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Das Ziel dieser Masterarbeit ist es zu klären, ob potenzielle KundInnen dazu bereit sind, für ein Produkt oder eine Dienstleistung eines Social Business mehr zu zahlen als für ein gleichwertiges Produkt oder eine gleichwertige Dienstleistung eines gewinnorientierten Unternehmens. Um dies analysieren zu können, wurde die Arbeit in einen theoretischen und einen praktischen Abschnitt gegliedert. Zunächst werden im theoretischen Teil, anhand einer Literaturrecherche, die Themengebiete rund um Social Business und die Zahlungsbereitschaft definiert. Dabei ist festzuhalten, dass das Themengebiet der Social Businesses noch recht neu ist und, dass es dementsprechend wenige, repräsentative Studien dazu gibt. Insbesondere die Zahlungsbereitschaft von potentiellen KundInnen eines Social Business ist noch kaum erforscht. Jedoch erlangten Social Business, aufgrund ihrer Verbindung von wirtschaftlichen, ökologischen und sozialen Komponenten in den vergangenen Jahren wachsende Aufmerksamkeit. Aus diesem Grund werden im praktischen Teil, im Rahmen eines Online-Fragebogens, zwei Conjoint-Analyse durchgeführt. Hierbei liegt das Augenmerk darin, die Zahlungsbereitschaft der KundInnen und die Bedeutung des ökologischen/sozialen Einflusses eines Produktes oder einer Dienstleistung festzustellen. Zusammenfassend zeigen die Ergebnisse, dass die ProbandInnen für Produkte und Dienstleistungen eines Social Businesseine eine höhere Zahlungsbereitschaft aufweisen als für ein gleichwertiges Produkt oder eine gleichwertige Dienstleistung eins gewinnorientierten Unternehmens. Weiters konnte im Rahmen der Hypothesentestung festgestellt werden, dass einige soziodemographische Merkmale einen Einfluss auf die Zahlungsbereitschaft haben. Weiters konnte festgestellt werden, dass es einen positiven Zusammenhang zwischen der Selbsteinschätzung der ProbandInnen hinsichtlich der Nachhaltigkeit ihres Lebensstils und den Wichtigkeitswerten des Faktors sozialer/ökologischer Einfluss gibt.*****The aim of this m

Aim To assess whether an adenoviral vector carrying the bone morphogenetic protein genes (Ad.BMP-2) can transduce human muscle tissue and direct it toward osteogenic differentiation within one hour. Methods This in vitro study, performed at the Department of Molecular Biology, Faculty of Science, Zagreb from 2012 to 2017, used human muscle tissue samples collected during anterior cruciate ligament reconstructions performed in St Catherine Hospital, Zabok. Samples from 28 patients were transduced with adenoviral vector carrying firefly luciferase cDNA (Ad.luc) by using different doses and times of transduction, and with addition of positive ions for transduction enhancement. The optimized protocol was further tested on muscle samples from three new patients, which were transduced with Ad.BMP-2. Released bone morphogenetic protein 2 (BMP-2) levels in osteogenic medium were measured every three days during a period of 21 days. Expression of osteogenic markers was measured at day 14 and 21. After 21 days of cultivation, muscle tissue was immunohistochemically stained for collagen type I detection (COL-I). Results The new transduction protocol was established using 108 plaque-forming units (P < 0.001) as an optimal dose of adenoviral vector and 30 minutes (P < 0.001) as an optimal contact time. Positive ions did not enhance transduction. Samples transduced with Ad.BMP-2 according to the optimized protocol showed enhanced expression of osteogenic markers (P < 0.050), BMP-2 (P < 0.001), and COL I. Conclusion This study confirms that Ad.BMP-2 can transduce human muscle tissue and direct it toward osteogenic differentiation within 30 minutes.

