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10 results on '"Antonijevic I"'

1. Influence of COX-2 and OXTR polymorphisms on treatment outcome in treatment resistant depression

Author

Mendlewicz, J, Crisafulli, C, Calati, R, Kocabas, N, Massat, I, Linotte, S, Kasper, S, Fink, M, Sidoti, A, Scantamburlo, G, Ansseau, M, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Montgomery, S, Zohar, J, Souery, D, Serretti, A, Mendlewicz J, Crisafulli C, Calati R, Kocabas NA, Massat I, Linotte S, Kasper S, Fink M, Sidoti A, Scantamburlo G, Ansseau M, Antonijevic I, Forray C, Snyder L, Bollen J, Montgomery S, Zohar J, Souery D, Serretti A, Mendlewicz, J, Crisafulli, C, Calati, R, Kocabas, N, Massat, I, Linotte, S, Kasper, S, Fink, M, Sidoti, A, Scantamburlo, G, Ansseau, M, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Montgomery, S, Zohar, J, Souery, D, Serretti, A, Mendlewicz J, Crisafulli C, Calati R, Kocabas NA, Massat I, Linotte S, Kasper S, Fink M, Sidoti A, Scantamburlo G, Ansseau M, Antonijevic I, Forray C, Snyder L, Bollen J, Montgomery S, Zohar J, Souery D, and Serretti A

Abstract

Inflammatory pathways play a crucial role in the pathomechanisms of antidepressant efficacy. The aim of this study was to investigate whether a set of single nucleotide polymorphisms (SNPs) within cyclooxygenase-2 (COX-2, rs5275 and rs20417) and oxytocin receptor (OXTR, rs53576 and rs2254298) genes was associated with antidepressant treatment resistance, response or remission. Three hundred seventy-two patients were recruited in the context of a multicenter resistant depression study. They were genotyped for COX-2 and OXTR SNPs. Treatment resistance (according to two different definitions), response and remission were recorded. We did not observe any association between the genotypes or alleles of the selected SNPs within COX-2 and OXTR genes and treatment resistance, response and remission in the whole sample. Our results are consistent with those of some studies but not with those of other ones. Indeed, several factors could be involved in the discrepancy observed across studies. They include sample size, environmental factors, differences in ethnicity, different study designs, and different definitions of treatment resistance. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

Published
2012

2. Failure to Replicate Influence of GRIK4 and GNB3 Polymorphisms on Treatment Outcome in Major Depression

Author

Serretti, A, Chiesa, A, Crisafulli, C, Massat, I, Linotte, S, Calati, R, Kasper, S, Bailer, U, Lecrubier, Y, Fink, M, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Mendlewicz, J, Serretti A, Chiesa A, Crisafulli C, Massat I, Linotte S, Calati R, Kasper S, Bailer U, Lecrubier Y, Fink M, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D, Souery D, Mendlewicz J, Serretti, A, Chiesa, A, Crisafulli, C, Massat, I, Linotte, S, Calati, R, Kasper, S, Bailer, U, Lecrubier, Y, Fink, M, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Mendlewicz, J, Serretti A, Chiesa A, Crisafulli C, Massat I, Linotte S, Calati R, Kasper S, Bailer U, Lecrubier Y, Fink M, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D, Souery D, and Mendlewicz J

Abstract

In the present study, we aimed to confirm the previous finding of an association between GRIK4 and GNB3 variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. We did not find any supporting evidence for such associations. These conflicting data may result from difficulties in the replication of candidate gene association studies. Copyright (C) 2012 S. Karger AG, Basel

Published
2012

3. COMT and age at onset in mood disorders: A replication and extension study

Author

Massat, I, Kocabas, N, Crisafulli, C, Chiesa, A, Calati, R, Linotte, S, Kasper, S, Fink, M, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Serretti, A, Mendlewicz, J, Massat I, Kocabas NA, Crisafulli C, Chiesa A, Calati R, Linotte S, Kasper S, Fink M, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D, Souery D, Serretti A, Mendlewicz J, Massat, I, Kocabas, N, Crisafulli, C, Chiesa, A, Calati, R, Linotte, S, Kasper, S, Fink, M, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Serretti, A, Mendlewicz, J, Massat I, Kocabas NA, Crisafulli C, Chiesa A, Calati R, Linotte S, Kasper S, Fink M, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D, Souery D, Serretti A, and Mendlewicz J

Abstract

Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD). We included 462 MD, 147 bipolar disorders (BD) subjects and 295 healthy controls. We could partially replicate previous findings. In particular, rs4680 GG + AG genotypes were more represented in the subgroup of early onset MD patients (p=0.04). Additionally, we observed an association between rs737865 alleles and early onset MD (p=0.04). Rs4680 genotype was associated with early onset BD as well (p=0.01). In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes.

