:The impact of pain on quality of life and mental health of women with endometriosis is well known. However, the role that personality traits and coping strategies might have in influencing pain experience is still poorly understood and was the chief purpose of this study.Materials and Methods:We conducted a mixed-method sequential explanatory study, composed of a quantitative survey followed by qualitative interviews. The first quantitative phase included 162 women with endometriosis who completed a battery of validated questionnaires. After statistical analysis, a semistructured qualitative interview has been developed and conducted with 6 of them, in order to help explain findings obtained in the first phase. Thereafter, both analyses were combined in a metamatrix.Results:From the metamatrix, it emerged that acute pain experience, fear of its occurrence, its unpredictability, and control difficulties are the main concerns of women with endometriosis. Worry trait characteristics (ie, the need for control, anticipatory anxiety, intrusive worry thoughts) and maladaptive thoughts such as coping strategies (ie, self-blame, rumination, catastrophizing) were common in this sample and seem to indirectly affect pain experience. Indeed, the unsuccessful struggle in controlling pain reinforces negative thoughts/beliefs and feelings of powerlessness, leading, in turn, to psychological distress and higher pain experience.Discussion:From the study emerged a model of onset and maintenance of acute pain in women with endometriosis. Findings have clinical implications for the medical team and psychologists.

Objective: Infertility has a severe impact on quality of life and mental health. This condition could be exacerbated by the existence of comorbid medical disease, like endometriosis. The aim of this critical narrative review is the examination of the state of the art about the quality of life and mental health in infertile women with endometriosis. Methods: We performed a rigorous and systematic search for studies on multiple electronic databases. A total of 6 papers were included in the review and were subjected to interpretative and critical narrative synthesis. Results and Discussion: Major findings are resumed in the following points: (a) infertile women with endometriosis when compared to infertile ones without endometriosis show higher depression, stress perception, and anxiety, and lower general quality of life; (b) quality of life specifically related to infertility is similar among women with and without endometriosis and seems to be related to personality and beliefs factors; (c) giving birth to a child is related to better mental quality of life; (d) during assisted reproductive treatment (ART) stimulation, infertile women with endometriosis have a decrease of dysmenorrhea and dyspareunia; (e) satisfaction of ART is related to the number of attempts, treatment accomplishment and pregnancy test outcomes. Clinical implications of these findings and suggestions for future researches were discussed. Conclusion: Concluding, it is crucial to assess the psychological factors related to endometriosis and infertility to reduce the impact of these diseases on quality of life and mental health, provide adequate support to these patients, improve their satisfaction and increase the change to get pregnant.

The study aims to evaluate the effectiveness of foot revascularization in persons with diabetic foot ulcers (DFUs) and below-the-ankle (BTA) arterial disease. Consecutive patients referred for a new active ischaemic DFU requiring lower limb revascularization were considered. Among those, only patients with a BTA arterial disease were included. Revascularization procedures were retrospectively analysed: in the case of successful foot revascularization (recanalization of pedal artery, or plantar arteries or both) or not, patients were respectively divided in two groups, successful foot perfusion (SFP) and failed foot perfusion (FFP). Healing, minor and major amputation at 12 months of follow-up were evaluated and compared. Eighty patients (80) were included. The mean age was 70.5 ± 10.9 years, 55 (68.7%) were male, 72 (90%) were affected by type 2 diabetes with a mean duration of 22.7 ± 11.3 years. Overall 45 (56.2%) patients healed, 47 (58.7%) had minor amputation and 13 (16.2%) major amputation. Outcomes for SFP and FFP were respectively: healing (89.3 vs. 9.1%, p < 0.0001), minor amputation (44.7 vs. 78.8%, p = 0.0001), major amputation (2.1 vs. 36.3%, p < 0.0001). Failed foot revascularization resulted an independent predictor of non-healing, minor amputation, and major amputation. Foot revascularization is mandatory to achieve healing and avoid major amputation in persons with ischaemic DFU and BTA arterial disease., Depto. de Enfermería, Fac. de Enfermería, Fisioterapia y Podología, TRUE, pub

