233 results on 'LN cat08778a'
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2. A History of Population Health. Rise and Fall of Disease in Europe.
- Author
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Mackenbach, Johan P.
- Subjects
History of medicine ,Medicine - Abstract
Summary: In A history of Population Health Johan P. Mackenbach offers a comparative study of trends in 40 specific diseases in Europe and their explanation, focusing on the causes of the spectacular improvements in people's health since the early 18th century. ; Readership: Health care professionals with an interest in medical history, students and scientists in public health, economics, sociology, and related disciplines, and anyone interested in the history of health and disease.
3. A Practical Guide to Clinical Application of OCT in Ophthalmology.
- Author
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Michele Lanza
- Subjects
Medicine ,Ophthalmology ,Health Sciences - Abstract
Summary: I am very proud and excited to introduce to you this book, which provides many interesting indications on how to better understand and handle the world of opticalcoherence tomography (OCT). Reading the chapters, you will be aware that this device is extremely important not just in the clinical practice of retinal diseases, but is also very useful as a surgical tool. Moreover, application of OCT has crossed the borders of the retina and is currently being applied to corneal diseases and glaucoma. I amconfident you will find enough useful information to improve your practice using OCT and to provide a better quality of care for your patients.
4. Abdominal Aortic Aneurysm - From Basic Research to Clinical Practice.
- Author
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Igor Koncar
- Subjects
Medicine ,Surgery ,Vascular Surgery ,Health Sciences - Abstract
Summary: This book, intended for all physicians who are facing patients with abdominal aortic aneurysms, has been assembled by interested, invited authors and contains important topics from basic research to clinical practice. Experimental studies focus on biomechanical and biochemical factors. In clinical practice, the decision to treat, based on risk-benefit ratio, is very delicate in patients with concomitant malignant diseases. Periprocedural risk is determined by anatomy, while aneurysms causing neck pain are one of the most frequent challenges for both open and endovascular methods. Finally, careful planning is crucial. Postoperative complications are different from post-implantation syndrome, which is still an underestimated problem, toward detection and treatment of endoleaks and eventual conversion.
5. Adolescent Psychiatry. A Contemporary Perspective for Health Professionals.
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Merrick, Joav and Sher, Leo
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Medicine ,Adolescence ,Public Health ,Medicine & Public Health ,Psychiatric disorders - Abstract
Summary: Psychiatric disorders in adolescents are an important social problem relevant to almost all healthcare professionals. The prevalence of mood, anxiety, substance use and other psychiatric disorders among adolescents is high. However, medical professionals are not sufficiently trained about adolescent psychiatric disorders. Primary care providers correctly identify less than a fourth of youth with a depressive or anxiety disorder and many clinicians underestimate the importance of the problem of adolescent psychiatric illnesses and suicidal behavior. Multiple clinical, neurobiological, cultural and legal aspects of psychiatric disorders in adolescents are discussed in this book.
6. Advanced Concepts in Endocarditis.
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Michael S. Firstenberg
- Subjects
Medicine ,Cardiac Surgery ,Cardiology and Cardiovascular Medicine ,Health Sciences - Abstract
Summary: Endocarditis is a disease process that involves an infection of the heart, cardiac structures, or implantable cardiac support devices and can be a difficult clinical problem. As patients get older and have more comorbidities, their risks for infection increase. In addition, the growing problem of intravenous substance abuse has led to a considerable increase in these patients developing endocarditis. Advances in medical technology have facilitated diagnosis and management, particularly with greater emphasis on early surgical intervention. Nevertheless, success requires a team approach and individualization of care in the setting of very complex medical, surgical, and ethical problems. The goal of this book is to illustrate some of the evolving challenges and controversies in managing these very complex and often extremely sick patients.
7. Advances in Autism Research.
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Narzisi, Antonio and Narzisi, Antonio
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Medicine ,Neurosciences ,autism spectrum disorder ,infants ,frontal EEG alpha asymmetry ,early detection ,autism spectrum disorders ,toddlers ,eye tracking ,joint attention ,longitudinal ,regression ,cytokines ,PAI-1 ,neuroinflammation ,gastrointestinal ,autism ,literature review ,comorbidity ,early intervention ,early intensive behavioral intervention ,behavioral intervention ,First Year Inventory ,early screening ,risk ,cross-cultural generalisability ,validity ,preschool teachers ,self-efficacy ,knowledge ,belief ,skills ,identify ,autism spectrum disorder (ASD) ,level 1 and level 2 screening tools ,systematic review ,COSMIN ,PRISMA ,screening ,infection ,prion ,meta-analysis ,motion analysis ,video signal processing ,neurodevelopmental disorders ,infant screening ,n/a ,developmental language disorder ,semantic features ,word learning ,central coherence ,biomarker ,p-cresol ,mouse social behavior ,dopamine ,ASD ,vision ,proprioception ,self-motion ,immersive virtual reality ,IVR ,HMD ,technology ,persuasive text writing ,perspective-taking ,adolescence ,intervention ,sign language ,imitation ,cognition ,language acquisition ,prevalence estimate ,predictors ,surveillance review ,Autism Spectrum Disorder (ASD) ,early intensive intervention ,developmental trajectories ,moderators and mediators of intervention ,psychosis ,schizophrenia ,psychopathology ,AQ ,accuracy ,attention to detail ,self-awareness ,insight ,preconception risk factor ,Gilles de la Tourette ,obsession ,compulsion ,social behavior ,social impairment ,sensory profile ,sensory responsiveness ,feeding problems ,short sensory profile (SSP) ,sensory experience questionnaire (SEQ) ,coronavirus ,2019-nCoV ,neurodevelopment ,child and adolescent psychiatry ,mental health prevention ,Asperger syndrome ,adults ,cerebrospinal fluid ,antibodies ,blood-brain barrier ,GAD65 ,Early Start Denver Model ,high-risk infants ,motor development ,high-functioning autism ,language ,experience ,communication ,autonomic nervous system ,wearable technologies ,EEG ,theory of mind ,adults and adolescents ,human figure drawings ,Draw-a-Man ,drawings maturity ,social perception ,ERP ,reward response ,RewP ,sensitization ,social skills intervention ,PEERS® ,adulthood ,diagnosis ,autistic traits ,action observation ,action prediction ,context ,priors ,hypothalamus ,amygdala ,oxytocin ,social cognition ,social interaction ,affiliative behavior ,neuroimaging ,COVID-19 ,challenging behavior ,dental care ,oral health ,medical procedures ,ICT ,wearable sensors ,migration ,Europe ,health system ,autism in adulthood ,intellectual disability ,regressive autism ,epilepsy ,challenging behaviors ,empathy ,executive functions ,attention deficit and hyperactivity disorder ,disruptive behavior disorders ,alexithymia ,anxiety ,depression ,TAS-20 ,TSIA ,parents ,broader autism phenotype ,autistic-like features ,social-cognitive development ,stereotypical behaviors ,visual impairment ,language profiles ,grammatical comprehension ,cannabinoids ,cannabidiol ,cannabidivarin ,THC ,problem behaviors ,sleep ,hyperactivity ,side effects ,motor performance skills ,Gulf ,BOT-2 ,machine learning ,employment ,telehealth ,ABA ,RCT ,cortisol ,group activity ,stress ,art ,assessment ,sensorimotor integration ,postural balance ,false positive report probability (FPRP) ,Bayesian false-discovery probability (BFDP) ,Genome-Wide Association Studies (GWAS) ,microbiome ,metabolomics ,study design ,biomarker discovery ,precise medicine ,bipolar disorder ,suicidal ideation ,suicidal attempts - Abstract
Summary: This book represents one of the most up-to-date collections of articles on clinical practice and research in the field of Autism Spectrum Disorders (ASD). The scholars who contributed to this book are experts in their field, carrying out cutting edge research in prestigious institutes worldwide (e.g., Harvard Medical School, University of California, MIND Institute, King's College, Karolinska Institute, and many others). The book addressed many topics, including (1) The COVID-19 pandemic; (2) Epidemiology and prevalence; (3) Screening and early behavioral markers; (4) Diagnostic and phenotypic profile; (5) Treatment and intervention; (6) Etiopathogenesis (biomarkers, biology, and genetic, epigenetic, and risk factors); (7) Comorbidity; (8) Adulthood; and (9) Broader Autism Phenotype (BAP). This book testifies to the complexity of performing research in the field of ASD. The published contributions underline areas of progress and ongoing challenges in which more certain data is expected in the coming years. It would be desirable that experts, clinicians, researchers, and trainees could have the opportunity to read this updated text describing the challenging heterogeneity of Autism Spectrum Disorder.
8. Advances in HIV and AIDS Control.
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Samuel Okware
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Medicine ,Internal Medicine ,Infectious Diseases ,Health Sciences - Abstract
Summary: The HIV epidemic has had a significant and profound impact on the world and health resources. Considerable progress has been made in understanding the risks and drivers of the epidemic. Antiretroviral drugs have relieved human suffering and prolonged life. However, access to quality management needs to scale up and be made universal. This book discusses critical issues related to the treatment of HIV infection and related co-infections and challenges in adherence and discordancy. New vaccine approaches discussed may provide the ultimate solution for eradication. Sharing knowledge from various experts in medical and basic sciences improves the quality of care for this persistent global threat. This book discusses emerging advances in HIV-AIDS management to support strategies for control and elimination.
9. Advances in Nanomaterials in Biomedicine.
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Ryabchikova, Elena I. and Ryabchikova, Elena I.
