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9 results on '"Athanasopoulou, K"'

1. Unveiling the Human Gastrointestinal Tract Microbiome: The Past, Present, and Future of Metagenomics

Author

Athanasopoulou, K. Adamopoulos, P.G. Scorilas, A. and Athanasopoulou, K. Adamopoulos, P.G. Scorilas, A.

Abstract

Over 1014 symbiotic microorganisms are present in a healthy human body and are responsible for the synthesis of vital vitamins and amino acids, mediating cellular pathways and supporting immunity. However, the deregulation of microbial dynamics can provoke diverse human diseases such as diabetes, human cancers, cardiovascular diseases, and neurological disorders. The human gastrointestinal tract constitutes a hospitable environment in which a plethora of microbes, including diverse species of archaea, bacteria, fungi, and microeukaryotes as well as viruses, inhabit. In particular, the gut microbiome is the largest microbiome community in the human body and has drawn for decades the attention of scientists for its significance in medical microbiology. Revolutions in sequencing techniques, including 16S rRNA and ITS amplicon sequencing and whole genome sequencing, facilitate the detection of microbiomes and have opened new vistas in the study of human microbiota. Especially, the flourishing fields of metagenomics and metatranscriptomics aim to detect all genomes and transcriptomes that are retrieved from environmental and human samples. The present review highlights the complexity of the gastrointestinal tract microbiome and deciphers its implication not only in cellular homeostasis but also in human diseases. Finally, a thorough description of the widely used microbiome detection methods is discussed. © 2023 by the authors.

Published
2023

3. Recent Advances in Genome-Engineering Strategies

Author

Boti, M.A. Athanasopoulou, K. Adamopoulos, P.G. Sideris, D.C. Scorilas, A. and Boti, M.A. Athanasopoulou, K. Adamopoulos, P.G. Sideris, D.C. Scorilas, A.

Abstract

In October 2020, the chemistry Nobel Prize was awarded to Emmanuelle Charpentier and Jennifer A. Doudna for the discovery of a new promising genome-editing tool: the genetic scissors of CRISPR-Cas9. The identification of CRISPR arrays and the subsequent identification of cas genes, which together represent an adaptive immunological system that exists not only in bacteria but also in archaea, led to the development of diverse strategies used for precise DNA editing, providing new insights in basic research and in clinical practice. Due to their advantageous features, the CRISPR-Cas systems are already employed in several biological and medical research fields as the most suitable technique for genome engineering. In this review, we aim to describe the CRISPR-Cas systems that have been identified among prokaryotic organisms and engineered for genome manipulation studies. Furthermore, a comprehensive comparison between the innovative CRISPR-Cas methodology and the previously utilized ZFN and TALEN editing nucleases is also discussed. Ultimately, we highlight the contribution of CRISPR-Cas methodology in modern biomedicine and the current plethora of available applications for gene KO, repression and/or overexpression, as well as their potential implementation in therapeutical strategies that aim to improve patients’ quality of life. © 2023 by the authors.

Published
2023

5. The Transition from Cancer “omics” to “epi-omics” through Next- and Third-Generation Sequencing

Author

Athanasopoulou, K. Daneva, G.N. Boti, M.A. Dimitroulis, G. Adamopoulos, P.G. Scorilas, A. and Athanasopoulou, K. Daneva, G.N. Boti, M.A. Dimitroulis, G. Adamopoulos, P.G. Scorilas, A.

Abstract

Deciphering cancer etiopathogenesis has proven to be an especially challenging task since the mechanisms that drive tumor development and progression are far from simple. An astonishing amount of research has revealed a wide spectrum of defects, including genomic abnormalities, epigenomic alterations, disturbance of gene transcription, as well as post-translational protein modifications, which cooperatively promote carcinogenesis. These findings suggest that the adoption of a multidimensional approach can provide a much more precise and comprehensive picture of the tumor landscape, hence serving as a powerful tool in cancer research and precision oncology. The introduction of next- and third-generation sequencing technologies paved the way for the decoding of genetic information and the elucidation of cancer-related cellular compounds and mechanisms. In the present review, we discuss the current and emerging applications of both generations of sequencing technologies, also referred to as massive parallel sequencing (MPS), in the fields of cancer genomics, transcriptomics and proteomics, as well as in the progressing realms of epi-omics. Finally, we provide a brief insight into the expanding scope of sequencing applications in personalized cancer medicine and pharmacogenomics. © 2022 by the authors.

Published
2022

6. Structural characterization and expression analysis of novel MAPK1 transcript variants with the development of a multiplexed targeted nanopore sequencing approach

Author

Athanasopoulou, K. Adamopoulos, P.G. Scorilas, A. and Athanasopoulou, K. Adamopoulos, P.G. Scorilas, A.

