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Start Over Author "Agaton C" Publication Type Electronic Resources
5 results on '"Agaton C"'

1. Microfluidic analysis of antibodies in a compact disc format

Author

Eriksson, C., Agaton, C., Kange, R., Nilsson, P., Uhlén, Mathias, Gustafsson, M., Hober, Sophia, Eriksson, C., Agaton, C., Kange, R., Nilsson, P., Uhlén, Mathias, Gustafsson, M., and Hober, Sophia

Abstract

QC 20190205

Published
2005

2. Affinity proteomics for systematic protein profiling of chromosome 21 gene products in human tissues

Author

Agaton, C., Galli, J., Guthenberg, I. H., Janzon, L., Hansson, M., Asplund, A., Brundell, E., Lindberg, S., Ruthberg, I., Wester, K., Wurtz, D., Hoog, C., Lundeberg, Joakim, Ståhl, Stefan, Ponten, F., Uhlén, Mathias, Agaton, C., Galli, J., Guthenberg, I. H., Janzon, L., Hansson, M., Asplund, A., Brundell, E., Lindberg, S., Ruthberg, I., Wester, K., Wurtz, D., Hoog, C., Lundeberg, Joakim, Ståhl, Stefan, Ponten, F., and Uhlén, Mathias

Abstract

Here we show that an affinity proteomics strategy using affinity-purified antibodies raised against recombinant human protein fragments can be used for chromosome-wide protein profiling. The approach is based on affinity reagents raised toward bioinformatics-designed protein epitope signature tags corresponding to unique regions of individual gene loci. The genes of human chromosome 21 identified by the genome efforts were investigated, and the success rates for de novo cloning, protein production, and antibody generation were 85, 76, and 56%, respectively. Using human tissue arrays, a systematic profiling of protein expression and subcellular localization was undertaken for the putative gene products. The results suggest that this affinity proteomics strategy can be used to produce a proteome atlas, describing distribution and expression of proteins in normal tissues as well as in common cancers and other forms of diseased tissues., QC 20100525

Published
2003
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3. Affinity proteomics for systematic protein profiling of chromosome 21 geneproducts in human tissues.

Author

Agaton, C, Galli, J, Hoiden Guthenberg, I, Janzon, L, Hansson, M, Asplund, A, Brundell, E, Lindberg, S, Ruthberg, I, Wester, K, Wurtz, D, Hoog, C, Lundeberg, J, Stahl, S, Ponten, F, Uhlen, M, Agaton, C, Galli, J, Hoiden Guthenberg, I, Janzon, L, Hansson, M, Asplund, A, Brundell, E, Lindberg, S, Ruthberg, I, Wester, K, Wurtz, D, Hoog, C, Lundeberg, J, Stahl, S, Ponten, F, and Uhlen, M

Published
2003

5. Affinity proteomics for systematic protein profiling of chromosome 21 geneproducts in human tissues.

Author

Agaton, C, Galli, J, Hoiden Guthenberg, I, Janzon, L, Hansson, M, Asplund, A, Brundell, E, Lindberg, S, Ruthberg, I, Wester, K, Wurtz, D, Hoog, C, Lundeberg, J, Stahl, S, Ponten, F, Uhlen, M, Agaton, C, Galli, J, Hoiden Guthenberg, I, Janzon, L, Hansson, M, Asplund, A, Brundell, E, Lindberg, S, Ruthberg, I, Wester, K, Wurtz, D, Hoog, C, Lundeberg, J, Stahl, S, Ponten, F, and Uhlen, M

Published
2003

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