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Medicine ,bone marrow-derived mesenchymal stromal cells ,rAAV vectors ,carbon dots ,SOX9 ,TGF-β ,cartilage repair ,silver nanoparticles ,Entada spiralis ,Ceiba pentandra ,antibacterial assay ,catalytic dye reduction ,osteoarthritis ,human articular cartilage ,polymeric micelles ,pro-inflammatory cytokines ,IL-1β ,TNF-α ,nanomaterials ,nanomedicine ,immunotherapy ,oncotherapy ,immune-checkpoint inhibitors ,immunogenic cell death ,nano-vaccines ,nano-conjugates ,immune response ,oxidative stress ,antioxidants ,nanoparticles ,biological nano-antioxidants ,gold nanoparticles ,radiation ,chemotherapy ,radiosensitizer ,drug delivery system ,chemoradiotherapy ,magnetoliposomes ,hydrogels ,magnetolipogels ,self-assembly ,fluorescence ,Förster resonance energy transfer ,polypropylenimine dendrimers ,polyethylenimines ,tyrosine-modified polypropylene-imines ,tyrosine-modified polyethlyenimines ,PPI-Y ,siRNA transfection ,polymeric nanoparticles ,carbosilane ,dendron ,triazine ,amphiphile ,vesicles ,pH-sensitive ,doxorubicin ,methotrexate ,leukaemia ,molecular ultrasound ,nanobubbles ,active targeting ,targeted microbubbles ,angiogenesis ,inflammation ,thrombosis ,clinical translation ,molecular imaging ,liver fibrosis ,diagnosis ,therapy ,theranostics ,targeted drug delivery ,lipid conjugates ,amphiphilic oligonucleotides ,phosphoryl guanidines ,nucleic acid delivery ,leukemia ,iron nanoparticles ,RNA-Seq ,cytotoxicity ,polymers ,biodegradable ,drug delivery ,pharmaceutical ,SQUID ,magnetic properties ,iron content ,magnetite nanoparticles ,superoxide ,aorta ,heart ,nano-biomaterials ,nanotechnology ,scaffolds ,hard tissue engineering ,AuNPs ,AuPEI-NPs ,AuBSA-NPs ,electron microscopy ,ultrastructure of HepG2 cells and spheroids ,ultrastructure of HEK293 cells and spheroids ,penetration of NPs into monolayer and spheroids ,gold nanostars ,photothermal therapy ,photoacoustic imaging ,computed tomography ,cancer ,theranostic agents ,biocompatible nanomaterials ,diagnostics ,nanocarriers ,tissue engineering - Abstract
Summary: Advances in Nanomaterials in Biomedicine" provided a platform for more than 110 researchers from different countries to present their latest investigations in various fields of nanotechnology, new methods and nanomaterials intended for medical applications. Modern achievements in the field of nanoparticle-based diagnostics, drug delivery and the use of various nanomaterials in the treatment of diseases are presented in 11 original articles. The published reviews provide a comprehensive analysis of the current information on the use of nanomedicine in the treatment and diagnosis of cancer and liver fibrosis, in the field of solid tissue engineering and in drug delivery systems.
10. Advances in Research on Down Syndrome.
- Author
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Subrata Dey
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Medicine ,Medical Genetics ,Clinical Genetics ,Health Sciences - Abstract
Summary: This book provides a concise yet comprehensive source of current information on Down syndrome. It focuses on exciting areas of research on chromosome editing, neurogenomics and diseases associated with Down syndrome. Research workers, scientists, medical graduates and physicians will find this book as an excellent source for consultation and references. Key features of this book are chromosome engineering in Down syndrome, mental retardation and cognitive disability, prenatal diagnosis and diseases associated with Down syndrome. Although aimed primarily for research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be exciting to wider audience, especially parents, relatives and health care providers who work with infants and children with Down syndrome.
11. Advances in the Diagnosis and Management of Uveitis.
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C. Stephen Foster and Alejandro Rodriguez-Garcia
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Medicine ,Ophthalmic Pathology ,Ophthalmology ,Health Sciences - Abstract
Summary: Uveitis is the fifth cause of visual loss in the developed world, accounting for up to 20% of legal blindness. Visual loss due to uveitis currently has a significant impact on the productivity and quality of life of many patients worldwide. Therefore, advances in diagnostic techniques and therapeutic strategies are crucial for patients suffering from the disease. Improvements in our understanding of the pathogenic mechanisms, development of more accurate diagnostic tests, and better treatment alternatives come from the continuous efforts of researchers from all over the world who are committed to improving the standard of care of patients suffering from these potentially blinding diseases.This book focuses on the most recent advances in diagnostic techniques for primary and systemic-associated autoimmune and infectious uveitis, as well as new therapeutic strategies that have significantly reduced the rate of ocular complications and improved the visual outcome of patients suffering from these devastating disorders.
12. Advances on Scoliogeny, Diagnosis and Management of Scoliosis and Spinal Disorders.
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Grivas, Theodoros B. and Grivas, Theodoros B.
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Medicine ,idiopathic scoliosis ,health-related quality of life ,cultural adaptation ,Italian Spine Youth Quality of Life Questionnaire ,systematic review ,meta-analysis ,adolescent idiopathic scoliosis ,brace therapy ,brace concepts ,rigid brace ,night time brace ,ring apophysis ,maturation ,ossification ,fusion ,scoliosis ,nighttime orthotic treatment ,surgery ,quality of life ,paraspinal muscles ,cross-sectional area ,posterior approach ,computed tomography ,Italian spine youth quality of life questionnaire ,SRS-22 ,22q11.2 deletion syndrome ,human model ,neuromuscular scoliosis ,radiography ,MRI ,curve morphology ,intraspinal anomaly ,body height ,pulmonary function test ,Cobb angle ,iTRAQ ,α-actin ,progressive ,differentially expressed proteins ,bracing ,physiotherapeutic scoliosis-specific exercise ,physical activity ,adherence ,spinal appearance ,shared decision-making ,personalised approach ,sclerostin ,osteocytes ,β-catenin ,Wnt signaling pathway ,scoliometer ,truncal asymmetry ,lateral spinal profile ,surface topography ,aetiology ,spinal deformities ,pathobiomechanics ,follow-up study ,Rett syndrome ,motor skills ,telerehabilitation ,physical therapy modalities ,home exercise program ,neurodynamic functions ,assessment ,pain ,treatment ,early onset scoliosis ,non-operative treatment ,body posture ,sports activity ,corrective exercises ,digital photography ,n/a - Abstract
Summary: This book contains research articles on the advances in the aetiology of idiopathic scoliosis (IS), the spinal growth related to the implementation of growth modulation for the surgical treatment of early-onset IS, the non-surgical treatment of IS using Physiotheraputic Scoliosis Specific Exercises, and braces. Additionally, it focuses on issues related to surgical treatment, issues related to body posture and the quality of life of this sensitive group of people. The high quality of published papers in this Special Issue of the JCM serve these objectives.
13. Advancing the Science of Cancer in Latinos.
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Ramirez, Amelie G., Trapido, Edward J., and Ramirez, Amelie G.
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Social issues & processes ,Public health & preventive medicine ,Oncology ,Medicine ,Health promotion ,Social structure ,Social inequality ,Cancer research - Abstract
Summary: This open access book gives an overview of the sessions, panel discussions, and outcomes of the Advancing the Science of Cancer in Latinos conference, held in February 2018 in San Antonio, Texas, USA, and hosted by the Mays Cancer Center and the Institute for Health Promotion Research at UT Health San Antonio. Latinos - the largest, youngest, and fastest-growing minority group in the United States - are expected to face a 142% rise in cancer cases in coming years. Although there has been substantial advancement in cancer prevention, screening, diagnosis, and treatment over the past few decades, addressing Latino cancer health disparities has not nearly kept pace with progress. The diverse and dynamic group of speakers and panelists brought together at the Advancing the Science of Cancer in Latinos conference provided in-depth insights as well as progress and actionable goals for Latino-focused basic science research, clinical best practices, community interventions, and what can be done by way of prevention, screening, diagnosis, and treatment of cancer in Latinos. These insights have been translated into the chapters included in this compendium; the chapters summarize the presentations and include current knowledge in the specific topic areas, identified gaps, and top priority areas for future cancer research in Latinos. Topics included among the chapters: Colorectal cancer disparities in Latinos: Genes vs. Environment Breast cancer risk and mortality in women of Latin American origin Differential cancer risk in Latinos: The role of diet Overcoming barriers for Latinos on cancer clinical trials Es tiempo: Engaging Latinas in cervical cancer research Emerging policies in U.S. health care Advancing the Science of Cancer in Latinos proves to be an indispensable resource offering key insights into actionable targets for basic science research, suggestions for clinical best practices and community interventions, and novel strategies and advocacy opportunities to reduce health disparities in Latino communities. It will find an engaged audience among researchers, academics, physicians and other healthcare professionals, patient advocates, students, and others with an interest in the broad field of Latino cancer.
14. Agricultural Products Processing and Postharvest Storage.
- Author
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Wu, Bengang and Wu, Bengang
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Medicine ,fresh-cut ,electric peeling ,gas composition ,tray ,micro-perforated film ,rice ,starch structure ,physicochemical quality ,storage ,Acmella oleracea ,foam mat ,drying kinetics ,bending force ,bionic finger ,damage ,elasticity coefficient ,force loading ,low-loss picking ,microstructure ,pressure ,tea buds ,tension ,walnut ,physical properties ,crack ,broken shell experiment ,multi-point extrusion ,central composite design (CCD) ,parameter optimization ,jujube polysaccharide ,drying methods ,physicochemical property ,structural characteristic ,antioxidant activity ,potato ,pretreatment ,drying ,three-dimensional appearance ,quality ,polyphenols ,Sicily ,chemometrics ,Grillo ,wine ,grape ,potato flour ,gelatinization ,viscosity ,X-ray diffraction ,volatile aroma components ,gas-containing conditioning technology ,mild sterilization ,scheduled process ,preservation - Abstract
Summary: Agricultural products such as fruit, vegetables, and cereal are believed to be some of the most crucial sources of certain phytonutrients necessary for humans, such as vitamins, dietary fibers, and minerals. However, agricultural products are prone to quality deterioration during storage under ambient temperatures. Currently, the annual post-harvest loss rate of agricultural products can reach up to 20-30%. Owing to their perishable nature, the development of processing and preservation technologies for agricultural products is an important research topic closely associated with the national economy and people's livelihoods that has attracted ever-increasing attention. In view of the prominent issues of high energy consumption, high costs, serious pollution, and low-quality properties in agricultural product manufacturing, our journal mainly focuses on research articles on novel techniques and the underlying mechanisms of the processing, preservation, and quality control of agricultural products, so as to promote the upgrading and updating of the agricultural product industry.
