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Your search keyword '"Zhou, Hualan"' showing total 3 results
Start Over Author "Zhou, Hualan" Publication Type Conference Materials
3 results on '"Zhou, Hualan"'

2. Synthesis of phenyl (6-(2-fluoro-4-nitrophenoxy)pyrimidin-4-yl)carbamate.

Author

Gan, Wenhui, Wu, Jinjin, Zhou, Hualan, Liao, Min, Zhu, Wufu, Zheng, Pengwu, Xiao, Jun, Ke, Xiaotian, and Yang, Lv

Subjects
ANTINEOPLASTIC agents, ACYLATION
Abstract

Phenyl (6-(2-fluoro-4-nitrophenoxy)pyrimidin-4-yl)carbamate (7) was an important intermediate of many antitumor drugs, especially, it is widely used in small molecular inhibitors of anti-tumor. Compound 7 was synthesized from 6-chloropyrimidine-4-amine by acylation and nucleophilic substitution. The structures of the intermediates were confirmed by MS and 1H NMR. Furthermore, the synthetic method was optimized. [ABSTRACT FROM AUTHOR]

Published
2020
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