Published
2011

4. No influence of PTGS2 polymorphisms on response and remission to antidepressants in major depression

Author

Serretti, A, Chiesa, A, Calati, R, Massat, I, Linotte, S, Kasper, S, Lecrubier, Y, Fink, M, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Mendlewicz, J, Serretti A, Chiesa A, Calati R, Massat I, Linotte S, Kasper S, Lecrubier Y, Fink M, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D, Souery D, Mendlewicz J, Serretti, A, Chiesa, A, Calati, R, Massat, I, Linotte, S, Kasper, S, Lecrubier, Y, Fink, M, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Mendlewicz, J, Serretti A, Chiesa A, Calati R, Massat I, Linotte S, Kasper S, Lecrubier Y, Fink M, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D, Souery D, and Mendlewicz J

Abstract

In the present study, aimed at investigating whether a set of single nucleotide polymorphisms (SNPs) within PTGS2 gene (rs4648276, rs2066826 and rs689466) could be associated with antidepressant response, remission and treatment resistance in a sample of major depression patients, we did not find evidence supporting any of such associations. © 2010 Elsevier Ltd.

Published
2011

5. A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression

Author

Serretti, A, Chiesa, A, Calati, R, Massat, I, Linotte, S, Kasper, S, Lecrubier, Y, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Mendlewicz, J, Serretti A, Chiesa A, Calati R, Massat I, Linotte S, Kasper S, Lecrubier Y, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D, Souery D, Mendlewicz J, Serretti, A, Chiesa, A, Calati, R, Massat, I, Linotte, S, Kasper, S, Lecrubier, Y, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Mendlewicz, J, Serretti A, Chiesa A, Calati R, Massat I, Linotte S, Kasper S, Lecrubier Y, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D, Souery D, and Mendlewicz J

Abstract

Background: The transcription factor Cyclic adenosine monophosphate Response Element Binding (CREB) protein has been repeatedly involved in the aetiology and pharmacotherapy of major depression (MD). The aim of this study was to investigate the potential association of a set of single nucleotide polymorphisms (SNPs) in CREB1 gene and both MD and response, remission and treatment resistance to antidepressants. Methods: One hundred-ninety MD patients collected in the context of a resistant depression study and treated with antidepressants for at least 4 weeks were genotyped for 5 CREB1 SNPs (rs2709376, rs2253206, rs7569963, rs7594560, and rs4675690). Response, remission and treatment resistance were recorded. Results: An allele of rs7569963 as well as rs2253206-rs7569963 A-A and rs7569963-rs4675690 A-C haplotypes were associated with the status of treatment resistance. Additionally, rs7569963 GG genotype was positively associated with remission. No further significant associations were observed. Limitations: Limitations of the present study include a relatively small sample size and the incomplete ascertainment of data which could influence the outcome. Conclusions: Our results preliminary suggest that some genetic polymorphisms in CREB1 could be associated to treatment resistance. Although such finding needs to be replicated in larger samples, it increases current knowledge about the genetic predictors of response to antidepressants that will probably lead to enhance treatment outcomes by addressing each individual to the most appropriate treatment strategy in the early stages of treatment. (C) 2010 Elsevier B.V. All rights reserved.

Published
2011

6. A preliminary investigation of CREB1, PTGS2 GRIK4 and GNB3 polymorphisms on treatment resistance in major depression

Author

Serretti, A, Chiesa, A, Crisafulli, C, Calati, R, Massat, I, Linotte, S, Kasper, S, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Mendlewicz, J, Serretti A, Chiesa A, Crisafulli C, Calati R, Massat I, Linotte S, Kasper S, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D, Souery D, Mendlewicz J, Serretti, A, Chiesa, A, Crisafulli, C, Calati, R, Massat, I, Linotte, S, Kasper, S, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Mendlewicz, J, Serretti A, Chiesa A, Crisafulli C, Calati R, Massat I, Linotte S, Kasper S, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D, Souery D, and Mendlewicz J

