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The possibilities of realizing a low-neutron fusion reactor with a mixture of deuterium and helium-3 are analyzed. Various systems of magnetic confinement are considered taking into account the current state of research. The concepts of fusion reactors involve the use of current technologies and the extrapolation of plasma parameters to the fusion conditions when scaling the size and power. The possibilities of helium-3 production and the expediency of its delivery from the Moon are discussed. The main advantage of the reactor on a mixture of deuterium and helium-3 is low radioactivity. Therefore, the realization of energy production through nuclear fusion reactions may be associated with the use of this type of fuel cycle. The delivery of helium-3 from the Moon may be necessary not only for low-neutron fusion energy, but also inevitable in connection with the needs of neutron monitoring and radioactive material detection systems. [ABSTRACT FROM AUTHOR]