Aim To analyze clinical and functional effects of intra-articular injection of autologous micro-fragmented lipoaspirate (MLA) in patients with late stage knee osteoarthritis (KOA). Secondary aims included classifying cell types contributing to the treatment effect, performing detailed MRIbased classification of KOA, and elucidating the predictors for functional outcomes. Methods This prospective, non-randomized study was conducted from June 2016 to February 2018 and enrolled 20 patients with late stage symptomatic KOA (Kellgren Lawrence grade III, n = 4; and IV, n = 16) who received an intra-articular injection of autologous MLA in the index knee joint. At baseline radiological KOA grade and MRI were assessed in order to classify the morphology of KOA changes. Stromal vascular fraction cells obtained from MLA samples were stained with antibodies specific for cell surface markers. Patients were evaluated at baseline and 12-months after treatment with visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Knee Injury and Osteoarthritis Outcome Score (KOOS).Results Three patients (15%) received a total knee replacement and were not followed up completely. Seventeen patients (85%) showed a substantial pattern of KOOS and WOMAC improvement, significant in all accounts. KOOS score improved from 46 to 176% when compared with baseline, WOMAC decreased from 40 to 45%, while VAS rating decreased from 54% to 82% (all P values were <0.001). MLA contained endothelial progenitor cells, pericytes, and supra-adventitial adipose stromal cells as most abundant cell phenotypes. Conclusion This study is among the first to show a positive effect of MLA on patients with late stages KOA.

Aim To analyze clinical and functional effects of intra-articular injection of autologous micro-fragmented lipoaspirate (MLA) in patients with late stage knee osteoarthritis (KOA). Secondary aims included classifying cell types contributing to the treatment effect, performing detailed MRIbased classification of KOA, and elucidating the predictors for functional outcomes. Methods This prospective, non-randomized study was conducted from June 2016 to February 2018 and enrolled 20 patients with late stage symptomatic KOA (Kellgren Lawrence grade III, n = 4; and IV, n = 16) who received an intra-articular injection of autologous MLA in the index knee joint. At baseline radiological KOA grade and MRI were assessed in order to classify the morphology of KOA changes. Stromal vascular fraction cells obtained from MLA samples were stained with antibodies specific for cell surface markers. Patients were evaluated at baseline and 12-months after treatment with visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Knee Injury and Osteoarthritis Outcome Score (KOOS).Results Three patients (15%) received a total knee replacement and were not followed up completely. Seventeen patients (85%) showed a substantial pattern of KOOS and WOMAC improvement, significant in all accounts. KOOS score improved from 46 to 176% when compared with baseline, WOMAC decreased from 40 to 45%, while VAS rating decreased from 54% to 82% (all P values were <0.001). MLA contained endothelial progenitor cells, pericytes, and supra-adventitial adipose stromal cells as most abundant cell phenotypes. Conclusion This study is among the first to show a positive effect of MLA on patients with late stages KOA.

Aim To assess whether an adenoviral vector carrying the bone morphogenetic protein genes (Ad.BMP-2) can transduce human muscle tissue and direct it toward osteogenic differentiation within one hour. Methods This in vitro study, performed at the Department of Molecular Biology, Faculty of Science, Zagreb from 2012 to 2017, used human muscle tissue samples collected during anterior cruciate ligament reconstructions performed in St Catherine Hospital, Zabok. Samples from 28 patients were transduced with adenoviral vector carrying firefly luciferase cDNA (Ad.luc) by using different doses and times of transduction, and with addition of positive ions for transduction enhancement. The optimized protocol was further tested on muscle samples from three new patients, which were transduced with Ad.BMP-2. Released bone morphogenetic protein 2 (BMP-2) levels in osteogenic medium were measured every three days during a period of 21 days. Expression of osteogenic markers was measured at day 14 and 21. After 21 days of cultivation, muscle tissue was immunohistochemically stained for collagen type I detection (COL-I). Results The new transduction protocol was established using 108 plaque-forming units (P < 0.001) as an optimal dose of adenoviral vector and 30 minutes (P < 0.001) as an optimal contact time. Positive ions did not enhance transduction. Samples transduced with Ad.BMP-2 according to the optimized protocol showed enhanced expression of osteogenic markers (P < 0.050), BMP-2 (P < 0.001), and COL I. Conclusion This study confirms that Ad.BMP-2 can transduce human muscle tissue and direct it toward osteogenic differentiation within 30 minutes.