Published
2011

7. A preliminary investigation of CREB1, PTGS2, GRIK4 and GNB3 polymorphisms on treatment resistance in major depression

Author

Serretti, A, Chiesa, A, Crisafulli, C, Calati, R, Massat, I, Linotte, S, Kasper, S, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Mendlewicz, J, Serretti A, Chiesa A, Crisafulli C, Calati R, Massat I, Linotte S, Kasper S, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D, Souery D, Mendlewicz J, Serretti, A, Chiesa, A, Crisafulli, C, Calati, R, Massat, I, Linotte, S, Kasper, S, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Mendlewicz, J, Serretti A, Chiesa A, Crisafulli C, Calati R, Massat I, Linotte S, Kasper S, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D, Souery D, and Mendlewicz J

Published
2011

8. A preliminary investigation of CREB1 and PTGS2 polymorphisms on treatment resistance in major depression

Author

Serretti, A, Chiesa, A, Calati, R, Massat, I, Linotte, S, Kasper, S, Lecrubier, Y, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, D., M, J, Serretti A, Chiesa A, Calati R, Massat I, Linotte S, Kasper S, Lecrubier Y, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D Souery, D. Mendlewicz, Serretti, A, Chiesa, A, Calati, R, Massat, I, Linotte, S, Kasper, S, Lecrubier, Y, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, D., M, J, Serretti A, Chiesa A, Calati R, Massat I, Linotte S, Kasper S, Lecrubier Y, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D Souery, and D. Mendlewicz

Published
2010

9. 5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder.

Author

Noro, Magali, Antonijevic, I., Forray, C., Kasper, Siegfried, Aygun Kocabas, Neslihan, Lecrubier, Yves, Linotte, Sylvie, Mendlewicz, Julien, Montgomery, Stuart, Snyder, L., Souery, Daniel, Verbanck, Paul, Zohar, Joseph, Massat, Isabelle, Noro, Magali, Antonijevic, I., Forray, C., Kasper, Siegfried, Aygun Kocabas, Neslihan, Lecrubier, Yves, Linotte, Sylvie, Mendlewicz, Julien, Montgomery, Stuart, Snyder, L., Souery, Daniel, Verbanck, Paul, Zohar, Joseph, and Massat, Isabelle

Abstract

The 5HT2A (5HTR2A) and 5HT1A receptor (5HTR1A) genes are plausible candidate genes for major depressive disorders. Two single nucleotide polymorphisms, the rs7997012 in 5HTR2A and the -1019C/G in 5HTR1A, were analyzed in 206 patients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition major depressive disorder. Patients were retrospectively characterized for clinical response to antidepressant treatment. We found a significant difference in the rs7997012 allele frequency between resistant and nonresistant patients. However, following the Bonferroni correction we could not find any association between this single nucleotide polymorphism and treatment resistance phenotype. Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result., Journal Article, Research Support, Non-U.S. Gov't, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2010

10. 5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder.

Author

Noro, Magali, Antonijevic, I., Forray, C., Kasper, Siegfried, Aygun Kocabas, Neslihan, Lecrubier, Yves, Linotte, Sylvie, Mendlewicz, Julien, Montgomery, Stuart, Snyder, L., Souery, Daniel, Verbanck, Paul, Zohar, Joseph, Massat, Isabelle, Noro, Magali, Antonijevic, I., Forray, C., Kasper, Siegfried, Aygun Kocabas, Neslihan, Lecrubier, Yves, Linotte, Sylvie, Mendlewicz, Julien, Montgomery, Stuart, Snyder, L., Souery, Daniel, Verbanck, Paul, Zohar, Joseph, and Massat, Isabelle

Abstract

The 5HT2A (5HTR2A) and 5HT1A receptor (5HTR1A) genes are plausible candidate genes for major depressive disorders. Two single nucleotide polymorphisms, the rs7997012 in 5HTR2A and the -1019C/G in 5HTR1A, were analyzed in 206 patients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition major depressive disorder. Patients were retrospectively characterized for clinical response to antidepressant treatment. We found a significant difference in the rs7997012 allele frequency between resistant and nonresistant patients. However, following the Bonferroni correction we could not find any association between this single nucleotide polymorphism and treatment resistance phenotype. Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result., Journal Article, Research Support, Non-U.S. Gov't, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2010

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