Background: The Coronavirus-2 (SARS-CoV-2) pandemic has generated negative psychological effects in the whole population. Our objective was to describe this impact on health care workers of Argentina. Methods: This was a cross-sectional, multicenter study evaluating anxiety, depression, burnout, and lifestyle and alterations in lifestyle and interpersonal relationships by means of an anonymous survey carried out from June to September 2020. Results: A total of 1221 healthcare workers, with median age 42 years (IQR 34.5-52) and 65% women were surveyed for the study. Among them, 77.2% lived in the Autonomous City of Buenos Aires and the Buenos Aires province; 66.7% were specialist physicians or nurses, 41.1% were clinical specialists, 29.8% intensive care or coronary care unit physicians and 10.2% kinesiologists or nurses. In 51.8% of cases, healthcare workers reported that all biosafety recommendations were not met in their workplaces. Anxiety was detected in 40.5% of cases, major depression in 22.1% (4.5% referred frequent suicidal ideation), minor depression in10.9% and burnout in 38.7%. Smoking increased in 9.4% of healthcare workers and alcohol in 22%; 62.1% declared worse sleep quality, 50.2% reduced physical activity, 18.4% worsened their affective relationship and 40.4% suffered discrimination for being health workers. Conclusion: The Coronavirus pandemic has produced an increase in depression, anxiety, burnout and unhealthy lifestyle habits in healthcare workers surveyed in Argentina., Introducción: La pandemia por el Coronavirus-2 (SARS-CoV-2) generó efectos psicológicos negativos en toda la población. Nuestro objetivo es describir ese impacto en los trabajadores de la salud de la República Argentina. Material y métodos: Estudio de corte transversal, multicéntrico, desde junio a septiembre de 2020, que evaluó ansiedad, depresión, burnout, alteraciones de los estilos de vida y las relaciones personales mediante una encuesta anónima. Resultados: Se encuestó a 1221 trabajadores de la salud, con una mediana de edad de 42 años (RIQ 34,5-52), 65,9% eran mujeres. El 77,2% residía en la Ciudad Autónoma de Buenos Aires y en la provincia de Buenos Aires. El 66,7% eran médicos o enfermeros especialistas, el 41,1%, de especialidades clínicas, 29,8% médicos de unidades de cuidados intensivos o unidades coronarias y 10,2% kinesiólogos o enfermeros. El 51,8% manifestó que en su trabajo no se cumplían todas las recomendaciones de bioseguridad. Se detectó el 40,5% de ansiedad, 22,1% de depresión mayor (4,5% refirió ideación suicida frecuente), 10,9% depresión menor y 38,7% burnout. El 9,4% aumentó el consumo tabáquico y el 22% el de alcohol; el 62,1% empeoró su calidad de sueño, el 50,2% redujo la realización de ejercicio físico, y el 18,4% deterioró su relación afectiva. El 40,4% sufrió discriminación por ser personal de salud. Conclusión: La pandemia por Coronavirus ha generado un aumento de depresión, ansiedad, burnout y hábitos de vida no saludables en los trabajadores de la salud de Argentina encuestados.

[eng] Even though plants represent an essential part of our lives offering exploitational, supporting and cultural services, we know very little about the biology of the rarest and most threatened plant species, and even less about their conservation status. Rapid changes in the environment and climate, today more pronounced than ever, affect their fitness and distribution causing rapid species declines, sometimes even before they had been discovered. Despite the high goals set by conservationists to protect native plants from further degradation and extinction, the initiatives for the conservation of threatened species in Europe are scattered and have not yielded the desired results. The main aim of this Action is to improve plant conservation in Europe through the establishment of a network of scientists and other stakeholders who deal with different aspects of plant conservation, from plant taxonomy, ecology, conservation genetics, conservation physiology and reproductive biology to protected area's managers, not forgetting social scientists, who are crucial when dealing with the general public.

Daniel Cassuto,1 Giovanni Pellacani,2 Antonello Tateo,1 Ofir Artzi,3 Fabio Massimo Ingallina,4 Giovanni Salti,5 Elena Rossi,2 Arturo Lanzarotti,6 Malika Laouedj,7 Nicolas Dapis,7 Gilberto Bellia8 1Private Practice, Milan, Italy; 2Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy; 3Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; 4Private Practice, Catania, Italy; 5Private Practice, Florence, Italy; 6IBSA Institut Biochimique SA, Lugano, Switzerland; 7Quantificare SA, Valbonne, France; 8IBSA Farmaceutici Italia, Lodi, ItalyCorrespondence: Gilberto BelliaIBSA Farmaceutici Italia, Lodi, ItalyEmail gilberto.bellia@ibsa.itObjective: To describe the development and validation of the 5-grade photographic IBSA inner upper arm scale.Methods: From 2 real-life pictures, a scale made up of 5 morphed images showing increasing severity of inner upper arm laxity was created. For validation, a set of 50 images (half of which real and the other morphed) was developed and sent to 5 trained physicians in two rounds 30 days apart. Raters’ task was to make a selection of each image according to the given scale. Inter-rater and intra-rater reliability were evaluated in both rounds.Results: As to intra-rater reliability, single-rater kappa scores between 0.74 and 1.00 and a global kappa score of 0.846 were observed, while inter-rater agreement was calculated with intra-class correlation coefficient reporting scores higher than 0.91, which indicate excellent reliability.Conclusion: IBSA inner upper arm laxity scale proved to be a validated and reliable tool.Keywords: photographic scale, upper inner arm, laxity, aesthetic medicine, scale validation, scale development