Christian List has recently proposed a category-theoretic model of a system of levels, applying it to various pertinent metaphysical questions. We modify and extend this framework to correct some minor defects and better adapt it to application in philosophy of science. This includes a richer use of category theoretic ideas and some illustrations using social choice theory.

This paper aims to provide a new criterion of formal equivalence of theories that is suitable for being supplemented with preservation conditions concerning interpretation. I argue that both the internal structure of models and choices of morphisms between models are aspects of formalisms that are relevant when it comes to their interpretations. So an adequate criterion should take these aspects into account. The two most important criteria presently discussed in philosophy of science---generalised definitional equivalence (Morita equivalence) and categorical equivalence---are not optimal in this respect. Generalised definitional equivalence neglects choices of morphisms, whereas categorical equivalence neglects the internal structure of models. I put forward the new criterion of definable categorical equivalence which takes into account both aspects and connects the category-theoretic approach and the definability-theoretic approach to formal equivalence.

The transition from wakefulness to sleep represents the most conspicuous change in behavior and the level of consciousness occurring in the healthy brain. It is accompanied by similarly conspicuous changes in neural dynamics, traditionally exemplified by the change from "desynchronized” electroencephalogram activity in wake to globally synchronized slow wave activity of early sleep. However, unit and local field recordings indicate that the transition is more gradual than it might appear: On one hand, local slow waves already appear during wake; on the other hand, slow sleep waves are only rarely global. Studies with functional magnetic resonance imaging also reveal changes in resting-state functional connectivity (FC) between wake and slow wave sleep. However, it remains unclear how resting-state networks may change during this transition period. Here, we employ large-scale modeling of the human cortico-cortical anatomical connectivity to evaluate changes in resting-state FC when the model "falls asleep” due to the progressive decrease in arousal-promoting neuromodulation. When cholinergic neuromodulation is parametrically decreased, local slow waves appear, while the overall organization of resting-state networks does not change. Furthermore, we show that these local slow waves are structured macroscopically in networks that resemble the resting-state networks. In contrast, when the neuromodulator decrease further to very low levels, slow waves become global and resting-state networks merge into a single undifferentiated, broadly synchronized network

Several philosophers of science construe models of scientific theories as set-theoretic structures. Some of them moreover claim that models should not be construed as structures in the sense of model theory because the latter are language-dependent. I argue that if we are ready to construe models as set-theoretic structures (strict semantic view), we could equally well construe them as model-theoretic structures of higher-order logic (liberal semantic view). I show that every family of set-theoretic structures has an associated language of higher-order logic and an up to signature isomorphism unique model-theoretic counterpart, which is able to serve the same purposes. This allows to carry over every syntactic criterion of equivalence for theories in the sense of the liberal semantic view to theories in the sense of the strict semantic view. Taken together, these results suggest that the recent dispute about the semantic view and its relation to the syntactic view can be resolved.

Causal set theory and the theory of linear structures (which has recently been developed by Tim Maudlin as an alternative to standard topology) share some of their main motivations. In view of that, I raise and answer the question how these two theories are related to each other and to standard topology. I show that causal set theory can be embedded into Maudlin’s more general framework and I characterise what Maudlin’s topological concepts boil down to when applied to discrete linear structures that correspond to causal sets. Moreover, I show that all topological aspects of causal sets that can be described in Maudlin’s theory can also be described in the framework of standard topology. Finally, I discuss why these results are relevant for evaluating Maudlin’s theory. The value of this theory depends crucially on whether it is true that (a) its conceptual framework is as expressive as that of standard topology when it comes to describing well-known continuous as well as discrete models of spacetime and (b) it is even more expressive or fruitful when it comes to analysing topological aspects of discrete structures that are intended as models of spacetime. On the one hand, my theorems support (a): the theory is rich enough to incorporate causal set theory and its definitions of topological notions yield a plausible outcome in the case of causal sets. On the other hand, the results undermine (b): standard topology, too, has the conceptual resources to capture those topological aspects of causal sets that are analysable within Maudlin’s framework. This fact poses a challenge for the proponents of Maudlin’s theory to prove it fruitful.

