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Neutrophils are the most abundant effector cells of the innate immune system and represent the first line of defense against infection. However, in many common pathologies, including autoimmune diseases, excessive recruitment and activation of neutrophils can drive a chronic inflammatory response leading to unwanted tissue destruction. Several strategies have been investigated to tackle pathologic neutrophil biology, and thus provide a novel therapy for chronic inflammatory diseases. The chemokine receptor CXCR2 plays a crucial role in regulating neutrophil homeostasis and is a promising pharmaceutical target. In this study, we report the discovery and validation of a humanized anti-human CXCR2 monoclonal antibody. To enable in vivo studies, we developed a surrogate anti-mouse CXCR2 antibody, as well as a human knock-in CXCR2 mouse. When administered in models of atopic dermatitis (AD) and rheumatoid arthritis (RA), the antibodies rapidly clear inflammation. Our findings support further developments of anti-CXCR2 mAb approaches not only for RA and AD, but also for other neutrophil-mediated inflammatory conditions where neutrophils are pathogenic and medical needs are unmet.

BACKGROUND: Jambadyarista is an Ayurvedic polyherbal formulation widely prescribed by Ayurvedic practitioners for the management of diabetes and its associated complications. About 39 companies have marketed this formulation in Bangladesh with consent from the Directorate General of Drug Administration (DGDA). AIM: This study investigated the sub-acute oral toxicity of Jambadyarista in the Sprague-Dawley rat model. METHODS: The sub-acute toxicity studies were executed in Sprague-Dawley rats. Jambadyarista formulation was given for 28-days through oral gavage at 10 mL/kg and 20 mL/kg dose to two different groups comprising 6 rats of both sex/groups. Across the experimental period mortality, adverse reactions were closely monitored. After 28-day feeding hematological, biochemical, and relative organ weights were quantified. RESULTS: No mortality and/or signs of morbidity were observed for 28-day of repeated-dose sub-acute toxicity. Any pernicious change in body weight, biochemical, and hematological parameters along with relative organ weight were not observed for Jambadyarista. Correlation study among parameters of the renal profile, liver profile, lipid profile also metabolic hormones (T3 and TSH), and enzymes showed the non-toxic rather beneficial role (hypolipidemic) of Jambadyarista in Sprague-Dawley rats. CONCLUSION: Jambadyarista preparation did not cause any potential toxic effect in repeated dose subacute toxicity study over Sprague-Dawley rats orally. Therefore, low dose administration of Jambadyarista could have a beneficial effect on diabetes and can be considered safe before the chronic study.

We study balanced circle packings and circle-contact representations for planar graphs, where the ratio of the largest circle’s diameter to the smallest circle’s diameter is polynomial in the number of circles. We provide a number of positive and negative results for the existence of such balanced configurations.

We study balanced circle packings and circle-contact representations for planar graphs, where the ratio of the largest circle’s diameter to the smallest circle’s diameter is polynomial in the number of circles. We provide a number of positive and negative results for the existence of such balanced configurations.

The popularity of 3D video is increasing daily due to the availability of low-cost 3D televisions and high-speed Internet access. However, currently the contents of 3D video can be distributed illegally without any protection. For views generated using a depth-image-based rendering technique, not only the left and right views can be distributed as 3D content, but also the center, left, or right views individually as 2D content. As digital video watermarking is a possible way of protecting these views from unauthorized distribution, in this paper, we propose a digital watermarking method for depth-image-based rendered 3D video. In this method, the watermark is embedded in both of the chrominance channels of a YUV representation of the center view using the dual-tree complex wavelet transform. Then, the left and right views are generated from the watermarked center view and depth map using a depth-image based rendering technique. Finally, the watermark can be extracted from the center, left, and right views in a blind fashion without using the original unwatermarked center, left, or right views. This watermark is robust to geometric distortions, such as upscaling, rotation and cropping, downscaling to an arbitrary resolution, and the most common video distortions, including lossy compression and additive noise. Due to the approximate shift invariance characteristic of the dual-tree complex wavelet transform, the technique is robust against distortions in the left and right views generated using depth-image based rendering. The proposed method can also survive baseline distance adjustment and both 2D and 3D camcording.

Recent advances in motion modelling have largely focused on careful partitioning of motion blocks in the vicinity of object boundaries. The need for such fine partitioning can be avoided by using motion hints which provide a global description of motion over specific domains. Experimental results show that, with a hybrid setting, more than 50% of the motion discontinuity macroblocks are coded using the motion hints mode in low bit rate cases. The use of this mode leads to a gain of prediction PSNR of 1.11 dB, or equivalently 17.05% savings in bit rate, when compared to the H.264/AVC reference and considering both low and high bit rate applications.