15. An Update of Dental Implantology and Biomaterial.
- Author
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Mazen Ahmad Almasri
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Medicine ,Oral Implantology ,Dentistry ,Health Sciences - Abstract
Summary: The aim of An Update in Dental Implantology and Biomaterial is to continue the challenge of reconstruction and implantology into another volume with unique updates. As a surgeon who is usually asked to accomplish the reconstructive skeleton of the rehabilitation plan, questions like ""Doc, I am in a hurry, how fast can you finish the treatment?"" are becoming very common in practice these days. This phenomenon goes hand in hand with people's current lifestyles. Another challenge is the inapplicable prosthetic plan due to the difficulty at the patient side or the surgical intervention side. The advancement in reconstruction is appreciated, but apparently it has not reached the limit of placing the factors of cost, time, and invasiveness into one location. I believe that cases should be treated and rehabilitated as soon as possible, with reasonable cost and feasible technicality, so that clients can focus on their daily lives. With this book I am honored to present a homogeneous gathering of literature on implantology, elaborated with up-to-date techniques of grafting, the improvement of anterior aesthetics, and answers to questions concerning postoperative implant complications and microbiota care.
16. Animal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications.
- Author
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Zicha, Josef, Vaněčková, Ivana, and Zicha, Josef
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Medicine ,Cardiovascular medicine ,developmental origins of health and disease (DOHaD) ,gut microbiota ,hypertension ,short chain fatty acid ,oxidative stress ,probiotics ,prebiotics ,renin-angiotensin system ,fibroblast growth factor-23 ,left ventricular hypertrophy ,renin-angiotensin-aldosterone system ,losartan ,canrenone ,Hyp mice ,X-linked hypophosphatemia ,hairless SHRM ,cold acclimation ,cardiac Cx43 ,extracellular matrix ,thyroid hormones ,SHR ,sacubitril/valsartan ,ARNI ,ivabradine ,remodelling ,cardiac dysfunction ,fibrosis ,angiotensin II ,angiotensin 1-7 ,knock-out ,genome-editing ,SHRSP ,Dahl SS ,foetal programming of hypertension ,sympathetic neurotransmission ,sympathetic innervation ,vascular remodelling ,foetal undernutrition ,old SHR ,antihypertensive therapy ,blood pressure monitoring ,LV hypertrophy ,ECM markers ,cardiac fibrosis ,SHR-CRP ,SGLT-2 inhibitor ,gene expression ,age ,lipid metabolism ,nitric oxide ,l-NAME ,rostral ventrolateral medulla ,aging ,reactive oxygen species ,NADPH oxidase activator 1 ,mitochondria ,chloride ,calcium-activated chloride channel ,Na+-K+-2Cl− cotransporter 1 ,TMEM16A ,smooth muscle ,fetal undernutrition programming ,cross-fostering ,lactation period ,cardiovascular hypertrophy ,adipose tissue browning ,cardiovascular disease ,catecholamines ,liquid chromatography-tandem mass spectrometry ,SGLT-2 inhibition ,proteinuria ,uninephrectomized salt-loaded ,two-kidney ,one-clip hypertension ,fawn-hooded hypertensive rat ,ApoE KO ,apolipoprotein E knockout mice ,atherosclerosis ,Na,K-ATPase ,TCTP ,TCTP-overexpressing transgenic mice ,translationally controlled tumor protein ,TCTP-TG ,experimental hypertension ,bone ,rats ,taurine ,magnesium ,24 h urine(24U) ,stroke-prone spontaneously hypertensive rat ,young SHR ,combination therapy ,treatment effect ,systolic blood pressure - Abstract
Summary: Essential hypertension is still an important health care problem. It is necessary to investigate its mechanisms in animal models. The potential clinical importance of such experimental research might be expected. This Special Issue concerned several important topics. First, several studies focused on the pathophysiological mechanisms responsible for blood pressure elevation during hypertension development, organ damage in chronic hypertension, and drugs targeting hypertension and/or its complications. Other studies were interested in the participation of central and peripheral blood pressure control, changes in vascular structure and function, and neural, humoral, and endocrine factors. Furthermore, the contribution of altered redox signaling, chronic inflammation, microbiome changes, and interactions of genetic and environmental factors were evaluated in multiple papers. Finally, special attention was paid to the progress in pharmacological tools for the control of hypertension and associated organ damage, genetic modifications to alter blood pressure levels, and non-pharmacological interventions attenuating hypertension or its complications. The original articles or reviews covered the interesting aspects of the pathophysiology of hypertension and associated end-organ damage, the use of various experimental hypertensive models, and the importance of specific environmental factors acting in distinct phases of the ontogeny. We especially appreciate the presentation of new ideas and the critical discussion of traditional theories.
17. Antimicrobial Prescribing and Stewardship, 1st Volume.
- Author
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Ashiru-Oredope, Diane and Ashiru-Oredope, Diane
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Medicine ,antimicrobial stewardship ,pharmacy ,sepsis ,wound management ,culture and sensitivity testing ,resistance patterns ,low-and middle-income countries ,Uganda ,antibiotic ,antimicrobial resistance ,veterinary ,animal health ,Africa ,bone infection ,joint infection ,osteomyelitis ,pediatric infectious disease ,septic arthritis ,antibiotics ,microbial resistance ,upper respiratory tract infections ,fosfomycin ,urinary infection ,resistance ,CwPAMS App ,smartphone apps ,antimicrobial prescribing ,low- and middle-income countries ,barriers and enablers ,training ,antibiotics use ,behavior change ,Helicobacter pylori ,therapy ,metronidazole ,clarithromycin ,fluoroquinolones ,amoxicillin ,proton pump inhibitors ,ethical trials ,obesity ,bloodstream infection ,antimicrobials ,prescription ,community health workers ,health practitioners ,infection prevention and control ,multidisciplinary ,one health ,UK ,antimicrobial resistance (AMR) ,antimicrobial stewardship (AMS) ,delayed/back-up prescribing ,developing countries ,LMICs ,Ghana ,knowledge ,attitudes ,medical students ,antimicrobial ,stewardship ,prescribing ,meningitis ,encephalitis ,FilmArray ,multiplex PCR ,rapid diagnostic technology ,children ,adolescents ,outcomes ,antibiotic stewardship program ,complementarity ,prospective audit and feedback ,antibiotic stewardship ,pharyngitis ,acute otitis media ,clinical pathways ,emergency departments ,antibiotic use ,prescribing appropriateness ,follow-up blood cultures ,Gram negative bacteremia ,critically ill patients ,antibiotic therapy ,general practice ,family practice ,health policy ,quality of health care ,public health ,pharmacist ,nurse ,COVID-19 ,antibiotic resistance ,wound care ,burn care ,Nepal ,AMS ,antimicrobial stewardship intervention ,PDSA cycle ,enterococcal ,bacteremia ,epidemiology ,risk factors ,mortality ,urinary tract infections (UTI) ,older adults ,qualitative ,leaflet ,Theoretical Domains Framework ,coronavirus ,SARS-CoV-2 ,anti-infective agents ,candidemia ,hematologic diseases ,complex intervention - Abstract
Summary: This Antimicrobial Prescribing and Stewardship Issue (volume 1) consist of manuscripts, including original research, review articles, case series, and opinion papers for topics related to antimicrobial (antibiotic, antifungal) stewardship, including: Disease-based/organism-based antimicrobial stewardship;Diagnostic stewardship;Influence of antimicrobial utilisation changes in antimicrobial resistance;Impact of antimicrobial stewardship on quality performance measures and patient outcomes;Novel antimicrobial stewardship education and training approaches or interventions aimed at the public and/or healthcare workers;Behavioural change approaches to antimicrobial stewardship;Collaborative practice agreements in antimicrobial stewardship;Antimicrobial stewardship in special populations (e.g., paediatrics, geriatrics, emergency medicine, hematology/oncology);Tackling AMR through antimicrobial stewardship in low- and middle-income countries;Antimicrobial stewardship for animal health;Antimicrobial stewardship in alternative settings (e.g., community practice, long-term care, and resource-limited small and rural hospitals);Antimicrobial use and stewardship in the context of the COVID-19 pandemic;Global collaborations to tackle AMR through antimicrobial stewardship.
18. Antioxidants in Sport Nutrition.
- Author
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Lamprecht, Manfred and Lamprecht, Manfred
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Diets & dieting ,Dietetics & nutrition ,Sports injuries & medicine ,Food & beverage technology ,Nutrition ,Sports Medicine ,Sports Performance Analysis ,NUTRITION ,SCI-TECH ,MEDICINE ,STM ,free ,lipid ,oxidative ,oxygen ,peroxidation ,radical ,reactive ,species ,stress ,supplementation - Abstract
Summary: Antioxidant use in sports is controversial due to existing evidence that it both supports and hurts athletic performance. This book presents information on antioxidants, specifically for athletes, and their roles in sports nutrition. It stresses how antioxidants affect exercise performance, health, and immunity. Chapters cover oxidative stress; basic nutrition for athletes; major dietary antioxidants; sports supplements; performance/adaptation to exercise; antioxidants role in health and immunity; reviews on vitamins C, E, beta-carotene, and minerals in sports nutrition; and roles polyphenols play in high-performance sport.
19. Aortic Stenosis - Current Perspectives.
- Author
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Peter Magnusson
- Subjects
Medicine ,Cardiac Surgery ,Cardiology and Cardiovascular Medicine ,Health Sciences - Abstract
Summary: As the most common cardiac valve disease, aortic stenosis is frequently encountered by healthcare providers in clinical practice. It may be suspected from a cardiac murmur found at a routine clinical exam, signs on ECG, heart failure, or an episode of syncope or arrhythmia. Echocardiography as well as other imaging tools provide information about the degree of severity of the stenosis. Nevertheless, careful judgement of potential symptoms is crucial. When it comes to treatment, a catheter-based approach has emerged as the preferred option in many cases, even though open-chest surgery is still standard treatment. Regardless of treatment modality, a multidisciplinary team is needed to provide optimal management of patients with aortic stenosis. This book provides all the necessary information on aortic stenosis, including etiology, diagnosis, treatment, and follow-up.