Causal set theory and the theory of linear structures (which has recently been developed by Tim Maudlin as an alternative to standard topology) share some of their main motivations. In view of that, I raise and answer the question how these two theories are related to each other and to standard topology. I show that causal set theory can be embedded into Maudlin’s more general framework and I characterise what Maudlin’s topological concepts boil down to when applied to discrete linear structures that correspond to causal sets. Moreover, I show that all topological aspects of causal sets that can be described in Maudlin’s theory can also be described in the framework of standard topology. Finally, I discuss why these results are relevant for evaluating Maudlin’s theory. The value of this theory depends crucially on whether it is true that (a) its conceptual framework is as expressive as that of standard topology when it comes to describing well-known continuous as well as discrete models of spacetime and (b) it is even more expressive or fruitful when it comes to analysing topological aspects of discrete structures that are intended as models of spacetime. On the one hand, my theorems support (a): the theory is rich enough to incorporate causal set theory and its definitions of topological notions yield a plausible outcome in the case of causal sets. On the other hand, the results undermine (b): standard topology, too, has the conceptual resources to capture those topological aspects of causal sets that are analysable within Maudlin’s framework. This fact poses a challenge for the proponents of Maudlin’s theory to prove it fruitful.

Osteogenesis imperfecta or brittle bone disease, a heritable disorder of connective tissue, is the most common of the inherited disorders primarily affecting bone. There are approximately 400 individuals with OI in Croatia alone. It is estimated that twice that number is present, represented by individuals with mild OI in whom the diagnosis has not been made. Due to the relatively low number of patients in the general population, treating physicians have limited experience with this disease, either with children or adults. The basis of this disease in European populations is mostly the result of defects in the structure or processing of collagen type I, an important protein of the extracellular matrix of many tissues. Presently, molecular defects in 16 different genes have been discovered to result in at least one type of OI of which 14 are not COL1 mutation loci. Although fractures occurring with no injury or minor injury are the hallmark of OI, other non-mineralized tissues can be affected as well and the pathological changes can be present in skin, tendons, eyes, teeth and blood vessels. Clinical manifestations are very heterogeneous and numerous signs and symptoms such as blue sclera, deafness, abnormal teeth development, joint hypermobility, increased risk of hernias, capillary fragility, aneurysms etc. Although there is no cure for this disease, there are specific therapies that can reduce the pain and complications associated with OI. The purpose of this review is to provide a brief overview of the molecular basis of this disease, describe clinical presentations, as well as to present orthopaedic therapeutic modalities for the patients with OI.

