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Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that can cause significant social, communication, and behavioral challenges. Recently, Virtual Reality (VR) has emerged to play a significant role in enhancing some of the treatments of autism spectrum disorder. Studies have shown that VR has been used to enhance various aspects of communication, social, and cognitive skills among autism spectrum disorder patients. However, experts of the ASD community still lack a comprehensive understanding of how VR can be used in the autism spectrum disorder treatment process. This systematic review has the objective of exploring how VR has been applied in the ASD domain to date. The identification process produced 353 papers from 11 different databases. After applying the exclusion criteria, the set was reduced to 34 papers, which clearly fitted the criteria defined for the accomplishment of the systematic review, which were then further analyzed and classified. As a result, we highlight several key elements or factors that are imperative to understanding how VR is applied in the ASD domain. From the studies analyzed, there is evidence that indicates that VR based treatments can help children with ASD. Nevertheless, the promising results and the advantages of virtual reality (especially considering ASD symptomatology) should encourage the scientific community to further develop new or more advanced VR based treatments by further exploring the key factors that may hinder or challenge the development of VR for the ASD domain. [ABSTRACT FROM AUTHOR]