Daniel Cassuto,1,2 Gilberto Bellia,3 Chiara Schiraldi4 1Private Practice, Tel Aviv, Israel; 2Private Practice, Milan, Italy; 3IBSA Farmaceutici Italia Srl, Lodi, Italy; 4Department of Experimental Medicine, School of Medicine, University of Campania “Luigi Vanvitelli”, Naples, ItalyCorrespondence: Daniel Cassuto Email daniel.cassuto@gmail.comAbstract: Hyaluronic acid (HA)-based injectable filling agents are at the forefront of the current demand for noninvasive dermatological procedures for the correction of age-related soft tissue defects. The present review aims to summarize currently available HA-based products and critically appraise their differences in rheological nature and clinical application. Linear HA (LHA) gels may be supplemented with amino acids, lipoic acid, vitamins, nucleosides, or minerals for synergistic antiaging and antioxidant benefits (polycomponent LHA). HA hydrogels can be generated via chemical or physical crosslinking, which increases their elasticity and decreases viscosity. The performance of crosslinked fillers depends on HA concentration, degree of crosslinking, elastic modulus, cohesivity, and type of crosslinking agent employed. PEG-crosslinked LHA displays improved elasticity and resistance to degradation, and lower swelling rates as compared to BDDE-crosslinked LHA. Physical crosslinking stabilizes HA hydrogels without employing exogenous chemical compounds or altering hyaluronans’ natural molecular structure. Thermally stabilized hybrid cooperative HA complexes (HCC) are a formulation of high- and low-molecular-weight (H-HA and L-HA) hyaluronans, achieving high HA concentration, low viscosity with optimal tissue diffusion, and a duration comparable to weakly cross-linked gel. Our critical analysis evidences the importance of understanding different fillers’ properties to assist physicians in selecting the most appropriate filler for specific uses and for predictable and sustainable results.Keywords: hyaluronic acid, filler

Even though plants represent an essential part of our lives offering exploitational, supporting and cultural services, we know very little about the biology of the rarest and most threatened plant species, and even less about their conservation status. Rapid changes in the environment and climate, today more pronounced than ever, affect their fitness and distribution causing rapid species declines, sometimes even before they had been discovered. Despite the high goals set by conservationists to protect native plants from further degradation and extinction, the initiatives for the conservation of threatened species in Europe are scattered and have not yielded the desired results. The main aim of this Action is to improve plant conservation in Europe through the establishment of a network of scientists and other stakeholders who deal with different aspects of plant conservation, from plant taxonomy, ecology, conservation genetics, conservation physiology and reproductive biology to protected area's managers, not forgetting social scientists, who are crucial when dealing with the general public.

Antonello Tateo,1 Gabriel Siquier-Dameto,2– 4 Ofir Artzi,5 Dalvi Humzah,6 Beatriz Molina,7 Ravi Jain,6 Arturo Lanzarotti,8 Malika Laouedj,9 Nicolas Dapis,10 Gilberto Bellia11 1Private Practice, Milan, Italy; 2Private Practice, Amsterdam, the Netherlands; 3Private Practice, Mallorca, Spain; 4Research Group of Clinical Anatomy, Embryology and Neuroscience (NEOMA), Department of Medical Sciences, Universitat de Girona (UdG), Girona, Spain; 5Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; 6Private Practice, London, UK; 7Private Practice, Bristol, UK; 8Research & Development, IBSA Institut Biochimique SA, Lugano, Switzerland; 9Clinical Operations, Quantificare SA, Valbonne, France; 10Business Development, Quantificare SA, Valbonne, France; 11Medical Affair, IBSA Farmaceutici Italia, Lodi, ItalyCorrespondence: Gilberto BelliaIBSA Farmaceutici Italia, Lodi, LO, ItalyEmail gilberto.bellia@ibsa.itObjective: To describe the development and validation of the 5-grade photographic IBSA Neck Laxity Scale.Methods: The scale was developed from 2 real images, which led to the creation of 5 morphed images, representing different degrees of severity of laxity of the neck. For validation, a set of 50 images (25 real and 25 morphed) was created and sent for evaluation to 6 trained raters (physicians) in 2 rounds, 1 month apart. Raters had to assess each image according to the 5-image scale. Inter-rater and intra-rater reliability in both rounds was evaluated.Results: As to intra-rater reliability, single rater kappa scores between 0.69 and 0.87, and a global kappa score of 0.78 were observed. Inter-rater agreement was measured by means of the intra-class correlation coefficient and scores higher than 0.85 were reported, indicating excellent reliability.Conclusion: IBSA Neck Laxity Scale is a validated and reliable scale.Keywords: photographic scale, neck, laxity, aesthetic medicine, scale validation, scale development