20. Aspects in Continuous Renal Replacement Therapy.
- Author
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Ayman Karkar
- Subjects
Medicine ,Nephrology ,Urology ,Health Sciences - Abstract
Summary: Continuous renal replacement therapy (CRRT) is a slow and smooth continuous extracorporeal blood purification process. It is usually implemented over 24 hours to several days with gentle removal of fluid overload and excess uremic toxins. CRRT, which is based on the physiological principles of diffusion, ultrafiltration, convection, and adsorption, can be performed as slow continuous ultrafiltration, continuous veno-venous hemofiltration, continuous veno-venous hemodiafiltration, and continuous veno-venous hemodialysis. Over many years, CRRT has been shown to be an effective dialysis therapy for hemodynamically unstable patients with acute kidney injury, brain injury, and/or multiorgan failure in intensive care units. Aspects in CRRT covers selected important topics with a practical approach to the management of different aspects of CRRT. All chapters have been updated and are well referenced, supported by well-illustrated figures and tables, and written by distinguished and experienced authors. Aspects in CRRT is considered as a guide to daily practice in intensive care units, and a reference for medical and nursing staff involved in taking care of critically ill patients with acute kidney injury, sepsis, and multiorgan failure.
21. Aspects in Dialysis.
- Author
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Ayman Karkar
- Subjects
Medicine ,Nephrology ,Urology ,Health Sciences - Abstract
Summary: Dialysis (clearance of uremic toxins and removal of excess fluids) is a broad term for different modalities of treatment for patients with acute and end-stage kidney disease. These modalities include peritoneal dialysis, hemodialysis, hemofiltration, hemodiafiltration, and continuous renal replacement therapy for critically ill patients with acute kidney injury. Dialysis is a lifesaving measure and can be conducted in hospitals, in dialysis clinics, and at home. Recently, dialysis techniques have witnessed tremendous improvements in technology and performance. The book Aspects in Dialysis covers important aspects of dialysis-related topics and is empowered with well-established and experienced authors, who have written clear and informative chapters. It covers various aspects of dialysis modalities supported by well-established clinical studies. Aspects in Dialysis can be considered as a guide for daily practice and a reference for medical and nursing staff involved in taking care of dialysis patients.
22. Assessing Atmospheric Pollution and Its Impacts on the Human Health.
- Author
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Barbulescu, Alina and Barbulescu, Alina
- Subjects
Medicine ,Medical toxicology ,household air pollution ,fine particulate matter ,international environmental health ,cookstove ,respiratory disease ,brick worker ,particulate matter ,heavy metals ,Sulfate-Nitrate-Ammonium ,pollution levels ,mobile sources ,aerosols ,PAHs ,OC and EC ,transport sources ,urbanized coastal station ,grain dust ,health risk assessment ,Monte Carlo simulation ,disability adjusted life year ,multi-media exposure ,health risk ,probabilistic risk assessment ,Lake Chaohu ,PM10 ,health risks ,extreme learning machine ,echo state network ,neural networks ,pollution ,concentration ,indicators ,aberrant values ,nitrogen oxides ,ARIMA ,GRNN ,ARIMA-GRNN ,isolation forest ,LOF ,AOD ,classification ,dendrogram ,PCA ,air quality index ,polluting agents ,respiratory diseases ,monitoring stations ,n/a - Abstract
Summary: This reprint contains articles published in the Special Issue entitled "Assessing Atmospheric Pollution and Its Impacts on the Human Health" in the journal Atmosphere. The research focuses on the evaluation of atmospheric pollution by statistical methods on the one hand, and on the other hand, on the evaluation of the relationship between the level of pollution and the extent of its effect on the population's health, especially on pulmonary diseases.
23. Assessment of General Practitioners' Performance in Daily Practice. The EURACT Performance Agenda of General Practice/Family Medicine.
- Author
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Wilm, Stefan and Wilm, Stefan
- Subjects
Medicine ,EURACT ,Definition of General Practice ,European Academy of Teachers in General Practice ,General Practitioners ,Family Medicine - Abstract
Summary: The EURACT Performance Agenda (EUPA) of the European Academy of Teachers in General Practice/Family Medicine (EURACT) is the third paper in a row following the European Definition of General Practice/Family Medicine (WONCA Europe) in 2002 which identified 6 core competencies and 11 abilities every general practitioner (GP) should master, and the EURACT Educational Agenda in 2005 which provided a framework to teach the core competencies by setting learning aims and monitoring their achievement. Performance (in contrast to competence) is understood as the level of actual performance in clinical care and communication with patients in daily practice. Small groups of EURACT Council members from 40 European countries have discussed and developed EUPA since 2007. EUPA is a general, uniform and basic agenda of performance elements every GP masters in daily practice, applicable and adaptable to different countries with different systems. It deals with the process and result of actual work in daily practice, not with a teaching/learning situation. EUPA discusses in depth the psychometrics and edumetrics of performance assessment. Case vignettes of abilities in GPs' daily practice illustrate performance and its assessment in every chapter. Examples of common assessment tools are workplace-based assessment by a peer, feedback from patients or staff and audit of medical records. EUPA can help to shape various performance assessment activities held locally in general practice/family medicine, e. g. in continuing professional development cycles, re-certification/re-accreditation/licensing procedures, peer hospitation programmes and practice audit programmes in quality management. It can give orientation for self-assessment for reflective practitioners in their continuing professional development. The EURACT Performance Agenda (EUPA) encourages general practitioners to initialize performance agendas adapted to their national health system to further strengthen the role of general practice/family medicine in their country.
24. Atherosclerosis - Yesterday, Today and Tomorrow.
- Author
-
Luigi Gianturco
- Subjects
Medicine ,Cardiology and Cardiovascular Medicine ,Health Sciences - Abstract
Summary: Atherosclerosis is a subject of enormous contention for cardiologists and in general for all medical doctors. With this publication we have given you a concise ""state-of-the-art"" look at the world of atheroma. Many other elements could be included and so it is only a brief analysis of ""today"" (the preventive medicine era) and ""tomorrow"" (transforming the cure medicine era into the care medicine era) but also remembering ""yesterday"" (the ex-cathedra medicine era). Let's hope our arteries are free from atherosclerotic events: have a good read!
25. Autism - Paradigms, Recent Research and Clinical Applications.
- Author
-
Jane Yip and Michael Fitzgerald
- Subjects
Medicine ,Mental and Behavioural Disorders and Diseases of the Nervous System ,Health Sciences ,Neurodiversity - Abstract
Summary: This book opens with a discussion of neurodiversity and an elaboration of the diagnosis of autism. It then examines factors correlating with autism, including sex bias, month of birth, migration and impact of infant feeding. The next section is on the impact of autism. The neurobiology and genetic section deals with epigenetics and intracellular pathways associated with etiology. The development and behaviour section deals with proprioceptive profiles and joint attention in autism. The final section focuses on interventions including mindfulness, animal assisted activity, social/cultural perspective on autism intervention and physical activity. The book is relevant to all professionals and researchers working with persons with autism, including psychiatrists/psychologists, speech and language therapists, occupational therapists, teachers, nurses and care workers.
26. Autophagy in Tissue Injury and Homeostasis.
- Author
-
Lin, Pei-Hui and Lin, Pei-Hui
- Subjects
Medicine ,aging ,dietary restriction ,acute kidney injury ,mitochondria ,autophagy ,mitophagy ,ischemia ,renal tubular cells ,diabetic nephropathy ,exosomes ,mTOR ,innate immunity ,immune cell ,inflammasome ,Paneth cell ,inflammatory bowel disease ,Crohn's disease ,hepatocytes ,hepatic stellate cells ,sinusoidal endothelial cells ,macrophages ,fibrosis ,cirrhosis ,hepatocellular carcinoma ,biomarkers ,cell death ,glutaminase ,metabolism ,molecular rehabilitation ,kidney diseases ,oxidative stress ,inflammation ,ATGs ,intestinal homeostasis ,inflammatory bowel diseases ,HCC therapy ,Autophagy ,acute lung injury ,idiopathic pulmonary fibrosis ,COPD ,tuberculosis ,PAH ,cystic fibrosis ,Beclin-1 ,cardiac dysfunction ,sepsis ,endotoxemia ,muscle regeneration ,stem cell ,immune ,macrophage ,senescence ,exercise ,caloric restriction ,diabetic retinopathy ,PINK1 ,Notoginsenoside R1 ,ethanol ,LC3 ,apoptosis ,Sertoli cell ,Parkin ,TFEB ,infertility ,AMPK ,FOXO ,MTOR ,parkin ,spinal cord injury ,traumatic brain injury ,autophagic flux ,neuronal cell death ,lysosomal damage ,n/a - Abstract
Summary: Autophagy ("auto-digestion"), a lysosome-dependent process, degrades and turns over damaged or senescent organelles and proteins. Autophagy is a highly regulated process that impacts several vital cellular responses, including inflammation, cell death, energy metabolism, and homeostasis of organelles (mitochondria and others). Although the role of autophagy in the maintenance of tissue homeostasis is well documented, its role during tissue injury and regeneration is still emerging. In this Special Issue on "Autophagy in Tissue Injury and Homeostasis", we focus on the roles of autophagy in systemic, specific tissue (organs/cells) injury or organ failure associated with sepsis, inflammation, metabolic disorder, toxic chemicals, ischemia-reperfusion injury, hypoxic oxidative stress, tissue fibrosis, trauma, and nutrient starvation. The knowledge gained from the identification and characterization of new molecular mechanisms will shed light on biomedical applications for tissue protection through the modulation of autophagy.
