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BACKGROUND AND AIM: Colonoscopy quality, including lesion detectability, is variable, and factors influencing lesion detection are not fully understood. This study investigated lesion detection rates during colonoscopies and the associated factors in the SCREEning of Swedish COlons (SCREESCO) study. METHODS: In this cross-sectional analysis of data from SCREESCO, a large-scale randomized controlled trial of colorectal cancer screening in the Swedish population aged 60 years, we assessed data of first-time colonoscopies performed in both colonoscopy and fecal immunochemical test (FIT) arms. RESULTS: This study included 16 552 individuals. The adenoma detection rate was 23.9% and 37.8% in colonoscopy and FIT arms, respectively. Regarding colonoscopy procedures, a withdrawal time ≥ 6 min was associated with higher detection rates of advanced adenomas (adjusted odds ratio [AOR] 2.474, 95% confidence interval [CI] 1.295-4.723), adenomas (2.181, 1.515-3.140), and proximal serrated lesions (pSLs) (1.713, 1.007-2.915). Antispasmodic use was associated with higher detection rates of these lesions and sessile serrated lesions (SSLs) (AOR, 95% CI: 1.523, 1.295-1.791; 1.361, 1.217-1.522; 1.450, 1.247-1.687; and 1.810, 1.512-2.167, respectively). Insertion time > 20 min was related to lower detection rates of adenomas, pSLs, and SSLs (AOR, 95% CI: 0.753, 0.639-0.887; 0.640, 0.495-0.828; and 0.704, 0.518-0.955, respectively). The relationship between a recent period and higher detection rates of pSLs and SSLs was also demonstrated. CONCLUSION: Lesion detectability in SCREESCO was mostly acceptable with room for improvement. In addition to sufficient withdrawal time, antispasmodic use and acquiring skills enabling short insertion time may improve lesion detection. TRIAL REGISTRATION: ClinicalTrials.gov, ID: NCT02078804.

Ajwain is an herbal plant belonging to Apiceae family. Ajwain is also known as Trachyspermum ammi (L). Ajwain is growth in various countries like Pakistan, Iran, Afghanistan and India. Trachyspermum ammi (L) is an annual herb. Ajwain leaves and seed are mainly used by humans and mostly used in cooking for spice. Ajwain is medicinal plant used for various disease. Ajwain act as a germicide and fungicide. Various chemical constituents present in Ajwain like volatile oil, saponins, glycosides, fat, protein, fibre and minerals. Ajwain having the various pharmacological effects and it is various disease. Trachyspermum ammi show antimicrobial, antispasmodic, digestive stimulants, anti-inflammatory and gastroprotective activity. Ajwain relief the menstruation cycle pain. Trachyspermum ammi is used as a medicine. In the future, if we used as a medicine, then in the future we can avoid many diseases, Trachyspermum ammi is an herbal plant, so do not show any side effects. Trachyspermum ammi show various pharmacological activity like Antimicrobial, Antiulcer, Analgesic, Diuretic, Antiviral, Antioxidant, Antihypertensives, Bronchodilator and Antiplatelet.

Ajwain is an herbal plant belonging to Apiceae family. Ajwain is also known as Trachyspermum ammi (L). Ajwain is growth in various countries like Pakistan, Iran, Afghanistan and India. Trachyspermum ammi (L) is an annual herb. Ajwain leaves and seed are mainly used by humans and mostly used in cooking for spice. Ajwain is medicinal plant used for various disease. Ajwain act as a germicide and fungicide. Various chemical constituents present in Ajwain like volatile oil, saponins, glycosides, fat, protein, fibre and minerals. Ajwain having the various pharmacological effects and it is various disease. Trachyspermum ammi show antimicrobial, antispasmodic, digestive stimulants, anti-inflammatory and gastroprotective activity. Ajwain relief the menstruation cycle pain. Trachyspermum ammi is used as a medicine. In the future, if we used as a medicine, then in the future we can avoid many diseases, Trachyspermum ammi is an herbal plant, so do not show any side effects. Trachyspermum ammi show various pharmacological activity like Antimicrobial, Antiulcer, Analgesic, Diuretic, Antiviral, Antioxidant, Antihypertensives, Bronchodilator and Antiplatelet.

Ajwain is an herbal plant belonging to Apiceae family. Ajwain is also known as Trachyspermum ammi (L). Ajwain is growth in various countries like Pakistan, Iran, Afghanistan and India. Trachyspermum ammi (L) is an annual herb. Ajwain leaves and seed are mainly used by humans and mostly used in cooking for spice. Ajwain is medicinal plant used for various disease. Ajwain act as a germicide and fungicide. Various chemical constituents present in Ajwain like volatile oil, saponins, glycosides, fat, protein, fibre and minerals. Ajwain having the various pharmacological effects and it is various disease. Trachyspermum ammi show antimicrobial, antispasmodic, digestive stimulants, anti-inflammatory and gastroprotective activity. Ajwain relief the menstruation cycle pain. Trachyspermum ammi is used as a medicine. In the future, if we used as a medicine, then in the future we can avoid many diseases, Trachyspermum ammi is an herbal plant, so do not show any side effects. Trachyspermum ammi show various pharmacological activity like Antimicrobial, Antiulcer, Analgesic, Diuretic, Antiviral, Antioxidant, Antihypertensives, Bronchodilator and Antiplatelet.