Lucrezia Ferrario,1 Fabrizio Schettini,1 Angelo Avogaro,2 Chiara Bellia,3 Federico Bertuzzi,4 Graziella Bonetti,5 Antonio Ceriello,6 Marcello Ciaccio,3,7 Massimiliano Corsi Romanelli,8,9 Elena Dozio,9 Luca Falqui,10 Angela Girelli,11 Antonio Nicolucci,12 Gianluca Perseghin,13,14 Mario Plebani,15 Umberto Valentini,11 Martina Zaninotto,15 Silvana Castaldi,9,16 Emanuela Foglia1 1Centre for Health Economics, Social and Health Care Management, Università Carlo Cattaneo - LIUC, Castellanza, Italy; 2Department of Medicine, University-Hospital of Padova, Padova, Italy; 3Section of Clinical Biochemistry and Clinical Molecular Medicine, Department of Biopathology and Medical Biotechnologies, University of Palermo, Palermo, Italy; 4Diabetology Unit, Grande Ospedale Metropolitano Niguarda Hospital, Milan, Italy; 5Department of Medicine Services, Valcamonica Hospital, Esine, Italy; 6Department of Cardiovascular and Metabolic Diseases, Multimedica Research Institute, Milan, Italy; 7Department of Laboratory Medicine, University-Hospital of Palermo, Palermo, Italy; 8Service of Laboratory Medicine 1-Clinical Pathology, Policlinico San Donato, Milan, Italy; 9Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy; 10Department of Medicine, Diabetes and Endocrinology, Multimedica Research Institute, Milan, Italy; 11Diabetes Care Unit, Spedali Civili Hospital, Brescia, Italy; 12Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy; 13Department of Medicine and Surgery, Università degli Studi di Milano Bicocca, Milan, Italy; 14Department of Medicine and Rehabilitation, Unit of Metabolic Medicine, Policlinico di Monza, Monza, Italy; 15Department of Laboratory Medicine, University-Hospital of Padova, Padova, Italy; 16Fondazione Ca’ Granda Ospedale Maggiore Policlinico Research Institute of Milano, Milano, ItalyCorrespondence: Lucrezia FerrarioCentre for Health Economics, Social and Health Care

Comment on the Italian Supreme Court Decision ‘‘Vespa’’

Case Note on the Italian Supreme Court Decision “Reti Televisive Italiane” (Urheberrechtlicher Schutz für TV-Formate)

Commento agli artt. 2342-2345, 2360, 2362, 2414bis, 2420 Cod. Civ., in Franzoni-Rolli-De Marzo (a cura di), Codice Civile commentato con dottrina e giurisprudenza, Tomo II - Libro V, VI (Artt. 2060-2969), Giappichelli, 2018

Nowadays, there is an in-depth debate about the suitability of daylight saving time. The shift of one hour during summer time allows a better use of daylighting reducing energy consumptions. However, the impact of daylight saving time on the human health has not been quantified in most of the scenarios. The aim of this study is to determine the impact of daylight saving time on the health of occupants (by calculating Circadian Stimulus Autonomy) and on the energy consumptions for lighting (by calculating Daylight Autonomy) in office buildings. A standard office is analyzed in eleven representative locations of Europe and for three different time schedules: with daylight saving time, with continuous winter time and with continuous summer time. Despite restricted to a specific case study, results provide elements useful to evaluate pros and cons in maintaining daylight saving time, confirming that they are strongly dependent on the geographical position and on the local luminous climate. It was demonstrated that, abolishing daylight saving time, maintaining the local time all the year (winter time), would determine a reduction of Daylight Autonomy generally lower than 6% and that this decrease would be more consistent for cities characterized by higher latitude. At the same time an increase of Circadian Stimulus Autonomy values would be obtained, more consistent for northern cities (maximum observed increment 16%). On the other hand, applying the one-hour shift for the entire year (summer time) would not determine benefits in terms of energy savings nor of impact on circadian system.