Abstract

Mitogen-activated protein kinases (MAPKs) represent a protein family firmly involved in many signaling cascades, regulating a vast spectrum of stimulated cellular processes. Studies have shown that alternatively spliced isoforms of MAPKs play a crucial role in determining the desired cell fate in response to specific stimulations. Although the implication of most MAPKs transcript variants in the MAPK signaling cascades has been clarified, the transcriptional profile of a pivotal member, MAPK1, has not been investigated for the existence of additional isoforms. In the current study we developed and implemented targeted long-read and short-read sequencing approaches to identify novel MAPK1 splice variants. The combination of nanopore sequencing and NGS enabled the implementation of a long-read polishing pipeline using error-rate correction algorithms, which empowered the high accuracy of the results and increased the sequencing efficiency. The utilized multiplexing option in the nanopore sequencing approach allowed not only the identification of novel MAPK1 mRNAs, but also elucidated their expression profile in multiple human malignancies and non-cancerous cell lines. Our study highlights for the first time the existence of ten previously undescribed MAPK1 mRNAs (MAPK1 v.3 – v.12) and evaluates their relative expression levels in comparison to the main MAPK1 v.1. The optimization and employment of qPCR assays revealed that MAPK1 v.3 – v.12 can be quantified in a wide spectrum of human cell lines with notable specificity. Finally, our findings suggest that the novel protein-coding mRNAs are highly expected to participate in the regulation of MAPK pathways, demonstrating differential localizations and functionalities. © 2022

Published
2022

7. IMPACT-Global Hip Fracture Audit: Nosocomial infection, risk prediction and prognostication, minimum reporting standards and global collaborative audit. Lessons from an international multicentre study of 7,090 patients conducted in 14 nations during the COVID-19 pandemic

