1. Localization of hemoglobin in MS cortex and its relevance to MS neuropathology
- Author
-
Brown, Nolan J.
- Subjects
- Neurobiology, Biology, Multiple sclerosis, hemoglobin, neuron, disease, degenerative
- Abstract
Multiple sclerosis (MS) is a neurodegenerative disease characterized by demyelination and progressive disability. Previous research has shown that the hemoglobin beta subunit (Hbb) is present in greater quantities in mitochondrial fractions of MS brains compared to non-diseased brains. Characterizing the presence of the Hbb in MS brains can help elucidate the causes and pathology of MS. This thesis aims to determine whether the presence of Hbb is preferentially increased in specific neuron types or in particular regions of the brain using immunohistochemistry and in situ hybridization techniques. Hbb protein has been successfully co-localized with neurofilament, tyrosine hydroxylase, and CD68 in post-mortem MS brain samples, and research is currently ongoing to co-localize Hbb mRNA with neurofilament and Hbb proteins.
- Published
- 2014