Latar Belakang : Inflamasi merupakan respons imun bawaan bertujuan mengeliminasi antigen dan mencegah penyebarannya ke jaringan sehat. Rimpang jahe dan bangle merupakan tanaman obat Indonesia yang secara empiris digunakan sebagai ramuan obat. Kedua rimpang tersebut masing-masing memiliki potensi sebagai antiinflamasi, namun aktivitas kombinasinya belum diketahui. Ekstrak yang dikombinasikan diharapkan mampu berefek sinergis sebagai antiinflamasi. Oleh karena itu, penelitian ini bertujuan mengetahui aktivitas antiinflamasi pada kombinasi ekstraketanol jahe dan bangle. Metodologi : Jahe dan bangle secara terpisah diekstraksi menggunakan metode maserasi dengan pelarut etanol 96%, lalu dicuci menggunakan n-heksan. Evaluasi aktivitas antiinflamasi menggunakan metode rat hit paw udema dan tes motilitas. Seluruh kontrol dan ekstrak diberikan peroral dengan dosis Na CMC 1%, natrium diklofenak 4,5 mg/kg BB, ekstrak etanol jahe (EEJ) 200 mg/kg BB, ekstrak etanol bangle (EEB) 400 mg/kg BB, dan kombinasi ekstrak etanol jahe dan bangle (KEEJB) 100:200 mg/kg BB. Selanjutnya, data % daya antiinflamasi (DAI) dan skormotilitas dianalisis ANOVA dan LSD. Hasil : Persentase DAI pada ND, EEB, EEJ, dan KEEJB berturut-turut sebesar 13%, 20%, 31%, dan 36%. Sementara itu, hasil motility score berturut-turut sebesar 1,43, 1,26, 1,29, dan 1,29. Analisis statistik menunjukkan bahwa kelompok kombinasi ekstrak etanol jahe dan bangle tidak memiliki perbedaan bermakna dengan kelompok kontrol negatif dan natrium diklofenak (p>0,05). Kesimpulan : Berdasarkan hasil % DAI dan skor motilitas, kombinasi ekstrak etanol rimpang jahe dan bangle memiliki aktivitas antiinflamasi yang setara dengan natrium diklofenak.

Accurate neutron capture cross section data for minor actinides (MAs) are required to estimate the production and transmutation rates of MAs in light water reactors with a high burnup, critical fast reactors like Gen-IV systems and other innovative reactor systems such as accelerator driven systems (ADS). Capture reactions of 244Cm open the path for the formation of heavier Cm isotopes and of heavier elements such as Bk and Cf. In addition, 244Cm shares nearly 50% of the total actinide decay heat in irradiated reactor fuels with a high burnup, even after three years of cooling. Experimental data for this isotope are very scarce due to the difficulties of providing isotopically enriched samples and because the high intrinsic activity of the samples requires the use of neutron facilities with high instantaneous flux. The only two previous experimental data sets for this neutron capture cross section have been obtained in 1969 using a nuclear explosion and, more recently, at J-PARC in 2010. The neutron capture cross sections have been measured at n_TOF with the same samples that the previous experiments in J-PARC. The samples were measured at n_TOF Experimental Area 2 (EAR-2) with three C6D6 detectors and also in Experimental Area 1 (EAR-1) with the Total Absorption Calorimeter (TAC). Preliminary results assessing the quality and limitations of these new experimental datasets are presented for the experiments in both areas. Preliminary yields of both measurements will be compared with evaluated libraries for the first time.

We show that High Frequency Traders (HFTs) are not beneficial to the stock market during flash crashes. They actually consume liquidity when it is most needed, even when they are rewarded by the exchange to provide immediacy. The behavior of HFTs exacerbate the transient price impact, unrelated to fundamentals, typically observed during a flash crash. Slow traders provide liquidity instead of HFTs, taking advantage of the discounted price. We thus uncover a trade-o↵ between the greater liquidity and efficiency provided by HFTs in normal times, and the disruptive consequences of their trading activity during distressed times.

Background: Domestic violence (DV) and sexually transmitted infections (STIs) are major healthcare issues, with known detrimental health outcomes. Though evidence confirms that individuals who experience DV are at a greater risk of acquiring STIs, there is paucity in the literature focused on nurses’ knowledge of the relationship between DV and STIs. Aim: This study aimed to explore Registered Nurses’ (RNs’) knowledge of the association between DV and STIs. Methods: The study was approved by the relevant Human Research Ethics Committee. Data were collected via face-to-face, telephone and computer-mediated interviews guided by a semi-structured interview schedule. The interviews were digitally recorded, transcribed verbatim, and thematically analysed using Braun and Clarke (2006). Findings: Three themes emerged from the data: Knowledge of DV/STIs: My knowledge is just general; Education: I feel I need a bit more education, and Knowledge of Association between DV/STIs: I really don't know the answer. Discussion: The study found that as a result of participants having a lack of education and knowledge associated with DV and STIs, they were unable to identify and articulate a relationship between DV and STIs. Because of these knowledge deficits participants did not consider transmission of STIs in an intimate relationship where DV could exist. Conclusion: Our study suggests that nurses are unaware of the increased risk for STI acquisition within the context of DV. This lack of awareness would no doubt lead to missed opportunitites for screening and provision of appropriate care.

Elisabetta Garavaglia,1 Cinzia Sala,2 Manuela Busato,1 Gilberto Bellia,3 Nadia Tamburlin,1 Alberto Massirone1 1Agorà, Italian Scientific Society of Aesthetic Medicine, Milan, Italy; 2Private Practice, Milan, Italy; 3Medical Affair, IBSA Farmaceutici, Italia Srl, Lodi, ItalyCorrespondence: Elisabetta GaravagliaAgorà, Italian Scientific Society of Aesthetic Medicine, Piazza Caiazzo 1, Milan 20124, ItalyTel +39 3382731072Email Garavaglia.Elisabetta@hsr.itObjective: Evaluation of the impact of hyaluronan hybrid cooperative complex (HCC) injections in premenopausal and postmenopausal Italian women affected by vulvar-vaginal atrophy (VVA), one of the symptoms of genitourinary syndrome (GS), on self-reported quality-of-life, vaginal symptoms, and sexual activity, as well as treatment side-effects.Methods: We surveyed a sample of 26 women affected by VVA with follow-up at 6 and 12 months. Deep intradermal injections of HCC were delivered at 1-month intervals. Evaluation of the treatment impacting the VVA patients was assessed by three international validated questionnaires (Visual Analogic Scale, VAS; health-related quality-of-life test, SF12; Female Sexual Function Index, FSFI). The statistically significant differences between pre- and after-treatment responses have been assessed by Wilcoxon signed-rank test and repeated measures ANOVA test.Results: At 6– 12-month follow-up, general quality-of-life (SF12) did not show any significant improvement. On the contrary, VVA patients showed significant improvements of genital symptoms (VAS) and sexual function (FSFI). Global FSFI score increased by 58% and evidenced important satisfaction (P≤ 0.05).Conclusion: Vestibular HCC injection is an office, safe, fast, not expensive, and reproducible procedure effective in vulvar-vaginal atrophy. This study can be used as a pilot for future trials.Keywords: hyaluronic acid, bio-stimulation, vulvovaginal atrophy, genito-urinary syndrome of menopause

Adele Sparavigna,1 Annalisa La Gatta,2 Gilberto Bellia,3 Laura La Penna,1 Andrea Maria Giori,4 Gabriele Vecchi,4 Beatrice Tenconi,1 Chiara Schiraldi2 1DERMING Srl., Milan, Italy; 2Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, School of Medicine, University of Campania “L. Vanvitelli”, Naples, Italy; 3Medical Affairs, IBSA Farmaceutici Italia, Lodi, Italy; 4Research and Development, IBSA Farmaceutici Italia, Lodi, ItalyCorrespondence: Adele SparavignaDERMING Srl, Clinical Research and Bioengineering Institute, Via Valassina, 24, Milano, ItalyTel +39 2 2318 3475Email adele.sparavigna@derming.comPurpose: The primary aim of this study was to evaluate the performance of the study product, in terms of volumizing activity as well as the duration of the effect, in women with age-related midfacial volume defects. In addition, the study allowed the evaluation of the tolerability of the product by both volunteers and investigators.Patients and Methods: Twenty-two female volunteers, aged 42– 60 years, participated in this study, which was performed under dermatological control in a single center. After an initial visit at baseline to verify adherence to the protocol criteria, volunteers received an injection of Aliaxin® SV (IBSA Farmaceutici Italia Srl), followed 3– 4 weeks later by a second touch-up treatment to treat eventual asymmetries. Four subsequent visits, the last performed 9 months from the first injection, were performed to evaluate clinically and instrumentally the efficacy of the treatment.Results: Clinical and statistically significant improvement in cheek volume was recorded after the first postinjection visit, and the effect was maintained until the end of the study period. A clinically measurable amelioration of wrinkle severity was also observed. By 3D picture recording and subsequent quantitative analysis, it was possible to determine the efficacy in term

Comment on the Italian Supreme Court’s ‘‘Rotoloni’’ Decision

Comment on the Italian Supreme Court Decision Fiorucci

The neutron capture reactions of the 244Cm and 246Cm isotopes open the path for the formation of heavier Cm isotopes and heavier elements such as Bk and Cf in a nuclear reactor. In addition, both isotopes belong to the minor actinides with a large contribution to the decay heat and to the neutron emission in irradiated fuels. There are only two previous 244Cm and 246Cm capture cross section measurements: one in 1969 using a nuclear explosion [1] and the most recent data measured at J-PARC in 2010 [2]. The data for both isotopes are very scarce due to the difficulties in performing the measurements: high intrinsic activity of the samples and limited facilities capable of providing isotopically enriched samples. We have measured both neutron capture cross sections at the n_TOF Experimental Area 2 (EAR-2) with three C6 D6 detectors and also at Area 1 (EAR-1) with the TAC. Preliminary results assessing the quality and limitations (back-ground subtraction, measurement technique and counting statistics) of this new experimental datasets are presented and discussed.

Do competition and incentives offered to designated market makers (DMMs) improve market liquidity? Using data from NYSE Euronext Paris, we show that an exogenous increase in competition among DMMs leads to a significant decrease in quoted and effective spreads, mainly through a reduction in adverse selection costs. In contrast, changes in incentives, through small changes in rebates and requirements for DMMs, do not have any tangible effect on market liquidity. Our results are of relevance for designing optimal contracts between exchanges and DMMs and for regulatory market oversight.

Introduction: The knowledge of high sensitivity cardiac troponin I (hsTnI) distribution in a reference population is mandatory for its introduction in clinical practice. The aim of this study was to define the Upper Reference Limit (URL) of hsTnI measured by Single Molecule Counting technology (SMC) in an accurately selected reference population. Materials and methods: In the study 1140 blood donors were included and selected on the basis of medical history and biomarkers. High sensitivity cardiac troponin I was measured by SMC technology (Clarity, Singulex, Alamed, USA). The 99th percentile was calculated by the non-parametric method according to the Clinical and Laboratory Standard Institute - CLSI C28-A3. Results: The median age was 41 years (IQR: 28 - 50) and 69% were males. The overall 99th percentile was 5 ng/L (90% CI: 4.2 - 5.6). When considering sex-related differences, we found slight differences between the 99th percentile in males and females. Moreover, the 99th percentile trended with age, especially in females. Conclusions: We defined the 99th percentile of hs-cTnI measured by SMC technology in a highly selected healthy population, with only minor differences between males and females. Our findings provide the basic criteria for the reliable interpretation of hsTnI concentrations measured by the SMC technology in clinical settings.

Adele Sparavigna,1 Beatrice Tenconi,1 Andrea Maria Giori,2 Gilberto Bellia,3 Laura La Penna1 1DERMING S.r.l., Clinical Research and Bioengineering Institute, Milan, Italy; 2Research and Development, IBSA Farmaceutici Italia, Lodi, Italy; 3Dermoaesthetic Business Unit, IBSA Farmaceutici Italia, Lodi, Italy Purpose: Aim of the study was to determine both clinically and by noninvasive instrumental evaluations the efficacy, tolerability and the duration of the effects of a new hyaluronic acid (HA) gel in human volunteers with moderate aging/photoaging.Patients and methods: Eighteen volunteers (35–55 years) were enrolled in this single-center study. The subjects underwent five visits. The first visit was at baseline to determine the adherence to the inclusion criteria, followed by the first injection of the HA-based study product, and the second visit was at 48 hours after the injection. Two months later, a second injection was given (Visit 3) followed by a subsequent visit (Visit 4) after 48 hours. The last visit (Visit 5) was performed 5 months after the first injection. Clinical and instrumental evaluations as well as self-assessment by the subjects were recorded at each visit.Results: A significant improvement of wrinkles’ grade around the eyes, vertical lip lines and wrinkles’ severity of nasolabial folds was recorded after the first injection and the effect increased after the second injection. Aging/photoaging grade and surface microrelief improved 2 months after the first injection procedure. These clinical improvements were paralleled by amelioration of instrumental skin profilometry and optical colorimetry. The treatments were very well tolerated by the volunteers as determined by the self-grading score.Conclusion: The results confirm the good esthetic performance and the duration of the effect of the HA-based study product (Viscoderm® Hydrobooster) on dynamic facial wrinkles and/or static facial lines. These effects were p

