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During secretion of milk fat globules, triacylglycerol (TAG) droplets are enveloped by a phospholipid (PL) trilayer. Globule size has been found to be related to polar lipid composition and fat content, and milk fat content and fatty acid composition have been associated with the diacylglycerol acyltransferase 1 (DGAT1) K232A polymorphism; however, the association between the DGAT1 polymorphism and fat globule size and polar lipid composition has not been studied. The ratio between polar and neutral lipids as well as the composition of the polar lipids in milk has industrial as well as nutritional and health implications. Understanding phenotypic and genotypic factors influencing these parameters could contribute to improving milk lipid composition for dairy products. The focus of the present study was to determine the effect of both fat content and DGAT1 polymorphism on PL/TAG ratio, as a marker for milk fat globule size, and detailed PL composition. Milk samples were selected from 200 cows such that there were equal numbers of samples for the different fat contents as well as per DGAT1 genotype. Samples were analyzed for neutral and polar lipid concentration and composition. PL/TAG ratio was significantly associated with both fat content and DGAT1 genotype. Phosphatidylinositol and phosphatidylserine concentrations were associated with fat content*DGAT1 genotype with a stronger association for the AA than the KK genotype. Sphingomyelin concentration tended to interact with fat content*DGAT1 genotype. Phosphatidylethanolamine (PE) concentration showed a biphasic response to fat content, suggesting that multiple biological processes influence its concentration. These results provide a new direction for controlling polar lipid concentration and composition in milk through selective breeding of cows.

Employing a thermodynamic interpretation of gravity based on the holographic principle and assuming underlying particle statistics, fermionic or bosonic, for the excitations of the holographic screen leads to Modified Newtonian Dynamics (MOND). A connection between the acceleration scale $a_0$ appearing in MOND and the Fermi energy of the holographic fermionic degrees of freedom is obtained. In this formulation the physics of MOND results from the quantum-classical crossover in the fermionic specific heat. However, due to the dimensionality of the screen, the formalism is general and applies to two dimensional bosonic excitations as well. It is shown that replacing the assumption of the equipartition of energy on the holographic screen by a standard quantum-statistical-mechanics description wherein some of the degrees of freedom are frozen out at low temperatures is the physical basis for the MOND interpolating function ${\tilde \mu}$. The interpolating function ${\tilde \mu}$ is calculated within the statistical mechanical formalism and compared to the leading phenomenological interpolating functions, most commonly used. Based on the statistical mechanical view of MOND, its cosmological implications are re-interpreted: the connection between $a_0$ and the Hubble constant is described as a quantum uncertainty relation; and the relationship between $a_0$ and the cosmological constant is better understood physically.

Employing a thermodynamic interpretation of gravity based on the holographic principle and assuming underlying particle statistics, fermionic or bosonic, for the excitations of the holographic screen leads to Modified Newtonian Dynamics (MOND). A connection between the acceleration scale $a_0$ appearing in MOND and the Fermi energy of the holographic fermionic degrees of freedom is obtained. In this formulation the physics of MOND results from the quantum-classical crossover in the fermionic specific heat. However, due to the dimensionality of the screen, the formalism is general and applies to two dimensional bosonic excitations as well. It is shown that replacing the assumption of the equipartition of energy on the holographic screen by a standard quantum-statistical-mechanics description wherein some of the degrees of freedom are frozen out at low temperatures is the physical basis for the MOND interpolating function ${\tilde \mu}$. The interpolating function ${\tilde \mu}$ is calculated within the statistical mechanical formalism and compared to the leading phenomenological interpolating functions, most commonly used. Based on the statistical mechanical view of MOND, its cosmological implications are re-interpreted: the connection between $a_0$ and the Hubble constant is described as a quantum uncertainty relation; and the relationship between $a_0$ and the cosmological constant is better understood physically.