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48 results on '"Jakes A"'

5. Mepolizumab Reduces Clinically Significant Exacerbations in Patients With Severe Asthma Prior to and During the COVID-19 Pandemic: Results From the Real-world REALITI-A Study

Author

Schleich, F., primary, Lougheed, M.D., additional, Matucci, A., additional, Rodriguez Hermosa, J.L., additional, Pfeffer, P., additional, Verghis, R.M., additional, Jakes, R.W., additional, Alfonso-Cristancho, R., additional, Liu, M.C., additional, Welte, T., additional, Bals, R., additional, and Howarth, P., additional

Published
2023
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11. Mepolizumab effectiveness in severe asthma supported by federated analysis of European SHARP data

Author

Kroes, J A, primary, Alfonso-Cristancho, R, additional, Bansal, A T, additional, Berret, E, additional, Bieksiene, K, additional, Bourdin, A, additional, Brussino, L, additional, Canhoto, D, additional, Cardini, C, additional, Celik, G, additional, Csoma, Z, additional, Dahlén, B, additional, Damadoğlu, E, additional, Eger, K, additional, Gauquelin, L, additional, Gemicioglu, B, additional, Goksel, O, additional, Graff, S, additional, Heffler, E, additional, Hofstee, H B, additional, Howarth, P, additional, Jakes, R, additional, Jaun, F, additional, Kalinauskaite-Zukauske, V, additional, Kopač, P, additional, Kwon, N, additional, Loureiro, C C, additional, Lozoya García, V, additional, Masoli, M, additional, Paula Rezelj, M, additional, Pérez De Llano, L, additional, Popović-Grle, S, additional, Ramos-Barbon, D, additional, Sà Sousa, A, additional, Samitas, K, additional, Schleich, F, additional, Sirena, C, additional, Skrgat, S, additional, Zervas, E, additional, Zichnalis, G, additional, Bel, E H, additional, Sont, J K, additional, Hashimoto, S, additional, and Ten Brinke, A, additional

Published
2022
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15. The Impact of Comorbidities and Clinical Characteristics on Real-World Mepolizumab Effectiveness in Patients with Severe Asthma: Results from the REALITI-A Study

Author

Chupp, G.L., primary, Heaney, L.G., additional, Pelaia, G., additional, Welte, T., additional, Almonacid Sanchez, C., additional, Lee, J.K., additional, Maxwell, A., additional, Price, R.G., additional, Jakes, R.W., additional, Alfonso Cristancho, R., additional, Howarth, P., additional, and Brusselle, G., additional

Published
2022
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16. National Differences in Real-World Outcomes with Mepolizumab Treatment for Patients with Severe Asthma: Results from the REALITI-A Study

Author

Lee, J.K., primary, Schleich, F., additional, Canonica, G.W.W., additional, Muñoz, X., additional, Chaudhuri, R., additional, Lee, F.E.-H., additional, Howarth, P., additional, Price, R.G.G., additional, Yang, S., additional, Jakes, R.W.W., additional, Maxwell, A., additional, and Alfonso Cristancho, R., additional

Published
2022
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18. Late Breaking Abstract - International, prospective real-world study of mepolizumab in patients with severe asthma at one year: REALITI-A

Author

Pilette, Charles, primary, Canonica, Giorgio Walter, additional, Chaudhuri, Rekha, additional, Lee, F. Eun-Hyung, additional, Lee, Jason Kihyuk, additional, Almonacid Sanchez, Carlos, additional, Alfonso-Cristancho, Rafael, additional, Jakes, Rupert, additional, Maxwell, Aoife, additional, Price, Robert, additional, and Howarth, Peter, additional

Published
2021
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20. How Real-World Mepolizumab Users in the REALITI-A Study Relate to the Recruitment Criteria Applied in the Randomized, Placebo-Controlled Trials of Subcutaneous Mepolizumab in Severe Eosinophilic Asthma

Author

Ramos-Barbon, D., primary, Bals, R., additional, Crimi, N., additional, Menzies, D., additional, Pek, B., additional, Pilette, C., additional, Steven, G., additional, Alfonso-Cristancho, R., additional, Jakes, R., additional, Maxwell, A.C., additional, Price, R.G., additional, Yang, S., additional, and Howarth, P., additional

Published
2021
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29. School Closure Policy in Ontario.

Author

Jakes, Harold E.

Abstract

In contrast to the problems and policies of school boards of the 1950's and 1960's, when school enrollments increased at an unprecedented rate, the problems of school boards in the 1970's became those of retrenchment. Responding to the issues of declining enrollments and fiscal restraints, the Ontario Ministry of Education in 1981 required every school board in the province to develop, approve, and publicize a school closure policy for use within its jurisdiction. This document reports on a study of the 98 resulting school closure policies to determine (1) the criteria used in the decisionmaking, (2) the internal factors affecting the decision, (3) the external factors influencing the decisionmaking, and (4) the implementation of the plans themselves. The study also incorporated the data into a model depicting the process of school closure decisionmaking employed by Ontario school boards. After a description of the theoretical rationale and methodology of the study, the document presents the findings of three stages of the study: study and review, decisionmaking, and implementation. Most policies were very complete in stage 1, less complete in stage 2, and relatively incomplete in stage 3, indicating a need for further research of both successful and unsuccessful decision and implementation strategies. (IW)

Published
1984

41. EPR study of Sc[sub 3]N@C[sub 80] radical anions.

Author

Jakes, P. and Dinse, K.-P.