Author

Hall, A, Clement, N, Ojeda-Thies, C, Maclullich, A, Toro, G, Johansen, A, White, T, Duckworth, A, Abdul-Jabar, H, Abu-Rajab, R, Abugarja, A, Adam, K, Aguado Hernández, H, Améstica Lazcano, G, Anderson, S, Ansar, M, Antrobus, J, Aragón Achig, E, Archunan, M, Arrieta Salinas, M, Ashford-Wilson, S, Assens Gibert, C, Athanasopoulou, K, Awadelkarim, M, Baird, S, Bajada, S, Balakrishnan, S, Balasubramanian, S, Ballantyne, J, Bárcena Goitiandia, L, Barkham, B, Barmpagianni, C, Barres-Carsi, M, Barrett, S, Baskaran, D, Bell, J, Bell, K, Bell, S, Bellelli, G, Benchimol, J, Boietti, B, Boswell, S, Braile, A, Brennan, C, Brent, L, Brooke, B, Bruno, G, Burahee, A, Burns, S, Calabrò, G, Campbell, L, Carabelli, G, Carnegie, C, Carretero Cristobal, G, Caruana, E, Cassinello Ogea, M, Castellanos Robles, J, Castillon, P, Chakrabarti, A, Cecere, A, Chen, P, Clarke, J, Collins, G, Corrales Cardenal, J, Corsi, M, Cózar Adelantado, G, Craxford, S, Crooks, M, Cuarental-García, J, Cuthbert, R, Dall, G, Daskalakis, I, De Cicco, A, Diana, D, Demaria, P, Dereix, J, Díaz Jiménez, J, Dinamarca Montecinos, J, Do Le, H, Donoso Coppa, J, Drosos, G, Duffy, A, East, J, Eastwood, D, Elbahari, H, Elias de Molins Peña, C, Elmamoun, M, Emmerson, B, Escobar Sánchez, D, Faimali, M, Farré-Mercadé, M, Farrow, L, Fayez, A, Fell, A, Fenner, C, Ferguson, D, Finlayson, L, Flores Gómez, A, Freeman, N, French, J, Gabardo Calvo, S, Gagliardo, N, Garcia Albiñana, J, García Cruz, G, García de Cortázar Antolín, U, García Virto, V, Gealy, S, Gil Caballero, S, Gill, M, González González, M, Gopireddy, R, Guntley, D, Gurung, B, Guzmán Rosales, G, Haddad, N, Hafeez, M, Haller, P, Halligan, E, Hardie, J, Hawker, I, Helal, A, Herrera Cruz, M, Herreros Ruiz-Valdepeñas, R, Horton, J, Howells, S, Howieson, A, Hughes, L, Hünicken Torrez, F, Hurtado Ortega, A, Huxley, P, Hamid, H, Ilahi, N, Iliadis, A, Inman, D, Jadhao, P, Jandoo, R, Jawad, L, Jayatilaka, M, Jenkins, P, Jeyapalan, R, Johnson, D, Johnston, A, Joseph, S, Kapoor, S, Karagiannidis, G, Karanam, K, Kattakayam, F, Konarski, A, Kontakis, G, Labrador Hernández, G, Lancaster, V, Landi, G, Le, B, Liew, I, Logishetty, K, Lopez Marquez, A, Lopez, J, Lum, J, Macpherson, G, Madan, S, Mahroof, S, Malik-Tabassum, K, Mallina, R, Maqsood, A, Marson, B, Martin Legorburo, M, Martin-Perez, E, Martínez Jiménez, T, Martinez Martin, J, Mayne, A, Mayor, A, Mcalinden, G, Mclean, L, Mcdonald, L, Mcintyre, J, Mckay, P, Mckean, G, Mcshane, H, Medici, A, Meeke, C, Meldrum, E, Mendez, M, Mercer, S, Merino Perez, J, Mesa-Lampré, M, Mighton, S, Milne, K, Mohamed Yaseen, M, Moppett, I, Mora, J, Morales-Zumel, S, Moreno Fenoll, I, Mousa, A, Murray, A, Murray, E, Nair, R, Neary, F, Negri, G, Negus, O, Newham-Harvey, F, Ng, N, Nightingale, J, Noor Mohamed Anver, S, Nunag, P, O'Hare, M, Ollivere, B, Ortés Gómez, R, Owens, A, Page, S, Palloni, V, Panagiotopoulos, A, Panagiotopoulos, E, Panesar, P, Papadopoulos, A, Spyridon, P, Pareja Sierra, T, Park, C, Parwaiz, H, Paterson-Byrne, P, Patton, S, Pearce, J, Porter, M, Pellegrino, A, Pèrez Cuellar, A, Pezzella, R, Phadnis, A, Pinder, C, Piper, D, Powell-Bowns, M, Prieto Martín, R, Probert, A, Ramesh, A, Ramírez de Arellano, M, Renton, D, Rickman, S, Robertson, A, Roche Albero, A, Rodrigo Verguizas, J, Rodríguez Couso, M, Rooney, J, Sáez-López, P, Saldaña-Díaz, A, Santulli, A, Sanz Pérez, M, Sarraf, K, Scarsbrook, C, Scott, C, Scott, J, Shah, S, Sharaf, S, Sharma, S, Shirley, D, Siano, A, Simpson, J, Singh, A, Sinnett, T, Sisodia, G, Smith, P, Sophena Bert, E, Steel, M, Stewart, A, Stewart, C, Sugand, K, Sullivan, N, Sweeting, L, Symes, M, Tan, D, Tancredi, F, Tatani, I, Thomas, P, Thomson, F, Toner, N, Tong, A, Toro, A, Tosounidis, T, Tottas, S, Trinidad Leo, A, Tucker, D, Vemulapalli, K, Ventura Garces, D, Vernon, O, Viveros