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6 results on '"Aggazzotti G"'

1. Trihalomethanes in drinking water and bladder cancer burden in the European Union

Author

Evlampidou, I. (Iro), Font-Ribera, L. (Laia), Rojas-Rueda, D. (David), Gracia-Lavedan, E. (Esther), Costet, N. (Nathalie), Pearce, N. (Neil), Vineis, P. (Paolo), Jaakkola, J. J. (Jouni J. K.), Delloye, F. (Francis), Makris, K. C. (Konstantinos C.), Stephanou, E. G. (Euripides G.), Kargaki, S. (Sophia), Kozisek, F. (Frantisek), Sigsgaard, T. (Torben), Hansen, B. (Birgitte), Schullehner, J. (Jörg), Nahkur, R. (Ramon), Galey, C. (Catherine), Zwiener, C. (Christian), Vargha, M. (Marta), Righi, E. (Elena), Aggazzotti, G. (Gabriella), Kalnina, G. (Gunda), Grazuleviciene, R. (Regina), Polanska, K. (Kinga), Gubkova, D. (Dasa), Bitenc, K. (Katarina), Goslan, E. H. (Emma H.), Kogevinas, M. (Manolis), Villanueva, C. M. (Cristina M.), Evlampidou, I. (Iro), Font-Ribera, L. (Laia), Rojas-Rueda, D. (David), Gracia-Lavedan, E. (Esther), Costet, N. (Nathalie), Pearce, N. (Neil), Vineis, P. (Paolo), Jaakkola, J. J. (Jouni J. K.), Delloye, F. (Francis), Makris, K. C. (Konstantinos C.), Stephanou, E. G. (Euripides G.), Kargaki, S. (Sophia), Kozisek, F. (Frantisek), Sigsgaard, T. (Torben), Hansen, B. (Birgitte), Schullehner, J. (Jörg), Nahkur, R. (Ramon), Galey, C. (Catherine), Zwiener, C. (Christian), Vargha, M. (Marta), Righi, E. (Elena), Aggazzotti, G. (Gabriella), Kalnina, G. (Gunda), Grazuleviciene, R. (Regina), Polanska, K. (Kinga), Gubkova, D. (Dasa), Bitenc, K. (Katarina), Goslan, E. H. (Emma H.), Kogevinas, M. (Manolis), and Villanueva, C. M. (Cristina M.)

Abstract

Background: Trihalomethanes (THMs) are widespread disinfection by-products (DBPs) in drinking water, and long-term exposure has been consistently associated with increased bladder cancer risk. Objective: We assessed THM levels in drinking water in the European Union as a marker of DBP exposure and estimated the attributable burden of bladder cancer. Methods: We collected recent annual mean THM levels in municipal drinking water in 28 European countries (EU28) from routine monitoring records. We estimated a linear exposure–response function for average residential THM levels and bladder cancer by pooling data from studies included in the largest international pooled analysis published to date in order to estimate odds ratios (ORs) for bladder cancer associated with the mean THM level in each country (relative to no exposure), population-attributable fraction (PAF), and number of attributable bladder cancer cases in different scenarios using incidence rates and population from the Global Burden of Disease study of 2016. Results: We obtained 2005–2018 THM data from EU26, covering 75% of the population. Data coverage and accuracy were heterogeneous among countries. The estimated population-weighted mean THM level was 11.7μg/L [standard deviation (SD) of 11.2]. The estimated bladder cancer PAF was 4.9% [95% confidence interval (CI): 2.5, 7.1] overall (range: 0–23%), accounting for 6,561 (95% CI: 3,389, 9,537) bladder cancer cases per year. Denmark and the Netherlands had the lowest PAF (0.0% each), while Cyprus (23.2%), Malta (17.9%), and Ireland (17.2%) had the highest among EU26. In the scenario where no country would exceed the current EU mean, 2,868 (95% CI: 1,522, 4,060; 43%) annual attributable bladder cancer cases could potentially be avoided. Discussion: Efforts have been made to reduce THM levels in the European Union. However, assuming a causal association, current levels in certain countries still could lead to a considerable burden of bladder cancer

