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In the last ten years the prevalence of end-stage renal disease (ESRD) in women has risen from 281 to 485 per million. Chronic kidney disease (CKD) increases with age and is the precursor to ESRD. In this study, it was hypothesized that in women 50 years and older there is an association between reproductive factors and CKD. The National Health and Nutrition Examination Survey (NHANES) III and NHANES 1999-2002 datasets were used to examine this association. The reproductive portion of the NHANES gathered information on number of pregnancies and live births, having had a hysterectomy and age at first and last menses. After consideration of six estimating equations, the one published by Levey et al., adjusting for gender and race, was selected as optimum and used to estimate glomerular filtration rate (eGFR). An eGFR of