Ajwain is an herbal plant belonging to Apiceae family. Ajwain is also known as Trachyspermum ammi (L). Ajwain is growth in various countries like Pakistan, Iran, Afghanistan and India. Trachyspermum ammi (L) is an annual herb. Ajwain leaves and seed are mainly used by humans and mostly used in cooking for spice. Ajwain is medicinal plant used for various disease. Ajwain act as a germicide and fungicide. Various chemical constituents present in Ajwain like volatile oil, saponins, glycosides, fat, protein, fibre and minerals. Ajwain having the various pharmacological effects and it is various disease. Trachyspermum ammi show antimicrobial, antispasmodic, digestive stimulants, anti-inflammatory and gastroprotective activity. Ajwain relief the menstruation cycle pain. Trachyspermum ammi is used as a medicine. In the future, if we used as a medicine, then in the future we can avoid many diseases, Trachyspermum ammi is an herbal plant, so do not show any side effects. Trachyspermum ammi show various pharmacological activity like Antimicrobial, Antiulcer, Analgesic, Diuretic, Antiviral, Antioxidant, Antihypertensives, Bronchodilator and Antiplatelet.

Ajwain is an herbal plant belonging to Apiceae family. Ajwain is also known as Trachyspermum ammi (L). Ajwain is growth in various countries like Pakistan, Iran, Afghanistan and India. Trachyspermum ammi (L) is an annual herb. Ajwain leaves and seed are mainly used by humans and mostly used in cooking for spice. Ajwain is medicinal plant used for various disease. Ajwain act as a germicide and fungicide. Various chemical constituents present in Ajwain like volatile oil, saponins, glycosides, fat, protein, fibre and minerals. Ajwain having the various pharmacological effects and it is various disease. Trachyspermum ammi show antimicrobial, antispasmodic, digestive stimulants, anti-inflammatory and gastroprotective activity. Ajwain relief the menstruation cycle pain. Trachyspermum ammi is used as a medicine. In the future, if we used as a medicine, then in the future we can avoid many diseases, Trachyspermum ammi is an herbal plant, so do not show any side effects. Trachyspermum ammi show various pharmacological activity like Antimicrobial, Antiulcer, Analgesic, Diuretic, Antiviral, Antioxidant, Antihypertensives, Bronchodilator and Antiplatelet.

Ajwain is an herbal plant belonging to Apiceae family. Ajwain is also known as Trachyspermum ammi (L). Ajwain is growth in various countries like Pakistan, Iran, Afghanistan and India. Trachyspermum ammi (L) is an annual herb. Ajwain leaves and seed are mainly used by humans and mostly used in cooking for spice. Ajwain is medicinal plant used for various disease. Ajwain act as a germicide and fungicide. Various chemical constituents present in Ajwain like volatile oil, saponins, glycosides, fat, protein, fibre and minerals. Ajwain having the various pharmacological effects and it is various disease. Trachyspermum ammi show antimicrobial, antispasmodic, digestive stimulants, anti-inflammatory and gastroprotective activity. Ajwain relief the menstruation cycle pain. Trachyspermum ammi is used as a medicine. In the future, if we used as a medicine, then in the future we can avoid many diseases, Trachyspermum ammi is an herbal plant, so do not show any side effects. Trachyspermum ammi show various pharmacological activity like Antimicrobial, Antiulcer, Analgesic, Diuretic, Antiviral, Antioxidant, Antihypertensives, Bronchodilator and Antiplatelet.

Ajwain is an herbal plant belonging to Apiceae family. Ajwain is also known as Trachyspermum ammi (L). Ajwain is growth in various countries like Pakistan, Iran, Afghanistan and India. Trachyspermum ammi (L) is an annual herb. Ajwain leaves and seed are mainly used by humans and mostly used in cooking for spice. Ajwain is medicinal plant used for various disease. Ajwain act as a germicide and fungicide. Various chemical constituents present in Ajwain like volatile oil, saponins, glycosides, fat, protein, fibre and minerals. Ajwain having the various pharmacological effects and it is various disease. Trachyspermum ammi show antimicrobial, antispasmodic, digestive stimulants, anti-inflammatory and gastroprotective activity. Ajwain relief the menstruation cycle pain. Trachyspermum ammi is used as a medicine. In the future, if we used as a medicine, then in the future we can avoid many diseases, Trachyspermum ammi is an herbal plant, so do not show any side effects. Trachyspermum ammi show various pharmacological activity like Antimicrobial, Antiulcer, Analgesic, Diuretic, Antiviral, Antioxidant, Antihypertensives, Bronchodilator and Antiplatelet.

Thymus algeriensis have been vastly utilized for intestinal disorders. The purpose of this investigation was to scrutinize the probable mechanism for its utilization in the spasm disorder. Aqueous extract of this medicinal plant (AqTA) was tested in vitro on rat and rabbit jejunum. The extract produced relaxation of rabbit jejunum. This relaxation does not depend on the adrenergic pathway, the AqTA induces inhibition irrespective of the presence or absence of adrenergic inhibitors. AqTA engendered a concentration-dependent (0.1-5 mg/ml) relaxation of carbamylcholine chloride (CCh) and K+ provoked tones in rat intestine with IC50 values of 2.06 ± 0.26 and 3.55 ± 0.48 (mg/ml) respectively. This extract likewise induced a dosedependent (0.1-3 mg/ml) rightward shift in the CCh and Ca++ dose-response curves. The AqTA alone has decreased more significantly the percentage of contraction of rat jejunum than the AqTA pre-incubated with atropine or hexamethonium then contracted with KCl; but there is no significant difference by those pre-incubated with methylene blue or L-NAME. When the intestine was pretreated with nifedipine and contracted by CCh, the antispasmodic effect provoked by AqTA with and without pre-incubation with nifedipine is statistically not significant. In conclusion AqTA acts possibly on the voltage dependent Ca++ channel and cholinergic receptors but did not act on adrenergic receptors, NO and guanylatecyclase pathway. This investigation may explicate some of its traditional utilization in gut illnesses.