Subjects
ANIONS, ELECTRON paramagnetic resonance, COUPLING constants
Abstract

The EPR spectrum of radical anions of Sc[sub3]N-doped C[sub80] is characterized by a very large isotropic Scandium hyperfine coupling constant (hfcc) (a[subiso] = 5.56 mT). The existence of three magnetically equivalent Sc nuclei indicates fast internal motion of the encased cluster. The large hfcc could indicate that not only significant spin transfer but also charge transfer from cage to cluster occurs upon reduction. [ABSTRACT FROM AUTHOR]

Published
2001

44. Synthesis and EPR studies of N@C[sub 60] and N@C[sub 70] radical anions.

Author

Jakes, P., Goedde, B., Waiblinger, M., Weiden, N., Dinse, K.-P., and Weidinger, A.

Subjects
ANIONS, LITHIUM
Abstract

Dilute solutions of anion radicals produced from enriched endohedral N@C[sub 60] and N@C[sub 70] samples were prepared by reduction with lithium in tetrahydrofuran (THF). EPR spectra were measured at room temperature with a Bruker X-Band spectrometer. Although EPR signals from mono- to penta-anions of empty fullerenes gave characteristic signals, no signals could be detected for these reduction states originating from endohedral nitrogen. We believe that increased spin relaxation rates of states of higher spin multiplicity cause a line broadening impeding detection. Continuing reduction finally resulted in the diamagnetic hexaanions, detected by vanishing EPR signals of empty fullerenes and a reappearence of the characteristic three line spectrum of endofullerenes. The chemical shift was quite similar to those measured by the point-like ³He. [ABSTRACT FROM AUTHOR]

Published
2000

45. Squeezing and shielding of atoms in fullerene traps.

Author

Dinse, K.-P., Weiden, N., Goedde, B., Jakes, P., Waiblinger, M., and Weidinger, A.

Subjects
FULLERENES, NITROGEN
Abstract

Ideal trapping behaviour was recently discovered for nitrogen incased in C[sub 60] and C[sub 70], although significant increase of Fermi contact interaction gave evidence for compression of the atomic spin distribution. Fullerene cages therefor are candidates for the study of atomic orbital interaction with inert confinements. Prolate deformation of the spin and charge distribution of nitrogen in C[sub 70] was detected by high resolution ENDOR spectroscopy. Magnetic shielding averaged over the extended electronic orbitals in poly anions of fullerenes was found to be similar but not identical to the values measured for helium atoms at the cage center of the cages. [ABSTRACT FROM AUTHOR]

Published
2000

46. Magnetic interaction in diluted N@C[sub 60].

Author

Waiblinger, M., Goedde, B., Lips, K., Harneit, W., Jakes, P., Weidinger, A., and Dinse, K.-P.

Subjects
NITROGEN compounds, MAGNETIC dipoles
Abstract

Nitrogen in C[sub 60] is a paramagnetic atom with a magnetic moment corresponding to the S = 3/2 electronic spin. The dipolar interaction of two N@C[sub 60] at closest distance, i.e. 1 nm apart, reaches a maximum value of 1.85 mT or 52 MHz, more than three times larger than the hyperfine interaction with the nuclear spin. For diluted N@C[sub 60] in a C[sub 60] matrix, the distribution of interactions leads to a line broadening in EPR experiments. We report here on a EPR line width measurement for N@C[sub 60] in C[sub 60] with concentrations varying by a factor of 1000. For the first time a concentration in the percent range was reached by repeated HPLC enrichment. A surprising and completely unexpected result is that sharp lines appear superimposed on the broad lines. We attribute the sharp line to motional narrowing of N@C[sub 60] diffusing on the surface of C[sub 60] grains. It can be assumed that the diffusion seen here is a general phenomenon of C[sub 60], the doped fullerene being just the indicator. [ABSTRACT FROM AUTHOR]

Published
2000

47. N@C[sub 120]—the first step to endohedral polymers.

Author

Goedde, B., Waiblinger, M., Jakes, P., Weiden, N., Dinse, K.-P., and Weidinger, A.

Subjects
POLYMERIZATION, DIMERS
Abstract

Introducing an endohedral atom in one of the cages of the dimer opens the possibility to get information about changes in the electronic structure of the molecule due to polymerization. Nitrogen is known to form a stable endohedral fullerene and can be used for further chemical processing. In this contribution we will present first EPR results of the dimer being ‘doped’ with nitrogen in one of the cages. Zero Field Splitting induced by cage distortion is significantly larger than that found in the monoadduct (C[sub 2v]-N@C[sub 61] (COOCH[sub 2]CH[sub 3])[sub 2]). [ABSTRACT FROM AUTHOR]

Published
2000

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