Search

This review mainly focuses on the interaction of ionic liquids with two amphiphilic drugs. In this paper, the effect of amitriptyline hydrochloride (AMT) and promethazine hydrochloride on the aggregation behavior of two imidazolium based ionic liquids 1-dodecyl-3-methylimidazolium chloride and 1-decyl-3-methylimidazoliumhydrochloride respectively has been investigated at different concentrations and temperatures by employing conductivity measurements. As imidazolium based ionic liquids are biologically active because of the presence of imidazolium ring that is present in many amino acids. So the interaction between long alkyl chain ionic liquids and various drugs may have their role in drug delivery as these ionic liquids form micelles in aqueous solution. Various parameters such as critical micelle concentration other parameters have been obtained from conductivity measurement. The dependency of CMC value obtained from conductivity measurements in absence as well as in presence of different concentrations of drug have been used to evaluate various thermodynamic parameters. The CMC value rise with increasing concentration of drug AMT while an unusual trend was obtained in case of drug promethazine hydrochloride with rise in temperature. [ABSTRACT FROM AUTHOR]

Promethazine Hydrochloride (PTZ) is an antihistaminic drug widely used in various clinical applications. Due to the fact that PTZ is oxygen sensitive, in many applications it needs to be loaded into an insoluble matrix. Among the drug loading and release matrix, synthetic zeolite 13X is one of the most suitable. In this paper, we performed a study for the drug adsorption/release, using a zeolite matrix. The drug adsorption/release studies have been performed for different PTZ concentrations and different amount of zeolite, using UV-Vis spectroscopy. Langmuir and Freundlich adsorption isotherms were used to correlate the equilibrium adsorption data. Pseudo-first and pseudo-second order kinetic models were applied to describe the adsorption process. The adsorption yield was calculated to be 61.76%. Freundlich isotherm was found to be more suitable for describing the adsorption-desorption equilibrium data of PTZ into zeolites and the kinetic data fitted well the pseudo-second-order model. [ABSTRACT FROM AUTHOR]