27. Basic Cardiopulmonary Resuscitation Manual.
- Author
-
Jose A. Morales Gonzalez
- Subjects
Medicine ,Interventional Cardiology ,Cardiology and Cardiovascular Medicine ,Health Sciences - Abstract
Summary: The purpose of this publication is to systematize the knowledge necessary to make Cardiopulmonary Resuscitation (CPR) or Cardiorespiratory Resuscitation (CRR) known to nursing health specialists, which translates as a set of temporary and internationally standardized maneuvers assigned to ensure the oxygenation of the vital organs when the blood circulation of an individual stops suddenly, independently of the cause of the Cardiorespiratory arrest (CRA). This knowledge is found correctly delimited in The Basic Cardiopulmonary Resuscitation Manual, which especially emphasizes the step-by-step methodology and techniques to follow for Cardiopulmonary Resuscitation (CPR). This is a basic work that cannot be overlooked by health care specialists, the society, and the public in general, because of the high probability that this situation will present at some moment in life. Thus, it is recommended to be prepared to help some person in an emergency situation. The manual is an excellent consultation work for health professionals. Given that what is expressed in this work is fundamental for life, and its objective is to make known the relevant information concerning the knowledge of CPR.
28. Basic Research in Endocrinology. A Modern Strategy for the Development and Technologies of Personalized Medicine.
- Author
-
Voevoda, Mikhail Ivanovich, Ragino, Yuliya I., and Voevoda, Mikhail Ivanovich
- Subjects
Medicine ,diagnostic method ,severity of disturbances ,rheology ,diabetes mellitus ,erythrocyte ,dielectrophoresis ,anemia of chronic disease ,iron deficiency anemia ,hyperlipidemia ,inflammation ,C-reactive protein ,tumor necrosis factor-α ,erythrocyte sedimentation rate ,osteoporosis ,fracture ,menopause ,population ,chronic non-communicable diseases ,risk factors ,early IHD ,abdominal obesity ,blood cytokines/chemokines complex ,multiplex assay ,Flt3 ligand ,GM-CSF ,MCP-1 ,IL-4 ,maturity onset diabetes of the young type 14 ,APPL1 ,single-nucleotide variant ,Firmicutes ,Bacteroidetes ,gut microbiota ,bile microbiota ,gallstone patients ,maturity onset diabetes of the young ,MODY ,multiplex ligation-dependent probe amplification ,next-generation sequencing ,GCK ,HNF1A ,HNF4A ,HNF1B ,obesity ,BMI ,blood tests ,proteomics ,mass spectrometry ,norepinephrine concentration in the hypothalamus ,heart mass ,QTL analysis ,SNPs ,ISIAH hypertensive rat strain ,risk factor ,diabetes risk scale ,diabetes risk model ,type 1 diabetes mellitus ,type 2 diabetes mellitus ,proton spectroscopy ,hippocampus ,cognitive dysfunction ,n/a - Abstract
Summary: The first all-Russia conference with international participation "Basic Research in Endocrinology: A Modern Strategy for the Development and Technologies of Personalized Medicine" was held in Novosibirsk on 26-27 November 2020. The purpose of this conference was to disseminate the latest basic and clinical findings in the fields of etiology, clinical characteristics, and modern diagnostics and treatments of endocrine disorders among various relevant specialists. The conference was intended for practicing endocrinologists, primary care physicians, medical geneticists, pediatric endocrinologists, pediatricians, and physician-scientists. The main topics included epidemiology and pathogenesis of endocrine disorders; genomic research in endocrinology; biochemical characteristics of endocrine aberrations; immunology and immunogenetics in endocrinology; cellular technologies in endocrinology; metabolomic research in endocrinology; pharmacogenetics; basic pathomorphology; high-tech care of patients with endocrine disorders; iodine-deficiency-related, autoimmune, and oncological diseases of the thyroid; modern diagnostic and therapeutic strategies for diabetes mellitus; osteoporosis and osteopenias; polyendocrinopathies; an interdisciplinary approach to the diagnosis and treatment of obesity and metabolic syndrome; hypo- and hyperparathyroidism, vitamin D; neuroendocrine disorders; reproductive health; rehabilitation of patients with endocrine disorders; health resort and spa treatments of endocrine disorders and comorbid conditions.
29. Bedside and Community. 50 Years of Contributions to the Health of Albertans by the University of Calgary.
- Author
-
Stahnisch, Frank W., Mansell, Diana, Larsson, Paula, and Stahnisch, Frank W.
- Subjects
Medicine ,Education ,Medical ethics & professional conduct ,Nursing ,Health ,Veterinary ,Medical administration - Abstract
Summary: The University of Calgary's innovative and collaborative approach to health care education is celebrated in an interdisciplinary collection. Bedside and Community is the inside story of fifty years of health care and health research at the University of Calgary. Drawing on the first-person accounts of researchers, administrators, faculty, and students along with archival research, and faculty histories, this collection celebrates the many significant contributions the University of Calgary has made to the health of Albertans. With contributions from the Cumming School of Medicine, the Faculty of Nursing, Faculty of Kinesiology, Faculty of Veterinary Medicine, Faculty of Environmental Design, Department of Psychology, and Indigenous Health Initiatives Bedside and Community is a truly collaborative history. Addressing the links between departments, the relationship between the university and the community, and evolving research and teaching methods, this book places the University of Calgary within a wider national context and shows how it has addressed the unique health needs of Southern Alberta. With a pioneering focus on primary care and commitment to interdisciplinary connections, the University of Calgary has made strides in health research, health education, and community outreach. Bedside and Community tells the story of a tradition of excellence that will light the way to future outreach and discovery.
30. Bedside Procedures.
- Author
-
Gabriel Cismaru
- Subjects
Medicine ,Critical Care Medicine ,Pre-Hospital Emergency Medicine ,Health Sciences - Abstract
Summary: Shifting the performance of an invasive procedure from operating room or interventional lab to the ICU has advantages for both the patient and the doctor performing the procedure. The book is a guide to interventions that are commonly performed in the intensive care unit, without the need of an operating room. In the following chapters, the authors show that procedures like endotracheal intubation, videolaryngoscopy, pericardial puncture, lumbar puncture and percutaneous cholecystostomy, and intra-abdominal pressure monitoring can be safely performed outside the operating room, at the bed of the patient. All the chapters of the book are clinically orientated providing explanations and illustrations for invasive procedures. Practical recommendations are given in the book, accompanied by figures for techniques performed in critically ill patients. It will serve the experienced doctor who has not performed a procedure for a long time as well as the young doctors needing a practical assistance when facing a new patient.
31. Big Data in Dental Research and Oral Healthcare.
- Author
-
Joda, Tim and Joda, Tim
- Subjects
Medicine ,digital transformation ,rapid prototyping ,augmented and virtual reality (AR/VR) ,artificial intelligence (AI) ,machine learning (ML) ,personalized dental medicine ,tele-health ,patient-centered outcomes ,integrated care, medical-dental integration, simulation model, dental research ,oral medicine ,oral healthcare ,dentistry ,gerodontology ,elderly patient ,big data ,Big Data ,digital dentistry ,oral health ,ethical issues ,dental education ,augmented reality (AR) ,virtual reality (VR) ,artificial intelligence ,AI ,machine learning ,ML ,cone beam computed tomography (CBCT) ,intraoral scanning ,facial scanning ,healthcare cost ,medical healthcare cost ,dental healthcare cost ,zero-inflated model ,neural network - Abstract
Summary: Progress in information technology has fostered a global explosion of data generation. Accumulated big data are now estimated to be 4.4 zettabytes in the digital universe; and trends predict an exponential increase in the future. Health data are gathered from professional routine care and other expanded sources including the social determinants of health, such as Internet of Things. Biomedical research has recently moved through three stages in digital healthcare: (1) data collection; (2) data sharing; and (3) data analytics. With the explosion of stored health data, dental medicine is edging into its fourth stage of digitization using new technologies including augmented and virtual reality, artificial intelligence, and blockchain. Big data collaborations involve interactions between a diverse range of stakeholders with analytical, technical and political focus. In oral healthcare, data technology has many areas of application: prognostic analysis and predictive modeling, the identification of unknown correlations of diseases, clinical decision support for novel treatment concepts, public health surveys and population-based clinical research, as well as the evaluation of healthcare systems. The objective of this Special Issue is to provide an update on the current knowledge with state-of-the-art theory and practical information on human and social perspectives that determine the uptake of technological innovations in big data science in the field of dental medicine. Moreover, it will focus on the identification of future research needs to manage the continuous increase in health data and to accomplish its clinical translation for patient-centered research and personalized dentistry. This Special Issue welcomes all types of studies and reviews considering the perspectives of different stakeholders on technological innovations for big data science in all dental disciplines. Kind regards,
32. Biomarker.
- Author
-
Tapan Kumar Khan
- Subjects
Medicine ,Diagnostics ,Clinical Pathology ,Health Sciences - Abstract
Summary: Clinicians, scientists, and health care professionals use biomarkers or biological markers as a measure of a person's present health condition or response to interventions. An ideal -biomarker should have the following criteria: (I) ability to detect fundamental features of the disease, (II) ability to differentiate from other closely related diseases, (III) ability to detect early stages and stages of progression, (IV) the method should be highly reliable, easy to perform and inexpensive, and (V) sample sources should be easily accessible from body. Most of the chapters in this book follow the basic principle of biomarkers.
33. Bone Development and Disease in Infants.
- Author
-
Pavone, Vito and Pavone, Vito
- Subjects
Medicine ,pediatric ,growing age ,complex regional pain syndrome ,reflex sympathetic dystrophy ,multidisciplinary ,physical therapy ,cognitive behavioral therapy ,drugs ,pharmacological treatment ,occupational therapy ,supracondylar humerus fracture ,humerus fracture ,upper limb fracture ,fracture laterality ,handedness ,pediatric orthopedics ,developmental dysplasia of the hip ,DDH ,treatment ,conservative ,bracing ,dynamic splint ,static splint ,Legg-Calvé-Perthes disease ,Herring lateral pillar classification ,Stulberg classification ,Waldenström stage ,duration ,chronological age ,skeletal maturity ,Cervical Vertebral Maturation ,douple diapering ,neonatal hip ,DDH prevention ,hip positioning ,hip extension ,hip adduction ,clubfoot ,CTEV ,sport ,sport practice ,sport activity level ,young athletes ,ponseti method ,bone tumors ,Ewing's sarcoma ,infants ,children ,composite prosthesis ,Pirani score ,Dimeglio score ,interobserver reliability ,congenital talipes equinovarus ,hemophilia ,prophylaxis ,high-impact sports ,physical activity ,psychological wellness ,trauma ,lockdown ,pandemic ,SARS-Co-V-2 ,n/a - Abstract
Summary: Children's bone growth is continuous, and remodelling is always extensive. Growth proceeds from a vulnerable part of the bone, the growth plate. In remodelling, old bone tissue is gradually replaced by new tissue. Many bone disorders arise from the changes that occur in a growing child's musculoskeletal system, and these disorders can positively or negatively impact bone development. Other bone disorders may be inherited or occur in childhood for unknown reasons.Bone disorders in children can result from factors that affect people of all ages, including injury, infection (osteomyelitis), cancer, and metabolic diseases. Causes of bone disorders can involve the gradual misalignment of bones and stress on growth plates during growth. Congenital deformities such as clubfoot or developmental dysplasia of the hip can lead to important alterations of bone development, causing severe dysfunction. Certain rare connective tissue disorders can also affect the bones, such as Marfan syndrome, osteogenesis imperfecta, and osteochondrodysplasias.Many specialists are involved in the management of bone development disorders in children and adolescents, such as neurosurgeons, plastic surgeons, general surgeons, ORL surgeons, maxillofacial surgeons, orthopaedics, radiologists, and pediatric intensive care physicians.The aim of this Special Issue is to present the latest research on the etiology, physiopathology, diagnosis and screening, management, and rehabilitation related to bone development and disease in infants, focusing on congenital, developmental, post-traumatic, and post-infective disorders.
34. Breast Imaging.
- Author
-
Cherie M. Kuzmiak
- Subjects
Medicine ,Healthcare Informatics ,Engineering Technology in Medicine ,Health Sciences - Abstract
Summary: Early detection of breast cancer with screening mammography is still the best method we have in saving countless women's lives and decreasing the harms of overtreatment. This textbook encompasses relevant topics in daily patient care with breast imaging to technical innovations for improving breast cancer detection and treatment.
35. Cancer Epidemiology in China: What We Have Learnt So Far?
- Author
-
Ji, Jianguang, Chen, Tianhui, Shu, Xiaochen, Liu, Hao, and Ji, Jianguang
- Subjects
Medicine ,Oncology ,cancer burden in China ,cancer mortality ,China ,public health ,cancer epidemiology - Abstract
Summary: After several decades of development, the socialist market economy of China is now the world's second largest economy by nominal GDP. China is also the largest economy by purchasing power parity according to the International Monetary Fund. In tandem with the development of the Chinese economy, China's cancer burden is rising rapidly due to an ageing population and the adoption of unhealthy lifestyle behaviours. According to the data from the National Central Cancer Registry (NCCR) of China, the incidence and mortality of cancer have been increasing rapidly in China. In recent years, cancer has been the leading cause of death among city residents and the second cause of death among rural residents, which has become a stark public health issue in China. According to the NCCR, an estimated 4.29 million new incident cases (12 thousand per day) and 2.81 million death cases (7.5 thousand per day) would occur in 2015 in China. This corresponds to the age-standardized incidence rate (ASIR) of 201.1 per 100,000 and age-standardized mortality rate (ASMR) of 126.9 per 100,000, respectively. Due to the geographical and ethnical disparities in living habits and healthcare level, the cancer spectrum differs between different regions and ethnical groups in China. According to the estimation from IARC, the incidence of nasopharyngeal carcinoma and liver cancer is the world's highest in specific regions of China. The incidence of some cancer types in Chinese urban areas, such as colorectal, prostate, kidney and bladder cancers, is similar to that in developed countries or regions where the incidence of cancer is highly associated with obesity and westernised lifestyles. Nevertheless, the incidence of some common cancer types in rural areas, including oesophageal, stomach, liver and cervical cancers, shares similarity with less developed countries or regions in the world where cancers are associated with chronic infectious agents due to poverty. In addition, the mortality rate is higher in rural areas, which suggests a poorer cancer prognosis due to late diagnosis and/or unsatisfying clinical treatment. The distinct cancer patterns of different regions and/or ethnic groups indicate a need for precise cancer prevention and control plans tailored for different geographical regions and/or ethnic groups. The overarching goal of the proposed Frontiers in Oncology Research Topic is to present current perspectives on cancer epidemiology in Chinese characteristics and provide current knowledge of cancer burden as well as cancer mortality to academic investigators, clinicians and stakeholders from the translational, clinical and public health communities.
36. Capitalizing a Cure. How Finance Controls the Price and Value of Medicines.
- Author
-
Roy, Victor
- Subjects
Political economy ,Medicine ,Medicine; finance; biomedicine; public health - Abstract
Summary: Capitalizing a Cure takes readers into the struggle over a medical breakthrough to investigate the power of finance over business, biomedicine, and public health. When curative treatments for hepatitis C launched in 2013, sticker shock over their prices intensified the global debate over access to new medicines. Weaving historical research with insights from political economy and science and technology studies, Victor Roy demystifies an oft-missed dynamic in this debate: the reach of financialized capitalism into how medicines are made, priced, and valued. Roy's account moves between public and private labs, Wall Street and corporate board rooms, and public health meetings and health centers to trace the ways in which curative medicines became financial assets dominated by strategies of speculation and extraction at the expense of access and care. Provocative and sobering, this book illuminates the harmful impact of allowing financial markets to determine who heals and who suffers and points to the necessary work of building more equitable futures. "An important voice on the links between finance and health ecosystems, Victor Roy makes a valuable contribution to building an economy that is based on providing health for all." - Mariana Mazzucato, author of The Value of Everything: Making and Taking in the Global Economy and Chair of the WHO Council on the Economics of Health for All "This book is a riveting read that will strike fear in the heart of anybody who cares about the right to health or thinks that the drive for profits should not supersede democracy or human need." - Salmaan Keshavjee, author of Blind Spot: How Neoliberalism Infiltrated Global Health "The best piece of nonfiction I have read in a long time. This book offers a fantastic, relevant, and necessary case study to understand how the financialization of the economy has affected the organization of industrial sectors." - Marc-André Gagnon, Professor of Public Policy and Political Economy, Carleton University
37. Cardiac Arrhythmias.
- Author
-
Umashankar Lakshmanadoss
- Subjects
Medicine ,Cardiology and Cardiovascular Medicine ,Clinical Cardiac Electrophysiology ,Health Sciences - Abstract
Summary: This book is a comprehensive and practical updated review about the various aspects of cardiac arrhythmias. It covers a variety of aspects of both atrial and nonatrial arrhythmias, including genetics, clinical aspects, ECG manifestations, and practical approaches to complex cardiac arrhythmia management - office, hospital, intensive care unit, electrophysiology laboratory, and operating room. This book also presents comprehensive ECG reviews of cardiac arrhythmias like atrial flutter, Brugada pattern, Breijo ECG pattern, and PVCs. Practical aspects of preventing and managing arrhythmias - central venous catheter-induced, atrial flutter, and drug-induced cardiac arrhythmias - are described. Experts have demonstrated the approach for mapping and ablation of complex arrhythmias like atrial flutter, idiopathic ventricular tachycardia, and Brugada syndrome.
38. Caregiving and Home Care.
- Author
-
Mukadder Mollaoglu
- Subjects
Medicine ,Neurology ,Mental and Behavioural Disorders and Diseases of the Nervous System ,Health Sciences - Abstract
Summary: The management of chronic diseases is one of the tasks of all members of the health team, and different models need to be applied in the practice of chronic care management. One of these models is home care services. There are two main sections in this book. In the first part of the section, the concept of caregiving and care at home is explained. In the second part, the responsibilities of caregivers at home and the responsibilities of caregivers of people who have health problems that occur during different periods of life are discussed. In the second section, the problems of caregivers are also included. I would like to think that what is quoted in this book, which contains examples from different cultures of the world for home care approaches, will contribute to the development of home care services. This book is presented to all health professionals working in the field of health services as well as health politics professionals and students trained in these areas.
39. Caring for Those Who are Neglected and Forgotten: Psychiatry in Prison Environments.
- Author
-
Konrad, Norbert, Opitz-Welke, Annette, Angela Völlm, Birgit, and Konrad, Norbert
- Subjects
Medicine ,Psychiatry ,mental health ,prison ,risk ,suicide ,violence ,psychopathy - Abstract
Summary: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
40. Cellular and Molecular Mechanisms of Nephropathic Cystinosis.
- Author
-
Levtchenko, Elena N. and Levtchenko, Elena N.
- Subjects
Medicine ,Pharmacology ,cystinosis ,cysteamine ,bone ,osteoclast ,genotype ,CD34+ hematopoietic stem and progenitor cells ,gene therapy ,pre-clinical studies ,investigational new drug application ,clinical trial ,disulfiram ,mice ,zebrafish ,fertility ,azoospermia ,hypogonadism ,histopathology ,mouse model ,lysosomal storage disease ,cell and animal models ,infantile nephropathic cystinosis ,bone-muscle wasting ,fibroblast growth factor 23 ,osteoclasts ,sclerostin ,leptin ,fractures ,nephropathic cystinosis ,hollow fiber membrane ,3-dimensional models ,autophagy ,macrophages ,inflammasome ,proximal tubular cells ,endocytosis ,apoptosis ,chitotriosidase ,interleukins ,galectin-3 ,novel therapies ,endolysosome ,epithelial cell differentiation ,homeostasis ,lysosomal storage diseases ,mitochondrial distress ,kidney proximal tubule ,programmed cell death ,central nervous system ,cortical atrophy ,arterial spin labelling ,cystine blood level ,lysosomal storage disorder ,history ,treatment strategies for cystinosis ,newborn screening ,clinical course ,CTNS-pathogenic variants ,newborn screening for cystinosis ,kidney progenitors ,cell model ,biomarkers ,cystine ,kidney ,therapeutic monitoring - Abstract
Summary: Nephropathic cystinosis (MIM # 219800) is a rare autosomal recessive disorder caused by mutations in the lysosomal cystine transporter cystinosin, encoded by the CTNS gene (17p13.2). This devastating condition initially affects kidneys and subsequently many other organs including eyes, thyroid, pancreas, muscles, and brain. While lysosomal cystine storage is a key feature of the disease and the main target of current therapy, recent groundbreaking research has revealed that cystinosin has diverse functions in cells, being involved in vesicle trafficking, energy homeostasis, and cell death mechanisms. These discoveries deepen our insights into the mechanisms of cystinosis and of lysosomal biology in general. In this Special Issue dedicated to the pioneer of cystinosis research Dr. Jerry Schneider, we highlight the state-of-the-art understanding of cellular and molecular mechanisms of various disease features, opening new horizons for innovative treatment strategies for cystinosis and potentially other lysosomal storage diseases.
41. Cellular Oxidative Stress.
- Author
-
Marino, Angela, Dossena, Silvia, and Marino, Angela
- Subjects
Medicine ,neuroinflammation ,clinical ,palmitoylethanolamide ,luteolin ,co-ultramicronization ,CNS pathology ,adaptive immune response ,cell homeostasis ,legumes ,liver ,hepatic steatosis ,lipid dyshomeostasis ,ROS ,traumatic brain injury ,palmitoylethanolamide (PEA) ,therapeutic strategies ,oxidative stress ,RNA-Seq ,RPE ,Retinitis pigmentosa ,A2E ,diabetes ,glucose exposure ,Band 3 protein ,erythrocytes ,SO42− ,4-hydroxy-2-nonenal ,3-glutathionyl-4-hydroxynonanal ,astrocytoma cells ,soy ,soybeans ,soy foods ,antioxidants ,reactive oxygen species ,cardiovascular diseases ,cancer ,paw edema ,cashew nuts ,antioxidant ,inflammation ,polyphenols ,analgesic ,d-Galactose ,glycation ,SO42− uptake ,anion exchange ,diseases ,immune system ,NF-κB ,cigarette smoke extract ,nasal fibroblasts ,tissue inhibitor of metalloproteinases ,matrix metalloproteinase ,steroids ,Plasmodium falciparum ,syk kinase inhibitors ,artemisinin derivatives ,hemichromes ,cellular redox state ,mitochondrial function ,cisplatin nephrotoxicity ,acute pancreatitis ,obesity ,nitrosative stress ,PGC-1α ,microparticles ,vesiculation ,band 3 ,tert-Bytyl hydroperoxide t-BOOH ,nitric oxide donor ,calcium ionophore A23187 ,age-related macular degeneration (AMD) ,diet ,Substance-P ,adipose-derived stem cells ,paracrine factors ,epilepsy ,status epilepticus ,Trolox ,HeLa ,prooxidant ,AVD ,apoptosis ,neurodegeneration ,ncRNA ,miRNA ,tRNA fragments ,lncRNA ,circRNA ,preeclampsia ,hemostasis ,platelets ,coagulation ,fish ,mucosal immunity ,nasal immunity ,peroxide ,vitamin C ,NAC ,immunosenescence ,T cells ,vaccination ,aging ,microvascular permeability ,bradykinin ,interleukin 1β ,NADPH oxidase ,simvastatin ,molecular hydrogen ,autophagy ,matrix metalloproteinases ,reactive oxygen species (ROS) ,phytochemicals ,dietary chemicals ,natural compounds ,programmed cell death ,anoikis ,ferroptosis ,pyroptosis ,n/a - Abstract
Summary: This book collects 17 original research papers and 9 reviews that are part of the Special Issue "Cellular Oxidative Stress", published in the journal Antioxidants. Oxidative stress on a cellular level affects the function of tissues and organs and may eventually lead to disease. Therefore, a precise understanding of how oxidative stress develops and can be counteracted is of utmost importance. The scope of the book is to emphasize the latest findings on the cellular targets of oxidative stress and the potential beneficial effect of antioxidants on human health.
42. Centring Human Connections in the Education of Health Professionals.
- Author
-
Melrose, Sherri, Park, Caroline, and Perry, Beth
- Subjects
Nursing fundamentals & skills ,Pedagogy ,health care ,medical professionals ,vocational books ,above and beyond ,caregivers ,appreciative patients ,nursing ,learning ,teaching ,medical books ,medicine ,medical school - Abstract
Summary: Many of today's learning environments are dominated by technology or procedure-driven approaches that leave learners feeling alone and disconnected. The authors of Centring Human Connections in the Education of Health Professionals argue that educational processes in the health disciplines should model, integrate, and celebrate human connections because it is these connections that will foster the development of competent and caring health professionals. Centring Human Connections in the Education of Health Professionals equips educators working in clinical, classroom, and online settings with a variety of teaching strategies that facilitate essential human connections. Included is an overview of the educational theory that grounds the authors' thinking, enabling the educators who employ the strategies included in the book to assess their fit within curriculum requirements and personal teaching philosophies and understand how and why they work.
43. Challenges in Elder Care.
- Author
-
Edward T. Zawada Jr.
- Subjects
Medicine ,Geriatric Intensive-Care Unit ,Health Sciences ,Geriatrics and Gerontology - Abstract
Summary: This work is intended as a brief but focused compilation to assist with diagnosis and management of the most common serious medical problems in the rapidly growing geriatric population. The geriatric population recently expanded by the fact that the baby boomers have reached the milestone of 65 years of age in the past 5 years. Tips for diagnosis, medication administration, and logistics of cost-effective management in the health-care continuum are presented in this book. The latter often consists of a journey from home to medical office to emergency room to hospital bed to intensive care unit to long-term acute care hospital to skilled nursing facility to long-term residential facility and/or back home, which is also reviewed in the book Geriatrics.
44. Chinese Medical Therapies for Diabetes, Infertility, Silicosis and the Theoretical Basis.
- Author
-
Xing-Tai Li
- Subjects
Medicine ,Complementary Medicine ,Herbalism ,Health Sciences - Abstract
Summary: Traditional Chinese medicine (TCM) is the world's most comprehensive alternative and complementary medicine. With the rising morbidity of serious illnesses like diabetes, infertility, silicosis, etc., there are no highly effective treatments; even though Western medicine has made spectacular advances, this influenced us to seek Chinese medical therapies of health care. This book offers a unique perspective of Chinese medicine theories and therapies. It has practical chapters on diabetes, infertility, silicosis, kidney essence, and a compilation of contraindicated Chinese medicines for pregnancy. TCM is a treasure, and this ancient wisdom should be respected and applied to the modern medical system; it will provide more choices and a wider field of vision for Western medicine at the two cognitive crossroads of East and West.
45. Chronic HCV Infection: Clinical Advances and Eradication Perspectives.
- Author
-
Liberto, Maria Carla, Marascio, Nadia, and Liberto, Maria Carla
- Subjects
Medicine ,Epidemiology & medical statistics ,HCV ,rheumatic ,interferon ,mortality ,hepatitis C virus (HCV) ,phylogeny ,resistance-associated substitution (RAS) ,chronic hepatitis C ,vibration controlled transient elastography ,fibrosis ,steatosis ,hepatocellular carcinoma ,hepatitis C ,genotype 3 ,liver cirrhosis ,pangenotypic ,children ,ledipasvir/sofosbuvir ,real-life ,sustained virological response ,elimination ,model ,COVID-19 ,PWID ,homeless persons ,HCV eradication ,direct-acting antivirals ,out-of-hospital ,retention in care ,n/a - Abstract
Summary: Hepatitis C virus (HCV) chronic infection can determine liver fibrosis, cirrhosis and hepatocellular carcinoma, as well as several extra-hepatic manifestations (i.e., mixed cryoglobulinemia, metabolic syndrome, kidney disease, etc.). HCV infection is asymptomatic until severe stages of disease, thus screening policy in the general population and in specific risk categories is necessary to allow for timely intervention. Despite a high sustained virological response by direct-acting antiviral drugs, a limited percentage of treated subject failed therapy according to resistance associated substitution carried on viral isolates and comorbidities in infected patients. Therefore, tailored therapy is required to cure HCV infection. Failure to comply with these conditions may impair success of HCV eradication expected by 2030. This Special Issue aims to discuss eradication perspectives related to therapy efficacy in patients with chronic diseases, developments in diagnostic procedures and improvements in screening policy.
46. Clinical Features and Long-Term Outcomes of Systemic Lupus Erythematosus.
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Sjöwall, Christopher, Parodis, Ioannis, and Sjöwall, Christopher
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Medicine ,systemic lupus erythematosus ,quality of life ,cross-sectional studies ,surveys and questionnaires ,rheumatoid arthritis ,fatigue ,pain ,psychosocial ,disease activity ,health-related quality of life ,patient-reported outcomes ,clinical follow-up ,outcome measures ,abnormal liver function tests ,autoimmune liver diseases ,autoimmune hepatitis ,hepatic involvement ,liver biopsy ,primary biliary cholangitis ,COVID-19 ,hydroxychloroquine ,glucocorticoids ,epidemiology ,Systemic Lupus Erythematosus ,outcome ,mortality ,survival ,end-stage renal disease ,cancer ,cardiovascular disease ,infections ,neoplasm ,hospital admissions ,medication adherence ,compliance ,patient perspective ,qualitative research ,classification ,cluster analysis ,laboratory ,linear discriminant analysis ,genetics ,chronic damage ,polymorphisms ,TNFSF4 ,MIR1279 ,Ki/SL ,proteasome ,autoantibodies ,lupus ,SLE ,Sjögren syndrome ,flare ,damage ,long disease duration ,trajectories ,remission ,low disease activity ,comorbidities ,mood disorders ,low-disease activity ,patient outcome ,Afro-Caribbean ,systemic lupus ,lupus nephritis ,long-term prognosis ,dehydroepiandrosterone ,SLEDAI-2K ,n/a - Abstract
Summary: The clinical spectrum of systemic lupus erythematosus (SLE) is highly heterogeneous, ranging from mild disease, which can be limited to skin and joint involvement, to life-threatening conditions with renal impairment, severe cytopenias, central nervous system disease, and thromboembolic events. Apart from the host genetics, several environmental factors, such as sunlight, infections, drugs, and probably hormonal factors, can trigger the onset of symptoms related to SLE. Despite significant advances in our understanding of the pathophysiology and optimization of medical care, patients with SLE still have significant rates of premature mortality and many patients experience severe disease with increased risk of sustaining organ damage and having a reduced health-related quality of life. The development of effective drugs that can induce remission or low disease activity, the unanimous use of definitions of remission and low or high disease activity, flare, and response to therapy, the identification of non-invasive biomarkers of disease activity and long-term outcomes, and the implementation of SLE patients' perspectives as an integral part of the clinical assessment constitute only a few of the many unmet needs in the field of SLE.
47. Clinical Medicine for Healthcare and Sustainability.
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Meen, Teen-Hang, Matsumoto, Yusuke, Lee, Kuan-Han, and Meen, Teen-Hang
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Medicine ,sarcopenia ,bioimpedance analysis ,computed tomography ,discordance ,effect ,protection ,catheter ,hemodialysis ,meta-analysis ,trial sequential analysis ,Long-term oxygen therapy ,home mechanical ventilation ,patient-reported experience measures ,quality of care ,healthcare ,sustainability ,hepatocellular carcinoma ,health-related quality of life ,minimal clinically important difference ,survival ,serum urate ,menopause ,hypertension ,xanthine dehydrogenase ,cross-sectional cohort study ,diabetic foot ulcer ,peripheral arterial disease ,incidence ,prevalence ,cost ,National Health Insurance Service data ,erythrodermic psoriasis ,secukinumab ,addiction ,smoking ,alcohol ,cannabis ,virtual reality ,musculoskeletal disorders ,randomized controlled tria ,ceftaroline ,ceftriaxone ,community-acquired pneumonia ,safety ,eravacycline ,complicated intra-abdominal infection ,efficacy ,mortality ,laparoscopic ,open surgery ,non-metastatic colorectal cancer ,surgical complication ,oncologic outcome ,single surgeon experience ,doripenem ,acute bacterial infection ,pneumonia ,intra-abdominal infection ,complicated urinary tract infection ,ultrasound-guided injection ,laser assisted ,long-axis injection ,chronic disease ,multimorbidity ,suicidal thoughts ,suicidal plans ,stroke ,post-acute care ,medical referral system ,propensity score matching ,resistance training ,arterial pressure ,disease prevention ,caffeine ,older adults ,frailty ,medication ,primary care ,white matter hyperintensity ,MRI ,healthcare quotient ,chronic ,older adults living in super-aging society ,mild cognitive impairment ,walking speed ,depression ,urinary tract infection ,rapid culture ,antibiotic susceptibility testing (AST), evidence-based prescription ,antibiotics ,antimicrobial resistance (AMR), rapid diagnostics ,prediction ,deep learning ,conventional neural network ,bariatric surgery ,hospital emergency department ,queuing theory ,decision support ,cost optimization ,health behavior ,socioeconomic status ,Korea ,cardiovascular disease ,postprandial ,hypotension ,blood pressure ,elderly ,lung cancer ,physical activity ,season ,preoperative ,wearable ,macrosomia ,large for gestational age ,machine learning ,ensemble methods ,sensitivity ,specificity ,clinical deterioration ,early medical intervention ,electronic health records ,hospital rapid response team ,intensive care units ,medical records system ,computerized ,osteoporosis screening ,artificial intelligence ,convolutional neural networks ,dental panoramic radiographs ,palliative care ,nursing homes ,symptom assessment ,drug therapy ,therapeutics ,longitudinal studies ,occupational medicine ,forensic medicine ,insurance medicine ,psychoactive substances ,clinical ,forensic ,law ,ethics ,uric acid ,risk factor ,epidemiology ,cardiometabolic diseases ,healthcare and sustainability ,therapy of internal medicine diseases - Abstract
Summary: When the domestic government, the private sector, and people in various professional fields talk about long-term care issues, they all focus on creating a warm and home-like care institution. However, we actively emphasize the importance of community-based long-term care. For "aging in place", the development of domestic non-institutional care is still in its infancy, and some long-term care needs must still be met through institutional care, and the facilitation of the extension or outreach of community-based care and respite service platforms for the development of community-based long-term care still rely on institutional care. The history of the development of long-term care in Taiwan is much shorter than that of Japan, Europe, the United States, and Canada. Despite years of hard work and rapid development, the long-term care resources needed to establish a complete system in terms of universalization, fairness, accessibility, and selectivity are not available. In the future, based on the soundness of institutional care, it hoped that outreach will move toward the goals of community care and aging in place. We hope the studies in this Special Issue will help further develop clinical medicine for healthcare and stainability.
48. Clinical Studies, Big Data, and Artificial Intelligence in Nephrology and Transplantation.
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Cheungpasitporn, Wisit, Thongprayoon, Charat, Kaewput, Wisit, and Cheungpasitporn, Wisit
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Medicine ,tacrolimus ,C/D ratio ,tacrolimus metabolism ,everolimus ,conversion ,kidney transplantation ,gut microbiome ,renal transplant recipient ,diarrhea ,immunosuppressive medication ,gut microbiota ,16S rRNA sequencing ,butyrate-producing bacteria ,Proteobacteria ,torquetenovirus ,immunosuppression ,transplantation ,immunosuppressed host ,outcome ,renal transplantation ,Goodpasture syndrome ,anti-GBM disease ,epidemiology ,hospitalization ,outcomes ,acute kidney injury ,risk prediction ,artificial intelligence ,patent ductus arteriosus ,conservative management ,blood pressure ,eradication ,interferon-free regimen ,hepatitis C infection ,kidney transplant ,allograft steatosis ,lipopeliosis ,transplant numbers ,live donors ,public awareness ,Google TrendsTM ,machine learning ,big data ,nephrology ,chronic kidney disease ,NLR ,PLR ,RPGN ,predictive value ,hemodialysis ,withdrawal ,cellular crescent ,global sclerosis ,procurement kidney biopsy ,glomerulosclerosis ,minimally-invasive donor nephrectomy ,robot-assisted surgery ,laparoscopic surgery ,organ donation ,living kidney donation ,MeltDose® ,LCPT ,renal function ,liver transplantation ,metabolism ,erythropoietin ,fibroblast growth factor 23 ,death ,weekend effect ,in-hospital mortality ,comorbidity ,dialysis ,elderly ,klotho ,α-Klotho ,FGF-23 ,kidney donor ,Nephrology ,CKD-MBD ,CKD-Mineral and Bone Disorder ,deceased donor ,Eurotransplant Senior Program ,risk stratification ,intensive care ,kidney transplant recipients ,long-term outcomes ,graft failure ,cardiovascular mortality ,lifestyle ,inflammation ,vascular calcification ,bone mineral density ,dual-energy X-ray absorptiometry ,living donation ,repeated kidney transplantation ,graft survival ,prolonged ischaemic time ,patient survival ,pre-emptive transplantation ,metabolomics ,urine ,acute rejection ,allograft ,cystatin C ,hyperfiltration ,kidney injury molecule (KIM)-1 ,tubular damage ,genetic polymorphisms ,(cardiac) surgery ,inflammatory cytokines ,clinical studies ,chronic kidney disease (CKD) ,no known kidney disease (NKD) ,ICD-10 billing codes ,phenotyping ,electronic health record (EHR) ,estimated glomerular filtration rate (eGFR) ,machine learning (ML) ,generalized linear model network (GLMnet) ,random forest (RF) ,artificial neural network (ANN), clinical natural language processing (clinical NLP) ,discharge summaries ,laboratory values ,area under the receiver operating characteristic (AUROC) ,area under the precision-recall curve (AUCPR) ,fibrosis ,extracellular matrix ,collagen type VI ,living-donor kidney transplantation ,ethnic disparity - Abstract
Summary: In recent years, artificial intelligence has increasingly been playing an essential role in diverse areas in medicine, assisting clinicians in patient management. In nephrology and transplantation, artificial intelligence can be utilized to enhance clinical care, such as through hemodialysis prescriptions and the follow-up of kidney transplant patients. Furthermore, there are rapidly expanding applications and validations of comprehensive, computerized medical records and related databases, including national registries, health insurance, and drug prescriptions. For this Special Issue, we made a call to action to stimulate researchers and clinicians to submit their invaluable works and present, here, a collection of articles covering original clinical research (single- or multi-center), database studies from registries, meta-analyses, and artificial intelligence research in nephrology including acute kidney injury, electrolytes and acid-base, chronic kidney disease, glomerular disease, dialysis, and transplantation that will provide additional knowledge and skills in the field of nephrology and transplantation toward improving patient outcomes.
49. Clinical Trials in Vulnerable Populations.
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Milica Prostran
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Medicine ,Public Health ,Health Care ,Health Sciences - Abstract
Summary: This book Clinical Trials in Vulnerable Populations has 12 chapters divided into 4 sections: Minority Patients, Women, Medically Compromised Patients and Clinical Trials. Contributing authors came from several countries, from Serbia to Turkey. The book was edited by Professor Milica Prostran MD, Ph.D., specialist in Clinical Pharmacology. The potential reader is shown a modern approach to clinical trials in vulnerable populations, from different points of view. The chapters deal at length and clarity with their topics. Finally, I believe, that this book I edited and reviewed with dedication will capture the attention of many readers, from medical students to practicing doctors and pharmacists. All of whom must consider this very important field of medicine: clinical trials in vulnerable patients.
50. Contemporary and Innovative Practice in Palliative Care.
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Amanda Johnson and Esther Chang
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Medicine ,Public Health ,Global Health ,Health Sciences - Abstract
Summary: This book is designed to provide a comprehensive insight unto the key and most prevalent contemporary issues associated with palliation. The reader will find viewpoints that are challenging and sometimes discerning, but at the same time motivating and thought-provoking in the care of persons requiring palliation. This book is divided into three sections. Section 1 examines contemporary practice; Section 2 looks at the challenges in practice; Section 3 discusses models of care. This book is an excellent resource for students, practising clinicians and academics. By reading the book, reflecting on the issues, challenges and opportunities ahead, we hope it will create within the reader a passion to take on, explore and further develop their palliative care practice.
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