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Rapid growth in capacity makes flow-based micro fluidic biochips a promising candidate for biochemical analysis because they can integrate more complex functions. However, as the number of components grows, the total length of flow channels between components must increase exponentially. Recent empirical studies show that long flow channels are vulnerable due to blocking and leakage defects. Thus, it is desirable to minimize the total length of flow channels for robustness. Also, for timing-sensitive biochemical assays, increase in the longest length of flow channel will delay the assay completion time and lead to variation of fluid, thereby affecting the correctness of outcome. The increasing number of components, including the pre-placed components, on the chip makes the flow channel routing problem even more complicated. In this paper, we propose an efficient obstacle-avoiding rectilinear Steiner minimum tree algorithm to deal with flow channel routing problem in flow-based micro fluidic biochips. Based on the concept of Kruskal algorithm and formulating the considerations as a bi-criteria function, our algorithm is capable of simultaneously minimizing the total length and the longest length of flow channel. [ABSTRACT FROM AUTHOR]

We consider the multi-layer obstacle-avoiding rectilinear Steiner minimal tree (OARSMT) problem and propose a reduction to transform a multi-layer instance into a 3D instance. Based on the reduction we apply computational geometry techniques to develop an efficient algorithm, utilizing existing OARSMT heuristics. Experimental results show that our algorithm provides a solution with excellent quality and has a significant speed-up compared to previously known results. [ABSTRACT FROM AUTHOR]

We consider the multi-layer obstacle-avoiding rectilinear Steiner minimal tree (OARSMT) problem and propose a reduction to transform a multi-layer instance into a 3D instance. Based on the reduction we apply computational geometry techniques to develop an efficient algorithm, utilizing existing OARSMT heuristics. Experimental results show that our algorithm provides a solution with excellent quality and has a significant speed-up compared to previously known results. [ABSTRACT FROM AUTHOR]

Visual domain adaptation addresses the problem of adapting the sample distribution of the source domain to the target domain, where the recognition task is intended but the data distributions are different. In this paper, we present a low-rank reconstruction method to reduce the domain distribution disparity. Specifically, we transform the visual samples in the source domain into an intermediate representation such that each transformed source sample can be linearly reconstructed by the samples of the target domain. Unlike the existing work, our method captures the intrinsic relatedness of the source samples during the adaptation process while uncovering the noises and outliers in the source domain that cannot be adapted, making it more robust than previous methods. We formulate our problem as a constrained nuclear norm and ℓ2, 1 norm minimization objective and then adopt the Augmented Lagrange Multiplier (ALM) method for the optimization. Extensive experiments on various visual adaptation tasks show that the proposed method consistently and significantly beats the state-of-the-art domain adaptation methods. [ABSTRACT FROM PUBLISHER]