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Magnetically sensitive lipid composites containing cytostatic were synthesized, found their conditions of nondestructive sterilization. Investigation in the reactions in vitro and in vivo were carried out. [ABSTRACT FROM PUBLISHER]

The complexes of rare earth element Eu3+ and Dy3+ with quercetin were synthesized and characterized by elemental analysis, molar conductance, FTIR and UV-Vis spectra. The antitumor activities of the ligand and complexes were assayed against human hepatocarcinoma cell line HepG2 by MTT colorimetric assay. The results indicate that the formulas of the compounds are EuC15H8O7Cl10•6H2O and DyC15H8O7Cl2•6H2O. MTT assay showed that Quercetin, Eu3+-quercetin and Dy3+-quercetin dose dependently inhibited the proliferation of HepG2 cells, and the proliferation inhibition rates of cell treated with rare earth ion complexes of quercetin were significantly higher than those treated with quercetin. The antitumor activities of the complexes are markedly stronger than that of the ligand. [ABSTRACT FROM PUBLISHER]

As a part of trials to develop the antitumor agent from tannins, the antitumor activity of pedunculagin, an ellagitannin, isolated from eucalyptus leaves, was reported in this paper. In vitro, the antitumor activity was determined by MTT assay. Pedunculagin showed the dose-dependent antitumor activity against human liver tumor cells (QGY-7703), the 50% inhibition concentration (IC50) was (64.3±6.1)µg/mL, Under microscope, holes-like structure was observed on the membrane of tumor cells, which co-cultured with pedunculagin, but it was negative for human normal cell (HEB), this means pedunculagin can change the structure of tumor cell membrane specifically, when 5-Fu was mixed with 5µg/mL of pedunculagin, the IC50 of 5-Fu greatly reduced to (0.9±0.6) µg/mL from (5.9±2.2) µg/mL, the probably reason is that pedunculagin can improve the permeability of tumor cell membrane. This paper first reports the phenomena of holes-like structure on the membrane of tumor cells caused by pedunculagin. [ABSTRACT FROM PUBLISHER]