1. Implanted device for stress urinary incontinence by using soft technologies
- Author
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Chen, Hsing-Yu, Conn, Andrew, and Rossiter, Jonathan
- Subjects
soft robotics ,artificial muscle ,soft sensing ,wireless energy transfer ,soft actuator ,soft computing ,urinary incontinence - Abstract
Stress urinary incontinence refers to the unintentional leakage of urine, which is caused by weakening of, or damage to, urethral sphincters or pelvic floor muscles. Not only do the symptoms lead to physical discomfort or pain, but also the embarrassment and inconvenience significantly affects the quality of life, including social, familial, occupational, and sexual aspects. The use of inherently compliant and stretchable materials in soft robotics has driven a new class of biomedical devices which exhibit safe human interaction and embodied intelligent responses. This thesis focuses on the potential solutions for addressing the lack of occlusive pressure adaption in artificial urinary sphincter by employing soft robotic technologies. The research problem is decomposed into three different engineering topics: sensing, actuation, and control, which can correspond to receptors, muscles and the spinal cord or brain, respectively, in terms of human nervous system. For sensing, a stretchable sensor that can wirelessly measure various types of strain is developed, which can be used to remotely monitor physiological activities such as bladder volume or urethral pressure and provide essential information for feedback control. Regarding actuation, a new design of artificial urinary sphincter is proposed. It allows local urethral tissue to relax and potentially avoid ischemia, erosion or atrophy resulting from long-term compression. For control, a new approach of soft control and computing using liquid metal is investigated. The transformation from fluidic to electrical signals allows the device to respond to any sudden intra-abdominal pressure change and give extra support to the mid-urethra. In addition to the active modalities of sensing, actuation and control, an elastic artificial bladder is created which is more physically and physiologically similar to the proximal portion of the lower urinary tract system compared to the rigid funnel specified in the ISO standard, creating a novel platform for testing new catheters or artificial urinary sphincters. This thesis demonstrates different transformative soft technologies to solve the unmet health problems in urinary incontinence. The prototypes are experimentally characterised on the benchtop and demonstrate their functionalities, controllability, and the potential of being implanted. The combination of these technologies can lead to an active or passive pressure-adaptive device that can be compliant to physiological signals or user demands.
- Published
- 2022