Garcia, J, Ward, A, Ward, K, Watson, K, Weerasuriya, T, Wickramanayake, U, Wilkinson, H, Windley, J, Wood, J, Wynell-Mayow, W, Zatti, G, Zeiton, M, Zurrón Lobato, M, Hall, Andrew J., Clement, Nicholas D., Ojeda-Thies, Cristina, MacLullich, Alasdair MJ., Toro, Giuseppe, Johansen, Antony, White, Tim O., Duckworth, Andrew D., Abdul-Jabar, Hani, Abu-Rajab, Rashid, Abugarja, Ahmed, Adam, Karen, Aguado Hernández, Héctor J., Améstica Lazcano, Gedeón, Anderson, Sarah, Ansar, Mahmood, Antrobus, Jonathan, Aragón Achig, Esteban Javier, Archunan, Maheswaran, Arrieta Salinas, Mirentxu, Ashford-Wilson, Sarah, Assens Gibert, Cristina, Athanasopoulou, Katerina, Awadelkarim, Mohamed, Baird, Stuart, Bajada, Stefan, Balakrishnan, Shobana, Balasubramanian, Sathishkumar, Ballantyne, James A., Bárcena Goitiandia, Leopoldo, Barkham, Benjamin, Barmpagianni, Christina, Barres-Carsi, Mariano, Barrett, Sarah, Baskaran, Dinnish, Bell, Jean, Bell, Katrina, Bell, Stuart, Bellelli, Giuseppe, Benchimol, Javier Alberto, Boietti, Bruno Rafael, Boswell, Sally, Braile, Adriano, Brennan, Caitlin, Brent, Louise, Brooke, Ben, Bruno, Gaetano, Burahee, Abdus, Burns, Shirley, Calabrò, Giampiero, Campbell, Lucy, Carabelli, Guido Sebastian, Carnegie, Carol, Carretero Cristobal, Guillermo, Caruana, Ethan, Cassinello Ogea, M. a Concepción, Castellanos Robles, Juan, Castillon, Pablo, Chakrabarti, Anil, Cecere, Antonio Benedetto, Chen, Ping, Clarke, Jon V., Collins, Grace, Corrales Cardenal, Jorge E., Corsi, Maurizio, Cózar Adelantado, Gara María, Craxford, Simon, Crooks, Melissa, Cuarental-García, Javier, Cuthbert, Rory, Dall, Graham, Daskalakis, Ioannis, De Cicco, Annalisa, Diana, de la Fuente de Dios, Demaria, Pablo, Dereix, John, Díaz Jiménez, Julian, Dinamarca Montecinos, José Luis, Do Le, Ha Phuong, Donoso Coppa, Juan Pablo, Drosos, Georgios, Duffy, Andrew, East, Jamie, Eastwood, Deborah, Elbahari, Hassan, Elias de Molins Peña, Carmen, Elmamoun, Mamoun, Emmerson, Ben, Escobar Sánchez, Daniel, Faimali, Martina, Farré-Mercadé, Maria Victòria, Farrow, Luke, Fayez, Almari, Fell, Adam, Fenner, Christopher, Ferguson, David, Finlayson, Louise, Flores Gómez, Aldo, Freeman, Nicholas, French, Jonathan, Gabardo Calvo, Santiago, Gagliardo, Nicola, Garcia Albiñana, Joan, García Cruz, Guillermo, García de Cortázar Antolín, Unai, García Virto, Virginia, Gealy, Sophie, Gil Caballero, Sandra Marcela, Gill, Moneet, González González, María Soledad, Gopireddy, Rajesh, Guntley, Diane, Gurung, Binay, Guzmán Rosales, Guadalupe, Haddad, Nedaa, Hafeez, Mahum, Haller, Petra, Halligan, Emer, Hardie, John, Hawker, Imogen, Helal, Amr, Herrera Cruz, Mariana, Herreros Ruiz-Valdepeñas, Ruben, Horton, James, Howells, Sean, Howieson, Alan, Hughes, Luke, Hünicken Torrez, Flavia Lorena, Hurtado Ortega, Ana, Huxley, Peter, Hamid, Hytham K. S., Ilahi, Nida, Iliadis, Alexis, Inman, Dominic, Jadhao, Piyush, Jandoo, Rajan, Jawad, Lucy, Jayatilaka, Malwattage Lara Tania, Jenkins, Paul J., Jeyapalan, Rathan, Johnson, David, Johnston, Andrew, Joseph, Sarah, Kapoor, Siddhant, Karagiannidis, Georgios, Karanam, Krishna Saga, Kattakayam, Freddy, Konarski, Alastair, Kontakis, Georgios, Labrador Hernández, Gregorio, Lancaster, Victoria, Landi, Giovanni, Le, Brian, Liew, Ignatius, Logishetty, Kartik, Lopez Marquez, Andrew Carlomaria Daniel, Lopez, Judit, Lum, Joann, Macpherson, Gavin J., Madan, Suvira, Mahroof, Sabreena, Malik-Tabassum, Khalid, Mallina, Ravi, Maqsood, Afnan, Marson, Ben, Martin Legorburo, M José, Martin-Perez, Encarna, Martínez Jiménez, Tania, Martinez Martin, Javier, Mayne, Alistair, Mayor, Amy, McAlinden, Gavan, McLean, Lucille, McDonald, Lorna, McIntyre, Joshua, McKay, Pamela, McKean, Greg, McShane, Heather, Medici, Antonio, Meeke, Chelsea, Meldrum, Evonne, Mendez, Mijail, Mercer, Scott, Merino Perez, Josu, Mesa-Lampré, María-Pilar, Mighton, Shuna, Milne, Kirsty, Mohamed Yaseen, Muhammed, Moppett, Iain, Mora, Jesus, Morales-Zumel, Sira, Moreno Fenoll, Irene