1. Phytochemical analysis and antimicrobial activity of Thymus serphyllum against pathogenic bacteria and fungus.
- Author
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Sadiq, Arbeena, Antony, Louis Cojandaraj, and Murtaza, Imtiyaz
- Subjects
ANTI-infective agents ,ESCHERICHIA coli ,THYMUS ,PATHOGENIC fungi ,GALLIC acid ,PATHOGENIC bacteria - Abstract
Plants have been used since ancient times for the prevention and protection against infectious diseases. Plants from the genus Thymus are important medicinal herbs, which are known to contain antimicrobial agents. In this context, a study was done to evaluate the phytochemical and antimicrobial activity of Thymus serphyllum grown in the Kashmir valley. The aqueous extract of T. serphyllum showed a significant inhibitory effect against the growth of Eschernia coli (E. coli), Staphylococcus aureus, and Fusarium oxysporum but was resistant to Pseudomonas aeruginosa. The zone of inhibition for E. coli, S. aureus, and F. oxysporum ranged from 10 to 15 mm, 9 to 11mm, and 5 to 15mm respectively indicating a remarkable antibacterial effect when compared with that of antibiotics in the positive control, which ranged from 6 to 11mm, 7 to 10mm, 7 to 13mm and 4 to 12mm for E. coli, S. aureus, P. aeruginosa, and F. oxysporum respectively. Further, the aqueous extract of T. serphyllum revealed a total phenolic content of 18.065±2.51mg/100g gallic acid equivalent/g, flavonoid content of 414.4±0.152753mg/100g quercetin equivalent/g, and total antioxidant activity as 72.66±0.25 µM Ferric reducing ability of Plasma /gram (FRAP/g). Our findings suggest that the aqueous extract of T. serphyllum possessed antibacterial and antifungal properties due to its high phenolic, flavonoid, and antioxidant content as compared to the tested drug (Amoxicillin and Azithromycin). [ABSTRACT FROM AUTHOR]
- Published
- 2023
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