1. Preparations containing black cumin seed oil (BCSO) potential as an agent nephroprotective via P53 upregulation.
- Author
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Hidayati, Titiek and Akrom, Akrom
- Subjects
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BLACK cumin , *OILSEEDS , *VITAMIN C , *EXPERIMENTAL design , *CONTROL groups - Abstract
Study of the effect of administration of preparations containing BCSO on the expression of p53 in the kidney by means of immunohistochemistry. This study used the experimental design of the healthy control group I and the sick control group II, which was given alloxan. Group III BCSO dose of 6.8 mg/kg BW. Group IV BCSO dose of 68 mg/kgBB. Group V is the simvastatin-positive control group. Group VI is the positive control group for vitamin C. Group VII is the solvent control group. Use of the Mann-Whitney test. The results showed that the doses of BCSO 6.8 mg/KgBW and 68 mg/KgBW increased the percentage of p53 expression in alloxan-induced rat kidney tissue. The increase in p53 expression at doses of 6.8 and 68 mg/Kg BW was 92.93% and 218.38%, respectively. The BCSO dose of 6.8 mg/KgBW increased the percentage of p53 expression equivalent to the increase in p53 expression in the vitamin C group. The research results conclude that BCSO at a dose of 6.8 mg/KgBW and a dose of 68 mg/KgBW can increase the percentage of p53 expression in alloxan-induced rat kidney tissue and has the potential as a nephroprotective agent. agent. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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