Blanca, Mousa, Adham, Murray, Alastair W., Murray, Elspeth V., Nair, Radhika, Neary, Fiona, Negri, Giacomo, Negus, Oliver, Newham-Harvey, Fiona, Ng, Nigel, Nightingale, Jess, Noor Mohamed Anver, Sumiya, Nunag, Perrico, O'Hare, Matthew, Ollivere, Ben, Ortés Gómez, Raquel, Owens, AnneMarie, Page, Siobhan, Palloni, Valentina, Panagiotopoulos, Andreas, Panagiotopoulos, Elias, Panesar, Paul, Papadopoulos, Antonios, Spyridon, Papagiannis, Pareja Sierra, Teresa, Park, Chang, Parwaiz, Hammad, Paterson-Byrne, Paul, Patton, Sam, Pearce, Jack, Porter, Marina, Pellegrino, Achille, Pèrez Cuellar, Arturo, Pezzella, Raffaele, Phadnis, Ashish, Pinder, Charlotte, Piper, Danielle, Powell-Bowns, Matilda, Prieto Martín, Rocío, Probert, Annabel, Ramesh, Ashwanth, Ramírez de Arellano, Manuel Vicente Mejía, Renton, Duncan, Rickman, Stephen, Robertson, Alastair, Roche Albero, Adrian, Rodrigo Verguizas, José Alberto, Rodríguez Couso, Myriam, Rooney, Joanna, Sáez-López, Pilar, Saldaña-Díaz, Andres, Santulli, Adriano, Sanz Pérez, Marta Isabel, Sarraf, Khaled M., Scarsbrook, Christine, Scott, Chloe E. H., Scott, Jennifer, Shah, Sachi, Sharaf, Sharief, Sharma, Sidharth, Shirley, Denise, Siano, Antonio, Simpson, James, Singh, Abhinav, Singh, Amit, Sinnett, Tim, Sisodia, Gurudatt, Smith, Philomena, Sophena Bert, Eugenia, Steel, Michael, Stewart, Avril, Stewart, Claire, Sugand, Kapil, Sullivan, Niall, Sweeting, Lauren, Symes, Michael, Tan, Dylan Jun Hao, Tancredi, Francesco, Tatani, Irini, Thomas, Philip, Thomson, Fraser, Toner, Niamh S., Tong, Anna, Toro, Antonio, Tosounidis, Theodoros, Tottas, Stylianos, Trinidad Leo, Andrea, Tucker, Damien, Vemulapalli, Krishna, Ventura Garces, Diego, Vernon, Olivia Katherine, Viveros Garcia, Juan Carlos, Ward, Alex, Ward, Kirsty, Watson, Kate, Weerasuriya, Thisara, Wickramanayake, Udara, Wilkinson, Hannah, Windley, Joseph, Wood, Janet, Wynell-Mayow, William, Zatti, Giovanni, Zeiton, Moez, Zurrón Lobato, Miriam, Hall, A, Clement, N, Ojeda-Thies, C, Maclullich, A, Toro, G, Johansen, A, White, T, Duckworth, A, Abdul-Jabar, H, Abu-Rajab, R, Abugarja, A, Adam, K, Aguado Hernández, H, Améstica Lazcano, G, Anderson, S, Ansar, M, Antrobus, J, Aragón Achig, E, Archunan, M, Arrieta Salinas, M, Ashford-Wilson, S, Assens Gibert, C, Athanasopoulou, K, Awadelkarim, M, Baird, S, Bajada, S, Balakrishnan, S, Balasubramanian, S, Ballantyne, J, Bárcena Goitiandia, L, Barkham, B, Barmpagianni, C, Barres-Carsi, M, Barrett, S, Baskaran, D, Bell, J, Bell, K, Bell, S, Bellelli, G, Benchimol, J, Boietti, B, Boswell, S, Braile, A, Brennan, C, Brent, L, Brooke, B, Bruno, G, Burahee, A, Burns, S, Calabrò, G, Campbell, L, Carabelli, G, Carnegie, C, Carretero Cristobal, G, Caruana, E, Cassinello Ogea, M, Castellanos Robles, J, Castillon, P, Chakrabarti, A, Cecere, A, Chen, P, Clarke, J, Collins, G, Corrales Cardenal, J, Corsi, M, Cózar Adelantado, G, Craxford, S, Crooks, M, Cuarental-García, J, Cuthbert, R, Dall, G, Daskalakis, I, De Cicco, A, Diana, D, Demaria, P, Dereix, J, Díaz Jiménez, J, Dinamarca Montecinos, J, Do Le, H, Donoso Coppa, J, Drosos, G, Duffy, A, East, J, Eastwood, D, Elbahari, H, Elias de Molins Peña, C, Elmamoun, M, Emmerson, B, Escobar Sánchez, D, Faimali, M, Farré-Mercadé, M, Farrow, L, Fayez, A, Fell, A, Fenner, C, Ferguson, D, Finlayson, L, Flores Gómez, A, Freeman, N, French, J, Gabardo Calvo, S, Gagliardo, N, Garcia Albiñana, J, García Cruz, G, García de Cortázar Antolín, U, García Virto, V, Gealy, S, Gil Caballero, S, Gill, M, González González, M, Gopireddy, R, Guntley, D, Gurung, B, Guzmán Rosales, G, Haddad, N, Hafeez, M, Haller, P, Halligan, E, Hardie, J, Hawker, I, Helal, A, Herrera Cruz, M, Herreros Ruiz-Valdepeñas, R, Horton, J, Howells, S, Howieson, A, Hughes, L, Hünicken Torrez, F, Hurtado