Published
2020

2. Childhood asthma and environmental exposures at swimming pools: state of the science and research recommendations.

Author

Weisel, C.P., Richardson, S.D., Nemery, B., Aggazzotti, G., Baraldi, E., Blatchley, E.R., Blount, B.C., Carlsen, K.H., Eggleston, P.A., Frimmel, F.H., Goodman, M., Gordon, G., Grinshpun, S.A., Heederik, D.J.J., Kogevinas, M., LaKind, J.S., Nieuwenhuijsen, M.J., Piper, F.C., Sattar, S.A., Weisel, C.P., Richardson, S.D., Nemery, B., Aggazzotti, G., Baraldi, E., Blatchley, E.R., Blount, B.C., Carlsen, K.H., Eggleston, P.A., Frimmel, F.H., Goodman, M., Gordon, G., Grinshpun, S.A., Heederik, D.J.J., Kogevinas, M., LaKind, J.S., Nieuwenhuijsen, M.J., Piper, F.C., and Sattar, S.A.

Abstract

OBJECTIVES: Recent studies have explored the potential for swimming pool disinfection by-products (DBPs), which are respiratory irritants, to cause asthma in young children. Here we describe the state of the science on methods for understanding children's exposure to DBPs and biologics at swimming pools and associations with new-onset childhood asthma and recommend a research agenda to improve our understanding of this issue. DATA SOURCES: A workshop was held in Leuven, Belgium, 21-23 August 2007, to evaluate the literature and to develop a research agenda to better understand children's exposures in the swimming pool environment and their potential associations with new-onset asthma. Participants, including clinicians, epidemiologists, exposure scientists, pool operations experts, and chemists, reviewed the literature, prepared background summaries, and held extensive discussions on the relevant published studies, knowledge of asthma characterization and exposures at swimming pools, and epidemiologic study designs. SYNTHESIS: Childhood swimming and new-onset childhood asthma have clear implications for public health. If attendance at indoor pools increases risk of childhood asthma, then concerns are warranted and action is necessary. If there is no such relationship, these concerns could unnecessarily deter children from indoor swimming and/or compromise water disinfection. CONCLUSIONS: Current evidence of an association between childhood swimming and new-onset asthma is suggestive but not conclusive. Important data gaps need to be filled, particularly in exposure assessment and characterization of asthma in the very young. Participants recommended that additional evaluations using a multidisciplinary approach are needed to determine whether a clear association exists.

Published
2009

3. Childhood asthma and environmental exposures at swimming pools: state of the science and research recommendations.

Author

Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Weisel, C.P., Richardson, S.D., Nemery, B., Aggazzotti, G., Baraldi, E., Blatchley, E.R., Blount, B.C., Carlsen, K.H., Eggleston, P.A., Frimmel, F.H., Goodman, M., Gordon, G., Grinshpun, S.A., Heederik, D.J.J., Kogevinas, M., LaKind, J.S., Nieuwenhuijsen, M.J., Piper, F.C., Sattar, S.A., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Weisel, C.P., Richardson, S.D., Nemery, B., Aggazzotti, G., Baraldi, E., Blatchley, E.R., Blount, B.C., Carlsen, K.H., Eggleston, P.A., Frimmel, F.H., Goodman, M., Gordon, G., Grinshpun, S.A., Heederik, D.J.J., Kogevinas, M., LaKind, J.S., Nieuwenhuijsen, M.J., Piper, F.C., and Sattar, S.A.

Published
2009

4. Childhood asthma and environmental exposures at swimming pools: state of the science and research recommendations.

Author

Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Weisel, C.P., Richardson, S.D., Nemery, B., Aggazzotti, G., Baraldi, E., Blatchley, E.R., Blount, B.C., Carlsen, K.H., Eggleston, P.A., Frimmel, F.H., Goodman, M., Gordon, G., Grinshpun, S.A., Heederik, D.J.J., Kogevinas, M., LaKind, J.S., Nieuwenhuijsen, M.J., Piper, F.C., Sattar, S.A., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Weisel, C.P., Richardson, S.D., Nemery, B., Aggazzotti, G., Baraldi, E., Blatchley, E.R., Blount, B.C., Carlsen, K.H., Eggleston, P.A., Frimmel, F.H., Goodman, M., Gordon, G., Grinshpun, S.A., Heederik, D.J.J., Kogevinas, M., LaKind, J.S., Nieuwenhuijsen, M.J., Piper, F.C., and Sattar, S.A.

Published
2009

5. Childhood asthma and environmental exposures at swimming pools: state of the science and research recommendations.

Author

Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Weisel, C.P., Richardson, S.D., Nemery, B., Aggazzotti, G., Baraldi, E., Blatchley, E.R., Blount, B.C., Carlsen, K.H., Eggleston, P.A., Frimmel, F.H., Goodman, M., Gordon, G., Grinshpun, S.A., Heederik, D.J.J., Kogevinas, M., LaKind, J.S., Nieuwenhuijsen, M.J., Piper, F.C., Sattar, S.A., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Weisel, C.P., Richardson, S.D., Nemery, B., Aggazzotti, G., Baraldi, E., Blatchley, E.R., Blount, B.C., Carlsen, K.H., Eggleston, P.A., Frimmel, F.H., Goodman, M., Gordon, G., Grinshpun, S.A., Heederik, D.J.J., Kogevinas, M., LaKind, J.S., Nieuwenhuijsen, M.J., Piper, F.C., and Sattar, S.A.

Published
2009

6. Work-related injuries in young workers: An Italian multicentric epidemiological survey

Author

Aggazzotti, G, Righi, E, Patorno, E, Fantuzzi, G, Fabiani, L, Giuliani, A, Grappasonni, I, Petrelli, F, Ricciardi, W, La Torre, G, Sciacca, S, Angelillo, I, Bianco, A, Nobile, C, Gregorio, P, Lupi, S, Perlangeli, V, Bonazzi, M, Laviola, F, Triassi, M, Iorfida, E, Montegrosso, S, Rivosecchi, P, Serra, M, Adorisio, E, Gramiccia, A, Mura, I, Castiglia, P, Romano, G, Poli, A, Tardivo, S, Giuliani, AR, Serra, MC, Tardivo, S., BONAZZI, MARIA CHIARA, Aggazzotti, G, Righi, E, Patorno, E, Fantuzzi, G, Fabiani, L, Giuliani, A, Grappasonni, I, Petrelli, F, Ricciardi, W, La Torre, G, Sciacca, S, Angelillo, I, Bianco, A, Nobile, C, Gregorio, P, Lupi, S, Perlangeli, V, Bonazzi, M, Laviola, F, Triassi, M, Iorfida, E, Montegrosso, S, Rivosecchi, P, Serra, M, Adorisio, E, Gramiccia, A, Mura, I, Castiglia, P, Romano, G, Poli, A, Tardivo, S, Giuliani, AR, Serra, MC, Tardivo, S., and BONAZZI, MARIA CHIARA

Abstract

Emergency departments records from 33 hospitals were reviewed to disclose work-related injuries occurred in teen-subjects living in 14 Italian cities. During January-June 2000, 317 work-related injuries were reported. Male subjects, 17 year old, working in the industrial field, resulted the most affected, probably due to the fact that among young workers this sex and age class is the most represented one. Cluster analysis identified two groups of work-related injuries: one includes mainly transportation injuries causing lower extremities or multiple body sites traumas. The other is more strictly related to specific working tasks and includes mostly traumas and cut wounds in hand/wrist and head, together with eye lesions. A more intensive supervision on the use of protective equipment, a more appropriate training in hazard recognition and safe work practices, including operation of vehicles in the work site, must be implemented to reduce work-related injuries.

Published
2006

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