Flavonoids have been shown to modulate GLP-1 in obesity. GLP-1 induces some of its effects through the intestinal GLP-1 receptor (GLP-1R), though no data exist on how flavonoids affect this receptor. Here, we examine how a dose of grape seed proanthocyanidin extract (GSPE) with anti-obesity activity affects intestinal GLP-1R and analyze whether epigenetics play a role in the long-lasting effects of GSPE. We found that 10-day GSPE administration prior to the cafeteria diet upregulated GLP-1R mRNA in the ileum 17 weeks after the GSPE treatment. This was associated with a hypomethylation of the GLP-1R promoter near the region where the SP1 transcription factor binds. In the colon, the cafeteria diet upregulated GLP-1R without showing any GSPE effect. In conclusion, we have identified long-lasting GSPE effects on GLP-1R gene expression in the ileum that are partly mediated by hypomethylation at the gene promoter and may affect the SP1 binding factor.

Comment on ‘‘Metalco’’ – ‘‘Top-Tier Design’’, Copyright Protection, and the Assessment of the ‘‘Artistic Value’’ Requirement Under Italian Law

Comment on “Salame Felino”: National Protection of Geographical Indications not Registered at the EU Level

We report on the measurement of the $^{7}$Be($n, p$)$^{7}$Li cross section from thermal to approximately 325 keV neutron energy, performed in the high-flux experimental area (EAR2) of the n_TOF facility at CERN. This reaction plays a key role in the lithium yield of the Big Bang Nucleosynthesis (BBN) for standard cosmology. The only two previous time-of-flight measurements performed on this reaction did not cover the energy window of interest for BBN, and showed a large discrepancy between each other. The measurement was performed with a Si-telescope, and a high-purity sample produced by implantation of a $^{7}$Be ion beam at the ISOLDE facility at CERN. While a significantly higher cross section is found at low-energy, relative to current evaluations, in the region of BBN interest the present results are consistent with the values inferred from the time-reversal $^{7}$Li($p, n$)$^{7}$Be reaction, thus yielding only a relatively minor improvement on the so-called Cosmological Lithium Problem (CLiP). The relevance of these results on the near-threshold neutron production in the p+$^{7}$Li reaction is also discussed., Comment: arXiv admin note: This submission has been withdrawn by arXiv administrators as it is a duplicate of arXiv:1806.03050. Please refer to that document for any more recent versions

This paper analyses whether the post-crisis regulatory reforms developed by global-standard-setting bodies have created appropriate incentives for different types of market participants to centrally clear Over-The-Counter (OTC) derivative contracts. Beyond documenting the observed facts, we analyze four main drivers for the decision to clear: 1) the liquidity and riskiness of the reference entity; 2) the credit risk of the counterparty; 3) the clearing member’s portfolio net exposure with the Central Counterparty Clearing House (CCP) and 4) post trade transparency. We use confidential European trade repository data on single-name Sovereign Credit Derivative Swap (CDS) transactions, and show that for all the transactions reported in 2016 on Italian, German and French Sovereign CDS 48% were centrally cleared, 42% were not cleared despite being eligible for central clearing, while 9% of the contracts were not clearable because they did not satisfy certain CCP clearing criteria. However, there is a large difference between CCP clearing members that clear about 53% of their transactions and non-clearing members, even those that are subject to counterparty risk capital requirements, that almost never clear their trades. Moreover, we find that diverse factors explain clearing members’ decision to clear different CDS contracts: for Italian CDS, counterparty credit risk exposures matter most for the decision to clear, while for French and German CDS, margin costs are the most important factor for the decision. Clearing members use clearing to reduce their exposures to the CCP and largely clear contracts when at least one of the traders has a high counterparty credit risk.

Comment on "Vorwerk Folletto": An Important Decision Concerning Trade Mark Reproduction on Replacement Components

La legittimazione passiva della società consorella per fatti commessi da altra società del gruppo (in nota a Trib. Milano 28.2.2014)