Ortega, A, Huxley, P, Hamid, H, Ilahi, N, Iliadis, A, Inman, D, Jadhao, P, Jandoo, R, Jawad, L, Jayatilaka, M, Jenkins, P, Jeyapalan, R, Johnson, D, Johnston, A, Joseph, S, Kapoor, S, Karagiannidis, G, Karanam, K, Kattakayam, F, Konarski, A, Kontakis, G, Labrador Hernández, G, Lancaster, V, Landi, G, Le, B, Liew, I, Logishetty, K, Lopez Marquez, A, Lopez, J, Lum, J, Macpherson, G, Madan, S, Mahroof, S, Malik-Tabassum, K, Mallina, R, Maqsood, A, Marson, B, Martin Legorburo, M, Martin-Perez, E, Martínez Jiménez, T, Martinez Martin, J, Mayne, A, Mayor, A, Mcalinden, G, Mclean, L, Mcdonald, L, Mcintyre, J, Mckay, P, Mckean, G, Mcshane, H, Medici, A, Meeke, C, Meldrum, E, Mendez, M, Mercer, S, Merino Perez, J, Mesa-Lampré, M, Mighton, S, Milne, K, Mohamed Yaseen, M, Moppett, I, Mora, J, Morales-Zumel, S, Moreno Fenoll, I, Mousa, A, Murray, A, Murray, E, Nair, R, Neary, F, Negri, G, Negus, O, Newham-Harvey, F, Ng, N, Nightingale, J, Noor Mohamed Anver, S, Nunag, P, O'Hare, M, Ollivere, B, Ortés Gómez, R, Owens, A, Page, S, Palloni, V, Panagiotopoulos, A, Panagiotopoulos, E, Panesar, P, Papadopoulos, A, Spyridon, P, Pareja Sierra, T, Park, C, Parwaiz, H, Paterson-Byrne, P, Patton, S, Pearce, J, Porter, M, Pellegrino, A, Pèrez Cuellar, A, Pezzella, R, Phadnis, A, Pinder, C, Piper, D, Powell-Bowns, M, Prieto Martín, R, Probert, A, Ramesh, A, Ramírez de Arellano, M, Renton, D, Rickman, S, Robertson, A, Roche Albero, A, Rodrigo Verguizas, J, Rodríguez Couso, M, Rooney, J, Sáez-López, P, Saldaña-Díaz, A, Santulli, A, Sanz Pérez, M, Sarraf, K, Scarsbrook, C, Scott, C, Scott, J, Shah, S, Sharaf, S, Sharma, S, Shirley, D, Siano, A, Simpson, J, Singh, A, Sinnett, T, Sisodia, G, Smith, P, Sophena Bert, E, Steel, M, Stewart, A, Stewart, C, Sugand, K, Sullivan, N, Sweeting, L, Symes, M, Tan, D, Tancredi, F, Tatani, I, Thomas, P, Thomson, F, Toner, N, Tong, A, Toro, A, Tosounidis, T, Tottas, S, Trinidad Leo, A, Tucker, D, Vemulapalli, K, Ventura Garces, D, Vernon, O, Viveros Garcia, J, Ward, A, Ward, K, Watson, K, Weerasuriya, T, Wickramanayake, U, Wilkinson, H, Windley, J, Wood, J, Wynell-Mayow, W, Zatti, G, Zeiton, M, Zurrón Lobato, M, Hall, Andrew J., Clement, Nicholas D., Ojeda-Thies, Cristina, MacLullich, Alasdair MJ., Toro, Giuseppe, Johansen, Antony, White, Tim O., Duckworth, Andrew D., Abdul-Jabar, Hani, Abu-Rajab, Rashid, Abugarja, Ahmed, Adam, Karen, Aguado Hernández, Héctor J., Améstica Lazcano, Gedeón, Anderson, Sarah, Ansar, Mahmood, Antrobus, Jonathan, Aragón Achig, Esteban Javier, Archunan, Maheswaran, Arrieta Salinas, Mirentxu, Ashford-Wilson, Sarah, Assens Gibert, Cristina, Athanasopoulou, Katerina, Awadelkarim, Mohamed, Baird, Stuart, Bajada, Stefan, Balakrishnan, Shobana, Balasubramanian, Sathishkumar, Ballantyne, James A., Bárcena Goitiandia, Leopoldo, Barkham, Benjamin, Barmpagianni, Christina, Barres-Carsi, Mariano, Barrett, Sarah, Baskaran, Dinnish, Bell, Jean, Bell, Katrina, Bell, Stuart, Bellelli, Giuseppe, Benchimol, Javier Alberto, Boietti, Bruno Rafael, Boswell, Sally, Braile, Adriano, Brennan, Caitlin, Brent, Louise, Brooke, Ben, Bruno, Gaetano, Burahee, Abdus, Burns, Shirley, Calabrò, Giampiero, Campbell, Lucy, Carabelli, Guido Sebastian, Carnegie, Carol, Carretero Cristobal, Guillermo, Caruana, Ethan, Cassinello Ogea, M. a Concepción, Castellanos Robles, Juan, Castillon, Pablo, Chakrabarti, Anil, Cecere, Antonio Benedetto, Chen, Ping, Clarke, Jon V., Collins, Grace, Corrales Cardenal, Jorge E., Corsi, Maurizio, Cózar Adelantado, Gara María, Craxford, Simon, Crooks, Melissa, Cuarental-García, Javier, Cuthbert, Rory, Dall, Graham, Daskalakis, Ioannis, De Cicco, Annalisa, Diana, de la Fuente de Dios, Demaria, Pablo, Dereix, John, Díaz Jiménez, Julian, Dinamarca Montecinos, José Luis, Do Le, Ha Phuong, Donoso Coppa, Juan Pablo, Drosos, Georgios, Duffy, Andrew, East, Jamie, Eastwood, Deborah, Elbahari, Hassan, Elias de Molins Peña, Carmen, Elmamoun, Mamoun, Emmerson, Ben, Escobar Sánchez, Daniel, Faimali, Martina, Farré-Mercadé, Maria