1. Paramagnetic Europium Salen Complex and Sickle-Cell Anemia.
- Author
-
Wynter, Clive I., Ryan, D. H., May, Leopold, Oliver, F. W., Brown, Eugene, Hoffman, Eugene J., and Bernstein, David
- Subjects
SICKLE cell anemia ,ANALYTICAL chemistry ,SPECTRUM analysis ,BLOOD cells ,QUALITATIVE chemical analysis ,BLOOD diseases - Abstract
A new europium salen complex, Eu(salen)2NH4, was synthesized, and its composition was confirmed by chemical analysis and infrared spectroscopy. Further characterization was carried out by 151 Eu Mössbauer spectroscopy and magnetic susceptibility measurements. Mössbauer spectroscopic measurements were made at varying temperatures between 9 K and room temperature and a value of Debye temperature of 133 ±5 K was computed. Both Mössbauer and magnetic susceptibility measurements confirmed the paramagnetic behavior of this complex and the trivalent state of the europium ion. In view of the fact that the “odd” paramagnetic molecule NO has been shown to reverse sickling of red blood cells in sickle cell anemia, the interaction between the paramagnetic europium salen complex and sickle cells was examined after incubation with this europium complex and shown to have similar effects. © 2005 American Institute of Physics [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF