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The search for new biomaterials in the bone reconstitution field is growing continuously as humane life expectation and bone fractures increase. For this purpose, composite materials with biodegradable polymers and hydroxyapatite (HA) have been used. A composite material formed by a film, nanofibers and HA has been made. Both, the films and the non-woven mats of nanofibers were formed by nanocomposites made of butylene adipate-co-terephthalate (PBAT) and HA. The techniques used to produce the films and nanofibers were spin coating and electrospinning, respectively. The composite production and morphology were evaluated. The composite showed an adequate morphology and fibers size to be used as scaffold for cell growth. [ABSTRACT FROM AUTHOR]

In the present work we describe a novel route for preparation of biomimetic bone scaffolds based on biopolymers as chitosan (Cs), hyaluronic acid (Hya), chondroitin sulfate (ChS) and calcium phosphate (CP). The biopolymers-CP composite scaffolds were analyzed by Fourier transformed infrared spectroscopy, scanning electron microscopy, X-ray diffraction, mechanical test, cell culture and MTS (3-(4, 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfo-phenyl)-2H-tetrazolium) assay. The results show the interactions among biopolymers and CP through chemical bond interactions between Ca ions and -OH groups of CP, -NH3+ groups of Cs and -OSO3• groups of ChS or -COO• groups of Hya and -NH2 or -OH groups of Cs. The different forms of CP obtained, combined with the mixture of biopolymers highlight the prospective use of these composite scaffolds in bone tissue engineering. The scaffolds compositions have no negative effect on cell, emphasizing a good biocompatibility. [ABSTRACT FROM PUBLISHER]