Victòria, Farrow, Luke, Fayez, Almari, Fell, Adam, Fenner, Christopher, Ferguson, David, Finlayson, Louise, Flores Gómez, Aldo, Freeman, Nicholas, French, Jonathan, Gabardo Calvo, Santiago, Gagliardo, Nicola, Garcia Albiñana, Joan, García Cruz, Guillermo, García de Cortázar Antolín, Unai, García Virto, Virginia, Gealy, Sophie, Gil Caballero, Sandra Marcela, Gill, Moneet, González González, María Soledad, Gopireddy, Rajesh, Guntley, Diane, Gurung, Binay, Guzmán Rosales, Guadalupe, Haddad, Nedaa, Hafeez, Mahum, Haller, Petra, Halligan, Emer, Hardie, John, Hawker, Imogen, Helal, Amr, Herrera Cruz, Mariana, Herreros Ruiz-Valdepeñas, Ruben, Horton, James, Howells, Sean, Howieson, Alan, Hughes, Luke, Hünicken Torrez, Flavia Lorena, Hurtado Ortega, Ana, Huxley, Peter, Hamid, Hytham K. S., Ilahi, Nida, Iliadis, Alexis, Inman, Dominic, Jadhao, Piyush, Jandoo, Rajan, Jawad, Lucy, Jayatilaka, Malwattage Lara Tania, Jenkins, Paul J., Jeyapalan, Rathan, Johnson, David, Johnston, Andrew, Joseph, Sarah, Kapoor, Siddhant, Karagiannidis, Georgios, Karanam, Krishna Saga, Kattakayam, Freddy, Konarski, Alastair, Kontakis, Georgios, Labrador Hernández, Gregorio, Lancaster, Victoria, Landi, Giovanni, Le, Brian, Liew, Ignatius, Logishetty, Kartik, Lopez Marquez, Andrew Carlomaria Daniel, Lopez, Judit, Lum, Joann, Macpherson, Gavin J., Madan, Suvira, Mahroof, Sabreena, Malik-Tabassum, Khalid, Mallina, Ravi, Maqsood, Afnan, Marson, Ben, Martin Legorburo, M José, Martin-Perez, Encarna, Martínez Jiménez, Tania, Martinez Martin, Javier, Mayne, Alistair, Mayor, Amy, McAlinden, Gavan, McLean, Lucille, McDonald, Lorna, McIntyre, Joshua, McKay, Pamela, McKean, Greg, McShane, Heather, Medici, Antonio, Meeke, Chelsea, Meldrum, Evonne, Mendez, Mijail, Mercer, Scott, Merino Perez, Josu, Mesa-Lampré, María-Pilar, Mighton, Shuna, Milne, Kirsty, Mohamed Yaseen, Muhammed, Moppett, Iain, Mora, Jesus, Morales-Zumel, Sira, Moreno Fenoll, Irene Blanca, Mousa, Adham, Murray, Alastair W., Murray, Elspeth V., Nair, Radhika, Neary, Fiona, Negri, Giacomo, Negus, Oliver, Newham-Harvey, Fiona, Ng, Nigel, Nightingale, Jess, Noor Mohamed Anver, Sumiya, Nunag, Perrico, O'Hare, Matthew, Ollivere, Ben, Ortés Gómez, Raquel, Owens, AnneMarie, Page, Siobhan, Palloni, Valentina, Panagiotopoulos, Andreas, Panagiotopoulos, Elias, Panesar, Paul, Papadopoulos, Antonios, Spyridon, Papagiannis, Pareja Sierra, Teresa, Park, Chang, Parwaiz, Hammad, Paterson-Byrne, Paul, Patton, Sam, Pearce, Jack, Porter, Marina, Pellegrino, Achille, Pèrez Cuellar, Arturo, Pezzella, Raffaele, Phadnis, Ashish, Pinder, Charlotte, Piper, Danielle, Powell-Bowns, Matilda, Prieto Martín, Rocío, Probert, Annabel, Ramesh, Ashwanth, Ramírez de Arellano, Manuel Vicente Mejía, Renton, Duncan, Rickman, Stephen, Robertson, Alastair, Roche Albero, Adrian, Rodrigo Verguizas, José Alberto, Rodríguez Couso, Myriam, Rooney, Joanna, Sáez-López, Pilar, Saldaña-Díaz, Andres, Santulli, Adriano, Sanz Pérez, Marta Isabel, Sarraf, Khaled M., Scarsbrook, Christine, Scott, Chloe E. H., Scott, Jennifer, Shah, Sachi, Sharaf, Sharief, Sharma, Sidharth, Shirley, Denise, Siano, Antonio, Simpson, James, Singh, Abhinav, Singh, Amit, Sinnett, Tim, Sisodia, Gurudatt, Smith, Philomena, Sophena Bert, Eugenia, Steel, Michael, Stewart, Avril, Stewart, Claire, Sugand, Kapil, Sullivan, Niall, Sweeting, Lauren, Symes, Michael, Tan, Dylan Jun Hao, Tancredi, Francesco, Tatani, Irini, Thomas, Philip, Thomson, Fraser, Toner, Niamh S., Tong, Anna, Toro, Antonio, Tosounidis, Theodoros, Tottas, Stylianos, Trinidad Leo, Andrea, Tucker, Damien, Vemulapalli, Krishna, Ventura Garces, Diego, Vernon, Olivia Katherine, Viveros Garcia, Juan Carlos, Ward, Alex, Ward, Kirsty, Watson, Kate, Weerasuriya, Thisara, Wickramanayake, Udara, Wilkinson, Hannah, Windley, Joseph, Wood, Janet, Wynell-Mayow, William, Zatti, Giovanni, Zeiton, Moez, and Zurrón Lobato, Miriam