Entezitis tetiva aduktora longusa i/ili trbušnih mišića definiramo kao sindrom bolne prepone. Jedan od čestih uzroka nastanka sindroma bolne prepone jest slabost trbušne stijenke. Za nj danas postoji uvriježeni naziv sportska hernija. Sindrom bolne prepone najčešće se pojavljuje u nogometaša (u Hrvatskoj 6,24%). Inicijalno se pojavljuju mukle boli u području preponske regije kao rezultat opterećenja tokom sportske aktivnosti. U kliničkom pregledu osobito je važan aduktorski test. Liječenje sindroma bolne prepone je složeno, kao i uzroci nastanka sindroma. U početku treba smanjiti intenzitet treninga ili potpuno prestati sa sportskom aktivnošću. Primjenjuju se nesteroidni protuupalni lijekovi i miorelaksansi. Provode se vježbe istezanja i jačanja aduktora, trbušne muskulature, iliopsoasa, kvadricepsa te mišića stražnje lože natkoljenice. Ako konzervativno liječenje ne dovodi do poboljšanja, potrebno je kirurško liječenje., Groin pain is defined as tendon enthesitis of adductor longus muscle and/or abdominal muscles that may lead to degenerative arthropathy of pubic symphisis in an advanced stage. Pubic region is a point where kinematic forces cross. The balance between the adductor and abdominal muscles is of great importance, as well as the elasticity of pubic symphisis which enables movement of up to 2 mm and rotation of up to 3 degrees. The weakness of the abdominal muscle wall, known as the sportsman's hernia, is the most common cause of painful groin. Groin pain is the most common in soccer players (6.24% in Croatia). Most authors believe that the main cause of groin pain is the adductor muscle overload. When active, sportsmen start to feel a dull pain in the groin region. The adductor test is of great importance for physical examination; the patient should be lying supine with his hips abducted and flexed at 80 degrees. The test is positive if the patient, while attempting to pull his/her legs against pressing in the opposite direction, feels a sharp pain in the groins. The treatment of groin pain is complex and individual, as its causes may vary from patient to patient. Gradual physical therapy combined with pharmacotherapy should be effective in most cases. The latter includes nonsteroid anti-inflammatory drugs and muscle relaxants. A physical therapy programme usually involves stretching and strengthening of adductor muscles, abdominal wall muscles, iliopsoas muscle, quadriceps, and hamstrings. In case that physical therapy and pharmacotherapy fail, surgery is needed, depending on the cause.

Christian List (Noûs, forthcoming, 2018, [24]) has recently proposed a category-theoretic model of a system of levels, applying it to various pertinent metaphysical questions. We modify and extend this framework to correct some minor defects and better adapt it to application in philosophy of science. This includes a richer use of category theoretic ideas and some illustrations using social choice theory.

This article proposes to explicate theoretical equivalence by supplementing formal equivalence criteria with preservation conditions concerning interpretation. I argue that both the internal structure of models and choices of morphisms are aspects of formalisms that are relevant when it comes to their interpretation. Hence, a formal criterion suitable for being supplemented with preservation conditions concerning interpretation should take these two aspects into account. The two currently most important criteria—gener-alized definitional equivalence (Morita equivalence) and categorical equivalence—are not optimal in this respect. I put forward a criterion that takes both aspects into account: the criterion of definable categorical equivalence.

Several philosophers of science construe models of scientifc theories as set-theoretic structures. Some of them moreover claim that models should not be construed as structures in the sense of model theory because the latter are language dependent. I argue that if we are ready to construe models as set-theoretic structures (strict semantic view), we could equally well construe them as model-theoretic structures of higher-order logic (liberal semantic view). I show that every family of set-theoretic structures has an associated language of higher-order logic and an up to signature isomorphism unique model-theoretic counterpart, which is able to serve the same purposes. This allows to carry over every syntactic criterion of equivalence for theories in the sense of the liberal semantic view to theories in the sense of the strict semantic view. Taken together, these results suggest that the recent dispute about the semantic view and its relation to the syntactic view can be resolved.

The transition from wakefulness to sleep represents the most conspicuous change in behavior and the level of consciousness occurring in the healthy brain. It is accompanied by similarly conspicuous changes in neural dynamics, traditionally exemplified by the change from "desynchronized” electroencephalogram activity in wake to globally synchronized slow wave activity of early sleep. However, unit and local field recordings indicate that the transition is more gradual than it might appear: On one hand, local slow waves already appear during wake; on the other hand, slow sleep waves are only rarely global. Studies with functional magnetic resonance imaging also reveal changes in resting-state functional connectivity (FC) between wake and slow wave sleep. However, it remains unclear how resting-state networks may change during this transition period. Here, we employ large-scale modeling of the human cortico-cortical anatomical connectivity to evaluate changes in resting-state FC when the model "falls asleep” due to the progressive decrease in arousal-promoting neuromodulation. When cholinergic neuromodulation is parametrically decreased, local slow waves appear, while the overall organization of resting-state networks does not change. Furthermore, we show that these local slow waves are structured macroscopically in networks that resemble the resting-state networks. In contrast, when the neuromodulator decrease further to very low levels, slow waves become global and resting-state networks merge into a single undifferentiated, broadly synchronized network