Abstract

Aims: This international study aimed to assess: 1) the prevalence of preoperative and postoperative COVID-19 among patients with hip fracture, 2) the effect on 30-day mortality, and 3) clinical factors associated with the infection and with mortality in COVID-19-positive patients. Methods: A multicentre collaboration among 112 centres in 14 countries collected data on all patients presenting with a hip fracture between 1st March-31st May 2020. Demographics, residence, place of injury, presentation blood tests, Nottingham Hip Fracture Score, time to surgery, management, ASA grade, length of stay, COVID-19 and 30-day mortality status were recorded. Results: A total of 7090 patients were included, with a mean age of 82.2 (range 50–104) years and 4959 (69.9%) being female. Of 651 (9.2%) patients diagnosed with COVID-19, 225 (34.6%) were positive at presentation and 426 (65.4%) were positive postoperatively. Positive COVID-19 status was independently associated with male sex (odds ratio (OR) 1.38, p = 0.001), residential care (OR 2.15, p < 0.001), inpatient fall (OR 2.23, p = 0.003), cancer (OR 0.63, p = 0.009), ASA grades 4 (OR 1.59, p = 0.008) or 5 (OR 8.28, p < 0.001), and longer admission (OR 1.06 for each increasing day, p < 0.001). Patients with COVID-19 at any time had a significantly lower chance of 30-day survival versus those without COVID-19 (72.7% versus 92.6%, p < 0.001). COVID-19 was independently associated with an increased 30-day mortality risk (hazard ratio (HR) 2.83, p < 0.001). Increasing age (HR 1.03, p = 0.028), male sex (HR 2.35, p < 0.001), renal disease (HR 1.53, p = 0.017), and pulmonary disease (HR 1.45, p = 0.039) were independently associated with a higher 30-day mortality risk in patients with COVID-19 when adjusting for confounders. Conclusion: The prevalence of COVID-19 in hip fracture patients during the first wave of the pandemic was 9%, and was independently associated with a three-fold increased 30-day mortality risk.

Published
2022

9. Estimating sex using discriminant analysis of mandibular measurements from a modern greek sample

Author

Bertsatos, A. Athanasopoulou, K. Chovalopoulou, M.-E. and Bertsatos, A. Athanasopoulou, K. Chovalopoulou, M.-E.

Abstract

Background: Sex determination is an integral and fundamental step in biological profile construction. The mandible, which holds many dimorphic traits, can be useful for sex estimation in the forensic context. However, reliable sex estimation usually relies on population-specific mandibular morphometric criteria. To date, no such criteria are available for the modern Greek population, and the present study aims to fill this lack of data by identifying the most sexually dimorphic mandibular traits on a modern Greek population sample and reporting the discriminant functions that can most effectively be used for estimating sex. Materials and methods: For the purposes of this research, the 3D models of 194 adult mandibles (105 males and 89 females) from the Athens skeletal reference collection were used. A battery of 20 linear and 3 angular measurements was calculated from the 3D coordinates of anatomical landmarks positioned on the respective models and was analyzed by means of ANOVA and discriminant function analysis to investigate the expression of sexual dimorphism. Results: The coronoid height, theramus height, andthemaximum mandibular length are the most sexually dimorphic metric traits of the mandible, while the produced sex discriminant functions yielded cross-validated classification accuracy up to 85.7% for the Greek sample. Furthermore, most of the examined combinations of measurements exhibited the same sex discriminant capacity between different reference samples, despite their respective discriminant functions being population specific. Conclusions: Our findings indicate that the produced sex discriminant functions can be effectively used for sex determination in forensic casework and to verify the population specificity of these functions but also suggest that the expression of sexual dimorphism in the mandible shares certain features across different populations. © The Author(s).

Published
2019

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